TIM16_HUMAN
Evidence for PS localization
Functions
Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TIM16_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 35.7143 | 4 | no |
| GO:0017076 | purine nucleotide binding | 32.1429 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 32.1429 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.1429 | 4 | no |
| GO:0005524 | ATP binding | 21.4286 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 21.4286 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.4286 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.4286 | 6 | no |
| GO:0030554 | adenyl nucleotide binding | 21.4286 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.4286 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TIM16_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.5714 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.4286 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.8571 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.2857 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.2857 | 4 | no |
| GO:0006996 | organelle organization | 35.7143 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.7143 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.7143 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.7143 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 35.7143 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.7143 | 5 | no |
| GO:0022607 | cellular component assembly | 35.7143 | 4 | no |
| GO:0008104 | protein localization | 32.1429 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 32.1429 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.1429 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.1429 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.1429 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.1429 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 32.1429 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.1429 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0006886 | intracellular protein transport | 21.4286 | 4 | yes |
| GO:0015031 | protein transport | 21.4286 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 21.4286 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.4286 | 5 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.4286 | 7 | no |
| GO:0007005 | mitochondrion organization | 21.4286 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.4286 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.4286 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.4286 | 5 | no |
| GO:0080134 | regulation of response to stress | 21.4286 | 4 | no |
| GO:0033365 | protein localization to organelle | 17.8571 | 5 | yes |
| GO:0065002 | intracellular protein transmembrane transport | 17.8571 | 4 | yes |
| GO:0070585 | protein localization to mitochondrion | 17.8571 | 6 | yes |
| GO:0006839 | mitochondrial transport | 14.2857 | 4 | yes |
| GO:0030150 | protein import into mitochondrial matrix | 14.2857 | 4 | yes |
| GO:0044743 | protein transmembrane import into intracellular organelle | 14.2857 | 4 | yes |
| GO:0072594 | establishment of protein localization to organelle | 14.2857 | 4 | yes |
| GO:0072655 | establishment of protein localization to mitochondrion | 14.2857 | 5 | yes |
| GO:0032780 | negative regulation of ATP-dependent activity | 7.1429 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DJC15_HUMAN | [view interactions] | Low throughput | no | no |
| TI17B_HUMAN | [view interactions] | Low throughput | no | no |
| TIM14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TIM44_HUMAN | [view interactions] | Low throughput | no | yes |
| BL1S2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP70_HUMAN | [view interactions] | High throughput | no | yes |
| DNM3B_HUMAN | [view interactions] | High throughput | no | yes |
| FEZ1_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOFA1_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEP_HUMAN | [view interactions] | High throughput | no | no |
| NPY2R_HUMAN | [view interactions] | High throughput | no | no |
| RNBP6_HUMAN | [view interactions] | High throughput | no | yes |
| MIX23_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA13B_HUMAN | [view interactions] | High throughput | no | yes |
| SOMA_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR6P1_HUMAN | [view interactions] | High throughput | no | yes |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| MARC1_HUMAN | [view interactions] | High throughput | no | yes |
| MCATL_HUMAN | [view interactions] | High throughput | no | no |
| TFB2M_HUMAN | [view interactions] | High throughput | no | no |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| TI17A_HUMAN | [view interactions] | High throughput | no | yes |
| TIM16_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| TEX29_HUMAN | [view interactions] | High throughput | no | no |
| ANTR1_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| MAIP1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| PCDAC_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| CD53_HUMAN | [view interactions] | High throughput | no | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMOD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP9_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPMK_HUMAN | [view interactions] | High throughput | no | no |
| COX7C_HUMAN | [view interactions] | High throughput | no | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CH082_HUMAN | [view interactions] | High throughput | no | yes |
| MCUR1_HUMAN | [view interactions] | High throughput | no | no |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| S2551_HUMAN | [view interactions] | High throughput | no | no |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC28_HUMAN | [view interactions] | High throughput | no | yes |
| TOM22_HUMAN | [view interactions] | Computational | no | yes |
| ROMO1_HUMAN | [view interactions] | Computational | no | yes |
| GRPE2_HUMAN | [view interactions] | Computational | no | yes |
| TIM9_HUMAN | [view interactions] | Computational | no | yes |
| TIM21_HUMAN | [view interactions] | Computational | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TIM50_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TIM10_HUMAN | [view interactions] | Computational | no | yes |
| TIM23_HUMAN | [view interactions] | Computational | no | yes |
| TIM13_HUMAN | [view interactions] | Computational | no | yes |
| TIM22_HUMAN | [view interactions] | Computational | no | no |
| GRPE1_HUMAN | [view interactions] | Computational | no | yes |
| TIM8A_HUMAN | [view interactions] | Computational | no | yes |