Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RB11B_HUMAN

GO
G2C
SynGO

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RB11B_HUMAN
GO:0017076 purine nucleotide binding 36.7647 4 yes
GO:0032555 purine ribonucleotide binding 36.7647 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 36.7647 4 yes
GO:0016462 pyrophosphatase activity 29.4118 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 29.4118 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 29.4118 6 yes
GO:0019001 guanyl nucleotide binding 29.4118 5 yes
GO:0032561 guanyl ribonucleotide binding 29.4118 5 yes
GO:0003924 GTPase activity 27.9412 7 yes
GO:0005525 GTP binding 27.9412 5 yes
GO:0019900 kinase binding 23.5294 4 no
GO:0019901 protein kinase binding 23.5294 5 no
GO:0046872 metal ion binding 23.5294 4 no
GO:0019003 GDP binding 16.1765 4 yes
GO:0045296 cadherin binding 14.7059 4 yes
GO:0017022 myosin binding 7.3529 4 yes
GO:0031489 myosin V binding 5.8824 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RB11B_HUMAN
GO:0048522 positive regulation of cellular process 55.8824 4 no
GO:0008104 protein localization 54.4118 4 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0010646 regulation of cell communication 48.5294 4 no
GO:0071702 organic substance transport 47.0588 4 yes
GO:0031323 regulation of cellular metabolic process 47.0588 4 no
GO:0060255 regulation of macromolecule metabolic process 47.0588 4 no
GO:0071705 nitrogen compound transport 45.5882 4 yes
GO:0015031 protein transport 44.1176 4 yes
GO:0016192 vesicle-mediated transport 44.1176 4 yes
GO:0009893 positive regulation of metabolic process 42.6471 4 no
GO:0051171 regulation of nitrogen compound metabolic process 42.6471 4 no
GO:0080090 regulation of primary metabolic process 42.6471 4 no
GO:0022607 cellular component assembly 41.1765 4 no
GO:0051128 regulation of cellular component organization 39.7059 4 no
GO:0006996 organelle organization 39.7059 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.7647 5 no
GO:0009966 regulation of signal transduction 33.8235 4 no
GO:0060341 regulation of cellular localization 32.3529 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 32.3529 5 no
GO:0051246 regulation of protein metabolic process 32.3529 5 no
GO:0031325 positive regulation of cellular metabolic process 32.3529 5 no
GO:0006886 intracellular protein transport 30.8824 4 no
GO:0032880 regulation of protein localization 30.8824 5 yes
GO:0009892 negative regulation of metabolic process 26.4706 4 no
GO:0010468 regulation of gene expression 26.4706 5 no
GO:0051247 positive regulation of protein metabolic process 26.4706 6 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 23.5294 5 no
GO:1902531 regulation of intracellular signal transduction 23.5294 5 no
GO:0033043 regulation of organelle organization 23.5294 5 no
GO:0010647 positive regulation of cell communication 23.5294 5 no
GO:0043085 positive regulation of catalytic activity 23.5294 4 no
GO:0050804 modulation of chemical synaptic transmission 23.5294 5 no
GO:0099177 regulation of trans-synaptic signaling 23.5294 4 no
GO:0019220 regulation of phosphate metabolic process 23.5294 6 no
GO:0051174 regulation of phosphorus metabolic process 23.5294 5 no
GO:0061024 membrane organization 23.5294 4 no
GO:0043269 regulation of ion transport 22.0588 5 yes
GO:0060627 regulation of vesicle-mediated transport 22.0588 4 yes
GO:0009889 regulation of biosynthetic process 22.0588 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.0588 5 no
GO:0031324 negative regulation of cellular metabolic process 22.0588 5 no
GO:0031399 regulation of protein modification process 22.0588 6 no
GO:0042981 regulation of apoptotic process 22.0588 6 no
GO:0043067 regulation of programmed cell death 22.0588 5 no
GO:0051050 positive regulation of transport 22.0588 4 no
GO:0051726 regulation of cell cycle 22.0588 4 no
GO:0048584 positive regulation of response to stimulus 22.0588 4 no
GO:0044087 regulation of cellular component biogenesis 22.0588 4 no
GO:0031326 regulation of cellular biosynthetic process 20.5882 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 20.5882 5 no
GO:0043933 protein-containing complex organization 20.5882 4 no
GO:0009967 positive regulation of signal transduction 20.5882 5 no
GO:0031344 regulation of cell projection organization 20.5882 5 no
GO:0042325 regulation of phosphorylation 20.5882 7 no
GO:0072657 protein localization to membrane 17.6471 4 yes
GO:0046903 secretion 16.1765 4 yes
GO:0016197 endosomal transport 16.1765 4 yes
GO:0090150 establishment of protein localization to membrane 13.2353 4 yes
GO:0006811 ion transport 13.2353 4 yes
GO:0006812 cation transport 13.2353 5 yes
GO:0030001 metal ion transport 11.7647 6 yes
GO:0032386 regulation of intracellular transport 11.7647 5 yes
GO:0098876 vesicle-mediated transport to the plasma membrane 10.2941 4 yes
GO:0006887 exocytosis 10.2941 4 yes
GO:0045055 regulated exocytosis 8.8235 5 yes
GO:0023061 signal release 8.8235 4 yes
GO:0035592 establishment of protein localization to extracellular region 7.3529 4 yes
GO:0042886 amide transport 7.3529 5 yes
GO:0051650 establishment of vesicle localization 7.3529 4 yes
GO:0071692 protein localization to extracellular region 7.3529 5 yes
GO:0002790 peptide secretion 7.3529 5 yes
GO:0009306 protein secretion 7.3529 4 yes
GO:0015833 peptide transport 7.3529 5 yes
GO:0032456 endocytic recycling 7.3529 5 yes
GO:0046879 hormone secretion 5.8824 5 yes
GO:0009914 hormone transport 5.8824 4 yes
GO:0010447 response to acidic pH 5.8824 4 yes
GO:0030072 peptide hormone secretion 5.8824 6 yes
GO:0035773 insulin secretion involved in cellular response to glucose stimulus 4.4118 4 yes
GO:0051875 pigment granule localization 4.4118 4 yes
GO:0051904 pigment granule transport 4.4118 4 yes
GO:0051905 establishment of pigment granule localization 4.4118 5 yes
GO:0071467 cellular response to pH 4.4118 4 yes
GO:0071468 cellular response to acidic pH 4.4118 5 yes
GO:0030073 insulin secretion 4.4118 5 yes
GO:0032400 melanosome localization 4.4118 5 yes
GO:0032401 establishment of melanosome localization 4.4118 6 yes
GO:0032402 melanosome transport 4.4118 5 yes
GO:0044070 regulation of anion transport 2.9412 6 yes
GO:2000008 regulation of protein localization to cell surface 2.9412 6 yes
GO:0000041 transition metal ion transport 2.9412 7 yes
GO:0006826 iron ion transport 2.9412 8 yes
GO:0033572 transferrin transport 2.9412 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in RB11B_HUMAN
DOID:0050155 sensory system disease 2.9412 3 no
DOID:5614 eye disease 2.9412 4 no
DOID:0050700 cardiomyopathy 2.9412 4 no
DOID:0060036 intrinsic cardiomyopathy 2.9412 5 no
DOID:114 heart disease 2.9412 3 no
DOID:2843 long QT syndrome 2.9412 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
RIMS1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
KGP2_HUMAN [view entry] [view interactions] Low throughput yes yes
TBC14_HUMAN [view interactions] Low throughput no yes
EVI5_HUMAN [view interactions] Low throughput no yes
RAB3I_HUMAN [view interactions] Low throughput no no
MYO5B_HUMAN [view entry] [view interactions] Low throughput yes yes
OPTN_HUMAN [view interactions] Low throughput no yes
SNH28_HUMAN [view interactions] High throughput no no
DSG4_HUMAN [view interactions] High throughput no no
TRI27_HUMAN [view interactions] High throughput no yes
EPCR_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
RBM42_HUMAN [view interactions] High throughput no yes
SCEL_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
RFIP4_HUMAN [view interactions] High throughput no yes
ACOX1_HUMAN [view interactions] High throughput no yes
RL34_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL1_HUMAN [view interactions] High throughput no yes
EVI5L_HUMAN [view interactions] High throughput no yes
PIAS4_HUMAN [view interactions] High throughput no yes
BT3A3_HUMAN [view interactions] High throughput no yes
MMAB_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
ELOV1_HUMAN [view interactions] High throughput no yes
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
S35F2_HUMAN [view interactions] High throughput no yes
SCAM1_HUMAN [view interactions] High throughput no no
SCAM3_HUMAN [view interactions] High throughput no no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
SCAM2_HUMAN [view interactions] High throughput no no
SCAM4_HUMAN [view interactions] High throughput no yes
SC61B_HUMAN [view interactions] High throughput no yes
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
TMEDA_HUMAN [view interactions] High throughput no yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
VAMP8_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
VATH_HUMAN [view entry] [view interactions] High throughput yes yes
HNRL1_HUMAN [view interactions] High throughput no yes
DDX28_HUMAN [view interactions] High throughput no yes
MRP2_HUMAN [view interactions] High throughput no no
HNRL2_HUMAN [view interactions] High throughput no yes
DUT_HUMAN [view interactions] High throughput no yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
NTF2_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
PGAM1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB6A_HUMAN [view entry] [view interactions] High throughput yes yes
UAP1L_HUMAN [view interactions] High throughput no yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
AATM_HUMAN [view entry] [view interactions] High throughput yes yes
HCDH_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
AGR2_HUMAN [view interactions] High throughput no no
RFFL_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
BAP31_HUMAN [view interactions] High throughput no yes
DEN6A_HUMAN [view interactions] High throughput no yes
RAB3B_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
H2AX_HUMAN [view interactions] High throughput no yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
NEMO_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RFIP1_HUMAN [view interactions] High throughput no yes
RCC1_HUMAN [view interactions] High throughput no yes
SNP29_HUMAN [view interactions] High throughput no yes
CROCC_HUMAN [view interactions] High throughput no no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
KLC3_HUMAN [view interactions] High throughput no no
JAK3_HUMAN [view interactions] High throughput no no
GOT1B_HUMAN [view interactions] High throughput no yes
IFIT2_HUMAN [view interactions] High throughput no no
F217B_HUMAN [view interactions] High throughput no yes
PADI3_HUMAN [view interactions] High throughput no no
DNPEP_HUMAN [view interactions] High throughput no yes
RFIP5_HUMAN [view entry] [view interactions] High throughput yes yes
LYG2_HUMAN [view interactions] High throughput no no
3BP5L_HUMAN [view interactions] High throughput no yes
HPHL1_HUMAN [view interactions] High throughput no no
BSPRY_HUMAN [view interactions] High throughput no no
VSIG8_HUMAN [view interactions] High throughput no no
CAHM4_HUMAN [view interactions] High throughput no no
RFIP2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB25_HUMAN [view interactions] High throughput no no
PLCD1_HUMAN [view entry] [view interactions] High throughput yes yes
SPB5_HUMAN [view interactions] High throughput no no
S10A3_HUMAN [view interactions] High throughput no no
CALL3_HUMAN [view interactions] High throughput no yes
RAE2_HUMAN [view interactions] High throughput no yes
RAE1_HUMAN [view interactions] High throughput no yes
H2A1_HUMAN [view interactions] High throughput no yes
DUS14_HUMAN [view interactions] High throughput no yes
3BP5_HUMAN [view interactions] High throughput no yes
5NT3A_HUMAN [view interactions] High throughput no yes
EKI2_HUMAN [view interactions] High throughput no yes
MOT11_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
BICL1_HUMAN [view interactions] High throughput no yes
PI4KB_HUMAN [view interactions] High throughput no yes
DUX4_HUMAN [view interactions] High throughput no no
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
AAPK1_HUMAN [view interactions] High throughput no no
CAV3_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
CD177_HUMAN [view interactions] High throughput no no
FOS_HUMAN [view interactions] High throughput no yes
GRIA1_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
SPRE1_HUMAN [view interactions] High throughput no yes
SRBP2_HUMAN [view interactions] High throughput no yes
NOE2_HUMAN [view entry] [view interactions] High throughput yes yes
GLMP_HUMAN [view interactions] High throughput no no
FBF1_HUMAN [view interactions] High throughput no no
UBP7_HUMAN [view interactions] High throughput no yes
TLL1_HUMAN [view interactions] High throughput no no
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
RABL3_HUMAN [view interactions] High throughput no yes
SBNO2_HUMAN [view interactions] High throughput no yes
STAT6_HUMAN [view interactions] High throughput no yes
SCLT1_HUMAN [view interactions] High throughput no yes
OFD1_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
TANK_HUMAN [view interactions] High throughput no yes
RFIP3_HUMAN [view entry] [view interactions] High throughput yes no
MEOX2_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
WDR44_HUMAN [view interactions] High throughput no yes
SBP1_HUMAN [view interactions] High throughput no no
LRC15_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
CAGE1_HUMAN [view interactions] Computational no no
TBCD1_HUMAN [view interactions] Computational no no