AP3D1_HUMAN
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in AP3D1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 25.9259 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 25.9259 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.9259 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in AP3D1_HUMAN |
---|---|---|---|---|
GO:0008104 | protein localization | 59.2593 | 4 | yes |
GO:0071702 | organic substance transport | 53.7037 | 4 | yes |
GO:0071705 | nitrogen compound transport | 53.7037 | 4 | yes |
GO:0015031 | protein transport | 46.2963 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 44.4444 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 42.5926 | 4 | yes |
GO:0016192 | vesicle-mediated transport | 42.5926 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 40.7407 | 4 | yes |
GO:0051049 | regulation of transport | 37.0370 | 4 | no |
GO:0010646 | regulation of cell communication | 37.0370 | 4 | no |
GO:0006886 | intracellular protein transport | 37.0370 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 35.1852 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 35.1852 | 4 | no |
GO:0006996 | organelle organization | 35.1852 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 35.1852 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 31.4815 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.6296 | 5 | yes |
GO:0009966 | regulation of signal transduction | 27.7778 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 27.7778 | 5 | yes |
GO:0010468 | regulation of gene expression | 25.9259 | 5 | yes |
GO:0048584 | positive regulation of response to stimulus | 24.0741 | 4 | no |
GO:0022607 | cellular component assembly | 24.0741 | 4 | no |
GO:0036211 | protein modification process | 24.0741 | 4 | no |
GO:0043412 | macromolecule modification | 24.0741 | 4 | no |
GO:0010647 | positive regulation of cell communication | 24.0741 | 5 | no |
GO:0023056 | positive regulation of signaling | 24.0741 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 24.0741 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 24.0741 | 4 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.0741 | 5 | yes |
GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 22.2222 | 4 | no |
GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
GO:0007034 | vacuolar transport | 22.2222 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 22.2222 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 22.2222 | 5 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.3704 | 6 | yes |
GO:0061024 | membrane organization | 20.3704 | 4 | yes |
GO:0099111 | microtubule-based transport | 20.3704 | 4 | yes |
GO:0032880 | regulation of protein localization | 20.3704 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 20.3704 | 6 | no |
GO:0010648 | negative regulation of cell communication | 20.3704 | 5 | no |
GO:0023057 | negative regulation of signaling | 20.3704 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 20.3704 | 5 | yes |
GO:0010970 | transport along microtubule | 20.3704 | 4 | yes |
GO:0016050 | vesicle organization | 20.3704 | 5 | yes |
GO:0030705 | cytoskeleton-dependent intracellular transport | 20.3704 | 4 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 20.3704 | 6 | yes |
GO:0051252 | regulation of RNA metabolic process | 18.5185 | 5 | yes |
GO:0007041 | lysosomal transport | 18.5185 | 5 | yes |
GO:0008088 | axo-dendritic transport | 18.5185 | 5 | yes |
GO:0051650 | establishment of vesicle localization | 16.6667 | 4 | yes |
GO:0072384 | organelle transport along microtubule | 16.6667 | 4 | yes |
GO:0097479 | synaptic vesicle localization | 16.6667 | 4 | yes |
GO:0098930 | axonal transport | 16.6667 | 6 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 16.6667 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 16.6667 | 6 | yes |
GO:0006355 | regulation of DNA-templated transcription | 16.6667 | 6 | yes |
GO:0008089 | anterograde axonal transport | 16.6667 | 7 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 16.6667 | 6 | yes |
GO:0033365 | protein localization to organelle | 16.6667 | 5 | yes |
GO:0047496 | vesicle transport along microtubule | 14.8148 | 5 | yes |
GO:0048489 | synaptic vesicle transport | 14.8148 | 4 | yes |
GO:0048878 | chemical homeostasis | 14.8148 | 4 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 14.8148 | 4 | yes |
GO:0099518 | vesicle cytoskeletal trafficking | 14.8148 | 5 | yes |
GO:0048490 | anterograde synaptic vesicle transport | 12.9630 | 7 | yes |
GO:0051254 | positive regulation of RNA metabolic process | 12.9630 | 6 | yes |
GO:0099514 | synaptic vesicle cytoskeletal transport | 12.9630 | 5 | yes |
GO:0099517 | synaptic vesicle transport along microtubule | 12.9630 | 6 | yes |
GO:0008333 | endosome to lysosome transport | 12.9630 | 5 | yes |
GO:0045595 | regulation of cell differentiation | 12.9630 | 4 | yes |
GO:0045893 | positive regulation of DNA-templated transcription | 11.1111 | 7 | yes |
GO:0048193 | Golgi vesicle transport | 11.1111 | 5 | yes |
GO:0050801 | ion homeostasis | 11.1111 | 5 | yes |
GO:0051094 | positive regulation of developmental process | 11.1111 | 4 | yes |
GO:0072657 | protein localization to membrane | 11.1111 | 4 | yes |
GO:1902680 | positive regulation of RNA biosynthetic process | 11.1111 | 7 | yes |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 11.1111 | 8 | yes |
GO:0002684 | positive regulation of immune system process | 11.1111 | 4 | yes |
GO:0006357 | regulation of transcription by RNA polymerase II | 11.1111 | 7 | yes |
GO:0045944 | positive regulation of transcription by RNA polymerase II | 9.2593 | 8 | yes |
GO:0050865 | regulation of cell activation | 9.2593 | 4 | yes |
GO:0051249 | regulation of lymphocyte activation | 9.2593 | 5 | yes |
GO:0072594 | establishment of protein localization to organelle | 9.2593 | 4 | yes |
GO:0002694 | regulation of leukocyte activation | 9.2593 | 4 | yes |
GO:0045597 | positive regulation of cell differentiation | 9.2593 | 5 | yes |
GO:0048753 | pigment granule organization | 7.4074 | 6 | yes |
GO:0050863 | regulation of T cell activation | 7.4074 | 6 | yes |
GO:0050867 | positive regulation of cell activation | 7.4074 | 5 | yes |
GO:0051251 | positive regulation of lymphocyte activation | 7.4074 | 6 | yes |
GO:0072665 | protein localization to vacuole | 7.4074 | 6 | yes |
GO:0072666 | establishment of protein localization to vacuole | 7.4074 | 5 | yes |
GO:0002696 | positive regulation of leukocyte activation | 7.4074 | 5 | yes |
GO:0006605 | protein targeting | 7.4074 | 5 | yes |
GO:0006623 | protein targeting to vacuole | 7.4074 | 5 | yes |
GO:0006892 | post-Golgi vesicle-mediated transport | 7.4074 | 6 | yes |
GO:0006896 | Golgi to vacuole transport | 7.4074 | 5 | yes |
GO:0030155 | regulation of cell adhesion | 7.4074 | 4 | yes |
GO:0032438 | melanosome organization | 7.4074 | 7 | yes |
GO:0045785 | positive regulation of cell adhesion | 7.4074 | 5 | yes |
GO:0050870 | positive regulation of T cell activation | 5.5556 | 7 | yes |
GO:0061462 | protein localization to lysosome | 5.5556 | 7 | yes |
GO:0099003 | vesicle-mediated transport in synapse | 5.5556 | 5 | yes |
GO:1902105 | regulation of leukocyte differentiation | 5.5556 | 5 | yes |
GO:1903037 | regulation of leukocyte cell-cell adhesion | 5.5556 | 6 | yes |
GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 5.5556 | 7 | yes |
GO:1903706 | regulation of hemopoiesis | 5.5556 | 4 | yes |
GO:2000026 | regulation of multicellular organismal development | 5.5556 | 4 | yes |
GO:0022407 | regulation of cell-cell adhesion | 5.5556 | 5 | yes |
GO:0022409 | positive regulation of cell-cell adhesion | 5.5556 | 6 | yes |
GO:0046634 | regulation of alpha-beta T cell activation | 3.7037 | 7 | yes |
GO:0046635 | positive regulation of alpha-beta T cell activation | 3.7037 | 8 | yes |
GO:0046637 | regulation of alpha-beta T cell differentiation | 3.7037 | 8 | yes |
GO:0046638 | positive regulation of alpha-beta T cell differentiation | 3.7037 | 9 | yes |
GO:0048003 | antigen processing and presentation of lipid antigen via MHC class Ib | 3.7037 | 4 | yes |
GO:0048007 | antigen processing and presentation, exogenous lipid antigen via MHC class Ib | 3.7037 | 4 | yes |
GO:0051136 | regulation of NK T cell differentiation | 3.7037 | 9 | yes |
GO:0051138 | positive regulation of NK T cell differentiation | 3.7037 | 10 | yes |
GO:0061088 | regulation of sequestering of zinc ion | 3.7037 | 4 | yes |
GO:0070142 | synaptic vesicle budding | 3.7037 | 6 | yes |
GO:1902107 | positive regulation of leukocyte differentiation | 3.7037 | 6 | yes |
GO:1903708 | positive regulation of hemopoiesis | 3.7037 | 5 | yes |
GO:0006900 | vesicle budding from membrane | 3.7037 | 5 | yes |
GO:0016182 | synaptic vesicle budding from endosome | 3.7037 | 4 | yes |
GO:0035646 | endosome to melanosome transport | 3.7037 | 5 | yes |
GO:0043485 | endosome to pigment granule transport | 3.7037 | 4 | yes |
GO:0045580 | regulation of T cell differentiation | 3.7037 | 7 | yes |
GO:0045582 | positive regulation of T cell differentiation | 3.7037 | 8 | yes |
GO:0045619 | regulation of lymphocyte differentiation | 3.7037 | 6 | yes |
GO:0045621 | positive regulation of lymphocyte differentiation | 3.7037 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
VAMP7_HUMAN | [view interactions] | Low throughput | no | yes |
CALY_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VPS41_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KIF3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ACM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
TY3H_HUMAN | [view interactions] | Low throughput | no | no |
AP3S1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
AP3S2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PAR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP3B2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP3M1_HUMAN | [view interactions] | Low throughput | no | yes |
RUFY1_HUMAN | [view interactions] | Low throughput | no | yes |
RNF13_HUMAN | [view interactions] | Low throughput | no | yes |
AP3B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
BMX_HUMAN | [view interactions] | High throughput | no | no |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
PI4KB_HUMAN | [view interactions] | High throughput | no | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DUX4_HUMAN | [view interactions] | High throughput | no | no |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HG2A_HUMAN | [view interactions] | High throughput | no | yes |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
VGFR2_HUMAN | [view interactions] | High throughput | no | no |
SH2B3_HUMAN | [view interactions] | High throughput | no | yes |
STAM2_HUMAN | [view interactions] | High throughput | no | yes |
STAP2_HUMAN | [view interactions] | High throughput | no | yes |
NUAK1_HUMAN | [view interactions] | High throughput | no | no |
JAK3_HUMAN | [view interactions] | High throughput | no | no |
MYLK4_HUMAN | [view interactions] | High throughput | no | no |
CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEK7_HUMAN | [view interactions] | High throughput | no | yes |
AURKB_HUMAN | [view interactions] | High throughput | no | yes |
NUAK2_HUMAN | [view interactions] | High throughput | no | yes |
SIK3_HUMAN | [view interactions] | High throughput | no | yes |
ROS1_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
MET_HUMAN | [view interactions] | High throughput | no | yes |
IFT27_HUMAN | [view interactions] | High throughput | no | yes |
RAB37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCNA_HUMAN | [view interactions] | High throughput | no | no |
PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NIN_HUMAN | [view interactions] | High throughput | no | no |
CEP19_HUMAN | [view interactions] | High throughput | no | no |
CENPJ_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
VGFR1_HUMAN | [view interactions] | High throughput | no | no |
FLT3_HUMAN | [view interactions] | High throughput | no | no |
GRK5_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
AGO3_HUMAN | [view interactions] | High throughput | no | yes |
DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
RT29_HUMAN | [view interactions] | High throughput | no | yes |
KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VP33B_HUMAN | [view interactions] | High throughput | no | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPS18_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VPS39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
PPARG_HUMAN | [view interactions] | High throughput | no | yes |
AP3M2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPC2_HUMAN | [view interactions] | High throughput | no | no |
CSCL1_HUMAN | [view interactions] | High throughput | no | no |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S15A3_HUMAN | [view interactions] | High throughput | no | yes |
TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRD7_HUMAN | [view interactions] | High throughput | no | yes |
K1107_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
UBR5_HUMAN | [view interactions] | High throughput | no | no |
LRC31_HUMAN | [view interactions] | High throughput | no | no |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
TSN10_HUMAN | [view interactions] | High throughput | no | no |
SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
ZN460_HUMAN | [view interactions] | High throughput | no | no |
ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
WDR55_HUMAN | [view interactions] | High throughput | no | yes |
VPP3_HUMAN | [view interactions] | High throughput | no | no |
FRIL_HUMAN | [view interactions] | High throughput | no | yes |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
PLCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PEG10_HUMAN | [view interactions] | High throughput | no | no |
COMD2_HUMAN | [view interactions] | High throughput | no | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HTSF1_HUMAN | [view interactions] | High throughput | no | yes |
CD11B_HUMAN | [view interactions] | High throughput | no | yes |
CDC73_HUMAN | [view interactions] | High throughput | no | yes |
COPG1_HUMAN | [view interactions] | High throughput | no | yes |
RBM25_HUMAN | [view interactions] | High throughput | no | yes |
ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS12A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZNT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DPY30_HUMAN | [view interactions] | High throughput | no | yes |
ENY2_HUMAN | [view interactions] | High throughput | no | yes |
E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PACS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCOC_HUMAN | [view interactions] | High throughput | no | yes |
SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
PI42C_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RN183_HUMAN | [view interactions] | High throughput | no | no |
HS12B_HUMAN | [view interactions] | High throughput | no | yes |
CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |
RNF43_HUMAN | [view interactions] | High throughput | no | yes |