Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AP3S2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AP3S2_HUMAN
GO:0000166 nucleotide binding 23.0769 4 no
GO:0003924 GTPase activity 23.0769 7 no
GO:0005525 GTP binding 23.0769 5 no
GO:0016462 pyrophosphatase activity 23.0769 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.0769 4 no
GO:0017076 purine nucleotide binding 23.0769 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.0769 6 no
GO:0019001 guanyl nucleotide binding 23.0769 6 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0032561 guanyl ribonucleotide binding 23.0769 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 no
GO:0043168 anion binding 23.0769 4 no
GO:0051020 GTPase binding 23.0769 4 no
GO:0003723 RNA binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AP3S2_HUMAN
GO:0008104 protein localization 92.3077 4 yes
GO:0006996 organelle organization 76.9231 4 yes
GO:0006886 intracellular protein transport 69.2308 4 yes
GO:0015031 protein transport 69.2308 4 yes
GO:0071702 organic substance transport 69.2308 4 yes
GO:0071705 nitrogen compound transport 69.2308 4 yes
GO:0008088 axo-dendritic transport 53.8462 5 yes
GO:0010970 transport along microtubule 53.8462 4 yes
GO:0016050 vesicle organization 53.8462 5 yes
GO:0022607 cellular component assembly 53.8462 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 53.8462 4 yes
GO:0099111 microtubule-based transport 53.8462 4 yes
GO:0048522 positive regulation of cellular process 53.8462 4 no
GO:0060255 regulation of macromolecule metabolic process 53.8462 4 no
GO:0008089 anterograde axonal transport 46.1538 7 yes
GO:0047496 vesicle transport along microtubule 46.1538 5 yes
GO:0048490 anterograde synaptic vesicle transport 46.1538 5 yes
GO:0051650 establishment of vesicle localization 46.1538 4 yes
GO:0072384 organelle transport along microtubule 46.1538 4 yes
GO:0097479 synaptic vesicle localization 46.1538 4 yes
GO:0098930 axonal transport 46.1538 6 yes
GO:0099517 synaptic vesicle transport along microtubule 46.1538 4 yes
GO:0099518 vesicle cytoskeletal trafficking 46.1538 5 yes
GO:0033365 protein localization to organelle 46.1538 5 no
GO:0051128 regulation of cellular component organization 46.1538 4 no
GO:0032438 melanosome organization 38.4615 7 yes
GO:0033363 secretory granule organization 38.4615 6 yes
GO:0035459 vesicle cargo loading 38.4615 4 yes
GO:0035652 clathrin-coated vesicle cargo loading 38.4615 5 yes
GO:0035654 clathrin-coated vesicle cargo loading, AP-3-mediated 38.4615 6 yes
GO:0048753 pigment granule organization 38.4615 6 yes
GO:0060155 platelet dense granule organization 38.4615 7 yes
GO:0070925 organelle assembly 38.4615 5 yes
GO:0010646 regulation of cell communication 38.4615 4 no
GO:0030030 cell projection organization 38.4615 4 no
GO:0048523 negative regulation of cellular process 38.4615 4 no
GO:0051049 regulation of transport 38.4615 4 no
GO:0072657 protein localization to membrane 38.4615 4 no
GO:0009889 regulation of biosynthetic process 38.4615 4 no
GO:0010468 regulation of gene expression 38.4615 6 no
GO:0010556 regulation of macromolecule biosynthetic process 38.4615 5 no
GO:0031323 regulation of cellular metabolic process 38.4615 4 no
GO:0031326 regulation of cellular biosynthetic process 38.4615 5 no
GO:0080090 regulation of primary metabolic process 38.4615 4 no
GO:0007034 vacuolar transport 30.7692 4 yes
GO:1903232 melanosome assembly 30.7692 6 yes
GO:0120036 plasma membrane bounded cell projection organization 30.7692 5 no
GO:0009891 positive regulation of biosynthetic process 30.7692 5 no
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.7692 6 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0031325 positive regulation of cellular metabolic process 30.7692 5 no
GO:0031328 positive regulation of cellular biosynthetic process 30.7692 6 no
GO:0061024 membrane organization 30.7692 4 no
GO:0006901 vesicle coating 23.0769 6 yes
GO:0016183 synaptic vesicle coating 23.0769 7 yes
GO:0036465 synaptic vesicle recycling 23.0769 4 yes
GO:0098657 import into cell 23.0769 4 no
GO:0007010 cytoskeleton organization 23.0769 5 no
GO:0009966 regulation of signal transduction 23.0769 4 no
GO:0030100 regulation of endocytosis 23.0769 5 no
GO:0031344 regulation of cell projection organization 23.0769 5 no
GO:0032880 regulation of protein localization 23.0769 5 no
GO:0033043 regulation of organelle organization 23.0769 5 no
GO:0034330 cell junction organization 23.0769 4 no
GO:0048259 regulation of receptor-mediated endocytosis 23.0769 6 no
GO:0050807 regulation of synapse organization 23.0769 5 no
GO:0060341 regulation of cellular localization 23.0769 4 no
GO:0060627 regulation of vesicle-mediated transport 23.0769 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 no
GO:0006355 regulation of DNA-templated transcription 23.0769 7 no
GO:0006357 regulation of transcription by RNA polymerase II 23.0769 8 no
GO:0006605 protein targeting 23.0769 4 no
GO:0006623 protein targeting to vacuole 23.0769 5 no
GO:0007041 lysosomal transport 23.0769 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0045893 positive regulation of DNA-templated transcription 23.0769 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 23.0769 9 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:0051254 positive regulation of RNA metabolic process 23.0769 6 no
GO:0061462 protein localization to lysosome 23.0769 7 no
GO:0072594 establishment of protein localization to organelle 23.0769 4 no
GO:0072665 protein localization to vacuole 23.0769 6 no
GO:0072666 establishment of protein localization to vacuole 23.0769 5 no
GO:1902680 positive regulation of RNA biosynthetic process 23.0769 7 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0010647 positive regulation of cell communication 23.0769 5 no
GO:0023056 positive regulation of signaling 23.0769 4 no
GO:0050804 modulation of chemical synaptic transmission 23.0769 5 no
GO:0099177 regulation of trans-synaptic signaling 23.0769 4 no
GO:0006892 post-Golgi vesicle-mediated transport 15.3846 4 yes
GO:0006896 Golgi to vacuole transport 15.3846 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AP3M1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP3D1_HUMAN [view entry] [view interactions] Low throughput yes no
AP3B1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
SCRB2_HUMAN [view interactions] Low throughput no yes
CSCL1_HUMAN [view interactions] High throughput no no
AP3M2_HUMAN [view entry] [view interactions] High throughput yes yes
RNF13_HUMAN [view interactions] High throughput no yes
PI4KB_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
E2F4_HUMAN [view interactions] High throughput no no
HUWE1_HUMAN [view interactions] High throughput no yes
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
VPP3_HUMAN [view interactions] High throughput no no
S10A6_HUMAN [view interactions] High throughput no yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
SIDT2_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
ATG9A_HUMAN [view interactions] High throughput no yes
ARF4_HUMAN [view entry] [view interactions] High throughput yes no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes