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PAR1_HUMAN

GO
G2C
SynGO
SynaptomeDB

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PAR1_HUMAN
GO:0001664 G protein-coupled receptor binding 40.0000 4 no
GO:0043169 cation binding 40.0000 4 no
GO:0046872 metal ion binding 40.0000 5 no
GO:0000166 nucleotide binding 30.0000 4 no
GO:0003924 GTPase activity 30.0000 7 no
GO:0005525 GTP binding 30.0000 5 no
GO:0016462 pyrophosphatase activity 30.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 30.0000 4 no
GO:0017076 purine nucleotide binding 30.0000 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 30.0000 6 no
GO:0019001 guanyl nucleotide binding 30.0000 6 no
GO:0032555 purine ribonucleotide binding 30.0000 4 no
GO:0032561 guanyl ribonucleotide binding 30.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 no
GO:0043168 anion binding 30.0000 4 no
GO:0001648 proteinase-activated receptor activity 20.0000 5 yes
GO:0004930 G protein-coupled receptor activity 20.0000 4 yes
GO:0008528 G protein-coupled peptide receptor activity 20.0000 4 yes
GO:0015057 thrombin-activated receptor activity 20.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PAR1_HUMAN
GO:0009966 regulation of signal transduction 70.0000 4 yes
GO:0010646 regulation of cell communication 70.0000 4 yes
GO:0031323 regulation of cellular metabolic process 70.0000 4 yes
GO:0048522 positive regulation of cellular process 70.0000 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 yes
GO:0042127 regulation of cell population proliferation 50.0000 4 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:0080090 regulation of primary metabolic process 50.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 50.0000 5 yes
GO:0006996 organelle organization 40.0000 4 yes
GO:0008284 positive regulation of cell population proliferation 40.0000 5 yes
GO:0009889 regulation of biosynthetic process 40.0000 4 yes
GO:0009893 positive regulation of metabolic process 40.0000 4 yes
GO:0009967 positive regulation of signal transduction 40.0000 5 yes
GO:0010468 regulation of gene expression 40.0000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 40.0000 5 yes
GO:0010647 positive regulation of cell communication 40.0000 5 yes
GO:0016050 vesicle organization 40.0000 5 yes
GO:0023056 positive regulation of signaling 40.0000 4 yes
GO:0030334 regulation of cell migration 40.0000 5 yes
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 yes
GO:0048584 positive regulation of response to stimulus 40.0000 4 yes
GO:0051046 regulation of secretion 40.0000 5 yes
GO:0051240 positive regulation of multicellular organismal process 40.0000 4 yes
GO:0051246 regulation of protein metabolic process 40.0000 5 yes
GO:1902533 positive regulation of intracellular signal transduction 40.0000 6 yes
GO:1903530 regulation of secretion by cell 40.0000 4 yes
GO:2000145 regulation of cell motility 40.0000 4 yes
GO:0008104 protein localization 40.0000 4 no
GO:0006355 regulation of DNA-templated transcription 30.0000 7 yes
GO:0006811 monoatomic ion transport 30.0000 4 yes
GO:0006812 monoatomic cation transport 30.0000 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 30.0000 4 yes
GO:0008285 negative regulation of cell population proliferation 30.0000 5 yes
GO:0009891 positive regulation of biosynthetic process 30.0000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 30.0000 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 30.0000 5 yes
GO:0010959 regulation of metal ion transport 30.0000 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.0000 5 yes
GO:0030001 metal ion transport 30.0000 6 yes
GO:0030335 positive regulation of cell migration 30.0000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 30.0000 6 yes
GO:0033363 secretory granule organization 30.0000 6 yes
GO:0034330 cell junction organization 30.0000 4 yes
GO:0034762 regulation of transmembrane transport 30.0000 4 yes
GO:0040017 positive regulation of locomotion 30.0000 4 yes
GO:0042981 regulation of apoptotic process 30.0000 5 yes
GO:0043066 negative regulation of apoptotic process 30.0000 6 yes
GO:0043067 regulation of programmed cell death 30.0000 4 yes
GO:0043069 negative regulation of programmed cell death 30.0000 5 yes
GO:0043085 positive regulation of catalytic activity 30.0000 4 yes
GO:0043122 regulation of canonical NF-kappaB signal transduction 30.0000 6 yes
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 30.0000 7 yes
GO:0043269 regulation of monoatomic ion transport 30.0000 5 yes
GO:0043408 regulation of MAPK cascade 30.0000 6 yes
GO:0043410 positive regulation of MAPK cascade 30.0000 7 yes
GO:0045216 cell-cell junction organization 30.0000 5 yes
GO:0045893 positive regulation of DNA-templated transcription 30.0000 8 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 30.0000 5 yes
GO:0050804 modulation of chemical synaptic transmission 30.0000 5 yes
GO:0051048 negative regulation of secretion 30.0000 5 yes
GO:0051050 positive regulation of transport 30.0000 4 yes
GO:0051051 negative regulation of transport 30.0000 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 30.0000 6 yes
GO:0051241 negative regulation of multicellular organismal process 30.0000 4 yes
GO:0051252 regulation of RNA metabolic process 30.0000 5 yes
GO:0051254 positive regulation of RNA metabolic process 30.0000 6 yes
GO:0051336 regulation of hydrolase activity 30.0000 4 yes
GO:0051345 positive regulation of hydrolase activity 30.0000 5 yes
GO:0051924 regulation of calcium ion transport 30.0000 7 yes
GO:0060155 platelet dense granule organization 30.0000 7 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 30.0000 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 30.0000 8 yes
GO:0098655 monoatomic cation transmembrane transport 30.0000 4 yes
GO:0098662 inorganic cation transmembrane transport 30.0000 4 yes
GO:0099177 regulation of trans-synaptic signaling 30.0000 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 30.0000 7 yes
GO:1903531 negative regulation of secretion by cell 30.0000 5 yes
GO:2000147 positive regulation of cell motility 30.0000 5 yes
GO:2001141 regulation of RNA biosynthetic process 30.0000 6 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 30.0000 4 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 30.0000 5 no
GO:0050865 regulation of cell activation 30.0000 4 no
GO:0015031 protein transport 30.0000 4 no
GO:0071702 organic substance transport 30.0000 4 no
GO:0071705 nitrogen compound transport 30.0000 4 no
GO:0001817 regulation of cytokine production 20.0000 4 yes
GO:0001819 positive regulation of cytokine production 20.0000 5 yes
GO:0001894 tissue homeostasis 20.0000 4 yes
GO:0001977 renal system process involved in regulation of blood volume 20.0000 5 yes
GO:0002237 response to molecule of bacterial origin 20.0000 4 yes
GO:0002248 connective tissue replacement involved in inflammatory response wound healing 20.0000 4 yes
GO:0003018 vascular process in circulatory system 20.0000 4 yes
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 20.0000 4 yes
GO:0003073 regulation of systemic arterial blood pressure 20.0000 4 yes
GO:0003093 regulation of glomerular filtration 20.0000 6 yes
GO:0003105 negative regulation of glomerular filtration 20.0000 5 yes
GO:0006816 calcium ion transport 20.0000 7 yes
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 20.0000 10 yes
GO:0006937 regulation of muscle contraction 20.0000 6 yes
GO:0006940 regulation of smooth muscle contraction 20.0000 7 yes
GO:0006954 inflammatory response 20.0000 4 yes
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 20.0000 4 yes
GO:0007529 establishment of synaptic specificity at neuromuscular junction 20.0000 6 yes
GO:0010628 positive regulation of gene expression 20.0000 7 yes
GO:0010712 regulation of collagen metabolic process 20.0000 4 yes
GO:0010714 positive regulation of collagen metabolic process 20.0000 5 yes
GO:0010950 positive regulation of endopeptidase activity 20.0000 7 yes
GO:0010952 positive regulation of peptidase activity 20.0000 6 yes
GO:0019229 regulation of vasoconstriction 20.0000 6 yes
GO:0030162 regulation of proteolysis 20.0000 6 yes
GO:0030193 regulation of blood coagulation 20.0000 4 yes
GO:0030194 positive regulation of blood coagulation 20.0000 5 yes
GO:0031644 regulation of nervous system process 20.0000 5 yes
GO:0032101 regulation of response to external stimulus 20.0000 4 yes
GO:0032496 response to lipopolysaccharide 20.0000 4 yes
GO:0032651 regulation of interleukin-1 beta production 20.0000 6 yes
GO:0032652 regulation of interleukin-1 production 20.0000 5 yes
GO:0032675 regulation of interleukin-6 production 20.0000 5 yes
GO:0032677 regulation of interleukin-8 production 20.0000 5 yes
GO:0032755 positive regulation of interleukin-6 production 20.0000 6 yes
GO:0032757 positive regulation of interleukin-8 production 20.0000 6 yes
GO:0032880 regulation of protein localization 20.0000 5 yes
GO:0032965 regulation of collagen biosynthetic process 20.0000 5 yes
GO:0032967 positive regulation of collagen biosynthetic process 20.0000 6 yes
GO:0033993 response to lipid 20.0000 4 yes
GO:0034331 cell junction maintenance 20.0000 5 yes
GO:0034764 positive regulation of transmembrane transport 20.0000 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 20.0000 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 20.0000 6 yes
GO:0035023 regulation of Rho protein signal transduction 20.0000 7 yes
GO:0035025 positive regulation of Rho protein signal transduction 20.0000 8 yes
GO:0035150 regulation of tube size 20.0000 4 yes
GO:0035296 regulation of tube diameter 20.0000 5 yes
GO:0043087 regulation of GTPase activity 20.0000 5 yes
GO:0043270 positive regulation of monoatomic ion transport 20.0000 5 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 20.0000 9 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 20.0000 8 yes
GO:0043523 regulation of neuron apoptotic process 20.0000 6 yes
GO:0043524 negative regulation of neuron apoptotic process 20.0000 7 yes
GO:0043547 positive regulation of GTPase activity 20.0000 6 yes
GO:0043954 cellular component maintenance 20.0000 4 yes
GO:0044057 regulation of system process 20.0000 4 yes
GO:0044060 regulation of endocrine process 20.0000 5 yes
GO:0045217 cell-cell junction maintenance 20.0000 6 yes
GO:0045862 positive regulation of proteolysis 20.0000 7 yes
GO:0045907 positive regulation of vasoconstriction 20.0000 5 yes
GO:0045933 positive regulation of muscle contraction 20.0000 5 yes
GO:0045987 positive regulation of smooth muscle contraction 20.0000 6 yes
GO:0046425 regulation of receptor signaling pathway via JAK-STAT 20.0000 6 yes
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 20.0000 7 yes
GO:0048873 homeostasis of number of cells within a tissue 20.0000 4 yes
GO:0050708 regulation of protein secretion 20.0000 5 yes
GO:0050709 negative regulation of protein secretion 20.0000 6 yes
GO:0050808 synapse organization 20.0000 5 yes
GO:0050818 regulation of coagulation 20.0000 4 yes
GO:0050820 positive regulation of coagulation 20.0000 5 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 20.0000 7 yes
GO:0051209 release of sequestered calcium ion into cytosol 20.0000 6 yes
GO:0051223 regulation of protein transport 20.0000 5 yes
GO:0051224 negative regulation of protein transport 20.0000 5 yes
GO:0051247 positive regulation of protein metabolic process 20.0000 6 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 20.0000 5 yes
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 20.0000 6 yes
GO:0051282 regulation of sequestering of calcium ion 20.0000 4 yes
GO:0051283 negative regulation of sequestering of calcium ion 20.0000 5 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 20.0000 6 yes
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 20.0000 7 yes
GO:0051928 positive regulation of calcium ion transport 20.0000 6 yes
GO:0051930 regulation of sensory perception of pain 20.0000 7 yes
GO:0051931 regulation of sensory perception 20.0000 6 yes
GO:0052547 regulation of peptidase activity 20.0000 5 yes
GO:0052548 regulation of endopeptidase activity 20.0000 6 yes
GO:0060341 regulation of cellular localization 20.0000 4 yes
GO:0061041 regulation of wound healing 20.0000 6 yes
GO:0070201 regulation of establishment of protein localization 20.0000 6 yes
GO:0070588 calcium ion transmembrane transport 20.0000 5 yes
GO:0080134 regulation of response to stress 20.0000 4 yes
GO:0090257 regulation of muscle system process 20.0000 5 yes
GO:0090303 positive regulation of wound healing 20.0000 6 yes
GO:0097553 calcium ion transmembrane import into cytosol 20.0000 6 yes
GO:0097746 blood vessel diameter maintenance 20.0000 5 yes
GO:0098801 regulation of renal system process 20.0000 5 yes
GO:0099536 synaptic signaling 20.0000 4 yes
GO:0099537 trans-synaptic signaling 20.0000 5 yes
GO:0099541 trans-synaptic signaling by lipid 20.0000 6 yes
GO:0099542 trans-synaptic signaling by endocannabinoid 20.0000 7 yes
GO:0099550 trans-synaptic signaling, modulating synaptic transmission 20.0000 6 yes
GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission 20.0000 7 yes
GO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission 20.0000 8 yes
GO:1900048 positive regulation of hemostasis 20.0000 4 yes
GO:1900133 regulation of renin secretion into blood stream 20.0000 5 yes
GO:1900134 negative regulation of renin secretion into blood stream 20.0000 6 yes
GO:1903034 regulation of response to wounding 20.0000 5 yes
GO:1903036 positive regulation of response to wounding 20.0000 5 yes
GO:1903169 regulation of calcium ion transmembrane transport 20.0000 7 yes
GO:1903522 regulation of blood circulation 20.0000 5 yes
GO:1903828 negative regulation of protein localization 20.0000 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 20.0000 6 yes
GO:1904064 positive regulation of cation transmembrane transport 20.0000 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 20.0000 7 yes
GO:1904892 regulation of receptor signaling pathway via STAT 20.0000 5 yes
GO:1904894 positive regulation of receptor signaling pathway via STAT 20.0000 6 yes
GO:1904950 negative regulation of establishment of protein localization 20.0000 6 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 20.0000 7 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 20.0000 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TMED2_HUMAN [view interactions] Low throughput no yes
CAV1_HUMAN [view interactions] Low throughput no no
EPCR_HUMAN [view interactions] Low throughput no yes
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
THRB_HUMAN [view interactions] Low throughput no no
PAR3_HUMAN [view interactions] Low throughput no no
PAR1_HUMAN [view entry] [view interactions] Low throughput yes yes
SNX1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNA12_HUMAN [view interactions] Low throughput no no
CHM4A_HUMAN [view interactions] Low throughput no no
PDC6I_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] Low throughput yes yes
FLOT2_HUMAN [view entry] [view interactions] Low throughput yes yes
AP3D1_HUMAN [view entry] [view interactions] Low throughput yes no
MK14_HUMAN [view interactions] Low throughput no yes
TAB1_HUMAN [view interactions] Low throughput no yes
TAB2_HUMAN [view interactions] Low throughput no yes
ARRD3_HUMAN [view interactions] Low throughput no no
CXL14_HUMAN [view interactions] Low throughput no yes
FURIN_HUMAN [view interactions] Low throughput no yes
PCSK7_HUMAN [view interactions] Low throughput no no
CHRD_HUMAN [view interactions] High throughput no no
GT2D1_HUMAN [view interactions] High throughput no yes
CRYL1_HUMAN [view interactions] High throughput no yes
GRPR_HUMAN [view interactions] High throughput no no
AT132_HUMAN [view interactions] High throughput no yes
MMP1_HUMAN [view interactions] High throughput no no
CAN1_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC6_HUMAN [view interactions] High throughput no yes