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ARF4_HUMAN

GO
G2C
SynaptomeDB

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ARF4_HUMAN
GO:0017076 purine nucleotide binding 33.3333 4 yes
GO:0032555 purine ribonucleotide binding 33.3333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 yes
GO:0016462 pyrophosphatase activity 21.6667 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.6667 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.6667 6 yes
GO:0003924 GTPase activity 20.0000 7 yes
GO:0005525 GTP binding 20.0000 5 yes
GO:0019001 guanyl nucleotide binding 20.0000 5 yes
GO:0032561 guanyl ribonucleotide binding 20.0000 5 yes
GO:0030695 GTPase regulator activity 10.0000 4 yes
GO:0070851 growth factor receptor binding 3.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ARF4_HUMAN
GO:0048522 positive regulation of cellular process 58.3333 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:0048523 negative regulation of cellular process 48.3333 4 yes
GO:0051128 regulation of cellular component organization 46.6667 4 yes
GO:0080090 regulation of primary metabolic process 46.6667 4 yes
GO:0010646 regulation of cell communication 46.6667 4 no
GO:0031323 regulation of cellular metabolic process 46.6667 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 45.0000 4 yes
GO:0006996 organelle organization 41.6667 4 yes
GO:0009893 positive regulation of metabolic process 41.6667 4 yes
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0008104 protein localization 40.0000 4 yes
GO:0010468 regulation of gene expression 40.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 36.6667 5 yes
GO:1902531 regulation of intracellular signal transduction 35.0000 5 no
GO:0071702 organic substance transport 33.3333 4 yes
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0009889 regulation of biosynthetic process 33.3333 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 yes
GO:0022607 cellular component assembly 33.3333 4 yes
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 yes
GO:0071705 nitrogen compound transport 31.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 31.6667 5 yes
GO:0051252 regulation of RNA metabolic process 30.0000 5 yes
GO:0051247 positive regulation of protein metabolic process 30.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 yes
GO:0016192 vesicle-mediated transport 30.0000 4 yes
GO:0036211 protein modification process 30.0000 4 yes
GO:0043412 macromolecule modification 30.0000 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 28.3333 7 yes
GO:2001141 regulation of RNA biosynthetic process 28.3333 6 yes
GO:0010647 positive regulation of cell communication 28.3333 5 no
GO:0023056 positive regulation of signaling 28.3333 4 no
GO:0006355 regulation of DNA-templated transcription 28.3333 6 yes
GO:0010941 regulation of cell death 28.3333 4 yes
GO:0015031 protein transport 28.3333 4 yes
GO:0030030 cell projection organization 28.3333 4 yes
GO:0120036 plasma membrane bounded cell projection organization 26.6667 5 yes
GO:0009892 negative regulation of metabolic process 26.6667 4 no
GO:0009967 positive regulation of signal transduction 26.6667 5 no
GO:0048584 positive regulation of response to stimulus 26.6667 4 no
GO:0071310 cellular response to organic substance 26.6667 4 no
GO:0033043 regulation of organelle organization 26.6667 5 no
GO:0051130 positive regulation of cellular component organization 26.6667 5 no
GO:0043085 positive regulation of catalytic activity 26.6667 4 yes
GO:0051049 regulation of transport 25.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 23.3333 5 no
GO:0019220 regulation of phosphate metabolic process 23.3333 6 no
GO:0031324 negative regulation of cellular metabolic process 23.3333 5 no
GO:0031399 regulation of protein modification process 23.3333 6 no
GO:0043408 regulation of MAPK cascade 23.3333 6 no
GO:0051174 regulation of phosphorus metabolic process 23.3333 5 no
GO:1902533 positive regulation of intracellular signal transduction 23.3333 6 no
GO:0006886 intracellular protein transport 23.3333 4 yes
GO:0042981 regulation of apoptotic process 23.3333 6 yes
GO:0043067 regulation of programmed cell death 23.3333 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.6667 6 yes
GO:0060548 negative regulation of cell death 21.6667 5 yes
GO:0009894 regulation of catabolic process 21.6667 4 no
GO:0042325 regulation of phosphorylation 21.6667 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.6667 5 no
GO:0031344 regulation of cell projection organization 21.6667 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.6667 6 no
GO:0009891 positive regulation of biosynthetic process 21.6667 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 21.6667 6 yes
GO:0006357 regulation of transcription by RNA polymerase II 20.0000 7 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 20.0000 6 yes
GO:0033365 protein localization to organelle 20.0000 5 yes
GO:0045893 positive regulation of DNA-templated transcription 18.3333 7 yes
GO:0051254 positive regulation of RNA metabolic process 18.3333 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 18.3333 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 18.3333 8 yes
GO:0043066 negative regulation of apoptotic process 18.3333 7 yes
GO:0043069 negative regulation of programmed cell death 18.3333 6 yes
GO:0051336 regulation of hydrolase activity 16.6667 4 yes
GO:0070925 organelle assembly 16.6667 5 yes
GO:0051345 positive regulation of hydrolase activity 15.0000 5 yes
GO:0050807 regulation of synapse organization 13.3333 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 11.6667 8 yes
GO:0050890 cognition 11.6667 4 yes
GO:0048193 Golgi vesicle transport 10.0000 5 yes
GO:0099175 regulation of postsynapse organization 8.3333 6 yes
GO:0120031 plasma membrane bounded cell projection assembly 8.3333 6 yes
GO:0030031 cell projection assembly 8.3333 5 yes
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 6.6667 4 yes
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 6.6667 6 yes
GO:0007612 learning 6.6667 4 yes
GO:0044782 cilium organization 5.0000 5 yes
GO:0060191 regulation of lipase activity 5.0000 5 yes
GO:0060193 positive regulation of lipase activity 5.0000 6 yes
GO:0060271 cilium assembly 5.0000 6 yes
GO:0061512 protein localization to cilium 5.0000 6 yes
GO:0010517 regulation of phospholipase activity 5.0000 6 yes
GO:0010518 positive regulation of phospholipase activity 5.0000 7 yes
GO:2000377 regulation of reactive oxygen species metabolic process 3.3333 5 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 3.3333 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in ARF4_HUMAN
DOID:0050686 organ system cancer 3.3333 3 no
DOID:120 female reproductive organ cancer 3.3333 5 no
DOID:193 reproductive organ cancer 3.3333 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EGFR_HUMAN [view interactions] Low throughput no no
APBA2_HUMAN [view interactions] Low throughput no yes
APBA1_HUMAN [view interactions] Low throughput no no
APBA3_HUMAN [view interactions] Low throughput no yes
SC5A5_HUMAN [view interactions] Low throughput no no
UBP7_HUMAN [view interactions] Low throughput no yes
NEMO_HUMAN [view interactions] Low throughput no yes
DEN1A_HUMAN [view interactions] Low throughput no no
DEN1B_HUMAN [view interactions] Low throughput no yes
CAPS2_HUMAN [view interactions] Low throughput no no
VAV_HUMAN [view interactions] High throughput no no
RHG31_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
HMGA2_HUMAN [view interactions] High throughput no yes
RFIP3_HUMAN [view entry] [view interactions] High throughput yes no
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
MED20_HUMAN [view interactions] High throughput no no
PGFRB_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
SNW1_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
LITD1_HUMAN [view interactions] High throughput no no
EGLN_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
SDCB2_HUMAN [view interactions] High throughput no yes
CSN3_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
CDK1_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
STK4_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
BET1_HUMAN [view interactions] High throughput no no
COX14_HUMAN [view interactions] High throughput no yes
FBRL_HUMAN [view interactions] High throughput no yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
PSA1_HUMAN [view interactions] High throughput no yes
PLRKT_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view interactions] High throughput no yes
TOM22_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
UFO_HUMAN [view interactions] High throughput no no
EPHA8_HUMAN [view interactions] High throughput no no
EPHB6_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
FGFR3_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
VGFR1_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
INSRR_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
MET_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
RON_HUMAN [view interactions] High throughput no yes
ROR1_HUMAN [view interactions] High throughput no no
STYK1_HUMAN [view interactions] High throughput no yes
TIE2_HUMAN [view interactions] High throughput no no
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
GRK5_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
CLN3_HUMAN [view interactions] High throughput no no
CLN5_HUMAN [view interactions] High throughput no yes
PLCB1_HUMAN [view entry] [view interactions] High throughput yes yes
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
ASB14_HUMAN [view interactions] High throughput no no
ASB17_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
PODO_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
OXDA_HUMAN [view interactions] High throughput no no
CDC73_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
PPP6_HUMAN [view interactions] High throughput no yes
TXTP_HUMAN [view entry] [view interactions] High throughput yes no
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK9_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
FGFR1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
REQU_HUMAN [view interactions] High throughput no yes
SNAI1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
CTCF_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
WWP1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ANR55_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
F16P1_HUMAN [view interactions] High throughput no no
APR_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
FZR1_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
ZBTB2_HUMAN [view interactions] High throughput no yes
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF3_HUMAN [view entry] [view interactions] High throughput yes no
SPRTN_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
NONO_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
SERPH_HUMAN [view interactions] High throughput no no
BAP31_HUMAN [view interactions] High throughput no yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
LMAN2_HUMAN [view interactions] High throughput no yes
WBP11_HUMAN [view interactions] High throughput no yes
ERP44_HUMAN [view interactions] High throughput no yes
COPB2_HUMAN [view entry] [view interactions] High throughput yes yes
COPE_HUMAN [view interactions] High throughput no yes
COPZ1_HUMAN [view interactions] High throughput no no
SHIP2_HUMAN [view interactions] High throughput no yes
RIT1_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
SHPS1_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view interactions] High throughput no yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
ACADM_HUMAN [view interactions] High throughput no yes
COF1_HUMAN [view entry] [view interactions] High throughput yes no
DAZP1_HUMAN [view interactions] High throughput no yes
ETFA_HUMAN [view interactions] High throughput no yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
LDH6A_HUMAN [view interactions] High throughput no no
LDH6B_HUMAN [view interactions] High throughput no no
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
LDHC_HUMAN [view interactions] High throughput no no
MTAP_HUMAN [view interactions] High throughput no no
TSPO_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
FUBP1_HUMAN [view interactions] High throughput no yes
FUBP3_HUMAN [view interactions] High throughput no yes
RACK1_HUMAN [view interactions] High throughput no yes
IDHC_HUMAN [view interactions] High throughput no no
LEG1_HUMAN [view interactions] High throughput no yes
PCBP2_HUMAN [view entry] [view interactions] High throughput yes yes
SERC_HUMAN [view interactions] High throughput no yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
PTH2_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
RPA34_HUMAN [view interactions] High throughput no yes
COIL_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
TFR1_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
NBR1_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
ZN363_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
AGO4_HUMAN [view interactions] High throughput no no
BABA1_HUMAN [view interactions] High throughput no yes
ATF2_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
XPP3_HUMAN [view interactions] High throughput no yes
SUCHY_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
COPG1_HUMAN [view interactions] Computational no yes
OPSD_HUMAN [view interactions] Computational no no
ARFG3_HUMAN [view entry] [view interactions] Computational yes no
RAB3I_HUMAN [view interactions] Computational no no
PKD2_HUMAN [view interactions] Computational no yes
RAB28_HUMAN [view interactions] Computational no yes
PKD1_HUMAN [view interactions] Computational no yes
PLD2_HUMAN [view interactions] Computational no yes
COPG2_HUMAN [view interactions] Computational no yes
ASAP1_HUMAN [view entry] [view interactions] Computational yes yes
EGF_HUMAN [view interactions] Computational no no
COPB_HUMAN [view interactions] Computational no yes
ARFG1_HUMAN [view interactions] Computational no no
ARFG2_HUMAN [view entry] [view interactions] Computational yes yes