AP3M1_HUMAN
Evidence for PS localization
Functions
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP3M1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 34.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 34.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 32.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.0000 | 4 | no |
| GO:0043168 | anion binding | 32.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.0000 | 6 | no |
| GO:0051020 | GTPase binding | 10.0000 | 4 | yes |
| GO:0031267 | small GTPase binding | 8.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP3M1_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 54.0000 | 4 | yes |
| GO:0008104 | protein localization | 52.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 52.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.0000 | 4 | no |
| GO:0071702 | organic substance transport | 46.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 46.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 44.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 44.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0015031 | protein transport | 38.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 38.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.0000 | 4 | no |
| GO:0006886 | intracellular protein transport | 34.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 34.0000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 34.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 32.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 32.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 30.0000 | 5 | no |
| GO:0016050 | vesicle organization | 28.0000 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 28.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 28.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 28.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.0000 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.0000 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 26.0000 | 5 | no |
| GO:0051650 | establishment of vesicle localization | 24.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 24.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 24.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 24.0000 | 5 | no |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 22.0000 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.0000 | 6 | no |
| GO:0036211 | protein modification process | 22.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 22.0000 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.0000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 22.0000 | 5 | no |
| GO:0007034 | vacuolar transport | 20.0000 | 4 | yes |
| GO:0010970 | transport along microtubule | 20.0000 | 4 | yes |
| GO:0072384 | organelle transport along microtubule | 20.0000 | 4 | yes |
| GO:0099111 | microtubule-based transport | 20.0000 | 4 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 20.0000 | 5 | yes |
| GO:0033365 | protein localization to organelle | 18.0000 | 5 | yes |
| GO:0047496 | vesicle transport along microtubule | 18.0000 | 5 | yes |
| GO:0008088 | axo-dendritic transport | 16.0000 | 5 | yes |
| GO:0008089 | anterograde axonal transport | 16.0000 | 7 | yes |
| GO:0048490 | anterograde synaptic vesicle transport | 16.0000 | 5 | yes |
| GO:0097479 | synaptic vesicle localization | 16.0000 | 4 | yes |
| GO:0098930 | axonal transport | 16.0000 | 6 | yes |
| GO:0099517 | synaptic vesicle transport along microtubule | 16.0000 | 4 | yes |
| GO:0007041 | lysosomal transport | 14.0000 | 5 | yes |
| GO:0035459 | vesicle cargo loading | 14.0000 | 4 | yes |
| GO:0035652 | clathrin-coated vesicle cargo loading | 14.0000 | 5 | yes |
| GO:0035654 | clathrin-coated vesicle cargo loading, AP-3-mediated | 14.0000 | 6 | yes |
| GO:0070925 | organelle assembly | 14.0000 | 5 | yes |
| GO:0032438 | melanosome organization | 12.0000 | 7 | yes |
| GO:0033363 | secretory granule organization | 12.0000 | 6 | yes |
| GO:0048753 | pigment granule organization | 12.0000 | 6 | yes |
| GO:0060155 | platelet dense granule organization | 12.0000 | 7 | yes |
| GO:0072594 | establishment of protein localization to organelle | 12.0000 | 4 | yes |
| GO:0098657 | import into cell | 12.0000 | 4 | yes |
| GO:0006605 | protein targeting | 10.0000 | 4 | yes |
| GO:1903232 | melanosome assembly | 10.0000 | 6 | yes |
| GO:0006623 | protein targeting to vacuole | 8.0000 | 5 | yes |
| GO:0061462 | protein localization to lysosome | 8.0000 | 7 | yes |
| GO:0072665 | protein localization to vacuole | 8.0000 | 6 | yes |
| GO:0072666 | establishment of protein localization to vacuole | 8.0000 | 5 | yes |
| GO:0006622 | protein targeting to lysosome | 6.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AP3S2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP7_HUMAN | [view interactions] | Low throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RUFY1_HUMAN | [view interactions] | Low throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| WDR48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLAK2_HUMAN | [view interactions] | High throughput | no | no |
| VASN_HUMAN | [view interactions] | High throughput | no | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3M2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| RSP14_HUMAN | [view interactions] | High throughput | no | no |
| DMB_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| BMX_HUMAN | [view interactions] | High throughput | no | no |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| PI4KB_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAT2_HUMAN | [view interactions] | High throughput | no | yes |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| CHD8_HUMAN | [view interactions] | High throughput | no | no |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| ARNT2_HUMAN | [view interactions] | High throughput | no | yes |
| I36RA_HUMAN | [view interactions] | High throughput | no | no |
| S12A4_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| MKS1_HUMAN | [view interactions] | High throughput | no | no |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| TECT1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| SPG16_HUMAN | [view interactions] | High throughput | no | yes |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| IDS_HUMAN | [view interactions] | High throughput | no | yes |
| AGO3_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9A_HUMAN | [view interactions] | High throughput | no | no |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKAP1_HUMAN | [view interactions] | High throughput | no | no |
| EDA_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| RABL6_HUMAN | [view interactions] | High throughput | no | yes |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD79B_HUMAN | [view interactions] | High throughput | no | no |
| LASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| M4K2_HUMAN | [view interactions] | High throughput | no | yes |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN460_HUMAN | [view interactions] | High throughput | no | no |
| UTP23_HUMAN | [view interactions] | High throughput | no | no |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| SSRB_HUMAN | [view interactions] | High throughput | no | no |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| PLCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CR3L3_HUMAN | [view interactions] | High throughput | no | no |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX16_HUMAN | [view interactions] | High throughput | no | yes |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| FGFP1_HUMAN | [view interactions] | High throughput | no | no |
| MESH1_HUMAN | [view interactions] | High throughput | no | yes |
| PHF6_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC9_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| PLD1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN3_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| KAT6A_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| PSB3_HUMAN | [view interactions] | High throughput | no | yes |
| PSA7_HUMAN | [view interactions] | High throughput | no | yes |
| PSB5_HUMAN | [view interactions] | High throughput | no | yes |
| UBF1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| MOB3A_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |