Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NFL_HUMAN

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks . [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in NFL_HUMAN
GO:0043169 cation binding 33.7662 4 no
GO:0046872 metal ion binding 32.4675 5 no
GO:0019900 kinase binding 29.8701 4 no
GO:0019901 protein kinase binding 24.6753 5 no
GO:0043274 phospholipase binding 3.8961 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NFL_HUMAN
GO:0006996 organelle organization 53.2468 4 yes
GO:0010646 regulation of cell communication 51.9481 4 yes
GO:0048522 positive regulation of cellular process 51.9481 4 yes
GO:0048523 negative regulation of cellular process 49.3506 4 yes
GO:0051128 regulation of cellular component organization 46.7532 4 yes
GO:0031323 regulation of cellular metabolic process 46.7532 4 no
GO:0060255 regulation of macromolecule metabolic process 46.7532 4 no
GO:0022607 cellular component assembly 45.4545 4 yes
GO:0080090 regulation of primary metabolic process 40.2597 4 no
GO:0009966 regulation of signal transduction 38.9610 4 no
GO:0008104 protein localization 37.6623 4 no
GO:0051246 regulation of protein metabolic process 37.6623 5 no
GO:0051049 regulation of transport 36.3636 4 no
GO:0071702 organic substance transport 31.1688 4 no
GO:0007010 cytoskeleton organization 29.8701 5 yes
GO:0030030 cell projection organization 29.8701 4 yes
GO:0071705 nitrogen compound transport 29.8701 4 no
GO:0009893 positive regulation of metabolic process 29.8701 4 no
GO:0009894 regulation of catabolic process 29.8701 4 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0050804 modulation of chemical synaptic transmission 27.2727 5 yes
GO:0099177 regulation of trans-synaptic signaling 27.2727 4 yes
GO:0009892 negative regulation of metabolic process 27.2727 4 no
GO:0031325 positive regulation of cellular metabolic process 27.2727 5 no
GO:0031399 regulation of protein modification process 27.2727 6 no
GO:0019220 regulation of phosphate metabolic process 27.2727 6 no
GO:0051174 regulation of phosphorus metabolic process 27.2727 5 no
GO:0010468 regulation of gene expression 27.2727 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.9740 5 yes
GO:0044087 regulation of cellular component biogenesis 25.9740 4 no
GO:0010604 positive regulation of macromolecule metabolic process 25.9740 5 no
GO:0031324 negative regulation of cellular metabolic process 25.9740 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.9740 5 no
GO:0031344 regulation of cell projection organization 24.6753 5 yes
GO:0043933 protein-containing complex organization 24.6753 4 yes
GO:0042325 regulation of phosphorylation 24.6753 7 no
GO:1902531 regulation of intracellular signal transduction 24.6753 5 no
GO:0022603 regulation of anatomical structure morphogenesis 23.3766 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.3766 6 yes
GO:0036211 protein modification process 23.3766 4 no
GO:0043412 macromolecule modification 23.3766 4 no
GO:0015031 protein transport 23.3766 4 no
GO:0051129 negative regulation of cellular component organization 23.3766 5 no
GO:0001932 regulation of protein phosphorylation 23.3766 7 no
GO:0060341 regulation of cellular localization 22.0779 4 no
GO:0010648 negative regulation of cell communication 22.0779 5 no
GO:0023057 negative regulation of signaling 22.0779 4 no
GO:0051130 positive regulation of cellular component organization 20.7792 5 yes
GO:0065003 protein-containing complex assembly 20.7792 5 yes
GO:0071310 cellular response to organic substance 20.7792 4 no
GO:0051247 positive regulation of protein metabolic process 20.7792 6 no
GO:0051248 negative regulation of protein metabolic process 20.7792 6 no
GO:0010243 response to organonitrogen compound 19.4805 4 yes
GO:0042981 regulation of apoptotic process 19.4805 5 yes
GO:0043067 regulation of programmed cell death 19.4805 4 yes
GO:0045595 regulation of cell differentiation 19.4805 4 yes
GO:0006915 apoptotic process 18.1818 4 yes
GO:0051094 positive regulation of developmental process 18.1818 4 yes
GO:0097435 supramolecular fiber organization 18.1818 4 yes
GO:0010975 regulation of neuron projection development 16.8831 7 yes
GO:0031175 neuron projection development 16.8831 6 yes
GO:2000026 regulation of multicellular organismal development 16.8831 4 yes
GO:0043066 negative regulation of apoptotic process 15.5844 6 yes
GO:0043069 negative regulation of programmed cell death 15.5844 5 yes
GO:0050807 regulation of synapse organization 14.2857 5 yes
GO:0051960 regulation of nervous system development 14.2857 5 yes
GO:0048812 neuron projection morphogenesis 12.9870 5 yes
GO:0050767 regulation of neurogenesis 12.9870 6 yes
GO:0051240 positive regulation of multicellular organismal process 12.9870 4 yes
GO:0060284 regulation of cell development 12.9870 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 12.9870 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 11.6883 4 yes
GO:0031346 positive regulation of cell projection organization 11.6883 6 yes
GO:0045597 positive regulation of cell differentiation 11.6883 5 yes
GO:0099111 microtubule-based transport 11.6883 4 yes
GO:0010970 transport along microtubule 10.3896 4 yes
GO:0014070 response to organic cyclic compound 10.3896 4 yes
GO:0032535 regulation of cellular component size 10.3896 4 yes
GO:0033993 response to lipid 10.3896 4 yes
GO:0043523 regulation of neuron apoptotic process 10.3896 6 yes
GO:0010720 positive regulation of cell development 9.0909 6 yes
GO:0045109 intermediate filament organization 9.0909 4 yes
GO:0050769 positive regulation of neurogenesis 9.0909 6 yes
GO:0051962 positive regulation of nervous system development 9.0909 5 yes
GO:0008088 axo-dendritic transport 7.7922 5 yes
GO:0043524 negative regulation of neuron apoptotic process 7.7922 7 yes
GO:0050770 regulation of axonogenesis 7.7922 5 yes
GO:0051402 neuron apoptotic process 7.7922 5 yes
GO:0007409 axonogenesis 6.4935 6 yes
GO:0043434 response to peptide hormone 6.4935 4 yes
GO:0050905 neuromuscular process 6.4935 4 yes
GO:0072384 organelle transport along microtubule 6.4935 4 yes
GO:0098930 axonal transport 6.4935 6 yes
GO:0050772 positive regulation of axonogenesis 5.1948 6 yes
GO:0051258 protein polymerization 5.1948 6 yes
GO:0061564 axon development 5.1948 7 yes
GO:0008090 retrograde axonal transport 3.8961 7 yes
GO:0019896 axonal transport of mitochondrion 3.8961 6 yes
GO:0033693 neurofilament bundle assembly 3.8961 6 yes
GO:0034643 establishment of mitochondrion localization, microtubule-mediated 3.8961 4 yes
GO:0045110 intermediate filament bundle assembly 3.8961 5 yes
GO:0047497 mitochondrion transport along microtubule 3.8961 5 yes
GO:0048545 response to steroid hormone 3.8961 4 yes
GO:0050885 neuromuscular process controlling balance 3.8961 5 yes
GO:0051654 establishment of mitochondrion localization 3.8961 4 yes
GO:0060052 neurofilament cytoskeleton organization 3.8961 4 yes
GO:0090128 regulation of synapse maturation 3.8961 4 yes
GO:0097305 response to alcohol 3.8961 4 yes
GO:0099170 postsynaptic modulation of chemical synaptic transmission 3.8961 6 yes
GO:0031102 neuron projection regeneration 2.5974 4 yes
GO:0031960 response to corticosteroid 2.5974 5 yes
GO:0051385 response to mineralocorticoid 2.5974 6 yes
GO:1901654 response to ketone 2.5974 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DYST_HUMAN [view entry] [view interactions] Low throughput yes yes
VIME_HUMAN [view entry] [view interactions] Low throughput yes no
MTMR2_HUMAN [view entry] [view interactions] Low throughput yes no
TRIM2_HUMAN [view entry] [view interactions] Low throughput yes yes
PKN1_HUMAN [view entry] [view interactions] Low throughput yes yes
TSC1_HUMAN [view entry] [view interactions] Low throughput yes yes
NDEL1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO5A_HUMAN [view entry] [view interactions] Low throughput yes yes
NFH_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
MTAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
TSC2_HUMAN [view entry] [view interactions] Low throughput yes yes
CHD3_HUMAN [view interactions] High throughput no yes
PIAS4_HUMAN [view interactions] High throughput no yes
BRD7_HUMAN [view interactions] High throughput no yes
PHLP1_HUMAN [view interactions] High throughput no yes
ANM6_HUMAN [view interactions] High throughput no yes
SPTCS_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
KSR1_HUMAN [view interactions] High throughput no yes
RABE1_HUMAN [view entry] [view interactions] High throughput yes yes
FA83H_HUMAN [view interactions] High throughput no yes
RMC1_HUMAN [view interactions] High throughput no no
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
RSPRY_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
RHG23_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2L_HUMAN [view interactions] High throughput no no
DEP1B_HUMAN [view interactions] High throughput no yes
ZBT18_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
TERF1_HUMAN [view interactions] High throughput no no
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
TBCK_HUMAN [view interactions] High throughput no yes
CDKL2_HUMAN [view entry] [view interactions] High throughput yes no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
MECP2_HUMAN [view interactions] High throughput no yes
BICD1_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
POC5_HUMAN [view interactions] High throughput no yes
PPR18_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
SKIL_HUMAN [view interactions] High throughput no yes
DESM_HUMAN [view entry] [view interactions] High throughput yes no
GORS1_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
K1C15_HUMAN [view interactions] High throughput no no
K1C13_HUMAN [view interactions] High throughput no no
K1C18_HUMAN [view interactions] High throughput no no
CC172_HUMAN [view interactions] High throughput no no
CCD13_HUMAN [view interactions] High throughput no no
SMYD1_HUMAN [view interactions] High throughput no no
UBP2_HUMAN [view interactions] High throughput no yes
MY15B_HUMAN [view interactions] High throughput no no
NDK7_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no
TDG_HUMAN [view interactions] High throughput no yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
ASPG_HUMAN [view interactions] High throughput no yes
ANXA8_HUMAN [view interactions] High throughput no no
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
EYA3_HUMAN [view interactions] High throughput no no
K1C19_HUMAN [view interactions] High throughput no no
KT33B_HUMAN [view interactions] High throughput no no
S100P_HUMAN [view interactions] High throughput no no
CLC11_HUMAN [view interactions] High throughput no no
ZKSC8_HUMAN [view interactions] High throughput no yes
ZSC9_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
K0408_HUMAN [view entry] [view interactions] High throughput yes no
RBM14_HUMAN [view interactions] High throughput no yes
NEBL_HUMAN [view entry] [view interactions] High throughput yes no
RAI2_HUMAN [view interactions] High throughput no no
MS18B_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
MLC1_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
ARFG3_HUMAN [view entry] [view interactions] High throughput yes no
CRLF3_HUMAN [view interactions] High throughput no yes
PELO_HUMAN [view interactions] High throughput no yes
GFOD1_HUMAN [view interactions] High throughput no yes
TASO2_HUMAN [view interactions] High throughput no yes
G2E3_HUMAN [view interactions] High throughput no yes
PAK5_HUMAN [view interactions] High throughput no yes
NUFP2_HUMAN [view interactions] High throughput no no
ES8L2_HUMAN [view interactions] High throughput no yes
FAKD1_HUMAN [view interactions] High throughput no yes
ZN436_HUMAN [view interactions] High throughput no yes
BAP18_HUMAN [view interactions] High throughput no yes
ZNF57_HUMAN [view interactions] High throughput no no
SMIP4_HUMAN [view interactions] High throughput no no
ZN572_HUMAN [view interactions] High throughput no yes
TCP1L_HUMAN [view interactions] High throughput no no
CH048_HUMAN [view interactions] High throughput no no
PPTC7_HUMAN [view interactions] High throughput no yes
FAM9A_HUMAN [view interactions] High throughput no no
SYT3_HUMAN [view entry] [view interactions] High throughput yes no
SYNCI_HUMAN [view interactions] High throughput no no
FANK1_HUMAN [view interactions] High throughput no no
PGRP3_HUMAN [view interactions] High throughput no no
RHPN1_HUMAN [view interactions] High throughput no yes
KRA81_HUMAN [view interactions] High throughput no no
VSX2_HUMAN [view interactions] High throughput no no
HSPB3_HUMAN [view interactions] High throughput no no
CK5P2_HUMAN [view interactions] High throughput no yes
RAN_HUMAN [view entry] [view interactions] High throughput yes no
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
RBM11_HUMAN [view interactions] High throughput no no
DSCAM_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
SCHI1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
CCNC_HUMAN [view interactions] High throughput no yes
KIFC3_HUMAN [view interactions] High throughput no no
MYOME_HUMAN [view interactions] High throughput no no
PP16B_HUMAN [view interactions] High throughput no yes
TEX11_HUMAN [view interactions] High throughput no no
ENKD1_HUMAN [view interactions] High throughput no yes
TXLNB_HUMAN [view interactions] High throughput no no
MTUS2_HUMAN [view interactions] High throughput no yes
USBP1_HUMAN [view interactions] High throughput no no
CE57L_HUMAN [view interactions] High throughput no yes
CCD33_HUMAN [view interactions] High throughput no no
KLC3_HUMAN [view interactions] High throughput no no
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
NEK6_HUMAN [view interactions] High throughput no yes
TRI55_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
OBSL1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
HXB5_HUMAN [view interactions] High throughput no no
RM04_HUMAN [view interactions] High throughput no yes
SKAP1_HUMAN [view interactions] High throughput no no
PSG9_HUMAN [view interactions] High throughput no no
PHAF1_HUMAN [view interactions] High throughput no yes
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
GAN_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
DPP9_HUMAN [view interactions] High throughput no yes
SC16A_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
RHG42_HUMAN [view interactions] High throughput no yes
ARHGJ_HUMAN [view interactions] High throughput no no
ARHGP_HUMAN [view interactions] High throughput no yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
GMIP_HUMAN [view interactions] High throughput no yes
MCF2_HUMAN [view interactions] High throughput no no
NGEF_HUMAN [view entry] [view interactions] High throughput yes yes
PKHG5_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
K1C27_HUMAN [view interactions] High throughput no no
K2C7_HUMAN [view interactions] High throughput no no
K1C23_HUMAN [view interactions] High throughput no no
IDE_HUMAN [view interactions] High throughput no yes
CCD96_HUMAN [view interactions] High throughput no no
K1H1_HUMAN [view interactions] High throughput no no
K1C14_HUMAN [view interactions] High throughput no no
MAP7_HUMAN [view interactions] High throughput no yes
NEST_HUMAN [view interactions] High throughput no no
CRBG1_HUMAN [view interactions] High throughput no no
RHBT2_HUMAN [view interactions] High throughput no no
ANM1_HUMAN [view interactions] High throughput no yes
IF2B3_HUMAN [view interactions] High throughput no no
BAP1_HUMAN [view interactions] High throughput no yes
RHG24_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
NEIL3_HUMAN [view interactions] High throughput no no
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
CC14A_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
CHCH1_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
QOR_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
MARH5_HUMAN [view interactions] High throughput no no
MCUB_HUMAN [view interactions] High throughput no no
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
S2551_HUMAN [view interactions] High throughput no no
SURF1_HUMAN [view interactions] High throughput no yes
FOXO1_HUMAN [view interactions] High throughput no yes