LIMA1_HUMAN
Evidence for PS localization
Functions
Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004346 | MOD_CDC14_SPxK_1 | MOD | 374 | 377 | - |
| ELMI004346 | MOD_CDC14_SPxK_1 | MOD | 374 | 377 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LIMA1_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 30.6931 | 4 | yes |
| GO:0043168 | anion binding | 29.7030 | 4 | no |
| GO:0000166 | nucleotide binding | 25.7426 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.2475 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.2574 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.7624 | 4 | no |
| GO:0043169 | cation binding | 20.7921 | 4 | yes |
| GO:0045296 | cadherin binding | 20.7921 | 4 | yes |
| GO:0046872 | metal ion binding | 20.2970 | 5 | yes |
| GO:0003785 | actin monomer binding | 0.9901 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LIMA1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.9406 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.0198 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 47.5248 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.0495 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.0594 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.5644 | 4 | no |
| GO:0022607 | cellular component assembly | 37.6238 | 4 | yes |
| GO:0006996 | organelle organization | 37.6238 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.6436 | 4 | no |
| GO:0008104 | protein localization | 35.1485 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.1584 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.1584 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.1584 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 34.1584 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 33.6634 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.6634 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.6733 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.1782 | 5 | no |
| GO:0033043 | regulation of organelle organization | 27.2277 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 27.2277 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.2376 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.7426 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.7426 | 5 | no |
| GO:0051049 | regulation of transport | 25.7426 | 4 | no |
| GO:0007010 | cytoskeleton organization | 24.7525 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 24.2574 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 24.2574 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.7624 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.7624 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 23.2673 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 23.2673 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 22.7723 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.7723 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.7723 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2772 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.2772 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.7822 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.7822 | 5 | no |
| GO:0007015 | actin filament organization | 21.2871 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 20.7921 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 20.7921 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.7921 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 20.2970 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.2970 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.2970 | 6 | no |
| GO:0030030 | cell projection organization | 19.3069 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 19.3069 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 18.3168 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 17.3267 | 5 | yes |
| GO:0032535 | regulation of cellular component size | 16.8317 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 14.8515 | 5 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 12.8713 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 12.8713 | 5 | yes |
| GO:0010639 | negative regulation of organelle organization | 10.8911 | 6 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 9.9010 | 7 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 9.4059 | 6 | yes |
| GO:0030834 | regulation of actin filament depolymerization | 7.9208 | 7 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 7.9208 | 5 | yes |
| GO:1901879 | regulation of protein depolymerization | 7.9208 | 6 | yes |
| GO:0030835 | negative regulation of actin filament depolymerization | 6.9307 | 7 | yes |
| GO:0043242 | negative regulation of protein-containing complex disassembly | 6.9307 | 6 | yes |
| GO:1901880 | negative regulation of protein depolymerization | 6.9307 | 7 | yes |
| GO:0051017 | actin filament bundle assembly | 5.4455 | 5 | yes |
| GO:0061572 | actin filament bundle organization | 5.4455 | 6 | yes |
| GO:0031529 | ruffle organization | 2.9703 | 6 | yes |
| GO:0008202 | steroid metabolic process | 2.4752 | 4 | yes |
| GO:1902652 | secondary alcohol metabolic process | 1.9802 | 4 | yes |
| GO:0008203 | cholesterol metabolic process | 1.4851 | 5 | yes |
| GO:0016125 | sterol metabolic process | 1.4851 | 4 | yes |
| GO:0050892 | intestinal absorption | 0.9901 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BIRC3_HUMAN | [view interactions] | Low throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CTNA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RUNX2_HUMAN | [view interactions] | Low throughput | no | no |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDC4_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
| CD44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADDG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1G3_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBX2A_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BACD2_HUMAN | [view interactions] | High throughput | no | no |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADX_HUMAN | [view interactions] | High throughput | no | no |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NP1L4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT20_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| CYTSB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN346_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEXN_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NP1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EURL_HUMAN | [view interactions] | High throughput | no | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDE1_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| GA2L3_HUMAN | [view interactions] | High throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| S10AA_HUMAN | [view interactions] | High throughput | no | no |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| AFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIR1_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHG6_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCL7C_HUMAN | [view interactions] | High throughput | no | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LSP1_HUMAN | [view interactions] | High throughput | no | no |
| RALA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN168_HUMAN | [view interactions] | High throughput | no | no |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEP50_HUMAN | [view interactions] | High throughput | no | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHF1_HUMAN | [view interactions] | High throughput | no | yes |
| 3BP5_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIPA1_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDCA5_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| CCD50_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PDLI1_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| CYBR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PLAK2_HUMAN | [view interactions] | High throughput | no | no |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| DECR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| PCX3_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| FER_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK3_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRGD_HUMAN | [view interactions] | High throughput | no | no |
| TWF2_HUMAN | [view interactions] | High throughput | no | no |
| JPH3_HUMAN | [view interactions] | High throughput | no | no |
| PACN3_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRA_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABRA_HUMAN | [view interactions] | High throughput | no | no |
| ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT5_HUMAN | [view interactions] | High throughput | no | no |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| EMB_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERLEC_HUMAN | [view interactions] | High throughput | no | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| RB40B_HUMAN | [view interactions] | High throughput | no | no |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| MTA2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RNF38_HUMAN | [view interactions] | High throughput | no | yes |
| ELK4_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OVOL2_HUMAN | [view interactions] | High throughput | no | no |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| RED_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| PPR3C_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOB1A_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAA_HUMAN | [view interactions] | High throughput | no | no |
| CELF1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| RAVR1_HUMAN | [view interactions] | High throughput | no | no |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| XRN1_HUMAN | [view interactions] | High throughput | no | yes |
| DPOLA_HUMAN | [view interactions] | High throughput | no | yes |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HARS1_HUMAN | [view interactions] | High throughput | no | yes |
| HRG_HUMAN | [view interactions] | High throughput | no | no |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| PRI1_HUMAN | [view interactions] | High throughput | no | no |
| CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PURA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| DPOA2_HUMAN | [view interactions] | High throughput | no | yes |
| ZCHC8_HUMAN | [view interactions] | High throughput | no | yes |
| DDX46_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRP39_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFHA1_HUMAN | [view interactions] | High throughput | no | yes |
| NRBP_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CPSF3_HUMAN | [view interactions] | High throughput | no | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| FAF1_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NADK_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MELK_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| F110B_HUMAN | [view interactions] | High throughput | no | yes |
| RED1_HUMAN | [view interactions] | High throughput | no | no |
| HDAC7_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRS12_HUMAN | [view interactions] | High throughput | no | no |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TESK2_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIN1_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| CDK16_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AN34A_HUMAN | [view interactions] | High throughput | no | no |
| LRCH3_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| PR15A_HUMAN | [view interactions] | High throughput | no | yes |
| MYCPP_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP2_HUMAN | [view interactions] | High throughput | no | no |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBL6_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INP5E_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA53C_HUMAN | [view interactions] | High throughput | no | yes |
| TPRN_HUMAN | [view interactions] | High throughput | no | yes |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| GAB2_HUMAN | [view interactions] | High throughput | no | yes |
| CBPM_HUMAN | [view interactions] | High throughput | no | no |
| STA13_HUMAN | [view interactions] | High throughput | no | yes |
| RAI3_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| COBL_HUMAN | [view interactions] | High throughput | no | yes |
| LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| HACE1_HUMAN | [view interactions] | High throughput | no | no |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| GTF2I_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| SSH2_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| LRRF2_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| DIXC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LUZP4_HUMAN | [view interactions] | High throughput | no | no |
| STON2_HUMAN | [view interactions] | High throughput | no | yes |
| LRC39_HUMAN | [view interactions] | High throughput | no | no |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FNDC4_HUMAN | [view interactions] | High throughput | no | no |
| RRAS2_HUMAN | [view interactions] | High throughput | no | yes |
| ZFP41_HUMAN | [view interactions] | High throughput | no | no |
| GLYR1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |