NK1R_HUMAN
Evidence for PS localization
Functions
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NK1R_HUMAN |
|---|---|---|---|---|
| GO:0008324 | monoatomic cation transmembrane transporter activity | 31.5789 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 31.5789 | 4 | no |
| GO:0015399 | primary active transmembrane transporter activity | 26.3158 | 4 | no |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 26.3158 | 4 | no |
| GO:0015078 | proton transmembrane transporter activity | 21.0526 | 5 | no |
| GO:0004930 | G protein-coupled receptor activity | 15.7895 | 4 | yes |
| GO:0008188 | neuropeptide receptor activity | 10.5263 | 5 | yes |
| GO:0008528 | G protein-coupled peptide receptor activity | 10.5263 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NK1R_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 42.1053 | 4 | no |
| GO:0051049 | regulation of transport | 31.5789 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 31.5789 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 31.5789 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 26.3158 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 26.3158 | 4 | yes |
| GO:0033993 | response to lipid | 26.3158 | 4 | yes |
| GO:0051046 | regulation of secretion | 21.0526 | 5 | yes |
| GO:0097305 | response to alcohol | 21.0526 | 4 | yes |
| GO:1901654 | response to ketone | 21.0526 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 21.0526 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 21.0526 | 4 | no |
| GO:1901137 | carbohydrate derivative biosynthetic process | 21.0526 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 21.0526 | 4 | no |
| GO:0048545 | response to steroid hormone | 15.7895 | 4 | yes |
| GO:0051050 | positive regulation of transport | 15.7895 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 15.7895 | 4 | yes |
| GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 15.7895 | 4 | yes |
| GO:0010646 | regulation of cell communication | 15.7895 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 15.7895 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 15.7895 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 15.7895 | 4 | yes |
| GO:0045471 | response to ethanol | 10.5263 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 10.5263 | 4 | yes |
| GO:0046887 | positive regulation of hormone secretion | 10.5263 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 10.5263 | 5 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 10.5263 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 10.5263 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 10.5263 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 10.5263 | 4 | yes |
| GO:1903532 | positive regulation of secretion by cell | 10.5263 | 5 | yes |
| GO:2000145 | regulation of cell motility | 10.5263 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 10.5263 | 5 | yes |
| GO:0006936 | muscle contraction | 10.5263 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 10.5263 | 5 | yes |
| GO:0030334 | regulation of cell migration | 10.5263 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 10.5263 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 10.5263 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OPRM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TKN1_HUMAN | [view interactions] | Low throughput | no | yes |
| TKN4_HUMAN | [view interactions] | Low throughput | no | no |
| GRK5_HUMAN | [view interactions] | Low throughput | no | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB5_HUMAN | [view interactions] | High throughput | no | yes |
| SNG2_HUMAN | [view interactions] | High throughput | no | no |
| FADS1_HUMAN | [view interactions] | High throughput | no | yes |
| TSN3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUC2_HUMAN | [view interactions] | High throughput | no | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| COX1_HUMAN | [view interactions] | High throughput | no | yes |
| NU1M_HUMAN | [view interactions] | High throughput | no | yes |
| NU4M_HUMAN | [view interactions] | High throughput | no | yes |
| NU5M_HUMAN | [view interactions] | High throughput | no | no |
| ATP8_HUMAN | [view interactions] | High throughput | no | no |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTR1L_HUMAN | [view interactions] | High throughput | no | no |
| TM164_HUMAN | [view interactions] | High throughput | no | yes |
| LMBD2_HUMAN | [view interactions] | High throughput | no | yes |
| RGPD2_HUMAN | [view interactions] | High throughput | no | no |
| MFSD5_HUMAN | [view interactions] | High throughput | no | yes |
| MBOA5_HUMAN | [view interactions] | High throughput | no | no |
| HACD2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| PAQR1_HUMAN | [view interactions] | High throughput | no | no |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| PXL2A_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| RDH14_HUMAN | [view interactions] | High throughput | no | yes |
| CC167_HUMAN | [view interactions] | High throughput | no | yes |
| TM147_HUMAN | [view interactions] | High throughput | no | no |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| ARVC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPHRA_HUMAN | [view interactions] | High throughput | no | no |
| AT12A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| PKP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPC5C_HUMAN | [view interactions] | High throughput | no | no |
| KIRR1_HUMAN | [view interactions] | High throughput | no | no |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| LMBR1_HUMAN | [view interactions] | High throughput | no | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| NDUB3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADCK1_HUMAN | [view interactions] | High throughput | no | no |
| CDS1_HUMAN | [view interactions] | High throughput | no | yes |
| APOB_HUMAN | [view interactions] | High throughput | no | no |
| ENDD1_HUMAN | [view interactions] | High throughput | no | yes |
| AOFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV2_HUMAN | [view interactions] | High throughput | no | no |
| PTSS2_HUMAN | [view interactions] | High throughput | no | yes |
| T126A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM9S3_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VKORL_HUMAN | [view interactions] | High throughput | no | yes |
| SGMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRP1_HUMAN | [view interactions] | High throughput | no | no |