CTNA1_HUMAN
Evidence for PS localization
Functions
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation . May play a crucial role in cell differentiation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CTNA1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 31.2057 | 4 | no |
| GO:0000166 | nucleotide binding | 30.4965 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.7872 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.9504 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.9504 | 4 | no |
| GO:0019900 | kinase binding | 23.4043 | 4 | no |
| GO:0019901 | protein kinase binding | 22.6950 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 20.5674 | 6 | no |
| GO:0045296 | cadherin binding | 19.8582 | 4 | yes |
| GO:0003779 | actin binding | 17.7305 | 4 | yes |
| GO:0003723 | RNA binding | 16.3121 | 4 | yes |
| GO:0017166 | vinculin binding | 3.5461 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CTNA1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.1206 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.0638 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 49.6454 | 4 | no |
| GO:0010646 | regulation of cell communication | 49.6454 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.8085 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.6809 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.6809 | 4 | no |
| GO:0022607 | cellular component assembly | 43.9716 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 41.1348 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.2979 | 4 | no |
| GO:0008104 | protein localization | 37.5887 | 4 | yes |
| GO:0006996 | organelle organization | 36.1702 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.1702 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 36.1702 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.4610 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.4610 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.0426 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.6241 | 4 | yes |
| GO:0010468 | regulation of gene expression | 32.6241 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 30.4965 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.4965 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 29.7872 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 29.0780 | 5 | no |
| GO:0030030 | cell projection organization | 29.0780 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOB_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANKY2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ANM3_HUMAN | [view interactions] | High throughput | no | yes |
| ANR26_HUMAN | [view interactions] | High throughput | no | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC8_HUMAN | [view interactions] | Low throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASPP1_HUMAN | [view interactions] | High throughput | no | yes |