Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AP3D1_HUMAN

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in AP3D1_HUMAN
GO:0000166 nucleotide binding 33.3333 4 no
GO:0017076 purine nucleotide binding 31.8182 5 no
GO:0032555 purine ribonucleotide binding 30.3030 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.3030 4 no
GO:0043168 anion binding 30.3030 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AP3D1_HUMAN
GO:0008104 protein localization 63.6364 4 yes
GO:0071702 organic substance transport 56.0606 4 yes
GO:0071705 nitrogen compound transport 54.5455 4 yes
GO:0006996 organelle organization 46.9697 4 yes
GO:0015031 protein transport 46.9697 4 yes
GO:0048522 positive regulation of cellular process 45.4545 4 yes
GO:0060255 regulation of macromolecule metabolic process 43.9394 4 yes
GO:0051128 regulation of cellular component organization 42.4242 4 no
GO:0010646 regulation of cell communication 39.3939 4 no
GO:0048523 negative regulation of cellular process 39.3939 4 no
GO:0080090 regulation of primary metabolic process 39.3939 4 yes
GO:0006886 intracellular protein transport 37.8788 4 yes
GO:0051049 regulation of transport 36.3636 4 no
GO:0031323 regulation of cellular metabolic process 36.3636 4 yes
GO:0009893 positive regulation of metabolic process 34.8485 4 yes
GO:0022607 cellular component assembly 34.8485 4 yes
GO:0009889 regulation of biosynthetic process 33.3333 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 31.8182 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 31.8182 5 yes
GO:0031326 regulation of cellular biosynthetic process 31.8182 5 yes
GO:0009966 regulation of signal transduction 30.3030 4 no
GO:0010468 regulation of gene expression 30.3030 6 yes
GO:0031325 positive regulation of cellular metabolic process 28.7879 5 yes
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0009891 positive regulation of biosynthetic process 27.2727 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 yes
GO:0051246 regulation of protein metabolic process 25.7576 5 no
GO:0044087 regulation of cellular component biogenesis 25.7576 4 no
GO:0060341 regulation of cellular localization 25.7576 4 no
GO:0016050 vesicle organization 25.7576 5 yes
GO:0010647 positive regulation of cell communication 24.2424 5 no
GO:0023056 positive regulation of signaling 24.2424 4 no
GO:0051050 positive regulation of transport 24.2424 4 no
GO:0007034 vacuolar transport 24.2424 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 24.2424 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 24.2424 6 yes
GO:0032880 regulation of protein localization 22.7273 5 no
GO:0060627 regulation of vesicle-mediated transport 22.7273 4 no
GO:0051252 regulation of RNA metabolic process 22.7273 5 yes
GO:2001141 regulation of RNA biosynthetic process 21.2121 6 yes
GO:0009892 negative regulation of metabolic process 21.2121 4 no
GO:0010605 negative regulation of macromolecule metabolic process 21.2121 5 no
GO:0010648 negative regulation of cell communication 21.2121 5 no
GO:0023057 negative regulation of signaling 21.2121 4 no
GO:0036211 protein modification process 21.2121 4 no
GO:0043412 macromolecule modification 21.2121 4 no
GO:0051247 positive regulation of protein metabolic process 21.2121 6 no
GO:0098657 import into cell 21.2121 4 no
GO:0006355 regulation of DNA-templated transcription 21.2121 7 yes
GO:0007041 lysosomal transport 21.2121 5 yes
GO:0033365 protein localization to organelle 21.2121 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.2121 5 yes
GO:0061024 membrane organization 21.2121 4 yes
GO:0099111 microtubule-based transport 19.6970 4 yes
GO:0010970 transport along microtubule 19.6970 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 19.6970 4 yes
GO:0008088 axo-dendritic transport 18.1818 5 yes
GO:0006357 regulation of transcription by RNA polymerase II 16.6667 8 yes
GO:0098930 axonal transport 15.1515 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 15.1515 7 yes
GO:0008089 anterograde axonal transport 15.1515 7 yes
GO:0045893 positive regulation of DNA-templated transcription 15.1515 8 yes
GO:0051240 positive regulation of multicellular organismal process 15.1515 4 yes
GO:0051254 positive regulation of RNA metabolic process 15.1515 6 yes
GO:0051650 establishment of vesicle localization 15.1515 4 yes
GO:0072384 organelle transport along microtubule 15.1515 4 yes
GO:0097479 synaptic vesicle localization 15.1515 4 yes
GO:0099518 vesicle cytoskeletal trafficking 13.6364 5 yes
GO:0045595 regulation of cell differentiation 13.6364 4 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 13.6364 9 yes
GO:0047496 vesicle transport along microtubule 13.6364 5 yes
GO:0070925 organelle assembly 13.6364 5 yes
GO:0099517 synaptic vesicle transport along microtubule 12.1212 4 yes
GO:0002684 positive regulation of immune system process 12.1212 4 yes
GO:0033363 secretory granule organization 12.1212 6 yes
GO:0048490 anterograde synaptic vesicle transport 12.1212 5 yes
GO:0051094 positive regulation of developmental process 12.1212 4 yes
GO:0060155 platelet dense granule organization 12.1212 7 yes
GO:0072657 protein localization to membrane 12.1212 4 yes
GO:0006811 monoatomic ion transport 10.6061 4 yes
GO:0006812 monoatomic cation transport 10.6061 5 yes
GO:0030001 metal ion transport 10.6061 6 yes
GO:0032438 melanosome organization 10.6061 7 yes
GO:0035459 vesicle cargo loading 10.6061 4 yes
GO:0035652 clathrin-coated vesicle cargo loading 10.6061 5 yes
GO:0035654 clathrin-coated vesicle cargo loading, AP-3-mediated 10.6061 6 yes
GO:0048753 pigment granule organization 10.6061 6 yes
GO:0072594 establishment of protein localization to organelle 10.6061 4 yes
GO:1903232 melanosome assembly 9.0909 6 yes
GO:0045597 positive regulation of cell differentiation 9.0909 5 yes
GO:0098655 monoatomic cation transmembrane transport 9.0909 4 yes
GO:0098662 inorganic cation transmembrane transport 9.0909 4 yes
GO:0006605 protein targeting 7.5758 4 yes
GO:0006623 protein targeting to vacuole 7.5758 5 yes
GO:0006892 post-Golgi vesicle-mediated transport 7.5758 4 yes
GO:0006896 Golgi to vacuole transport 7.5758 5 yes
GO:0006901 vesicle coating 7.5758 6 yes
GO:0016183 synaptic vesicle coating 7.5758 7 yes
GO:0036465 synaptic vesicle recycling 7.5758 4 yes
GO:0072665 protein localization to vacuole 7.5758 6 yes
GO:0072666 establishment of protein localization to vacuole 7.5758 5 yes
GO:2000026 regulation of multicellular organismal development 6.0606 4 yes
GO:0002694 regulation of leukocyte activation 6.0606 4 yes
GO:0030155 regulation of cell adhesion 6.0606 4 yes
GO:0045785 positive regulation of cell adhesion 6.0606 5 yes
GO:0050863 regulation of T cell activation 6.0606 6 yes
GO:0050865 regulation of cell activation 6.0606 4 yes
GO:0051249 regulation of lymphocyte activation 6.0606 5 yes
GO:0060284 regulation of cell development 6.0606 5 yes
GO:0061462 protein localization to lysosome 6.0606 7 yes
GO:1902105 regulation of leukocyte differentiation 4.5455 5 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 4.5455 6 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 4.5455 7 yes
GO:1903706 regulation of hemopoiesis 4.5455 4 yes
GO:0000041 transition metal ion transport 4.5455 7 yes
GO:0002696 positive regulation of leukocyte activation 4.5455 5 yes
GO:0010720 positive regulation of cell development 4.5455 6 yes
GO:0022407 regulation of cell-cell adhesion 4.5455 5 yes
GO:0022409 positive regulation of cell-cell adhesion 4.5455 6 yes
GO:0050867 positive regulation of cell activation 4.5455 5 yes
GO:0050870 positive regulation of T cell activation 4.5455 7 yes
GO:0051251 positive regulation of lymphocyte activation 4.5455 6 yes
GO:0140916 zinc ion import into lysosome 3.0303 4 yes
GO:1902107 positive regulation of leukocyte differentiation 3.0303 6 yes
GO:1903708 positive regulation of hemopoiesis 3.0303 5 yes
GO:0006829 zinc ion transport 3.0303 8 yes
GO:0006900 vesicle budding from membrane 3.0303 5 yes
GO:0016182 synaptic vesicle budding from endosome 3.0303 4 yes
GO:0035646 endosome to melanosome transport 3.0303 5 yes
GO:0043485 endosome to pigment granule transport 3.0303 4 yes
GO:0045580 regulation of T cell differentiation 3.0303 7 yes
GO:0045582 positive regulation of T cell differentiation 3.0303 8 yes
GO:0045619 regulation of lymphocyte differentiation 3.0303 6 yes
GO:0045621 positive regulation of lymphocyte differentiation 3.0303 7 yes
GO:0046634 regulation of alpha-beta T cell activation 3.0303 7 yes
GO:0046635 positive regulation of alpha-beta T cell activation 3.0303 8 yes
GO:0046637 regulation of alpha-beta T cell differentiation 3.0303 8 yes
GO:0046638 positive regulation of alpha-beta T cell differentiation 3.0303 9 yes
GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib 3.0303 4 yes
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib 3.0303 4 yes
GO:0051136 regulation of NK T cell differentiation 3.0303 9 yes
GO:0051138 positive regulation of NK T cell differentiation 3.0303 10 yes
GO:0062111 zinc ion import into organelle 3.0303 6 yes
GO:0070142 synaptic vesicle budding 3.0303 6 yes
GO:0071577 zinc ion transmembrane transport 3.0303 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VAMP7_HUMAN [view interactions] Low throughput no yes
CALY_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF3A_HUMAN [view entry] [view interactions] Low throughput yes yes
ACM5_HUMAN [view entry] [view interactions] Low throughput yes no
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
TY3H_HUMAN [view interactions] Low throughput no no
AP3S1_HUMAN [view entry] [view interactions] Low throughput yes no
AP3S2_HUMAN [view entry] [view interactions] Low throughput yes no
PAR1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP3B2_HUMAN [view entry] [view interactions] Low throughput yes yes
AP3M1_HUMAN [view entry] [view interactions] Low throughput yes yes
RUFY1_HUMAN [view interactions] Low throughput no yes
RNF13_HUMAN [view interactions] Low throughput no yes
AP3B1_HUMAN [view entry] [view interactions] Low throughput yes yes
GSK3A_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
MK06_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
BMX_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
RUVB1_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
PI4KB_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
DUX4_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
HG2A_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
VGFR2_HUMAN [view interactions] High throughput no no
SH2B3_HUMAN [view interactions] High throughput no yes
STAM2_HUMAN [view interactions] High throughput no yes
STAP2_HUMAN [view interactions] High throughput no yes
NUAK1_HUMAN [view interactions] High throughput no no
JAK3_HUMAN [view interactions] High throughput no no
MYLK4_HUMAN [view interactions] High throughput no no
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
NEK7_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
NUAK2_HUMAN [view interactions] High throughput no yes
SIK3_HUMAN [view interactions] High throughput no yes
ROS1_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
MET_HUMAN [view interactions] High throughput no yes
IFT27_HUMAN [view interactions] High throughput no yes
RAB37_HUMAN [view entry] [view interactions] High throughput yes no
AP1G1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
NIN_HUMAN [view interactions] High throughput no no
CEP19_HUMAN [view interactions] High throughput no no
CENPJ_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
VGFR1_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
GRK5_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
AGO3_HUMAN [view interactions] High throughput no yes
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
RT29_HUMAN [view interactions] High throughput no yes
KLC2_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
VP33B_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
VPS11_HUMAN [view entry] [view interactions] High throughput yes no
VPS18_HUMAN [view entry] [view interactions] High throughput yes no
VPS39_HUMAN [view entry] [view interactions] High throughput yes no
VPS41_HUMAN [view entry] [view interactions] High throughput yes yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
PO5F1_HUMAN [view interactions] High throughput no yes
PPARG_HUMAN [view interactions] High throughput no yes
AP3M2_HUMAN [view entry] [view interactions] High throughput yes yes
TPC2_HUMAN [view interactions] High throughput no no
CSCL1_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
S15A3_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
BRD7_HUMAN [view interactions] High throughput no yes
BTBD8_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
LRC31_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RBM39_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
TSN10_HUMAN [view interactions] High throughput no no
SIDT2_HUMAN [view interactions] High throughput no yes
ZN460_HUMAN [view interactions] High throughput no no
ZCH10_HUMAN [view interactions] High throughput no yes
WDR55_HUMAN [view interactions] High throughput no yes
VPP3_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
PLCD3_HUMAN [view entry] [view interactions] High throughput yes yes
PEG10_HUMAN [view interactions] High throughput no no
COMD2_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
UBP53_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
PARPT_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no
UBP1_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
HTSF1_HUMAN [view interactions] High throughput no yes
CD11B_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
COPG1_HUMAN [view interactions] High throughput no yes
RBM25_HUMAN [view interactions] High throughput no yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
PI42B_HUMAN [view entry] [view interactions] High throughput yes no
ZNT3_HUMAN [view entry] [view interactions] High throughput yes yes
CADM1_HUMAN [view entry] [view interactions] High throughput yes no
DPY30_HUMAN [view interactions] High throughput no yes
ENY2_HUMAN [view interactions] High throughput no yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
PACS1_HUMAN [view entry] [view interactions] High throughput yes yes
SCOC_HUMAN [view interactions] High throughput no yes
SNAPN_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
CHD8_HUMAN [view interactions] High throughput no no
BL1S6_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
RN183_HUMAN [view interactions] High throughput no no
HS12B_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
RNF43_HUMAN [view interactions] High throughput no yes
ATG9A_HUMAN [view interactions] High throughput no yes
PHLP1_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF3_HUMAN [view entry] [view interactions] High throughput yes no
ARF4_HUMAN [view entry] [view interactions] High throughput yes no
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes