RHG23_HUMAN
Evidence for PS localization
Functions
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RHG23_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 33.3333 | 4 | no |
| GO:0043169 | cation binding | 28.5714 | 4 | no |
| GO:0046872 | metal ion binding | 28.5714 | 5 | no |
| GO:0000166 | nucleotide binding | 23.8095 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.8095 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 23.8095 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.8095 | 4 | no |
| GO:0043168 | anion binding | 23.8095 | 4 | no |
| GO:0019900 | kinase binding | 23.8095 | 4 | no |
| GO:0019901 | protein kinase binding | 23.8095 | 5 | no |
| GO:0030695 | GTPase regulator activity | 14.2857 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RHG23_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 57.1429 | 4 | no |
| GO:0010646 | regulation of cell communication | 52.3810 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.3810 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.3810 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.3810 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 52.3810 | 4 | no |
| GO:0022607 | cellular component assembly | 38.0952 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.0952 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.0952 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.0952 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 38.0952 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | yes |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0007010 | cytoskeleton organization | 28.5714 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 28.5714 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 28.5714 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.5714 | 6 | no |
| GO:0031399 | regulation of protein modification process | 28.5714 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.5714 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 28.5714 | 4 | no |
| GO:0071310 | cellular response to organic substance | 28.5714 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.8095 | 5 | yes |
| GO:0030030 | cell projection organization | 23.8095 | 4 | no |
| GO:0031175 | neuron projection development | 23.8095 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.8095 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.8095 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.8095 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.8095 | 7 | no |
| GO:0031344 | regulation of cell projection organization | 23.8095 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 23.8095 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.8095 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 23.8095 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.8095 | 6 | no |
| GO:2000145 | regulation of cell motility | 23.8095 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 23.8095 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 23.8095 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.8095 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.8095 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.8095 | 4 | no |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 14.2857 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| ZA2G_HUMAN | [view interactions] | High throughput | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD1_HUMAN | [view interactions] | High throughput | no | yes |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| HP1B3_HUMAN | [view interactions] | High throughput | no | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO8_HUMAN | [view interactions] | High throughput | no | no |
| LS14A_HUMAN | [view interactions] | High throughput | no | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5NTC_HUMAN | [view interactions] | High throughput | no | yes |
| PLRG1_HUMAN | [view interactions] | High throughput | no | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| RU2B_HUMAN | [view interactions] | High throughput | no | yes |
| SRFB1_HUMAN | [view interactions] | High throughput | no | no |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR74_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| RPAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAPC1_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| CCD86_HUMAN | [view interactions] | High throughput | no | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN1_HUMAN | [view interactions] | High throughput | no | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| METK2_HUMAN | [view interactions] | High throughput | no | no |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| NOL7_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B6_HUMAN | [view interactions] | High throughput | no | yes |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3HE_HUMAN | [view interactions] | High throughput | no | yes |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| FER_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG10_HUMAN | [view interactions] | High throughput | no | no |
| RHG30_HUMAN | [view interactions] | High throughput | no | no |
| RPGFL_HUMAN | [view interactions] | High throughput | no | no |
| RHG28_HUMAN | [view interactions] | High throughput | no | no |
| ARHGC_HUMAN | [view interactions] | High throughput | no | yes |
| A0A590UK10_HUMAN | [view interactions] | High throughput | no | no |
| ARHGI_HUMAN | [view interactions] | High throughput | no | no |
| ARHG8_HUMAN | [view interactions] | High throughput | no | yes |
| RPGF5_HUMAN | [view interactions] | High throughput | no | yes |
| LAT1_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |