Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PAR1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PAR1_HUMAN
GO:0003924 GTPase activity 45.9459 7 no
GO:0016462 pyrophosphatase activity 45.9459 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 45.9459 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 45.9459 6 no
GO:0001664 G protein-coupled receptor binding 37.8378 4 no
GO:0017076 purine nucleotide binding 37.8378 4 no
GO:0032555 purine ribonucleotide binding 37.8378 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.8378 4 no
GO:0005525 GTP binding 35.1351 5 no
GO:0019001 guanyl nucleotide binding 35.1351 5 no
GO:0032561 guanyl ribonucleotide binding 35.1351 5 no
GO:0046872 metal ion binding 29.7297 4 no
GO:0004930 G protein-coupled receptor activity 16.2162 4 yes
GO:0001648 proteinase-activated receptor activity 8.1081 5 yes
GO:0008528 G protein-coupled peptide receptor activity 8.1081 4 yes
GO:0015057 thrombin-activated receptor activity 8.1081 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PAR1_HUMAN
GO:0010646 regulation of cell communication 51.3514 4 yes
GO:0009966 regulation of signal transduction 48.6486 4 yes
GO:0048522 positive regulation of cellular process 48.6486 4 yes
GO:0048523 negative regulation of cellular process 40.5405 4 yes
GO:0031323 regulation of cellular metabolic process 37.8378 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 37.8378 4 no
GO:0051049 regulation of transport 35.1351 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 35.1351 4 yes
GO:0060255 regulation of macromolecule metabolic process 35.1351 4 yes
GO:0080090 regulation of primary metabolic process 35.1351 4 yes
GO:1902531 regulation of intracellular signal transduction 35.1351 5 yes
GO:0009893 positive regulation of metabolic process 32.4324 4 yes
GO:0031325 positive regulation of cellular metabolic process 29.7297 5 yes
GO:0051246 regulation of protein metabolic process 29.7297 5 yes
GO:0006355 regulation of DNA-templated transcription 27.0270 6 yes
GO:0009889 regulation of biosynthetic process 27.0270 4 yes
GO:0009967 positive regulation of signal transduction 27.0270 5 yes
GO:0010468 regulation of gene expression 27.0270 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 27.0270 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 27.0270 5 yes
GO:0010647 positive regulation of cell communication 27.0270 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.0270 5 yes
GO:0023056 positive regulation of signaling 27.0270 4 yes
GO:0031326 regulation of cellular biosynthetic process 27.0270 5 yes
GO:0043085 positive regulation of catalytic activity 27.0270 4 yes
GO:0043269 regulation of ion transport 27.0270 5 yes
GO:0048584 positive regulation of response to stimulus 27.0270 4 yes
GO:0051050 positive regulation of transport 27.0270 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 27.0270 5 yes
GO:0051252 regulation of RNA metabolic process 27.0270 5 yes
GO:0051336 regulation of hydrolase activity 27.0270 4 yes
GO:1902533 positive regulation of intracellular signal transduction 27.0270 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 27.0270 7 yes
GO:2001141 regulation of RNA biosynthetic process 27.0270 6 yes
GO:0006996 organelle organization 24.3243 4 yes
GO:0009891 positive regulation of biosynthetic process 24.3243 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 24.3243 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 24.3243 6 yes
GO:0042127 regulation of cell population proliferation 24.3243 4 yes
GO:0051128 regulation of cellular component organization 24.3243 4 no
GO:0016192 vesicle-mediated transport 24.3243 4 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 21.6216 4 yes
GO:0010941 regulation of cell death 21.6216 4 yes
GO:0010959 regulation of metal ion transport 21.6216 6 yes
GO:0042981 regulation of apoptotic process 21.6216 6 yes
GO:0043067 regulation of programmed cell death 21.6216 5 yes
GO:0043408 regulation of MAPK cascade 21.6216 6 yes
GO:0043410 positive regulation of MAPK cascade 21.6216 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.6216 6 yes
GO:0051240 positive regulation of multicellular organismal process 21.6216 4 yes
GO:0051247 positive regulation of protein metabolic process 21.6216 6 yes
GO:0051345 positive regulation of hydrolase activity 21.6216 5 yes
GO:0008104 protein localization 21.6216 4 no
GO:0033043 regulation of organelle organization 21.6216 5 no
GO:0051130 positive regulation of cellular component organization 21.6216 5 no
GO:0009892 negative regulation of metabolic process 21.6216 4 no
GO:0006897 endocytosis 21.6216 5 no
GO:0016050 vesicle organization 18.9189 5 yes
GO:0030334 regulation of cell migration 18.9189 5 yes
GO:0033993 response to lipid 18.9189 4 yes
GO:0043066 negative regulation of apoptotic process 18.9189 7 yes
GO:0043069 negative regulation of programmed cell death 18.9189 6 yes
GO:0045893 positive regulation of DNA-templated transcription 18.9189 7 yes
GO:0051056 regulation of small GTPase mediated signal transduction 18.9189 6 yes
GO:0051254 positive regulation of RNA metabolic process 18.9189 6 yes
GO:0051924 regulation of calcium ion transport 18.9189 7 yes
GO:0060548 negative regulation of cell death 18.9189 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 18.9189 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 18.9189 8 yes
GO:2000145 regulation of cell motility 18.9189 4 yes
GO:0001817 regulation of cytokine production 16.2162 4 yes
GO:0008284 positive regulation of cell population proliferation 16.2162 5 yes
GO:0010628 positive regulation of gene expression 16.2162 6 yes
GO:0034762 regulation of transmembrane transport 16.2162 4 yes
GO:0034765 regulation of ion transmembrane transport 16.2162 5 yes
GO:0043270 positive regulation of ion transport 16.2162 5 yes
GO:0046578 regulation of Ras protein signal transduction 16.2162 7 yes
GO:0051241 negative regulation of multicellular organismal process 16.2162 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 16.2162 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 16.2162 8 yes
GO:1904062 regulation of cation transmembrane transport 16.2162 6 yes
GO:0008285 negative regulation of cell population proliferation 13.5135 5 yes
GO:0030335 positive regulation of cell migration 13.5135 6 yes
GO:0032880 regulation of protein localization 13.5135 5 yes
GO:0035023 regulation of Rho protein signal transduction 13.5135 8 yes
GO:0035025 positive regulation of Rho protein signal transduction 13.5135 9 yes
GO:0040017 positive regulation of locomotion 13.5135 4 yes
GO:0043087 regulation of GTPase activity 13.5135 5 yes
GO:0043523 regulation of neuron apoptotic process 13.5135 6 yes
GO:0043524 negative regulation of neuron apoptotic process 13.5135 7 yes
GO:0044057 regulation of system process 13.5135 4 yes
GO:0046579 positive regulation of Ras protein signal transduction 13.5135 8 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 13.5135 7 yes
GO:0060341 regulation of cellular localization 13.5135 4 yes
GO:0080134 regulation of response to stress 13.5135 4 yes
GO:1901214 regulation of neuron death 13.5135 5 yes
GO:1901215 negative regulation of neuron death 13.5135 6 yes
GO:2000147 positive regulation of cell motility 13.5135 5 yes
GO:0001819 positive regulation of cytokine production 10.8108 5 yes
GO:0006937 regulation of muscle contraction 10.8108 6 yes
GO:0006940 regulation of smooth muscle contraction 10.8108 7 yes
GO:0030162 regulation of proteolysis 10.8108 6 yes
GO:0032675 regulation of interleukin-6 production 10.8108 5 yes
GO:0034330 cell junction organization 10.8108 4 yes
GO:0034764 positive regulation of transmembrane transport 10.8108 5 yes
GO:0034767 positive regulation of ion transmembrane transport 10.8108 6 yes
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 10.8108 6 yes
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 10.8108 7 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 10.8108 8 yes
GO:0043547 positive regulation of GTPase activity 10.8108 6 yes
GO:0045216 cell-cell junction organization 10.8108 5 yes
GO:0051046 regulation of secretion 10.8108 5 yes
GO:0051051 negative regulation of transport 10.8108 4 yes
GO:0051223 regulation of protein transport 10.8108 5 yes
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 10.8108 4 yes
GO:0051928 positive regulation of calcium ion transport 10.8108 6 yes
GO:0052547 regulation of peptidase activity 10.8108 5 yes
GO:0052548 regulation of endopeptidase activity 10.8108 6 yes
GO:0070201 regulation of establishment of protein localization 10.8108 6 yes
GO:0090257 regulation of muscle system process 10.8108 5 yes
GO:0099537 trans-synaptic signaling 10.8108 4 yes
GO:1903169 regulation of calcium ion transmembrane transport 10.8108 7 yes
GO:1903522 regulation of blood circulation 10.8108 5 yes
GO:1903530 regulation of secretion by cell 10.8108 4 yes
GO:1904064 positive regulation of cation transmembrane transport 10.8108 7 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 10.8108 7 yes
GO:0002237 response to molecule of bacterial origin 8.1081 4 yes
GO:0003018 vascular process in circulatory system 8.1081 4 yes
GO:0003073 regulation of systemic arterial blood pressure 8.1081 4 yes
GO:0006811 ion transport 8.1081 4 yes
GO:0006812 cation transport 8.1081 5 yes
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 8.1081 4 yes
GO:0010712 regulation of collagen metabolic process 8.1081 4 yes
GO:0010714 positive regulation of collagen metabolic process 8.1081 5 yes
GO:0010950 positive regulation of endopeptidase activity 8.1081 7 yes
GO:0010952 positive regulation of peptidase activity 8.1081 6 yes
GO:0019229 regulation of vasoconstriction 8.1081 6 yes
GO:0030001 metal ion transport 8.1081 6 yes
GO:0032101 regulation of response to external stimulus 8.1081 4 yes
GO:0032496 response to lipopolysaccharide 8.1081 4 yes
GO:0032651 regulation of interleukin-1 beta production 8.1081 6 yes
GO:0032652 regulation of interleukin-1 production 8.1081 5 yes
GO:0032677 regulation of interleukin-8 production 8.1081 5 yes
GO:0032965 regulation of collagen biosynthetic process 8.1081 5 yes
GO:0032967 positive regulation of collagen biosynthetic process 8.1081 6 yes
GO:0033363 secretory granule organization 8.1081 6 yes
GO:0035150 regulation of tube size 8.1081 4 yes
GO:0035296 regulation of tube diameter 8.1081 5 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 8.1081 9 yes
GO:0045862 positive regulation of proteolysis 8.1081 7 yes
GO:0045907 positive regulation of vasoconstriction 8.1081 5 yes
GO:0045933 positive regulation of muscle contraction 8.1081 5 yes
GO:0045987 positive regulation of smooth muscle contraction 8.1081 6 yes
GO:0051048 negative regulation of secretion 8.1081 5 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 8.1081 5 yes
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 8.1081 6 yes
GO:0051282 regulation of sequestering of calcium ion 8.1081 4 yes
GO:0060155 platelet dense granule organization 8.1081 7 yes
GO:0061041 regulation of wound healing 8.1081 6 yes
GO:0090303 positive regulation of wound healing 8.1081 6 yes
GO:0097746 blood vessel diameter maintenance 8.1081 5 yes
GO:0098801 regulation of renal system process 8.1081 5 yes
GO:1903034 regulation of response to wounding 8.1081 5 yes
GO:1903036 positive regulation of response to wounding 8.1081 5 yes
GO:1903531 negative regulation of secretion by cell 8.1081 5 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 8.1081 7 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 8.1081 8 yes
GO:0001894 tissue homeostasis 5.4054 5 yes
GO:0001977 renal system process involved in regulation of blood volume 5.4054 5 yes
GO:0002248 connective tissue replacement involved in inflammatory response wound healing 5.4054 4 yes
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 5.4054 4 yes
GO:0003093 regulation of glomerular filtration 5.4054 6 yes
GO:0003105 negative regulation of glomerular filtration 5.4054 5 yes
GO:0006816 calcium ion transport 5.4054 7 yes
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 5.4054 10 yes
GO:0006954 inflammatory response 5.4054 4 yes
GO:0007529 establishment of synaptic specificity at neuromuscular junction 5.4054 6 yes
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 5.4054 6 yes
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 5.4054 7 yes
GO:0030193 regulation of blood coagulation 5.4054 4 yes
GO:0030194 positive regulation of blood coagulation 5.4054 5 yes
GO:0031644 regulation of nervous system process 5.4054 5 yes
GO:0032755 positive regulation of interleukin-6 production 5.4054 6 yes
GO:0032757 positive regulation of interleukin-8 production 5.4054 6 yes
GO:0034331 cell junction maintenance 5.4054 5 yes
GO:0043954 cellular component maintenance 5.4054 4 yes
GO:0044060 regulation of endocrine process 5.4054 5 yes
GO:0045217 cell-cell junction maintenance 5.4054 6 yes
GO:0046425 regulation of receptor signaling pathway via JAK-STAT 5.4054 6 yes
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 5.4054 7 yes
GO:0048872 homeostasis of number of cells 5.4054 4 yes
GO:0048873 homeostasis of number of cells within a tissue 5.4054 5 yes
GO:0050708 regulation of protein secretion 5.4054 5 yes
GO:0050709 negative regulation of protein secretion 5.4054 6 yes
GO:0050808 synapse organization 5.4054 5 yes
GO:0050818 regulation of coagulation 5.4054 4 yes
GO:0050820 positive regulation of coagulation 5.4054 5 yes
GO:0051209 release of sequestered calcium ion into cytosol 5.4054 6 yes
GO:0051224 negative regulation of protein transport 5.4054 5 yes
GO:0051283 negative regulation of sequestering of calcium ion 5.4054 5 yes
GO:0051930 regulation of sensory perception of pain 5.4054 7 yes
GO:0051931 regulation of sensory perception 5.4054 6 yes
GO:0060249 anatomical structure homeostasis 5.4054 4 yes
GO:0070588 calcium ion transmembrane transport 5.4054 6 yes
GO:0097553 calcium ion transmembrane import into cytosol 5.4054 7 yes
GO:0098655 cation transmembrane transport 5.4054 4 yes
GO:0098660 inorganic ion transmembrane transport 5.4054 4 yes
GO:0098662 inorganic cation transmembrane transport 5.4054 5 yes
GO:0099541 trans-synaptic signaling by lipid 5.4054 5 yes
GO:0099542 trans-synaptic signaling by endocannabinoid 5.4054 6 yes
GO:0099550 trans-synaptic signaling, modulating synaptic transmission 5.4054 5 yes
GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission 5.4054 6 yes
GO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission 5.4054 7 yes
GO:1900048 positive regulation of hemostasis 5.4054 4 yes
GO:1900133 regulation of renin secretion into blood stream 5.4054 5 yes
GO:1900134 negative regulation of renin secretion into blood stream 5.4054 6 yes
GO:1903828 negative regulation of protein localization 5.4054 5 yes
GO:1904892 regulation of receptor signaling pathway via STAT 5.4054 5 yes
GO:1904894 positive regulation of receptor signaling pathway via STAT 5.4054 6 yes
GO:1904950 negative regulation of establishment of protein localization 5.4054 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TMED2_HUMAN [view interactions] Low throughput no yes
CAV1_HUMAN [view interactions] Low throughput no no
EPCR_HUMAN [view interactions] Low throughput no yes
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
THRB_HUMAN [view interactions] Low throughput no no
PAR1_HUMAN [view entry] [view interactions] Low throughput yes yes
PAR3_HUMAN [view interactions] Low throughput no no
SNX1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNA12_HUMAN [view interactions] Low throughput no no
CHM4A_HUMAN [view interactions] Low throughput no no
PDC6I_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] Low throughput yes yes
FLOT2_HUMAN [view entry] [view interactions] Low throughput yes yes
AP3D1_HUMAN [view entry] [view interactions] Low throughput yes no
MK14_HUMAN [view interactions] Low throughput no yes
TAB1_HUMAN [view interactions] Low throughput no yes
TAB2_HUMAN [view interactions] Low throughput no yes
ARRD3_HUMAN [view interactions] Low throughput no no
CXL14_HUMAN [view interactions] Low throughput no yes
CHRD_HUMAN [view interactions] High throughput no no
GT2D1_HUMAN [view interactions] High throughput no yes
CRYL1_HUMAN [view interactions] High throughput no yes
GRPR_HUMAN [view interactions] High throughput no no
AT132_HUMAN [view interactions] High throughput no yes
MMP1_HUMAN [view interactions] High throughput no no
CAN1_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC6_HUMAN [view interactions] High throughput no yes
GNAO_HUMAN [view entry] [view interactions] Computational yes yes
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
GBGT2_HUMAN [view interactions] Computational no no
GBG5_HUMAN [view interactions] Computational no no
SNX2_HUMAN [view entry] [view interactions] Computational yes no
DYN1_HUMAN [view entry] [view interactions] Computational yes yes
GBB3_HUMAN [view interactions] Computational no yes
ARRB1_HUMAN [view entry] [view interactions] Computational yes yes
ARRB2_HUMAN [view entry] [view interactions] Computational yes no
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
GBG7_HUMAN [view entry] [view interactions] Computational yes yes
GBG3_HUMAN [view entry] [view interactions] Computational yes no
GBB1_HUMAN [view entry] [view interactions] Computational yes yes
GNA15_HUMAN [view interactions] Computational no yes
GBG2_HUMAN [view entry] [view interactions] Computational yes yes
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
GNA14_HUMAN [view entry] [view interactions] Computational yes yes
SYEP_HUMAN [view interactions] Computational no yes
GBG10_HUMAN [view interactions] Computational no no
GBB4_HUMAN [view entry] [view interactions] Computational yes yes
GBB2_HUMAN [view entry] [view interactions] Computational yes yes
GNB5_HUMAN [view entry] [view interactions] Computational yes yes
ZYX_HUMAN [view interactions] Computational no no
DYN2_HUMAN [view entry] [view interactions] Computational yes yes
CATG_HUMAN [view interactions] Computational no no
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
TRBM_HUMAN [view interactions] Computational no no
PLMN_HUMAN [view interactions] Computational no no
LPAR2_HUMAN [view interactions] Computational no yes
LPAR6_HUMAN [view interactions] Computational no no
PAR4_HUMAN [view entry] [view interactions] Computational yes no
GBG8_HUMAN [view interactions] Computational no no
GNA11_HUMAN [view entry] [view interactions] Computational yes yes
PROC_HUMAN [view interactions] Computational no no
GNAZ_HUMAN [view entry] [view interactions] Computational yes yes
PROS_HUMAN [view interactions] Computational no no
PLCB1_HUMAN [view entry] [view interactions] Computational yes yes
ARBK2_HUMAN [view entry] [view interactions] Computational yes yes
GBG4_HUMAN [view interactions] Computational no no
GBG12_HUMAN [view entry] [view interactions] Computational yes yes
ANGT_HUMAN [view interactions] Computational no no
GBG13_HUMAN [view interactions] Computational no no
GBG11_HUMAN [view interactions] Computational no no
CBPB2_HUMAN [view interactions] Computational no no
GBG1_HUMAN [view interactions] Computational no no
RASH_HUMAN [view entry] [view interactions] Computational yes no
LPAR4_HUMAN [view interactions] Computational no no
IL8_HUMAN [view interactions] Computational no no
LPAR3_HUMAN [view interactions] Computational no no
LPAR1_HUMAN [view entry] [view interactions] Computational yes no
ACM2_HUMAN [view entry] [view interactions] Computational yes yes
LPAR5_HUMAN [view interactions] Computational no yes