AP3S2_HUMAN
Evidence for PS localization
Functions
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP3S2_HUMAN |
|---|---|---|---|---|
| GO:0035615 | clathrin adaptor activity | 31.5789 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP3S2_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 100.0000 | 4 | yes |
| GO:0006886 | intracellular protein transport | 84.2105 | 4 | yes |
| GO:0015031 | protein transport | 84.2105 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 84.2105 | 4 | yes |
| GO:0071702 | organic substance transport | 84.2105 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 84.2105 | 4 | yes |
| GO:0006897 | endocytosis | 47.3684 | 5 | no |
| GO:0051049 | regulation of transport | 47.3684 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.3684 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 42.1053 | 4 | no |
| GO:0006996 | organelle organization | 42.1053 | 4 | no |
| GO:0008088 | axo-dendritic transport | 36.8421 | 5 | yes |
| GO:0008089 | anterograde axonal transport | 36.8421 | 7 | yes |
| GO:0010970 | transport along microtubule | 36.8421 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 36.8421 | 4 | yes |
| GO:0047496 | vesicle transport along microtubule | 36.8421 | 5 | yes |
| GO:0048489 | synaptic vesicle transport | 36.8421 | 4 | yes |
| GO:0048490 | anterograde synaptic vesicle transport | 36.8421 | 7 | yes |
| GO:0051650 | establishment of vesicle localization | 36.8421 | 4 | yes |
| GO:0072384 | organelle transport along microtubule | 36.8421 | 4 | yes |
| GO:0097479 | synaptic vesicle localization | 36.8421 | 4 | yes |
| GO:0098930 | axonal transport | 36.8421 | 6 | yes |
| GO:0099111 | microtubule-based transport | 36.8421 | 4 | yes |
| GO:0099514 | synaptic vesicle cytoskeletal transport | 36.8421 | 5 | yes |
| GO:0099517 | synaptic vesicle transport along microtubule | 36.8421 | 6 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 36.8421 | 5 | yes |
| GO:0006898 | receptor-mediated endocytosis | 36.8421 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 36.8421 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.5789 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.5789 | 4 | no |
| GO:0022607 | cellular component assembly | 31.5789 | 4 | no |
| GO:0030100 | regulation of endocytosis | 31.5789 | 5 | no |
| GO:0016050 | vesicle organization | 31.5789 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 26.3158 | 4 | no |
| GO:0061024 | membrane organization | 26.3158 | 4 | no |
| GO:0006892 | post-Golgi vesicle-mediated transport | 26.3158 | 6 | yes |
| GO:0007034 | vacuolar transport | 26.3158 | 4 | yes |
| GO:0048193 | Golgi vesicle transport | 26.3158 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 26.3158 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.3158 | 4 | no |
| GO:0072583 | clathrin-dependent endocytosis | 26.3158 | 7 | no |
| GO:0099003 | vesicle-mediated transport in synapse | 26.3158 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 26.3158 | 4 | no |
| GO:0033365 | protein localization to organelle | 26.3158 | 5 | no |
| GO:0072657 | protein localization to membrane | 21.0526 | 4 | no |
| GO:0010646 | regulation of cell communication | 21.0526 | 4 | no |
| GO:0030030 | cell projection organization | 21.0526 | 4 | no |
| GO:0048259 | regulation of receptor-mediated endocytosis | 21.0526 | 6 | no |
| GO:0006896 | Golgi to vacuole transport | 21.0526 | 5 | yes |
| GO:0032880 | regulation of protein localization | 21.0526 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.0526 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.0526 | 4 | no |
| GO:0032438 | melanosome organization | 21.0526 | 7 | no |
| GO:0048753 | pigment granule organization | 21.0526 | 6 | no |
| GO:0048878 | chemical homeostasis | 21.0526 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AP3M1_HUMAN | [view interactions] | Low throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AP3B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | Low throughput | no | yes |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| AP3M2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF13_HUMAN | [view interactions] | High throughput | no | yes |
| PI4KB_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| VPP3_HUMAN | [view interactions] | High throughput | no | no |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3B2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP5M1_HUMAN | [view interactions] | Computational | no | no |
| AP4M1_HUMAN | [view interactions] | Computational | no | yes |
| AP5B1_HUMAN | [view interactions] | Computational | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP5S1_HUMAN | [view interactions] | Computational | no | yes |
| AP1S1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP4E1_HUMAN | [view interactions] | Computational | no | no |
| AP2S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP2A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP4B1_HUMAN | [view interactions] | Computational | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AFTIN_HUMAN | [view interactions] | Computational | no | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |