Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AP3D1_HUMAN

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in AP3D1_HUMAN
GO:0017076 purine nucleotide binding 25.9259 4 no
GO:0032555 purine ribonucleotide binding 25.9259 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.9259 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AP3D1_HUMAN
GO:0008104 protein localization 59.2593 4 yes
GO:0071702 organic substance transport 53.7037 4 yes
GO:0071705 nitrogen compound transport 53.7037 4 yes
GO:0015031 protein transport 46.2963 4 yes
GO:0048522 positive regulation of cellular process 44.4444 4 yes
GO:0060255 regulation of macromolecule metabolic process 42.5926 4 yes
GO:0016192 vesicle-mediated transport 42.5926 4 yes
GO:0080090 regulation of primary metabolic process 40.7407 4 yes
GO:0051049 regulation of transport 37.0370 4 no
GO:0010646 regulation of cell communication 37.0370 4 no
GO:0006886 intracellular protein transport 37.0370 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 35.1852 4 yes
GO:0051128 regulation of cellular component organization 35.1852 4 no
GO:0006996 organelle organization 35.1852 4 yes
GO:0009893 positive regulation of metabolic process 35.1852 4 yes
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 31.4815 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 29.6296 5 yes
GO:0009966 regulation of signal transduction 27.7778 4 no
GO:0031325 positive regulation of cellular metabolic process 27.7778 5 yes
GO:0010468 regulation of gene expression 25.9259 5 yes
GO:0048584 positive regulation of response to stimulus 24.0741 4 no
GO:0022607 cellular component assembly 24.0741 4 no
GO:0036211 protein modification process 24.0741 4 no
GO:0043412 macromolecule modification 24.0741 4 no
GO:0010647 positive regulation of cell communication 24.0741 5 no
GO:0023056 positive regulation of signaling 24.0741 4 no
GO:0051246 regulation of protein metabolic process 24.0741 5 no
GO:0009889 regulation of biosynthetic process 24.0741 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.0741 5 yes
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0007034 vacuolar transport 22.2222 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 22.2222 5 yes
GO:0031326 regulation of cellular biosynthetic process 22.2222 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.3704 6 yes
GO:0061024 membrane organization 20.3704 4 yes
GO:0099111 microtubule-based transport 20.3704 4 yes
GO:0032880 regulation of protein localization 20.3704 5 no
GO:0051247 positive regulation of protein metabolic process 20.3704 6 no
GO:0010648 negative regulation of cell communication 20.3704 5 no
GO:0023057 negative regulation of signaling 20.3704 4 no
GO:0009891 positive regulation of biosynthetic process 20.3704 5 yes
GO:0010970 transport along microtubule 20.3704 4 yes
GO:0016050 vesicle organization 20.3704 5 yes
GO:0030705 cytoskeleton-dependent intracellular transport 20.3704 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 20.3704 6 yes
GO:0051252 regulation of RNA metabolic process 18.5185 5 yes
GO:0007041 lysosomal transport 18.5185 5 yes
GO:0008088 axo-dendritic transport 18.5185 5 yes
GO:0051650 establishment of vesicle localization 16.6667 4 yes
GO:0072384 organelle transport along microtubule 16.6667 4 yes
GO:0097479 synaptic vesicle localization 16.6667 4 yes
GO:0098930 axonal transport 16.6667 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 16.6667 7 yes
GO:2001141 regulation of RNA biosynthetic process 16.6667 6 yes
GO:0006355 regulation of DNA-templated transcription 16.6667 6 yes
GO:0008089 anterograde axonal transport 16.6667 7 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 16.6667 6 yes
GO:0033365 protein localization to organelle 16.6667 5 yes
GO:0047496 vesicle transport along microtubule 14.8148 5 yes
GO:0048489 synaptic vesicle transport 14.8148 4 yes
GO:0048878 chemical homeostasis 14.8148 4 yes
GO:0051240 positive regulation of multicellular organismal process 14.8148 4 yes
GO:0099518 vesicle cytoskeletal trafficking 14.8148 5 yes
GO:0048490 anterograde synaptic vesicle transport 12.9630 7 yes
GO:0051254 positive regulation of RNA metabolic process 12.9630 6 yes
GO:0099514 synaptic vesicle cytoskeletal transport 12.9630 5 yes
GO:0099517 synaptic vesicle transport along microtubule 12.9630 6 yes
GO:0008333 endosome to lysosome transport 12.9630 5 yes
GO:0045595 regulation of cell differentiation 12.9630 4 yes
GO:0045893 positive regulation of DNA-templated transcription 11.1111 7 yes
GO:0048193 Golgi vesicle transport 11.1111 5 yes
GO:0050801 ion homeostasis 11.1111 5 yes
GO:0051094 positive regulation of developmental process 11.1111 4 yes
GO:0072657 protein localization to membrane 11.1111 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 11.1111 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 11.1111 8 yes
GO:0002684 positive regulation of immune system process 11.1111 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 11.1111 7 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 9.2593 8 yes
GO:0050865 regulation of cell activation 9.2593 4 yes
GO:0051249 regulation of lymphocyte activation 9.2593 5 yes
GO:0072594 establishment of protein localization to organelle 9.2593 4 yes
GO:0002694 regulation of leukocyte activation 9.2593 4 yes
GO:0045597 positive regulation of cell differentiation 9.2593 5 yes
GO:0048753 pigment granule organization 7.4074 6 yes
GO:0050863 regulation of T cell activation 7.4074 6 yes
GO:0050867 positive regulation of cell activation 7.4074 5 yes
GO:0051251 positive regulation of lymphocyte activation 7.4074 6 yes
GO:0072665 protein localization to vacuole 7.4074 6 yes
GO:0072666 establishment of protein localization to vacuole 7.4074 5 yes
GO:0002696 positive regulation of leukocyte activation 7.4074 5 yes
GO:0006605 protein targeting 7.4074 5 yes
GO:0006623 protein targeting to vacuole 7.4074 5 yes
GO:0006892 post-Golgi vesicle-mediated transport 7.4074 6 yes
GO:0006896 Golgi to vacuole transport 7.4074 5 yes
GO:0030155 regulation of cell adhesion 7.4074 4 yes
GO:0032438 melanosome organization 7.4074 7 yes
GO:0045785 positive regulation of cell adhesion 7.4074 5 yes
GO:0050870 positive regulation of T cell activation 5.5556 7 yes
GO:0061462 protein localization to lysosome 5.5556 7 yes
GO:0099003 vesicle-mediated transport in synapse 5.5556 5 yes
GO:1902105 regulation of leukocyte differentiation 5.5556 5 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 5.5556 6 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 5.5556 7 yes
GO:1903706 regulation of hemopoiesis 5.5556 4 yes
GO:2000026 regulation of multicellular organismal development 5.5556 4 yes
GO:0022407 regulation of cell-cell adhesion 5.5556 5 yes
GO:0022409 positive regulation of cell-cell adhesion 5.5556 6 yes
GO:0046634 regulation of alpha-beta T cell activation 3.7037 7 yes
GO:0046635 positive regulation of alpha-beta T cell activation 3.7037 8 yes
GO:0046637 regulation of alpha-beta T cell differentiation 3.7037 8 yes
GO:0046638 positive regulation of alpha-beta T cell differentiation 3.7037 9 yes
GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib 3.7037 4 yes
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib 3.7037 4 yes
GO:0051136 regulation of NK T cell differentiation 3.7037 9 yes
GO:0051138 positive regulation of NK T cell differentiation 3.7037 10 yes
GO:0061088 regulation of sequestering of zinc ion 3.7037 4 yes
GO:0070142 synaptic vesicle budding 3.7037 6 yes
GO:1902107 positive regulation of leukocyte differentiation 3.7037 6 yes
GO:1903708 positive regulation of hemopoiesis 3.7037 5 yes
GO:0006900 vesicle budding from membrane 3.7037 5 yes
GO:0016182 synaptic vesicle budding from endosome 3.7037 4 yes
GO:0035646 endosome to melanosome transport 3.7037 5 yes
GO:0043485 endosome to pigment granule transport 3.7037 4 yes
GO:0045580 regulation of T cell differentiation 3.7037 7 yes
GO:0045582 positive regulation of T cell differentiation 3.7037 8 yes
GO:0045619 regulation of lymphocyte differentiation 3.7037 6 yes
GO:0045621 positive regulation of lymphocyte differentiation 3.7037 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VAMP7_HUMAN [view interactions] Low throughput no yes
CALY_HUMAN [view entry] [view interactions] Low throughput yes yes
VPS41_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF3A_HUMAN [view entry] [view interactions] Low throughput yes yes
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
ACM5_HUMAN [view entry] [view interactions] Low throughput yes no
TY3H_HUMAN [view interactions] Low throughput no no
AP3S1_HUMAN [view entry] [view interactions] Low throughput yes no
AP3S2_HUMAN [view entry] [view interactions] Low throughput yes no
PAR1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP3B2_HUMAN [view entry] [view interactions] Low throughput yes yes
AP3M1_HUMAN [view interactions] Low throughput no yes
RUFY1_HUMAN [view interactions] Low throughput no yes
RNF13_HUMAN [view interactions] Low throughput no yes
AP3B1_HUMAN [view entry] [view interactions] Low throughput yes yes
GSK3A_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
MK06_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
BMX_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
RUVB1_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
PI4KB_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
DUX4_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
HG2A_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view interactions] High throughput no yes
VGFR2_HUMAN [view interactions] High throughput no no
SH2B3_HUMAN [view interactions] High throughput no yes
STAM2_HUMAN [view interactions] High throughput no yes
STAP2_HUMAN [view interactions] High throughput no yes
NUAK1_HUMAN [view interactions] High throughput no no
JAK3_HUMAN [view interactions] High throughput no no
MYLK4_HUMAN [view interactions] High throughput no no
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
NEK7_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
NUAK2_HUMAN [view interactions] High throughput no yes
SIK3_HUMAN [view interactions] High throughput no yes
ROS1_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
MET_HUMAN [view interactions] High throughput no yes
IFT27_HUMAN [view interactions] High throughput no yes
RAB37_HUMAN [view entry] [view interactions] High throughput yes no
AP1G1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
NIN_HUMAN [view interactions] High throughput no no
CEP19_HUMAN [view interactions] High throughput no no
CENPJ_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
VGFR1_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
GRK5_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
AGO3_HUMAN [view interactions] High throughput no yes
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
RT29_HUMAN [view interactions] High throughput no yes
KLC2_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
VP33B_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
VPS11_HUMAN [view entry] [view interactions] High throughput yes yes
VPS18_HUMAN [view entry] [view interactions] High throughput yes no
VPS39_HUMAN [view entry] [view interactions] High throughput yes no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
PO5F1_HUMAN [view interactions] High throughput no yes
PPARG_HUMAN [view interactions] High throughput no yes
AP3M2_HUMAN [view entry] [view interactions] High throughput yes yes
TPC2_HUMAN [view interactions] High throughput no no
CSCL1_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
S15A3_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
BRD7_HUMAN [view interactions] High throughput no yes
K1107_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
LRC31_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RBM39_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
TSN10_HUMAN [view interactions] High throughput no no
SIDT2_HUMAN [view interactions] High throughput no yes
ZN460_HUMAN [view interactions] High throughput no no
ZCH10_HUMAN [view interactions] High throughput no yes
WDR55_HUMAN [view interactions] High throughput no yes
VPP3_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
PLCD3_HUMAN [view entry] [view interactions] High throughput yes yes
PEG10_HUMAN [view interactions] High throughput no no
COMD2_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
HTSF1_HUMAN [view interactions] High throughput no yes
CD11B_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
COPG1_HUMAN [view interactions] High throughput no yes
RBM25_HUMAN [view interactions] High throughput no yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
PI42B_HUMAN [view entry] [view interactions] High throughput yes no
ZNT3_HUMAN [view entry] [view interactions] High throughput yes yes
CADM1_HUMAN [view entry] [view interactions] High throughput yes no
DPY30_HUMAN [view interactions] High throughput no yes
ENY2_HUMAN [view interactions] High throughput no yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
PACS1_HUMAN [view entry] [view interactions] High throughput yes yes
SCOC_HUMAN [view interactions] High throughput no yes
SNAPN_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
RN183_HUMAN [view interactions] High throughput no no
HS12B_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
RNF43_HUMAN [view interactions] High throughput no yes