NDUB8_HUMAN
Evidence for PS localization
Functions
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NDUB8_HUMAN |
|---|---|---|---|---|
| GO:0015399 | primary active transmembrane transporter activity | 51.5625 | 4 | yes |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 46.8750 | 5 | yes |
| GO:0003954 | NADH dehydrogenase activity | 35.9375 | 4 | yes |
| GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 35.9375 | 5 | yes |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 35.9375 | 4 | yes |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 35.9375 | 4 | yes |
| GO:0050136 | NADH dehydrogenase (quinone) activity | 35.9375 | 5 | yes |
| GO:0046872 | metal ion binding | 28.1250 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NDUB8_HUMAN |
|---|---|---|---|---|
| GO:0022900 | electron transport chain | 51.5625 | 4 | yes |
| GO:0022904 | respiratory electron transport chain | 50.0000 | 5 | yes |
| GO:0009060 | aerobic respiration | 48.4375 | 6 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 48.4375 | 4 | yes |
| GO:0045333 | cellular respiration | 48.4375 | 5 | yes |
| GO:0019646 | aerobic electron transport chain | 46.8750 | 6 | yes |
| GO:0022607 | cellular component assembly | 40.6250 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 35.9375 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 35.9375 | 5 | yes |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 32.8125 | 7 | yes |
| GO:0033108 | mitochondrial respiratory chain complex assembly | 31.2500 | 6 | yes |
| GO:0010257 | NADH dehydrogenase complex assembly | 28.1250 | 6 | yes |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | 28.1250 | 7 | yes |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 23.4375 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 21.8750 | 4 | no |
| GO:0071702 | organic substance transport | 20.3125 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 20.3125 | 4 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in NDUB8_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.6875 | 3 | no |
| DOID:1289 | neurodegenerative disease | 3.1250 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NDUBA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS5_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUAB_HUMAN | [view interactions] | Low throughput | no | no |
| NDUA8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB5_HUMAN | [view interactions] | Low throughput | no | yes |
| ACPM_HUMAN | [view interactions] | Low throughput | no | yes |
| COX1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUBB_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUC2_HUMAN | [view interactions] | Low throughput | no | yes |
| NU5M_HUMAN | [view interactions] | Low throughput | no | no |
| NDUB7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB3_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUA1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUA3_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB2_HUMAN | [view interactions] | Low throughput | no | yes |
| NU2M_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NU4LM_HUMAN | [view interactions] | Low throughput | no | no |
| NU4M_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NU1M_HUMAN | [view interactions] | Low throughput | no | yes |
| NU6M_HUMAN | [view interactions] | Low throughput | no | no |
| NU3M_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUC1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB1_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1A_HUMAN | [view interactions] | High throughput | no | no |
| COA1_HUMAN | [view interactions] | High throughput | no | yes |
| TIM21_HUMAN | [view interactions] | High throughput | no | yes |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NK1R_HUMAN | [view interactions] | High throughput | no | no |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUT1_HUMAN | [view interactions] | High throughput | no | no |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| ENPP6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GALT6_HUMAN | [view interactions] | High throughput | no | yes |
| WBP1_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| ZAP70_HUMAN | [view interactions] | High throughput | no | no |
| VA0D2_HUMAN | [view interactions] | High throughput | no | no |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EI2BG_HUMAN | [view interactions] | High throughput | no | yes |
| PIM2_HUMAN | [view interactions] | High throughput | no | no |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP2J2_HUMAN | [view interactions] | High throughput | no | no |
| CXA8_HUMAN | [view interactions] | High throughput | no | no |
| CREL1_HUMAN | [view interactions] | High throughput | no | yes |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| DQB1_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL2RA_HUMAN | [view interactions] | High throughput | no | no |
| EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
| GPR34_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| V2R_HUMAN | [view interactions] | High throughput | no | no |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF2_HUMAN | [view interactions] | High throughput | no | yes |
| CSC1_HUMAN | [view interactions] | High throughput | no | no |
| XXLT1_HUMAN | [view interactions] | High throughput | no | no |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| SCO2_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| COPG2_HUMAN | [view interactions] | High throughput | no | yes |
| ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYOX_HUMAN | [view interactions] | High throughput | no | no |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| RCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| COA3_HUMAN | [view interactions] | High throughput | no | yes |
| MIC10_HUMAN | [view interactions] | High throughput | no | yes |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM5_HUMAN | [view interactions] | High throughput | no | yes |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX5B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PRDX3_HUMAN | [view interactions] | Computational | no | yes |
| COX5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ATP5E_HUMAN | [view interactions] | Computational | no | no |
| SDHB_HUMAN | [view interactions] | Computational | no | yes |
| PREP_HUMAN | [view interactions] | Computational | no | yes |
| ATPMK_HUMAN | [view interactions] | Computational | no | no |
| MASU1_HUMAN | [view interactions] | Computational | no | yes |
| ATPO_HUMAN | [view interactions] | Computational | no | yes |
| NDUCR_HUMAN | [view interactions] | Computational | no | yes |
| ATP5I_HUMAN | [view interactions] | Computational | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| QCR10_HUMAN | [view interactions] | Computational | no | no |
| ICT1_HUMAN | [view interactions] | Computational | no | yes |
| COX8A_HUMAN | [view interactions] | Computational | no | yes |
| QCR9_HUMAN | [view interactions] | Computational | no | no |
| COX7C_HUMAN | [view interactions] | Computational | no | yes |
| AT5G1_HUMAN | [view interactions] | Computational | no | no |
| CX6A2_HUMAN | [view interactions] | Computational | no | no |
| CYB_HUMAN | [view interactions] | Computational | no | yes |
| MPPB_HUMAN | [view interactions] | Computational | no | yes |
| AT5G3_HUMAN | [view interactions] | Computational | no | no |
| C560_HUMAN | [view interactions] | Computational | no | no |
| SUCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MPPA_HUMAN | [view interactions] | Computational | no | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ATP5J_HUMAN | [view interactions] | Computational | no | yes |
| CY1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AT5F1_HUMAN | [view interactions] | Computational | no | yes |
| QCR6_HUMAN | [view interactions] | Computational | no | yes |
| ATPD_HUMAN | [view interactions] | Computational | no | yes |
| ATPK_HUMAN | [view interactions] | Computational | no | yes |
| ATPG_HUMAN | [view interactions] | Computational | no | yes |
| CIA30_HUMAN | [view interactions] | Computational | no | yes |
| ATP5H_HUMAN | [view interactions] | Computational | no | yes |