Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RB11B_HUMAN

GO
G2C
SynGO

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RB11B_HUMAN
GO:0043168 anion binding 47.2973 4 yes
GO:0000166 nucleotide binding 41.8919 4 yes
GO:0017076 purine nucleotide binding 41.8919 5 yes
GO:0032555 purine ribonucleotide binding 40.5405 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 40.5405 4 yes
GO:0016462 pyrophosphatase activity 31.0811 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 31.0811 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 31.0811 6 yes
GO:0019001 guanyl nucleotide binding 27.0270 6 yes
GO:0032561 guanyl ribonucleotide binding 27.0270 5 yes
GO:0003924 GTPase activity 25.6757 7 yes
GO:0005525 GTP binding 25.6757 5 yes
GO:0019900 kinase binding 24.3243 4 no
GO:0043169 cation binding 22.9730 4 no
GO:0046872 metal ion binding 22.9730 5 no
GO:0019901 protein kinase binding 22.9730 5 no
GO:0003723 RNA binding 20.2703 4 no
GO:0045296 cadherin binding 14.8649 4 yes
GO:0019003 GDP binding 13.5135 5 yes
GO:0017022 myosin binding 8.1081 4 yes
GO:0031489 myosin V binding 6.7568 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RB11B_HUMAN
GO:0048522 positive regulation of cellular process 60.8108 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0008104 protein localization 48.6486 4 yes
GO:0080090 regulation of primary metabolic process 45.9459 4 no
GO:0009893 positive regulation of metabolic process 45.9459 4 no
GO:0051128 regulation of cellular component organization 43.2432 4 no
GO:0051049 regulation of transport 41.8919 4 yes
GO:0022607 cellular component assembly 41.8919 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.5405 5 no
GO:0071702 organic substance transport 37.8378 4 yes
GO:0006996 organelle organization 37.8378 4 no
GO:0009966 regulation of signal transduction 37.8378 4 no
GO:0048584 positive regulation of response to stimulus 37.8378 4 no
GO:0071705 nitrogen compound transport 36.4865 4 yes
GO:0009889 regulation of biosynthetic process 36.4865 4 no
GO:0015031 protein transport 35.1351 4 yes
GO:0023056 positive regulation of signaling 35.1351 4 no
GO:0010556 regulation of macromolecule biosynthetic process 35.1351 5 no
GO:0031326 regulation of cellular biosynthetic process 35.1351 5 no
GO:0051246 regulation of protein metabolic process 35.1351 5 no
GO:0060341 regulation of cellular localization 33.7838 4 yes
GO:0010647 positive regulation of cell communication 33.7838 5 no
GO:0010468 regulation of gene expression 33.7838 6 no
GO:0032880 regulation of protein localization 32.4324 5 yes
GO:0009967 positive regulation of signal transduction 31.0811 5 no
GO:0031325 positive regulation of cellular metabolic process 31.0811 5 no
GO:0044087 regulation of cellular component biogenesis 28.3784 4 no
GO:1902531 regulation of intracellular signal transduction 28.3784 5 no
GO:0051247 positive regulation of protein metabolic process 28.3784 6 no
GO:0033043 regulation of organelle organization 27.0270 5 no
GO:0009892 negative regulation of metabolic process 27.0270 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.0270 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.6757 5 no
GO:0031324 negative regulation of cellular metabolic process 25.6757 5 no
GO:0031399 regulation of protein modification process 25.6757 6 no
GO:0031344 regulation of cell projection organization 24.3243 5 no
GO:0043933 protein-containing complex organization 22.9730 4 no
GO:0098657 import into cell 22.9730 4 no
GO:0010648 negative regulation of cell communication 22.9730 5 no
GO:0023057 negative regulation of signaling 22.9730 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.9730 6 no
GO:0006886 intracellular protein transport 22.9730 4 no
GO:0009891 positive regulation of biosynthetic process 22.9730 5 no
GO:0050804 modulation of chemical synaptic transmission 21.6216 5 no
GO:0071310 cellular response to organic substance 21.6216 4 no
GO:0099177 regulation of trans-synaptic signaling 21.6216 4 no
GO:0042981 regulation of apoptotic process 21.6216 5 no
GO:0043067 regulation of programmed cell death 21.6216 4 no
GO:0042127 regulation of cell population proliferation 21.6216 4 no
GO:0051726 regulation of cell cycle 21.6216 4 no
GO:0002684 positive regulation of immune system process 21.6216 4 no
GO:0019220 regulation of phosphate metabolic process 21.6216 6 no
GO:0051174 regulation of phosphorus metabolic process 21.6216 5 no
GO:0051240 positive regulation of multicellular organismal process 21.6216 4 no
GO:0006355 regulation of DNA-templated transcription 21.6216 7 no
GO:0051252 regulation of RNA metabolic process 21.6216 5 no
GO:2001141 regulation of RNA biosynthetic process 21.6216 6 no
GO:0061024 membrane organization 20.2703 4 no
GO:0141124 intracellular signaling cassette 20.2703 4 no
GO:0009890 negative regulation of biosynthetic process 20.2703 5 no
GO:0009894 regulation of catabolic process 20.2703 4 no
GO:0051129 negative regulation of cellular component organization 20.2703 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.2703 6 no
GO:0031328 positive regulation of cellular biosynthetic process 20.2703 6 no
GO:0060627 regulation of vesicle-mediated transport 18.9189 4 yes
GO:0072657 protein localization to membrane 16.2162 4 yes
GO:0043269 regulation of monoatomic ion transport 14.8649 5 yes
GO:0046903 secretion 14.8649 4 yes
GO:0006811 monoatomic ion transport 13.5135 4 yes
GO:0006812 monoatomic cation transport 13.5135 5 yes
GO:0030001 metal ion transport 10.8108 6 yes
GO:0032386 regulation of intracellular transport 10.8108 5 yes
GO:0090150 establishment of protein localization to membrane 10.8108 4 yes
GO:0023061 signal release 8.1081 4 yes
GO:0032456 endocytic recycling 8.1081 4 yes
GO:0045055 regulated exocytosis 8.1081 4 yes
GO:0002790 peptide secretion 6.7568 5 yes
GO:0009306 protein secretion 6.7568 4 yes
GO:0015833 peptide transport 6.7568 5 yes
GO:0035592 establishment of protein localization to extracellular region 6.7568 4 yes
GO:0042886 amide transport 6.7568 5 yes
GO:0051650 establishment of vesicle localization 6.7568 4 yes
GO:0071692 protein localization to extracellular region 6.7568 5 yes
GO:0009914 hormone transport 5.4054 4 yes
GO:0010447 response to acidic pH 5.4054 4 yes
GO:0030072 peptide hormone secretion 5.4054 6 yes
GO:0046879 hormone secretion 5.4054 5 yes
GO:0030073 insulin secretion 4.0541 5 yes
GO:0032400 melanosome localization 4.0541 5 yes
GO:0032401 establishment of melanosome localization 4.0541 6 yes
GO:0032402 melanosome transport 4.0541 5 yes
GO:0035773 insulin secretion involved in cellular response to glucose stimulus 4.0541 4 yes
GO:0051875 pigment granule localization 4.0541 4 yes
GO:0051904 pigment granule transport 4.0541 4 yes
GO:0051905 establishment of pigment granule localization 4.0541 5 yes
GO:0071467 cellular response to pH 4.0541 4 yes
GO:0071468 cellular response to acidic pH 4.0541 5 yes
GO:2001135 regulation of endocytic recycling 4.0541 5 yes
GO:0000041 transition metal ion transport 2.7027 7 yes
GO:0006826 iron ion transport 2.7027 8 yes
GO:0033572 transferrin transport 2.7027 5 yes
GO:0044070 regulation of monoatomic anion transport 2.7027 6 yes
GO:2000008 regulation of protein localization to cell surface 2.7027 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
RIMS1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
KGP2_HUMAN [view entry] [view interactions] Low throughput yes yes
TBC14_HUMAN [view interactions] Low throughput no yes
EVI5_HUMAN [view interactions] Low throughput no yes
RAB3I_HUMAN [view interactions] Low throughput no no
MYO5B_HUMAN [view entry] [view interactions] Low throughput yes yes
OPTN_HUMAN [view interactions] Low throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
PJA2_HUMAN [view entry] [view interactions] High throughput yes yes
PD1L1_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
MIDN_HUMAN [view interactions] High throughput no no
GOLI_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
VATH_HUMAN [view entry] [view interactions] High throughput yes yes
HNRL1_HUMAN [view interactions] High throughput no yes
DDX28_HUMAN [view interactions] High throughput no yes
MRP2_HUMAN [view interactions] High throughput no no
HNRL2_HUMAN [view interactions] High throughput no yes
DUT_HUMAN [view interactions] High throughput no yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
NTF2_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
PGAM1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB6A_HUMAN [view entry] [view interactions] High throughput yes yes
UAP1L_HUMAN [view interactions] High throughput no yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
AATM_HUMAN [view entry] [view interactions] High throughput yes yes
HCDH_HUMAN [view entry] [view interactions] High throughput yes yes
UBP5_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
AGR2_HUMAN [view interactions] High throughput no no
RFFL_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
BAP31_HUMAN [view interactions] High throughput no yes
DEN6A_HUMAN [view interactions] High throughput no yes
RAB3B_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
H2AX_HUMAN [view interactions] High throughput no yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
NEMO_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RFIP1_HUMAN [view interactions] High throughput no yes
RCC1_HUMAN [view interactions] High throughput no yes
SNP29_HUMAN [view interactions] High throughput no yes
CROCC_HUMAN [view interactions] High throughput no no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
KLC3_HUMAN [view interactions] High throughput no no
JAK3_HUMAN [view interactions] High throughput no no
GOT1B_HUMAN [view interactions] High throughput no yes
IFIT2_HUMAN [view interactions] High throughput no no
F217B_HUMAN [view interactions] High throughput no yes
3BP5_HUMAN [view interactions] High throughput no yes
DUS14_HUMAN [view interactions] High throughput no yes
H2A1_HUMAN [view interactions] High throughput no yes
RAE1_HUMAN [view interactions] High throughput no yes
RAE2_HUMAN [view interactions] High throughput no yes
CALL3_HUMAN [view interactions] High throughput no yes
S10A3_HUMAN [view interactions] High throughput no no
SPB5_HUMAN [view interactions] High throughput no no
PLCD1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB25_HUMAN [view interactions] High throughput no no
RFIP2_HUMAN [view entry] [view interactions] High throughput yes yes
CAHM4_HUMAN [view interactions] High throughput no no
VSIG8_HUMAN [view interactions] High throughput no no
BSPRY_HUMAN [view interactions] High throughput no no
HPHL1_HUMAN [view interactions] High throughput no no
3BP5L_HUMAN [view interactions] High throughput no yes
LYG2_HUMAN [view interactions] High throughput no no
RFIP5_HUMAN [view entry] [view interactions] High throughput yes yes
DNPEP_HUMAN [view interactions] High throughput no yes
PADI3_HUMAN [view interactions] High throughput no no
5NT3A_HUMAN [view interactions] High throughput no yes
EKI2_HUMAN [view interactions] High throughput no yes
MOT11_HUMAN [view interactions] High throughput no no
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
FINC_HUMAN [view interactions] High throughput no yes
BICL1_HUMAN [view interactions] High throughput no yes
PI4KB_HUMAN [view interactions] High throughput no yes
DUX4_HUMAN [view interactions] High throughput no no
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
AAPK1_HUMAN [view interactions] High throughput no no
CAV3_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
CD177_HUMAN [view interactions] High throughput no no
FOS_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] High throughput yes yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
SPRE1_HUMAN [view interactions] High throughput no yes
SRBP2_HUMAN [view interactions] High throughput no yes
NOE2_HUMAN [view entry] [view interactions] High throughput yes yes
STAT6_HUMAN [view interactions] High throughput no yes
SBNO2_HUMAN [view interactions] High throughput no yes
RABL3_HUMAN [view interactions] High throughput no yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
TLL1_HUMAN [view interactions] High throughput no no
GLMP_HUMAN [view interactions] High throughput no no
UBP7_HUMAN [view interactions] High throughput no yes
FBF1_HUMAN [view interactions] High throughput no no
SCLT1_HUMAN [view interactions] High throughput no yes
OFD1_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
TANK_HUMAN [view interactions] High throughput no yes
RFIP3_HUMAN [view entry] [view interactions] High throughput yes no
MEOX2_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
WDR44_HUMAN [view interactions] High throughput no yes
SBP1_HUMAN [view interactions] High throughput no no
LRC15_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
SNH28_HUMAN [view interactions] High throughput no no
DSG4_HUMAN [view interactions] High throughput no no
TRI27_HUMAN [view interactions] High throughput no yes
EPCR_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
RBM42_HUMAN [view interactions] High throughput no yes
SCEL_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
RFIP4_HUMAN [view interactions] High throughput no yes
ACOX1_HUMAN [view interactions] High throughput no yes
RL34_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL1_HUMAN [view interactions] High throughput no yes
EVI5L_HUMAN [view interactions] High throughput no yes
PIAS4_HUMAN [view interactions] High throughput no yes
BT3A3_HUMAN [view interactions] High throughput no yes
MMAB_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
ELOV1_HUMAN [view interactions] High throughput no yes
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
S35F2_HUMAN [view interactions] High throughput no yes
SCAM1_HUMAN [view interactions] High throughput no no
SCAM3_HUMAN [view interactions] High throughput no no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
SCAM2_HUMAN [view interactions] High throughput no no
SCAM4_HUMAN [view interactions] High throughput no yes
SC61B_HUMAN [view interactions] High throughput no yes
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
TMEDA_HUMAN [view interactions] High throughput no yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
VAMP8_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
BAP1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes