AOFB_HUMAN
Evidence for PS localization
Functions
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AOFB_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 41.1765 | 4 | yes |
| GO:0000166 | nucleotide binding | 35.2941 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 23.5294 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.5294 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.5294 | 6 | no |
| GO:0008131 | primary amine oxidase activity | 17.6471 | 5 | yes |
| GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | 17.6471 | 4 | yes |
| GO:0050660 | flavin adenine dinucleotide binding | 17.6471 | 5 | yes |
| GO:0052595 | aliphatic amine oxidase activity | 17.6471 | 5 | yes |
| GO:0097621 | monoamine oxidase activity | 17.6471 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AOFB_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 58.8235 | 4 | no |
| GO:0051049 | regulation of transport | 52.9412 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 52.9412 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 52.9412 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 52.9412 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.0588 | 4 | yes |
| GO:0006996 | organelle organization | 47.0588 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.1765 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 41.1765 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.2941 | 4 | yes |
| GO:0008104 | protein localization | 35.2941 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 35.2941 | 5 | no |
| GO:0071310 | cellular response to organic substance | 35.2941 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.2941 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.2941 | 4 | no |
| GO:0051046 | regulation of secretion | 29.4118 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 29.4118 | 4 | yes |
| GO:0032880 | regulation of protein localization | 29.4118 | 5 | no |
| GO:0060341 | regulation of cellular localization | 29.4118 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 29.4118 | 4 | no |
| GO:0061024 | membrane organization | 29.4118 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 29.4118 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.4118 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.4118 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 29.4118 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 23.5294 | 4 | yes |
| GO:0033993 | response to lipid | 23.5294 | 4 | yes |
| GO:0048545 | response to steroid hormone | 23.5294 | 4 | yes |
| GO:0051051 | negative regulation of transport | 23.5294 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 23.5294 | 4 | yes |
| GO:0015031 | protein transport | 23.5294 | 4 | no |
| GO:0016050 | vesicle organization | 23.5294 | 5 | no |
| GO:0022607 | cellular component assembly | 23.5294 | 4 | no |
| GO:0050806 | positive regulation of synaptic transmission | 23.5294 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.5294 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 23.5294 | 6 | no |
| GO:0071702 | organic substance transport | 23.5294 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.5294 | 4 | no |
| GO:0098657 | import into cell | 23.5294 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 23.5294 | 5 | no |
| GO:1904951 | positive regulation of establishment of protein localization | 23.5294 | 6 | no |
| GO:0048168 | regulation of neuronal synaptic plasticity | 23.5294 | 4 | no |
| GO:0048169 | regulation of long-term neuronal synaptic plasticity | 23.5294 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.5294 | 7 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.5294 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.5294 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.5294 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.5294 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.5294 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.5294 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.5294 | 4 | no |
| GO:0050890 | cognition | 23.5294 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.5294 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.5294 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.5294 | 6 | no |
| GO:0033043 | regulation of organelle organization | 23.5294 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.5294 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.5294 | 4 | no |
| GO:0006576 | biogenic amine metabolic process | 17.6471 | 5 | yes |
| GO:0006584 | catecholamine metabolic process | 17.6471 | 6 | yes |
| GO:0009308 | amine metabolic process | 17.6471 | 4 | yes |
| GO:0009310 | amine catabolic process | 17.6471 | 5 | yes |
| GO:0009712 | catechol-containing compound metabolic process | 17.6471 | 5 | yes |
| GO:0010038 | response to metal ion | 17.6471 | 4 | yes |
| GO:0018958 | phenol-containing compound metabolic process | 17.6471 | 4 | yes |
| GO:0019336 | phenol-containing compound catabolic process | 17.6471 | 5 | yes |
| GO:0019614 | catechol-containing compound catabolic process | 17.6471 | 6 | yes |
| GO:0031960 | response to corticosteroid | 17.6471 | 5 | yes |
| GO:0042402 | cellular biogenic amine catabolic process | 17.6471 | 6 | yes |
| GO:0042417 | dopamine metabolic process | 17.6471 | 7 | yes |
| GO:0042420 | dopamine catabolic process | 17.6471 | 8 | yes |
| GO:0042424 | catecholamine catabolic process | 17.6471 | 7 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 17.6471 | 5 | yes |
| GO:0045471 | response to ethanol | 17.6471 | 5 | yes |
| GO:0051385 | response to mineralocorticoid | 17.6471 | 6 | yes |
| GO:0097305 | response to alcohol | 17.6471 | 4 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 17.6471 | 4 | yes |
| GO:1901616 | organic hydroxy compound catabolic process | 17.6471 | 4 | yes |
| GO:1901654 | response to ketone | 17.6471 | 4 | yes |
| GO:0002237 | response to molecule of bacterial origin | 11.7647 | 4 | yes |
| GO:0010044 | response to aluminum ion | 11.7647 | 5 | yes |
| GO:0010269 | response to selenium ion | 11.7647 | 4 | yes |
| GO:0014062 | regulation of serotonin secretion | 11.7647 | 5 | yes |
| GO:0014063 | negative regulation of serotonin secretion | 11.7647 | 6 | yes |
| GO:0021762 | substantia nigra development | 11.7647 | 4 | yes |
| GO:0032496 | response to lipopolysaccharide | 11.7647 | 4 | yes |
| GO:0033238 | regulation of amine metabolic process | 11.7647 | 4 | yes |
| GO:0033240 | positive regulation of amine metabolic process | 11.7647 | 5 | yes |
| GO:0042053 | regulation of dopamine metabolic process | 11.7647 | 6 | yes |
| GO:0042069 | regulation of catecholamine metabolic process | 11.7647 | 5 | yes |
| GO:0042743 | hydrogen peroxide metabolic process | 11.7647 | 4 | yes |
| GO:0043271 | negative regulation of monoatomic ion transport | 11.7647 | 5 | yes |
| GO:0045915 | positive regulation of catecholamine metabolic process | 11.7647 | 6 | yes |
| GO:0045964 | positive regulation of dopamine metabolic process | 11.7647 | 7 | yes |
| GO:0050665 | hydrogen peroxide biosynthetic process | 11.7647 | 4 | yes |
| GO:0051048 | negative regulation of secretion | 11.7647 | 5 | yes |
| GO:0051384 | response to glucocorticoid | 11.7647 | 6 | yes |
| GO:0051412 | response to corticosterone | 11.7647 | 5 | yes |
| GO:1903531 | negative regulation of secretion by cell | 11.7647 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AOFB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AOFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| UD2B7_HUMAN | [view interactions] | High throughput | no | no |
| NFYB_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| COX20_HUMAN | [view interactions] | High throughput | no | yes |
| CASP6_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| GLE1_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLF11_HUMAN | [view interactions] | High throughput | no | no |
| NUP58_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHBD2_HUMAN | [view interactions] | High throughput | no | yes |
| FGF14_HUMAN | [view interactions] | High throughput | no | no |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| CD226_HUMAN | [view interactions] | High throughput | no | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T4S18_HUMAN | [view interactions] | High throughput | no | no |
| SNG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| GP173_HUMAN | [view interactions] | High throughput | no | no |
| NK1R_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| ASB14_HUMAN | [view interactions] | High throughput | no | no |
| PIGN_HUMAN | [view interactions] | High throughput | no | yes |
| DOXA2_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| TSN3_HUMAN | [view interactions] | High throughput | no | yes |
| S35G2_HUMAN | [view interactions] | High throughput | no | yes |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| PPTC7_HUMAN | [view interactions] | High throughput | no | yes |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HACL1_HUMAN | [view interactions] | High throughput | no | no |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP1_HUMAN | [view interactions] | High throughput | no | no |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBC17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |