AFG32_HUMAN
Evidence for PS localization
Functions
ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed). Required for paraplegin (SPG7) maturation (PubMed). After its cleavage by mitochondrial-processing peptidase (MPP), it converts paraplegin into a proteolytically active mature form . Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed, PubMed). Involved in the regulation of OMA1-dependent processing of OPA1 (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AFG32_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 34.0206 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 34.0206 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.9897 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 25.7732 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.7732 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.7732 | 6 | yes |
| GO:0003723 | RNA binding | 23.7113 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 19.5876 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 19.5876 | 5 | yes |
| GO:0005524 | ATP binding | 18.5567 | 5 | yes |
| GO:0046872 | metal ion binding | 18.5567 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 10.3093 | 7 | yes |
| GO:0046914 | transition metal ion binding | 6.1856 | 5 | yes |
| GO:0008270 | zinc ion binding | 5.1546 | 6 | yes |
| GO:0004175 | endopeptidase activity | 4.1237 | 4 | yes |
| GO:0004222 | metalloendopeptidase activity | 3.0928 | 5 | yes |
| GO:0008237 | metallopeptidase activity | 3.0928 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AFG32_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.5155 | 4 | no |
| GO:0006996 | organelle organization | 46.3918 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.2062 | 4 | no |
| GO:0022607 | cellular component assembly | 39.1753 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 38.1443 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.1134 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 37.1134 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 35.0515 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.0206 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.0206 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.9897 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.9278 | 4 | no |
| GO:0010941 | regulation of cell death | 28.8660 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.8660 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.8660 | 5 | no |
| GO:0010468 | regulation of gene expression | 27.8351 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 27.8351 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 27.8351 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.8351 | 5 | no |
| GO:0008104 | protein localization | 26.8041 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 26.8041 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.8041 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.8041 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 24.7423 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.7423 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.7423 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.7113 | 4 | yes |
| GO:0030030 | cell projection organization | 22.6804 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 22.6804 | 5 | yes |
| GO:0051049 | regulation of transport | 22.6804 | 4 | no |
| GO:0071702 | organic substance transport | 22.6804 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.6804 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.6804 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.6804 | 6 | no |
| GO:0071705 | nitrogen compound transport | 21.6495 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.6495 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.6495 | 4 | no |
| GO:0033043 | regulation of organelle organization | 20.6186 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.6186 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.6186 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.6186 | 5 | no |
| GO:0007005 | mitochondrion organization | 18.5567 | 5 | yes |
| GO:0061024 | membrane organization | 18.5567 | 4 | yes |
| GO:0034330 | cell junction organization | 15.4639 | 4 | yes |
| GO:0032990 | cell part morphogenesis | 14.4330 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 12.3711 | 7 | yes |
| GO:0048858 | cell projection morphogenesis | 12.3711 | 5 | yes |
| GO:0050808 | synapse organization | 12.3711 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 12.3711 | 6 | yes |
| GO:0048878 | chemical homeostasis | 11.3402 | 4 | yes |
| GO:0006811 | ion transport | 9.2784 | 4 | yes |
| GO:0006873 | cellular ion homeostasis | 8.2474 | 4 | yes |
| GO:0007006 | mitochondrial membrane organization | 8.2474 | 5 | yes |
| GO:0048638 | regulation of developmental growth | 8.2474 | 4 | yes |
| GO:0050801 | ion homeostasis | 8.2474 | 5 | yes |
| GO:0098771 | inorganic ion homeostasis | 8.2474 | 6 | yes |
| GO:0006812 | cation transport | 7.2165 | 5 | yes |
| GO:0006875 | cellular metal ion homeostasis | 7.2165 | 6 | yes |
| GO:0007007 | inner mitochondrial membrane organization | 7.2165 | 6 | yes |
| GO:0030001 | metal ion transport | 7.2165 | 6 | yes |
| GO:0030003 | cellular cation homeostasis | 7.2165 | 5 | yes |
| GO:0055065 | metal ion homeostasis | 7.2165 | 7 | yes |
| GO:0055080 | cation homeostasis | 7.2165 | 6 | yes |
| GO:0006508 | proteolysis | 6.1856 | 4 | yes |
| GO:0007409 | axonogenesis | 6.1856 | 8 | yes |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 6.1856 | 6 | yes |
| GO:0072507 | divalent inorganic cation homeostasis | 6.1856 | 7 | yes |
| GO:0098655 | cation transmembrane transport | 6.1856 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 6.1856 | 4 | yes |
| GO:0006874 | cellular calcium ion homeostasis | 5.1546 | 7 | yes |
| GO:0007528 | neuromuscular junction development | 5.1546 | 6 | yes |
| GO:0042407 | cristae formation | 5.1546 | 7 | yes |
| GO:0055074 | calcium ion homeostasis | 5.1546 | 8 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 5.1546 | 5 | yes |
| GO:0042552 | myelination | 4.1237 | 4 | yes |
| GO:0051560 | mitochondrial calcium ion homeostasis | 4.1237 | 8 | yes |
| GO:0006816 | calcium ion transport | 3.0928 | 7 | yes |
| GO:0008053 | mitochondrial fusion | 3.0928 | 6 | yes |
| GO:0040014 | regulation of multicellular organism growth | 3.0928 | 4 | yes |
| GO:0048284 | organelle fusion | 3.0928 | 5 | yes |
| GO:0051604 | protein maturation | 3.0928 | 4 | yes |
| GO:0070588 | calcium ion transmembrane transport | 3.0928 | 6 | yes |
| GO:0006851 | mitochondrial calcium ion transmembrane transport | 2.0619 | 4 | yes |
| GO:0016485 | protein processing | 2.0619 | 5 | yes |
| GO:0016540 | protein autoprocessing | 2.0619 | 6 | yes |
| GO:0033619 | membrane protein proteolysis | 2.0619 | 5 | yes |
| GO:0034982 | mitochondrial protein processing | 2.0619 | 6 | yes |
| GO:0036444 | calcium import into the mitochondrion | 2.0619 | 5 | yes |
| GO:0055001 | muscle cell development | 2.0619 | 4 | yes |
| GO:0060013 | righting reflex | 2.0619 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in AFG32_HUMAN |
|---|---|---|---|---|
| DOID:700 | mitochondrial metabolism disease | 3.0928 | 3 | no |
| DOID:0111962 | combined immunodeficiency | 2.0619 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 2.0619 | 3 | no |
| DOID:0050686 | organ system cancer | 2.0619 | 3 | no |
| DOID:120 | female reproductive organ cancer | 2.0619 | 5 | no |
| DOID:193 | reproductive organ cancer | 2.0619 | 4 | no |
| DOID:0060286 | combined oxidative phosphorylation deficiency | 2.0619 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AFG32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| S2551_HUMAN | [view interactions] | High throughput | no | no |
| PDP2_HUMAN | [view interactions] | High throughput | no | yes |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| CXA10_HUMAN | [view interactions] | High throughput | no | no |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTK_HUMAN | [view interactions] | High throughput | no | no |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| M4A4A_HUMAN | [view interactions] | High throughput | no | no |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| TIM29_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| ST32C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RCC1L_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| DJC15_HUMAN | [view interactions] | High throughput | no | no |
| MYPC3_HUMAN | [view interactions] | High throughput | no | no |
| DJC28_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC4_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| PHC2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| HIPK4_HUMAN | [view interactions] | High throughput | no | no |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN167_HUMAN | [view interactions] | High throughput | no | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX14_HUMAN | [view interactions] | High throughput | no | yes |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| BROMI_HUMAN | [view interactions] | High throughput | no | no |
| INTU_HUMAN | [view interactions] | High throughput | no | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS6_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| GRWD1_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM41B_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS26_HUMAN | [view interactions] | High throughput | no | yes |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| DUS7_HUMAN | [view interactions] | High throughput | no | yes |
| DUS9_HUMAN | [view interactions] | High throughput | no | no |
| SSH1_HUMAN | [view interactions] | High throughput | no | yes |
| STYL1_HUMAN | [view interactions] | High throughput | no | yes |
| ANO7_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| SPTC1_HUMAN | [view interactions] | High throughput | no | yes |
| MOT1_HUMAN | [view interactions] | High throughput | no | no |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| RN139_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGAC_HUMAN | [view interactions] | High throughput | no | no |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZZZ3_HUMAN | [view interactions] | High throughput | no | yes |
| TIM16_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAGA2_HUMAN | [view interactions] | High throughput | no | no |
| ELYS_HUMAN | [view interactions] | High throughput | no | yes |
| MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| TBX2_HUMAN | [view interactions] | High throughput | no | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICU1_HUMAN | [view interactions] | High throughput | no | yes |
| CO039_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFHX4_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| TBX3_HUMAN | [view interactions] | High throughput | no | no |
| SUV3_HUMAN | [view interactions] | High throughput | no | yes |
| TIM14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COA3_HUMAN | [view interactions] | High throughput | no | yes |
| MIC10_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMCO1_HUMAN | [view interactions] | High throughput | no | yes |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| PURA1_HUMAN | [view interactions] | High throughput | no | no |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYCM_HUMAN | [view interactions] | High throughput | no | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAM1_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD8_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CH082_HUMAN | [view interactions] | High throughput | no | yes |
| MCUR1_HUMAN | [view interactions] | High throughput | no | no |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH1_HUMAN | [view interactions] | High throughput | no | yes |
| CLPB_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| QOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD2_HUMAN | [view interactions] | High throughput | no | no |
| JIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| UBP50_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BECN1_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S38A1_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAB_HUMAN | [view interactions] | High throughput | no | no |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7E_HUMAN | [view interactions] | High throughput | no | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| RT12_HUMAN | [view interactions] | High throughput | no | yes |
| ELL2_HUMAN | [view interactions] | High throughput | no | no |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| JUNB_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| TGS1_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBA2_HUMAN | [view interactions] | High throughput | no | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| TRIPB_HUMAN | [view interactions] | High throughput | no | yes |
| FMT_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| MTG1_HUMAN | [view interactions] | High throughput | no | yes |
| USF1_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM45_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| MAIP1_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| MIX23_HUMAN | [view interactions] | High throughput | no | yes |
| NGRN_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| OTC_HUMAN | [view interactions] | High throughput | no | no |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| RMND1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| CISD3_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | Computational | no | yes |