NDUA2_HUMAN
Evidence for PS localization
Functions
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NDUA2_HUMAN |
|---|---|---|---|---|
| GO:0015399 | primary active transmembrane transporter activity | 43.4211 | 4 | yes |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 40.7895 | 5 | yes |
| GO:0003954 | NADH dehydrogenase activity | 31.5789 | 4 | yes |
| GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 31.5789 | 5 | yes |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 31.5789 | 4 | yes |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 31.5789 | 4 | yes |
| GO:0050136 | NADH dehydrogenase (quinone) activity | 31.5789 | 5 | yes |
| GO:0046872 | metal ion binding | 25.0000 | 4 | no |
| GO:0003723 | RNA binding | 23.6842 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NDUA2_HUMAN |
|---|---|---|---|---|
| GO:0009060 | aerobic respiration | 43.4211 | 6 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 43.4211 | 4 | yes |
| GO:0022607 | cellular component assembly | 43.4211 | 4 | yes |
| GO:0045333 | cellular respiration | 43.4211 | 5 | yes |
| GO:0022900 | electron transport chain | 42.1053 | 4 | yes |
| GO:0022904 | respiratory electron transport chain | 42.1053 | 5 | yes |
| GO:0019646 | aerobic electron transport chain | 39.4737 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 36.8421 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 36.8421 | 5 | yes |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 28.9474 | 7 | yes |
| GO:0033108 | mitochondrial respiratory chain complex assembly | 27.6316 | 6 | yes |
| GO:0031323 | regulation of cellular metabolic process | 26.3158 | 4 | no |
| GO:0010257 | NADH dehydrogenase complex assembly | 25.0000 | 6 | yes |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | 25.0000 | 7 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 22.3684 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 22.3684 | 4 | no |
| GO:0071702 | organic substance transport | 22.3684 | 4 | no |
| GO:0008104 | protein localization | 21.0526 | 4 | no |
| GO:0006996 | organelle organization | 21.0526 | 4 | no |
| GO:0001835 | blastocyst hatching | 2.6316 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in NDUA2_HUMAN |
|---|---|---|---|---|
| DOID:700 | mitochondrial metabolism disease | 2.6316 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACPM_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUA6_HUMAN | [view interactions] | Low throughput | no | no |
| NDUA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NDUS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NDUS8_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUV3_HUMAN | [view interactions] | Low throughput | no | yes |
| NU1M_HUMAN | [view interactions] | High throughput | no | yes |
| NU4M_HUMAN | [view interactions] | High throughput | no | yes |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX14_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| FBX17_HUMAN | [view interactions] | High throughput | no | no |
| WNT9B_HUMAN | [view interactions] | High throughput | no | no |
| ZFP41_HUMAN | [view interactions] | High throughput | no | no |
| CISD3_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| PA2GD_HUMAN | [view interactions] | High throughput | no | no |
| F110D_HUMAN | [view interactions] | High throughput | no | no |
| HXA5_HUMAN | [view interactions] | High throughput | no | no |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| HXC9_HUMAN | [view interactions] | High throughput | no | no |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| MRM2_HUMAN | [view interactions] | High throughput | no | yes |
| TET5B_HUMAN | [view interactions] | High throughput | no | no |
| EMP3_HUMAN | [view interactions] | High throughput | no | no |
| SPY2_HUMAN | [view interactions] | High throughput | no | yes |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| TECTB_HUMAN | [view interactions] | High throughput | no | no |
| NDUA1_HUMAN | [view interactions] | High throughput | no | yes |
| WN10B_HUMAN | [view interactions] | High throughput | no | yes |
| TRMO_HUMAN | [view interactions] | High throughput | no | no |
| ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| CN178_HUMAN | [view interactions] | High throughput | no | no |
| IF4G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA25_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR61_HUMAN | [view interactions] | High throughput | no | yes |
| YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| MRP2_HUMAN | [view interactions] | High throughput | no | no |
| LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
| RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE4B_HUMAN | [view interactions] | High throughput | no | yes |
| THIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| PAF15_HUMAN | [view interactions] | High throughput | no | no |
| RBM27_HUMAN | [view interactions] | High throughput | no | yes |
| ZC11A_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOSB1_HUMAN | [view interactions] | High throughput | no | yes |
| RU1C_HUMAN | [view interactions] | High throughput | no | yes |
| ABCBA_HUMAN | [view interactions] | High throughput | no | yes |
| UBC9_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| RM43_HUMAN | [view interactions] | High throughput | no | no |
| RFX5_HUMAN | [view interactions] | High throughput | no | yes |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| CDV3_HUMAN | [view interactions] | High throughput | no | no |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| PIN4_HUMAN | [view interactions] | High throughput | no | yes |
| CPT1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBL2_HUMAN | [view interactions] | High throughput | no | no |
| P66B_HUMAN | [view interactions] | High throughput | no | yes |
| 5NTD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMX2_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM16_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5E_HUMAN | [view interactions] | High throughput | no | no |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| ATPK_HUMAN | [view interactions] | High throughput | no | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX7A2_HUMAN | [view interactions] | High throughput | no | no |
| NDUB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUCR_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT5L2_HUMAN | [view interactions] | High throughput | no | no |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CH082_HUMAN | [view interactions] | High throughput | no | yes |
| MCUR1_HUMAN | [view interactions] | High throughput | no | no |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH1_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD2_HUMAN | [view interactions] | High throughput | no | no |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RT12_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| FMT_HUMAN | [view interactions] | High throughput | no | yes |
| MTG1_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| NGRN_HUMAN | [view interactions] | High throughput | no | yes |
| OTC_HUMAN | [view interactions] | High throughput | no | no |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC15_HUMAN | [view interactions] | High throughput | no | no |
| TIM14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC28_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSG2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAB_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| SPT20_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBB_HUMAN | [view interactions] | High throughput | no | yes |
| NDUC2_HUMAN | [view interactions] | High throughput | no | yes |
| QCR10_HUMAN | [view interactions] | Computational | no | no |
| QCR9_HUMAN | [view interactions] | Computational | no | no |
| COA6_HUMAN | [view interactions] | Computational | no | yes |
| FXRD1_HUMAN | [view interactions] | Computational | no | no |
| CYB_HUMAN | [view interactions] | Computational | no | yes |
| COX7C_HUMAN | [view interactions] | Computational | no | yes |
| NU6M_HUMAN | [view interactions] | Computational | no | no |
| ROMO1_HUMAN | [view interactions] | Computational | no | yes |
| NDUF4_HUMAN | [view interactions] | Computational | no | yes |
| NDUB2_HUMAN | [view interactions] | Computational | no | yes |
| COX42_HUMAN | [view interactions] | Computational | no | no |
| ATPMK_HUMAN | [view interactions] | Computational | no | no |
| CX6B2_HUMAN | [view interactions] | Computational | no | no |
| NDUF5_HUMAN | [view interactions] | Computational | no | yes |
| NU2M_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NU4LM_HUMAN | [view interactions] | Computational | no | no |
| ATPD_HUMAN | [view interactions] | Computational | no | yes |
| QCR7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CIA30_HUMAN | [view interactions] | Computational | no | yes |
| M2OM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| COX5B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| COX5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NU3M_HUMAN | [view interactions] | Computational | no | yes |
| NDUC1_HUMAN | [view interactions] | Computational | no | yes |
| QCR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ATP5J_HUMAN | [view interactions] | Computational | no | yes |
| CY1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDUB1_HUMAN | [view interactions] | Computational | no | yes |
| NU5M_HUMAN | [view interactions] | Computational | no | no |
| AT5F1_HUMAN | [view interactions] | Computational | no | yes |