Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

VAMP2_HUMAN

Involved in the targeting and/or fusion of transport vesicles to their target membrane . Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (PubMed). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
75 Ser Pro Neurodevelopmentaldisorderwithhypotoniaandautisticfeatureswithorwithouthyperkineticmovements(NEDHAHM) -
77 Phe Ser Neurodevelopmentaldisorderwithhypotoniaandautisticfeatureswithorwithouthyperkineticmovements(NEDHAHM) -
78 Glu Ala Neurodevelopmentaldisorderwithhypotoniaandautisticfeatureswithorwithouthyperkineticmovements(NEDHAHM) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in VAMP2_HUMAN
GO:0043168 anion binding 38.8889 4 no
GO:0000166 nucleotide binding 33.3333 4 no
GO:0017076 purine nucleotide binding 31.4815 5 no
GO:0032555 purine ribonucleotide binding 31.4815 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.5556 4 no
GO:0016462 pyrophosphatase activity 28.7037 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.7037 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.7037 6 no
GO:0043169 cation binding 21.2963 4 no
GO:0046872 metal ion binding 21.2963 5 no
GO:0003924 GTPase activity 20.3704 7 no
GO:0019905 syntaxin binding 19.4444 4 yes
GO:0017075 syntaxin-1 binding 12.0370 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in VAMP2_HUMAN
GO:0048522 positive regulation of cellular process 53.7037 4 yes
GO:0051049 regulation of transport 50.9259 4 yes
GO:0010646 regulation of cell communication 49.0741 4 yes
GO:0008104 protein localization 47.2222 4 yes
GO:0006996 organelle organization 46.2963 4 yes
GO:0071702 organic substance transport 46.2963 4 yes
GO:0051128 regulation of cellular component organization 46.2963 4 no
GO:0071705 nitrogen compound transport 45.3704 4 yes
GO:0048523 negative regulation of cellular process 41.6667 4 no
GO:0015031 protein transport 37.0370 4 yes
GO:0022607 cellular component assembly 34.2593 4 yes
GO:0060255 regulation of macromolecule metabolic process 34.2593 4 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0060627 regulation of vesicle-mediated transport 32.4074 4 yes
GO:0061024 membrane organization 32.4074 4 yes
GO:0023056 positive regulation of signaling 31.4815 4 yes
GO:0044087 regulation of cellular component biogenesis 31.4815 4 no
GO:0010647 positive regulation of cell communication 29.6296 5 yes
GO:0080090 regulation of primary metabolic process 29.6296 4 no
GO:0009893 positive regulation of metabolic process 28.7037 4 no
GO:0098657 import into cell 27.7778 4 yes
GO:0051046 regulation of secretion 26.8519 5 yes
GO:0048584 positive regulation of response to stimulus 26.8519 4 no
GO:0060341 regulation of cellular localization 25.9259 4 yes
GO:1903530 regulation of secretion by cell 25.9259 4 yes
GO:0009889 regulation of biosynthetic process 25.9259 4 no
GO:0010604 positive regulation of macromolecule metabolic process 25.9259 5 no
GO:0016050 vesicle organization 25.0000 5 yes
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 yes
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0046903 secretion 24.0741 4 yes
GO:0051050 positive regulation of transport 24.0741 4 yes
GO:0010468 regulation of gene expression 24.0741 6 no
GO:0010556 regulation of macromolecule biosynthetic process 24.0741 5 no
GO:0032880 regulation of protein localization 23.1481 5 yes
GO:0033043 regulation of organelle organization 23.1481 5 no
GO:0006886 intracellular protein transport 23.1481 4 no
GO:0071310 cellular response to organic substance 22.2222 4 yes
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:0043933 protein-containing complex organization 21.2963 4 yes
GO:0051130 positive regulation of cellular component organization 21.2963 5 no
GO:0031324 negative regulation of cellular metabolic process 21.2963 5 no
GO:0051246 regulation of protein metabolic process 21.2963 5 no
GO:0031325 positive regulation of cellular metabolic process 21.2963 5 no
GO:0009967 positive regulation of signal transduction 20.3704 5 no
GO:0017157 regulation of exocytosis 19.4444 5 yes
GO:0061025 membrane fusion 18.5185 5 yes
GO:0023061 signal release 16.6667 4 yes
GO:0072657 protein localization to membrane 16.6667 4 yes
GO:0045055 regulated exocytosis 15.7407 4 yes
GO:0065003 protein-containing complex assembly 15.7407 5 yes
GO:0006906 vesicle fusion 14.8148 6 yes
GO:0048284 organelle fusion 14.8148 5 yes
GO:0090174 organelle membrane fusion 14.8148 6 yes
GO:1901701 cellular response to oxygen-containing compound 14.8148 4 yes
GO:0043269 regulation of monoatomic ion transport 13.8889 5 yes
GO:1903829 positive regulation of protein localization 13.8889 5 yes
GO:0070201 regulation of establishment of protein localization 12.9630 6 yes
GO:0099643 signal release from synapse 12.9630 5 yes
GO:0034762 regulation of transmembrane transport 12.0370 4 yes
GO:0050806 positive regulation of synaptic transmission 12.0370 5 yes
GO:0010243 response to organonitrogen compound 11.1111 4 yes
GO:0016079 synaptic vesicle exocytosis 11.1111 4 yes
GO:1990778 protein localization to cell periphery 11.1111 5 yes
GO:0010959 regulation of metal ion transport 10.1852 6 yes
GO:0017156 calcium-ion regulated exocytosis 10.1852 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 10.1852 5 yes
GO:0051223 regulation of protein transport 10.1852 5 yes
GO:0072659 protein localization to plasma membrane 10.1852 5 yes
GO:0090150 establishment of protein localization to membrane 10.1852 4 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 10.1852 6 yes
GO:0032386 regulation of intracellular transport 9.2593 5 yes
GO:0022898 regulation of transmembrane transporter activity 8.3333 4 yes
GO:0048488 synaptic vesicle endocytosis 8.3333 5 yes
GO:0140238 presynaptic endocytosis 8.3333 4 yes
GO:1901699 cellular response to nitrogen compound 8.3333 4 yes
GO:0006892 post-Golgi vesicle-mediated transport 7.4074 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 7.4074 5 yes
GO:0071417 cellular response to organonitrogen compound 7.4074 4 yes
GO:1904951 positive regulation of establishment of protein localization 7.4074 6 yes
GO:0032870 cellular response to hormone stimulus 6.4815 4 yes
GO:0035493 SNARE complex assembly 6.4815 6 yes
GO:0051222 positive regulation of protein transport 5.5556 5 yes
GO:0060291 long-term synaptic potentiation 5.5556 4 yes
GO:0061951 establishment of protein localization to plasma membrane 5.5556 5 yes
GO:2001257 regulation of cation channel activity 4.6296 6 yes
GO:0006893 Golgi to plasma membrane transport 3.7037 4 yes
GO:0009743 response to carbohydrate 3.7037 4 yes
GO:0032388 positive regulation of intracellular transport 3.7037 5 yes
GO:0032868 response to insulin 3.7037 5 yes
GO:0033157 regulation of intracellular protein transport 3.7037 6 yes
GO:0043001 Golgi to plasma membrane protein transport 3.7037 5 yes
GO:0043434 response to peptide hormone 3.7037 4 yes
GO:0090316 positive regulation of intracellular protein transport 2.7778 6 yes
GO:0009746 response to hexose 1.8519 6 yes
GO:0009749 response to glucose 1.8519 7 yes
GO:0032869 cellular response to insulin stimulus 1.8519 6 yes
GO:0034284 response to monosaccharide 1.8519 5 yes
GO:0043266 regulation of potassium ion transport 1.8519 7 yes
GO:0043308 eosinophil degranulation 1.8519 4 yes
GO:0071375 cellular response to peptide hormone stimulus 1.8519 5 yes
GO:1901016 regulation of potassium ion transmembrane transporter activity 1.8519 6 yes
GO:1901379 regulation of potassium ion transmembrane transport 1.8519 7 yes
GO:1902259 regulation of delayed rectifier potassium channel activity 1.8519 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VAMP3_HUMAN [view entry] [view interactions] Low throughput yes no
PRRT2_HUMAN [view entry] [view interactions] Low throughput yes no
VAPA_HUMAN [view entry] [view interactions] Low throughput yes yes
VAPB_HUMAN [view entry] [view interactions] Low throughput yes yes
BAP31_HUMAN [view interactions] Low throughput no yes
VAMP8_HUMAN [view interactions] Low throughput no no
BAG6_HUMAN [view entry] [view interactions] Low throughput yes yes
GET3_HUMAN [view interactions] Low throughput no yes
FKBP2_HUMAN [view interactions] Low throughput no yes
UN13B_HUMAN [view interactions] Low throughput no no
AQP2_HUMAN [view interactions] Low throughput no no
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
UN13A_HUMAN [view entry] [view interactions] Low throughput yes no
KPCD3_HUMAN [view interactions] Low throughput no yes
PRAF1_HUMAN [view interactions] Low throughput no yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
STX11_HUMAN [view interactions] Low throughput no yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] Low throughput yes no
POPD1_HUMAN [view interactions] Low throughput no yes
PICAL_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
STX4_HUMAN [view entry] [view interactions] Low throughput yes no
CPLX1_HUMAN [view entry] [view interactions] Low throughput yes yes
CPLX2_HUMAN [view entry] [view interactions] Low throughput yes yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
STXB3_HUMAN [view entry] [view interactions] Low throughput yes yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
SYT2_HUMAN [view entry] [view interactions] Low throughput yes no
SNP23_HUMAN [view entry] [view interactions] Low throughput yes no
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1B_HUMAN [view entry] [view interactions] Low throughput yes yes
STX3_HUMAN [view entry] [view interactions] Low throughput yes no
SNP29_HUMAN [view interactions] Low throughput no yes
SPN90_HUMAN [view entry] [view interactions] Low throughput yes no
CSTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
IKKB_HUMAN [view interactions] Low throughput no yes
DNJC5_HUMAN [view interactions] Low throughput no yes
SNAA_HUMAN [view entry] [view interactions] Low throughput yes yes
STX2_HUMAN [view interactions] Low throughput no no
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
ASPC1_HUMAN [view interactions] Low throughput no yes
SC6A4_HUMAN [view entry] [view interactions] Low throughput yes no
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC3_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX5_HUMAN [view entry] [view interactions] High throughput yes yes
MRP2_HUMAN [view interactions] High throughput no no
S10AG_HUMAN [view interactions] High throughput no no
TYDP1_HUMAN [view interactions] High throughput no no
UBP7_HUMAN [view interactions] High throughput no yes
ACAD9_HUMAN [view interactions] High throughput no yes
SEPT9_HUMAN [view interactions] High throughput no no
TMEDA_HUMAN [view interactions] High throughput no yes
ILF3_HUMAN [view interactions] High throughput no yes
RS12_HUMAN [view entry] [view interactions] High throughput yes yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
SF01_HUMAN [view interactions] High throughput no yes
TX1B3_HUMAN [view interactions] High throughput no no
ZNT5_HUMAN [view interactions] High throughput no yes
UBP2L_HUMAN [view interactions] High throughput no yes
THIM_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
UBXN1_HUMAN [view interactions] High throughput no no
SFXN3_HUMAN [view entry] [view interactions] High throughput yes yes
DHB4_HUMAN [view entry] [view interactions] High throughput yes yes
SCFD1_HUMAN [view entry] [view interactions] High throughput yes yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR3_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
AOFA_HUMAN [view entry] [view interactions] High throughput yes yes
AOFB_HUMAN [view entry] [view interactions] High throughput yes yes
SYN2_HUMAN [view entry] [view interactions] High throughput yes no
CPLX3_HUMAN [view interactions] High throughput no no
SNX30_HUMAN [view interactions] High throughput no no
STXB2_HUMAN [view interactions] High throughput no no
VAMP1_HUMAN [view interactions] High throughput no no
RAB8B_HUMAN [view entry] [view interactions] High throughput yes no
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
RN183_HUMAN [view interactions] High throughput no no
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
B3GA1_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
COX8A_HUMAN [view interactions] High throughput no yes
CXAR_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
ELOV5_HUMAN [view interactions] High throughput no yes
ERGI1_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
GOGA1_HUMAN [view interactions] High throughput no yes
DHB11_HUMAN [view interactions] High throughput no yes
3BHS7_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
TMT1A_HUMAN [view interactions] High throughput no no
OCLN_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
SEC62_HUMAN [view interactions] High throughput no yes
ZFPL1_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
MUC18_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
IQCB1_HUMAN [view interactions] High throughput no no
ARHGH_HUMAN [view interactions] High throughput no yes
DJC13_HUMAN [view entry] [view interactions] High throughput yes yes
LYST_HUMAN [view interactions] High throughput no no
DDX6L_HUMAN [view interactions] High throughput no yes
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
TPC2_HUMAN [view interactions] High throughput no no
STX19_HUMAN [view interactions] High throughput no yes
WDFY1_HUMAN [view interactions] High throughput no yes
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
VATL_HUMAN [view interactions] High throughput no no
VA0D1_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
AT1A2_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
GBB3_HUMAN [view interactions] High throughput no yes
SNAB_HUMAN [view entry] [view interactions] High throughput yes yes
ZNT3_HUMAN [view entry] [view interactions] High throughput yes yes
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
KASH5_HUMAN [view interactions] High throughput no yes
CR3L1_HUMAN [view interactions] High throughput no yes
S7A14_HUMAN [view interactions] High throughput no no
CERS4_HUMAN [view interactions] High throughput no yes
AR13B_HUMAN [view interactions] High throughput no yes
SCN3B_HUMAN [view interactions] High throughput no no
EBP_HUMAN [view interactions] High throughput no no
VMA21_HUMAN [view interactions] High throughput no no
ZNT8_HUMAN [view interactions] High throughput no no
MARH8_HUMAN [view interactions] High throughput no no
ERGI3_HUMAN [view interactions] High throughput no yes
DHB13_HUMAN [view interactions] High throughput no yes
JAGN1_HUMAN [view interactions] High throughput no no
AQP6_HUMAN [view interactions] High throughput no no
TM86B_HUMAN [view interactions] High throughput no no
TM101_HUMAN [view interactions] High throughput no no
3HIDH_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
AT132_HUMAN [view interactions] High throughput no yes
SOX4_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TECT2_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
PPM1H_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
TMM31_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
LPAR1_HUMAN [view entry] [view interactions] High throughput yes no
HUWE1_HUMAN [view interactions] High throughput no yes
OSBL2_HUMAN [view interactions] High throughput no yes
SYPL1_HUMAN [view interactions] High throughput no yes
MUC1_HUMAN [view interactions] High throughput no no
SEPT5_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
CENPM_HUMAN [view interactions] High throughput no yes
STX8_HUMAN [view interactions] High throughput no yes
LEG3_HUMAN [view interactions] High throughput no yes
SRGP3_HUMAN [view entry] [view interactions] High throughput yes yes
UT1_HUMAN [view interactions] High throughput no no
T185A_HUMAN [view interactions] High throughput no no
STX6_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
SEGN_HUMAN [view interactions] High throughput no no
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
NTNG1_HUMAN [view interactions] High throughput no no
SNAG_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOC_HUMAN [view interactions] High throughput no no
RND1_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes