RHG23_HUMAN
Evidence for PS localization
Functions
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
![](/static/images/legend1.gif)
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
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RHG23_HUMAN has binary interactions with 20 proteins
Isoforms
Interacting regions
Canonical [RHG23_HUMAN]
Isoform [Q9P227-2] alignment
Isoform [A0A9L9PXQ2] alignment
Isoform [A0A9L9PXS4] alignment
Isoform [A0A087X0Z0] alignment
Isoform [A0A087X1W6] alignment
Isoform [A0A087WTU4] alignment
Isoform [A0A087WXU2] alignment
Isoform [A0A087WZ73] alignment
Isoform [A0A087WZZ2] alignment
LOADING 96%
![](/static/images/legend3.gif)
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
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Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RHG23_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 33.3333 | 4 | no |
GO:0043169 | cation binding | 28.5714 | 4 | no |
GO:0046872 | metal ion binding | 28.5714 | 5 | no |
GO:0000166 | nucleotide binding | 23.8095 | 4 | no |
GO:0017076 | purine nucleotide binding | 23.8095 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 23.8095 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 23.8095 | 4 | no |
GO:0043168 | anion binding | 23.8095 | 4 | no |
GO:0019900 | kinase binding | 23.8095 | 4 | no |
GO:0019901 | protein kinase binding | 23.8095 | 5 | no |
GO:0030695 | GTPase regulator activity | 14.2857 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RHG23_HUMAN |
---|---|---|---|---|
GO:0060255 | regulation of macromolecule metabolic process | 57.1429 | 4 | no |
GO:0010646 | regulation of cell communication | 52.3810 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 52.3810 | 4 | no |
GO:0048523 | negative regulation of cellular process | 52.3810 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 52.3810 | 4 | no |
GO:0048522 | positive regulation of cellular process | 52.3810 | 4 | no |
GO:0022607 | cellular component assembly | 38.0952 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 38.0952 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 38.0952 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 38.0952 | 5 | no |
GO:0051128 | regulation of cellular component organization | 38.0952 | 4 | no |
GO:0009966 | regulation of signal transduction | 33.3333 | 4 | yes |
GO:0006996 | organelle organization | 33.3333 | 4 | no |
GO:0008104 | protein localization | 33.3333 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
GO:0007010 | cytoskeleton organization | 28.5714 | 5 | no |
GO:0097435 | supramolecular fiber organization | 28.5714 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 28.5714 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
5NTC_HUMAN | [view interactions] | High throughput | no | yes |
A0A590UK10_HUMAN | [view interactions] | High throughput | no | no |
ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARHG8_HUMAN | [view interactions] | High throughput | no | yes |
ARHGC_HUMAN | [view interactions] | High throughput | no | yes |
ARHGI_HUMAN | [view interactions] | High throughput | no | no |
BICD1_HUMAN | [view interactions] | High throughput | no | yes |
BRD2_HUMAN | [view interactions] | High throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAMP3_HUMAN | [view interactions] | High throughput | no | no |
CCD86_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
FAKD1_HUMAN | [view interactions] | High throughput | no | yes |
FER_HUMAN | [view interactions] | High throughput | no | yes |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
HMGB1_HUMAN | [view interactions] | High throughput | no | yes |