ARFG3_HUMAN
Evidence for PS localization
Functions
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARFG3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 45.0980 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 45.0980 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 45.0980 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 31.3725 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 31.3725 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 31.3725 | 6 | no |
| GO:0003924 | GTPase activity | 25.4902 | 7 | no |
| GO:0005525 | GTP binding | 25.4902 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 25.4902 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 25.4902 | 5 | no |
| GO:0046872 | metal ion binding | 21.5686 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 5.8824 | 4 | yes |
| GO:0005096 | GTPase activator activity | 3.9216 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARFG3_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 58.8235 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 56.8627 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 56.8627 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.9412 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.9412 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.9804 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 49.0196 | 4 | no |
| GO:0006996 | organelle organization | 45.0980 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 45.0980 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 45.0980 | 4 | no |
| GO:0008104 | protein localization | 43.1373 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.1373 | 5 | no |
| GO:0010646 | regulation of cell communication | 41.1765 | 4 | no |
| GO:0051049 | regulation of transport | 41.1765 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.2157 | 5 | no |
| GO:0071702 | organic substance transport | 37.2549 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 37.2549 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 37.2549 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.2549 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 37.2549 | 5 | no |
| GO:0022607 | cellular component assembly | 37.2549 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.2549 | 5 | no |
| GO:0033043 | regulation of organelle organization | 35.2941 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.2941 | 4 | no |
| GO:0015031 | protein transport | 33.3333 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0010941 | regulation of cell death | 33.3333 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 31.3725 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.3725 | 5 | no |
| GO:0031399 | regulation of protein modification process | 31.3725 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 31.3725 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 31.3725 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.3725 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 31.3725 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 31.3725 | 6 | no |
| GO:0023056 | positive regulation of signaling | 31.3725 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 31.3725 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 31.3725 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.3725 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.3725 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 31.3725 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 31.3725 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.4118 | 5 | no |
| GO:0006886 | intracellular protein transport | 27.4510 | 4 | yes |
| GO:0060548 | negative regulation of cell death | 27.4510 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 27.4510 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 27.4510 | 4 | no |
| GO:0043549 | regulation of kinase activity | 27.4510 | 5 | no |
| GO:0051338 | regulation of transferase activity | 27.4510 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.4902 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.4902 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.4902 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 25.4902 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.4902 | 7 | no |
| GO:0071310 | cellular response to organic substance | 25.4902 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.5294 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 23.5294 | 6 | no |
| GO:0007010 | cytoskeleton organization | 23.5294 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 23.5294 | 6 | no |
| GO:0030334 | regulation of cell migration | 23.5294 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 23.5294 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.5294 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.5294 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 23.5294 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.5294 | 6 | no |
| GO:2000145 | regulation of cell motility | 23.5294 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.5686 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.5686 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 21.5686 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.5686 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.5686 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.5686 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.5686 | 6 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.5686 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 21.5686 | 6 | no |
| GO:0030030 | cell projection organization | 21.5686 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.5686 | 8 | no |
| GO:0045595 | regulation of cell differentiation | 21.5686 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.5686 | 7 | no |
| GO:0061024 | membrane organization | 21.5686 | 4 | no |
| GO:0046903 | secretion | 13.7255 | 4 | yes |
| GO:0016050 | vesicle organization | 11.7647 | 5 | yes |
| GO:0006901 | vesicle coating | 3.9216 | 6 | yes |
| GO:0048200 | Golgi transport vesicle coating | 3.9216 | 7 | yes |
| GO:0048205 | COPI coating of Golgi vesicle | 3.9216 | 8 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ARFG3_HUMAN |
|---|---|---|---|---|
| DOID:440 | neuromuscular disease | 5.8824 | 5 | no |
| DOID:574 | peripheral nervous system disease | 5.8824 | 3 | no |
| DOID:870 | neuropathy | 5.8824 | 4 | no |
| DOID:0050155 | sensory system disease | 3.9216 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 3.9216 | 5 | no |
| DOID:0060038 | specific developmental disorder | 3.9216 | 3 | no |
| DOID:1059 | intellectual disability | 3.9216 | 4 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 3.9216 | 6 | no |
| DOID:2742 | auditory system disease | 3.9216 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD14_HUMAN | [view interactions] | High throughput | no | no |
| IL8_HUMAN | [view interactions] | High throughput | no | no |
| ZDH17_HUMAN | [view interactions] | High throughput | no | yes |
| RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
| SYPL1_HUMAN | [view interactions] | High throughput | no | yes |
| LIME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| CRYAA_HUMAN | [view interactions] | High throughput | no | no |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX1_HUMAN | [view interactions] | High throughput | no | no |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLK6_HUMAN | [view interactions] | High throughput | no | no |
| PGH1_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| TTHY_HUMAN | [view interactions] | High throughput | no | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX5_HUMAN | [view interactions] | High throughput | no | yes |
| BACE2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DRC5_HUMAN | [view interactions] | High throughput | no | no |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| MKS1_HUMAN | [view interactions] | High throughput | no | no |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUSK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| VIP2_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHPK_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| AN36B_HUMAN | [view interactions] | High throughput | no | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNPC4_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTND_HUMAN | [view interactions] | High throughput | no | yes |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPP3_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CP2C9_HUMAN | [view interactions] | High throughput | no | no |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| COPB_HUMAN | [view interactions] | Computational | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SC22B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ERD23_HUMAN | [view interactions] | Computational | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| COPG2_HUMAN | [view interactions] | Computational | no | yes |
| ERD22_HUMAN | [view interactions] | Computational | no | yes |
| COPG1_HUMAN | [view interactions] | Computational | no | yes |
| ERD21_HUMAN | [view interactions] | Computational | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CTBP2_HUMAN | [view interactions] | Computational | no | no |
| COPB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| COPZ1_HUMAN | [view interactions] | Computational | no | no |