Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MYO5B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
108 Val Gly Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
219 Arg His Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
656 Arg Cys Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
143 Ala Glu Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
168 Gly Arg Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
316 Gly Arg Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
401 Arg His Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
435 Gly Arg Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
456 Asn Ser Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
514 Cys Arg Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
660 Pro Leu Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
1556 Leu Arg Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
538 Phe Ser Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
550 Ile Phe Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
81 His Arg Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
82 Glu Lys Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
92 Arg Cys Cholestasis,progressivefamilialintrahepatic,10(PFIC10) -
266 Cys Arg Cholestasis,progressivefamilialintrahepatic,10(PFIC10) -
392 Met Thr Cholestasis,progressivefamilialintrahepatic,10(PFIC10) -
392 Met Thr Diarrhea2,withmicrovillusatrophy,withorwithoutcholestasis(DIAR2) -
401 Arg Cys Cholestasis,progressivefamilialintrahepatic,10(PFIC10) -
654 Tyr Cys Cholestasis,progressivefamilialintrahepatic,10(PFIC10) -
824 Arg Cys Cholestasis,progressivefamilialintrahepatic,10(PFIC10) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MYO5B_HUMAN
GO:0003779 actin binding 35.5556 4 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0000166 nucleotide binding 31.1111 4 yes
GO:0017076 purine nucleotide binding 31.1111 5 yes
GO:0043168 anion binding 31.1111 4 yes
GO:0019901 protein kinase binding 28.8889 5 no
GO:0032555 purine ribonucleotide binding 26.6667 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 24.4444 4 yes
GO:0030554 adenyl nucleotide binding 22.2222 6 yes
GO:0043169 cation binding 22.2222 4 no
GO:0046872 metal ion binding 22.2222 5 no
GO:0032559 adenyl ribonucleotide binding 17.7778 5 yes
GO:0005524 ATP binding 15.5556 5 yes
GO:0031267 small GTPase binding 15.5556 5 yes
GO:0051020 GTPase binding 15.5556 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MYO5B_HUMAN
GO:0048522 positive regulation of cellular process 68.8889 4 no
GO:0048523 negative regulation of cellular process 57.7778 4 no
GO:0031323 regulation of cellular metabolic process 53.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 53.3333 4 no
GO:0010646 regulation of cell communication 51.1111 4 no
GO:0051128 regulation of cellular component organization 48.8889 4 no
GO:0080090 regulation of primary metabolic process 46.6667 4 no
GO:0008104 protein localization 46.6667 4 yes
GO:0006996 organelle organization 42.2222 4 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0009889 regulation of biosynthetic process 37.7778 4 no
GO:0010468 regulation of gene expression 37.7778 6 no
GO:0010556 regulation of macromolecule biosynthetic process 37.7778 5 no
GO:0031326 regulation of cellular biosynthetic process 37.7778 5 no
GO:0048584 positive regulation of response to stimulus 37.7778 4 no
GO:0031325 positive regulation of cellular metabolic process 35.5556 5 no
GO:0051049 regulation of transport 35.5556 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0051247 positive regulation of protein metabolic process 31.1111 6 no
GO:0044087 regulation of cellular component biogenesis 31.1111 4 no
GO:0032880 regulation of protein localization 31.1111 5 no
GO:0060341 regulation of cellular localization 31.1111 4 no
GO:0019220 regulation of phosphate metabolic process 28.8889 6 no
GO:0031324 negative regulation of cellular metabolic process 28.8889 5 no
GO:0051174 regulation of phosphorus metabolic process 28.8889 5 no
GO:0009967 positive regulation of signal transduction 28.8889 5 no
GO:0030030 cell projection organization 28.8889 4 no
GO:0033043 regulation of organelle organization 28.8889 5 no
GO:0071310 cellular response to organic substance 28.8889 4 no
GO:0009892 negative regulation of metabolic process 28.8889 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.6667 5 no
GO:0042325 regulation of phosphorylation 26.6667 7 no
GO:0071702 organic substance transport 26.6667 4 yes
GO:0097435 supramolecular fiber organization 26.6667 4 yes
GO:0001932 regulation of protein phosphorylation 26.6667 7 no
GO:0031401 positive regulation of protein modification process 24.4444 7 no
GO:0022603 regulation of anatomical structure morphogenesis 24.4444 4 no
GO:0051130 positive regulation of cellular component organization 24.4444 5 no
GO:0120036 plasma membrane bounded cell projection organization 24.4444 5 no
GO:0007015 actin filament organization 24.4444 5 yes
GO:0071705 nitrogen compound transport 24.4444 4 yes
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0015031 protein transport 22.2222 4 yes
GO:0051650 establishment of vesicle localization 11.1111 4 yes
GO:0030050 vesicle transport along actin filament 4.4444 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 4.4444 4 yes
GO:0099515 actin filament-based transport 4.4444 5 yes
GO:0099518 vesicle cytoskeletal trafficking 4.4444 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
RB11A_HUMAN [view entry] [view interactions] Low throughput yes yes
MUC24_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
TFR1_HUMAN [view entry] [view interactions] Low throughput yes yes
RB11B_HUMAN [view entry] [view interactions] Low throughput yes no
RAB25_HUMAN [view interactions] Low throughput no no
RAB8A_HUMAN [view entry] [view interactions] Low throughput yes no
CXCR2_HUMAN [view interactions] Low throughput no no
TRIM3_HUMAN [view entry] [view interactions] Low throughput yes no
RFIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
DKK3_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX19_HUMAN [view interactions] High throughput no yes
MLRV_HUMAN [view interactions] High throughput no no
SH3L1_HUMAN [view interactions] High throughput no yes
MK07_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SNF5_HUMAN [view interactions] High throughput no yes
CHK2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
TBCK_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
BNIP2_HUMAN [view interactions] High throughput no yes
ITF2_HUMAN [view interactions] High throughput no yes
TRI54_HUMAN [view interactions] High throughput no no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SMCA2_HUMAN [view interactions] High throughput no yes
SSH1_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
DEFM_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
AMOL2_HUMAN [view interactions] High throughput no no
ATOSB_HUMAN [view interactions] High throughput no yes
GMCL1_HUMAN [view interactions] High throughput no yes
ZNHI1_HUMAN [view interactions] High throughput no yes
MEOX2_HUMAN [view interactions] High throughput no no
EFHC2_HUMAN [view interactions] High throughput no no
MEI4_HUMAN [view interactions] High throughput no no
PAN2_HUMAN [view interactions] High throughput no no
LRC39_HUMAN [view interactions] High throughput no no
EXOC6_HUMAN [view entry] [view interactions] High throughput yes yes
SYTL4_HUMAN [view interactions] High throughput no yes
RAB3B_HUMAN [view interactions] High throughput no no
STX3_HUMAN [view entry] [view interactions] High throughput yes no
TBC30_HUMAN [view interactions] High throughput no yes
EVI5_HUMAN [view interactions] High throughput no yes
PP6R2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
B2CL1_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
LTN1_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
CDCA5_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
DC8L2_HUMAN [view interactions] High throughput no no
CXCL6_HUMAN [view interactions] High throughput no no
DPM2_HUMAN [view interactions] High throughput no yes
TNNC1_HUMAN [view interactions] High throughput no no
CX001_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
GAGE5_HUMAN [view interactions] High throughput no no
SAAL1_HUMAN [view interactions] High throughput no yes
RBX1_HUMAN [view entry] [view interactions] High throughput yes no
TP4A3_HUMAN [view interactions] High throughput no no
MALL_HUMAN [view interactions] High throughput no no
UB2V2_HUMAN [view entry] [view interactions] High throughput yes no
ERLEC_HUMAN [view interactions] High throughput no yes
CLIC5_HUMAN [view interactions] High throughput no no
CASQ2_HUMAN [view interactions] High throughput no no
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
GBRA1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
SPOP_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
K1549_HUMAN [view entry] [view interactions] High throughput yes yes
COIL_HUMAN [view interactions] High throughput no yes
RPAC1_HUMAN [view interactions] High throughput no no
ALMS1_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
SKA3_HUMAN [view interactions] High throughput no no