AOFB_HUMAN
Evidence for PS localization
Functions
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AOFB_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 25.0000 | 4 | no |
| GO:0008131 | primary amine oxidase activity | 15.0000 | 5 | yes |
| GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | 15.0000 | 4 | yes |
| GO:0050660 | flavin adenine dinucleotide binding | 15.0000 | 4 | yes |
| GO:0097621 | monoamine oxidase activity | 15.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AOFB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 45.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 45.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | yes |
| GO:0006996 | organelle organization | 40.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 40.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 40.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.0000 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.0000 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 35.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 35.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.0000 | 4 | no |
| GO:0008104 | protein localization | 35.0000 | 4 | no |
| GO:0032880 | regulation of protein localization | 35.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 35.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 35.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | yes |
| GO:0043269 | regulation of ion transport | 30.0000 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 30.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0071702 | organic substance transport | 30.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.0000 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 30.0000 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 30.0000 | 4 | no |
| GO:0006576 | cellular biogenic amine metabolic process | 25.0000 | 5 | yes |
| GO:0006584 | catecholamine metabolic process | 25.0000 | 6 | yes |
| GO:0009308 | amine metabolic process | 25.0000 | 4 | yes |
| GO:0009712 | catechol-containing compound metabolic process | 25.0000 | 5 | yes |
| GO:0018958 | phenol-containing compound metabolic process | 25.0000 | 4 | yes |
| GO:0042417 | dopamine metabolic process | 25.0000 | 7 | yes |
| GO:0044106 | cellular amine metabolic process | 25.0000 | 4 | yes |
| GO:0051046 | regulation of secretion | 25.0000 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 25.0000 | 4 | yes |
| GO:1901616 | organic hydroxy compound catabolic process | 25.0000 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 25.0000 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0015031 | protein transport | 25.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0032386 | regulation of intracellular transport | 25.0000 | 5 | no |
| GO:0032388 | positive regulation of intracellular transport | 25.0000 | 5 | no |
| GO:0033157 | regulation of intracellular protein transport | 25.0000 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0051223 | regulation of protein transport | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0070201 | regulation of establishment of protein localization | 25.0000 | 6 | no |
| GO:0009310 | amine catabolic process | 20.0000 | 5 | yes |
| GO:0010038 | response to metal ion | 20.0000 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 20.0000 | 4 | yes |
| GO:0019336 | phenol-containing compound catabolic process | 20.0000 | 5 | yes |
| GO:0019439 | aromatic compound catabolic process | 20.0000 | 4 | yes |
| GO:0019614 | catechol-containing compound catabolic process | 20.0000 | 6 | yes |
| GO:0033238 | regulation of cellular amine metabolic process | 20.0000 | 5 | yes |
| GO:0042053 | regulation of dopamine metabolic process | 20.0000 | 6 | yes |
| GO:0042069 | regulation of catecholamine metabolic process | 20.0000 | 5 | yes |
| GO:0042135 | neurotransmitter catabolic process | 20.0000 | 4 | yes |
| GO:0042402 | cellular biogenic amine catabolic process | 20.0000 | 6 | yes |
| GO:0042420 | dopamine catabolic process | 20.0000 | 8 | yes |
| GO:0042424 | catecholamine catabolic process | 20.0000 | 7 | yes |
| GO:0051051 | negative regulation of transport | 20.0000 | 4 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 20.0000 | 4 | yes |
| GO:0031960 | response to corticosteroid | 15.0000 | 5 | yes |
| GO:0033993 | response to lipid | 15.0000 | 4 | yes |
| GO:0048545 | response to steroid hormone | 15.0000 | 4 | yes |
| GO:0051048 | negative regulation of secretion | 15.0000 | 5 | yes |
| GO:0051385 | response to mineralocorticoid | 15.0000 | 6 | yes |
| GO:1903531 | negative regulation of secretion by cell | 15.0000 | 5 | yes |
| GO:0002237 | response to molecule of bacterial origin | 10.0000 | 4 | yes |
| GO:0010044 | response to aluminum ion | 10.0000 | 5 | yes |
| GO:0010269 | response to selenium ion | 10.0000 | 4 | yes |
| GO:0014062 | regulation of serotonin secretion | 10.0000 | 5 | yes |
| GO:0014063 | negative regulation of serotonin secretion | 10.0000 | 6 | yes |
| GO:0021762 | substantia nigra development | 10.0000 | 4 | yes |
| GO:0032496 | response to lipopolysaccharide | 10.0000 | 4 | yes |
| GO:0033240 | positive regulation of cellular amine metabolic process | 10.0000 | 6 | yes |
| GO:0042743 | hydrogen peroxide metabolic process | 10.0000 | 4 | yes |
| GO:0043271 | negative regulation of ion transport | 10.0000 | 5 | yes |
| GO:0045471 | response to ethanol | 10.0000 | 5 | yes |
| GO:0045915 | positive regulation of catecholamine metabolic process | 10.0000 | 6 | yes |
| GO:0045964 | positive regulation of dopamine metabolic process | 10.0000 | 7 | yes |
| GO:0050665 | hydrogen peroxide biosynthetic process | 10.0000 | 4 | yes |
| GO:0051384 | response to glucocorticoid | 10.0000 | 6 | yes |
| GO:0051412 | response to corticosterone | 10.0000 | 5 | yes |
| GO:0097305 | response to alcohol | 10.0000 | 4 | yes |
| GO:1901654 | response to ketone | 10.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AOFB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AOFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| NFYB_HUMAN | [view interactions] | High throughput | no | yes |
| COX20_HUMAN | [view interactions] | High throughput | no | yes |
| CASP6_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| GLE1_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLF11_HUMAN | [view interactions] | High throughput | no | no |
| NUP58_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHBD2_HUMAN | [view interactions] | High throughput | no | yes |
| FGF14_HUMAN | [view interactions] | High throughput | no | no |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| CD226_HUMAN | [view interactions] | High throughput | no | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T4S18_HUMAN | [view interactions] | High throughput | no | no |
| SNG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| GP173_HUMAN | [view interactions] | High throughput | no | no |
| NK1R_HUMAN | [view interactions] | High throughput | no | no |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| ASB14_HUMAN | [view interactions] | High throughput | no | no |
| PIGN_HUMAN | [view interactions] | High throughput | no | yes |
| DOXA2_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK1_HUMAN | [view interactions] | High throughput | no | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| TSN3_HUMAN | [view interactions] | High throughput | no | yes |
| S35G2_HUMAN | [view interactions] | High throughput | no | yes |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| PPTC7_HUMAN | [view interactions] | High throughput | no | yes |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| HACL1_HUMAN | [view interactions] | High throughput | no | no |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP1_HUMAN | [view interactions] | High throughput | no | no |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBC17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOPO_HUMAN | [view interactions] | Computational | no | no |
| AOC2_HUMAN | [view interactions] | Computational | no | no |
| ALDH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CP2CJ_HUMAN | [view interactions] | Computational | no | no |
| SAT1_HUMAN | [view interactions] | Computational | no | yes |
| PNMT_HUMAN | [view interactions] | Computational | no | no |
| SAT2_HUMAN | [view interactions] | Computational | no | yes |
| LGUL_HUMAN | [view interactions] | Computational | no | yes |
| HNMT_HUMAN | [view interactions] | Computational | no | yes |
| AOC1_HUMAN | [view interactions] | Computational | no | no |
| I23O2_HUMAN | [view interactions] | Computational | no | no |
| AOC3_HUMAN | [view interactions] | Computational | no | no |
| AK1A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AL1B1_HUMAN | [view interactions] | Computational | no | yes |
| INMT_HUMAN | [view interactions] | Computational | no | no |
| AOXA_HUMAN | [view interactions] | Computational | no | no |
| OXLA_HUMAN | [view interactions] | Computational | no | no |
| COMT_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AL3A1_HUMAN | [view interactions] | Computational | no | no |
| I23O1_HUMAN | [view interactions] | Computational | no | no |
| DDC_HUMAN | [view interactions] | Computational | no | no |
| AL3A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNAT_HUMAN | [view interactions] | Computational | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AL3B1_HUMAN | [view interactions] | Computational | no | yes |
| AL3B2_HUMAN | [view interactions] | Computational | no | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | Computational | yes | no |