MYO5B_HUMAN
Evidence for PS localization
Functions
May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 108 | Val | Gly | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 219 | Arg | His | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 656 | Arg | Cys | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 143 | Ala | Glu | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 168 | Gly | Arg | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 316 | Gly | Arg | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 401 | Arg | His | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 435 | Gly | Arg | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 456 | Asn | Ser | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 514 | Cys | Arg | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 660 | Pro | Leu | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 1556 | Leu | Arg | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 538 | Phe | Ser | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
| 550 | Ile | Phe | Diarrhea2,withmicrovillusatrophy(DIAR2) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MYO5B_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 37.2093 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 27.9070 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 27.9070 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.9070 | 4 | yes |
| GO:0019900 | kinase binding | 27.9070 | 4 | no |
| GO:0019901 | protein kinase binding | 25.5814 | 5 | no |
| GO:0046872 | metal ion binding | 20.9302 | 4 | no |
| GO:0005524 | ATP binding | 16.2791 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 16.2791 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 16.2791 | 5 | yes |
| GO:0031267 | small GTPase binding | 13.9535 | 5 | yes |
| GO:0051020 | GTPase binding | 13.9535 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MYO5B_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.1395 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.1628 | 4 | no |
| GO:0006996 | organelle organization | 48.8372 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 46.5116 | 4 | no |
| GO:0008104 | protein localization | 44.1860 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.1860 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.1860 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.1860 | 4 | no |
| GO:0010646 | regulation of cell communication | 44.1860 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.8605 | 4 | no |
| GO:0051049 | regulation of transport | 41.8605 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.5349 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 37.2093 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.2093 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.2093 | 5 | no |
| GO:0022607 | cellular component assembly | 34.8837 | 4 | no |
| GO:0031399 | regulation of protein modification process | 34.8837 | 6 | no |
| GO:0009966 | regulation of signal transduction | 34.8837 | 4 | no |
| GO:0030030 | cell projection organization | 34.8837 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.5581 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 32.5581 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 30.2326 | 4 | yes |
| GO:0071702 | organic substance transport | 30.2326 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 27.9070 | 4 | yes |
| GO:0031401 | positive regulation of protein modification process | 27.9070 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.9070 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.9070 | 4 | no |
| GO:0015031 | protein transport | 25.5814 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 25.5814 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 25.5814 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 25.5814 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.5814 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.5814 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.5814 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.5814 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 25.5814 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.5814 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.5814 | 5 | no |
| GO:0007010 | cytoskeleton organization | 25.5814 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.5814 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.5814 | 4 | no |
| GO:0007015 | actin filament organization | 23.2558 | 5 | yes |
| GO:0010468 | regulation of gene expression | 23.2558 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.2558 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.2558 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.2558 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 23.2558 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 23.2558 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 23.2558 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.2558 | 4 | no |
| GO:0036211 | protein modification process | 23.2558 | 4 | no |
| GO:0043412 | macromolecule modification | 23.2558 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.2558 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.2558 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.9302 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.9302 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.9302 | 4 | no |
| GO:0061024 | membrane organization | 20.9302 | 4 | no |
| GO:0043269 | regulation of ion transport | 20.9302 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.9302 | 4 | no |
| GO:0051726 | regulation of cell cycle | 20.9302 | 4 | no |
| GO:0110053 | regulation of actin filament organization | 20.9302 | 6 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.9302 | 5 | no |
| GO:0072657 | protein localization to membrane | 20.9302 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 20.9302 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.9302 | 4 | no |
| GO:0016197 | endosomal transport | 13.9535 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 11.6279 | 4 | yes |
| GO:0030050 | vesicle transport along actin filament | 4.6512 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 4.6512 | 4 | yes |
| GO:0048878 | chemical homeostasis | 4.6512 | 4 | yes |
| GO:0099515 | actin filament-based transport | 4.6512 | 5 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 4.6512 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MYO5B_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 6.9767 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 6.9767 | 5 | no |
| DOID:114 | heart disease | 6.9767 | 3 | no |
| DOID:2843 | long QT syndrome | 4.6512 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRIM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MUC24_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TFR1_HUMAN | [view interactions] | Low throughput | no | yes |
| RB11B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAB25_HUMAN | [view interactions] | Low throughput | no | no |
| RAB8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CXCR2_HUMAN | [view interactions] | Low throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| K1549_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| RPAC1_HUMAN | [view interactions] | High throughput | no | no |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DKK3_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| MLRV_HUMAN | [view interactions] | High throughput | no | no |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| BNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| SSH1_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| DEFM_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| F214B_HUMAN | [view interactions] | High throughput | no | yes |
| GMCL1_HUMAN | [view interactions] | High throughput | no | yes |
| ZNHI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| EFHC2_HUMAN | [view interactions] | High throughput | no | no |
| MEI4_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| LRC39_HUMAN | [view interactions] | High throughput | no | no |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYTL4_HUMAN | [view interactions] | High throughput | no | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBC30_HUMAN | [view interactions] | High throughput | no | yes |
| EVI5_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| B2CL1_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA5_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| DC8L2_HUMAN | [view interactions] | High throughput | no | no |
| CXCL6_HUMAN | [view interactions] | High throughput | no | no |
| DPM2_HUMAN | [view interactions] | High throughput | no | yes |
| TNNC1_HUMAN | [view interactions] | High throughput | no | no |
| CX001_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAGE5_HUMAN | [view interactions] | High throughput | no | no |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| MALL_HUMAN | [view interactions] | High throughput | no | no |
| UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERLEC_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC5_HUMAN | [view interactions] | High throughput | no | no |
| CASQ2_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPTN_HUMAN | [view interactions] | Computational | no | yes |
| AQP2_HUMAN | [view interactions] | Computational | no | no |
| RAB10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |