FMNL1_HUMAN
Evidence for PS localization
Functions
May play a role in the control of cell motility and survival of macrophages . Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FMNL1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.7407 | 4 | no |
| GO:0000166 | nucleotide binding | 37.0370 | 4 | no |
| GO:0017076 | purine nucleotide binding | 37.0370 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 35.1852 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.1852 | 4 | no |
| GO:0003779 | actin binding | 31.4815 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 31.4815 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 31.4815 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 31.4815 | 6 | no |
| GO:0003723 | RNA binding | 24.0741 | 4 | no |
| GO:0051020 | GTPase binding | 22.2222 | 4 | yes |
| GO:0031267 | small GTPase binding | 20.3704 | 5 | yes |
| GO:0005525 | GTP binding | 20.3704 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 20.3704 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 20.3704 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FMNL1_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 59.2593 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 59.2593 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.1481 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.2963 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.4444 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.7407 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.7407 | 4 | no |
| GO:0007010 | cytoskeleton organization | 38.8889 | 5 | yes |
| GO:0022607 | cellular component assembly | 37.0370 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.0370 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.0370 | 5 | no |
| GO:0009966 | regulation of signal transduction | 35.1852 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 33.3333 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 33.3333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 31.4815 | 4 | no |
| GO:0033043 | regulation of organelle organization | 31.4815 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.4815 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.4815 | 5 | no |
| GO:0008104 | protein localization | 29.6296 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.6296 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.6296 | 5 | no |
| GO:0031399 | regulation of protein modification process | 27.7778 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | no |
| GO:0051049 | regulation of transport | 27.7778 | 4 | no |
| GO:0030334 | regulation of cell migration | 27.7778 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.7778 | 4 | no |
| GO:2000145 | regulation of cell motility | 27.7778 | 4 | no |
| GO:0007015 | actin filament organization | 25.9259 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.9259 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.9259 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.9259 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.9259 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.9259 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.9259 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.0741 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 24.0741 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.0741 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.0741 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 24.0741 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.0741 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.2222 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.2222 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 22.2222 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 22.2222 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 22.2222 | 5 | no |
| GO:2000147 | positive regulation of cell motility | 22.2222 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0015031 | protein transport | 20.3704 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.3704 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.3704 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 20.3704 | 4 | no |
| GO:0071702 | organic substance transport | 20.3704 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.3704 | 4 | no |
| GO:0030030 | cell projection organization | 20.3704 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 20.3704 | 5 | no |
| GO:0032535 | regulation of cellular component size | 20.3704 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 20.3704 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.3704 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 20.3704 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.3704 | 8 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.3704 | 5 | no |
| GO:0022604 | regulation of cell morphogenesis | 18.5185 | 5 | yes |
| GO:0030865 | cortical cytoskeleton organization | 11.1111 | 6 | yes |
| GO:0030866 | cortical actin cytoskeleton organization | 7.4074 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FMNL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PROF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FMNL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| TAP2_HUMAN | [view interactions] | High throughput | no | no |
| MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCF1_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| CD20_HUMAN | [view interactions] | High throughput | no | no |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN787_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MITOS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| THOC5_HUMAN | [view interactions] | High throughput | no | no |
| RPC5_HUMAN | [view interactions] | High throughput | no | yes |
| ARP5_HUMAN | [view interactions] | High throughput | no | yes |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| OTUD5_HUMAN | [view interactions] | High throughput | no | yes |
| TNKS2_HUMAN | [view interactions] | High throughput | no | no |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| CDC20_HUMAN | [view interactions] | High throughput | no | no |
| PP1RA_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HEY1_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| TCRG1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| FA50B_HUMAN | [view interactions] | High throughput | no | yes |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| CSRP3_HUMAN | [view interactions] | High throughput | no | no |
| DAAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP2_HUMAN | [view interactions] | High throughput | no | yes |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMN1_HUMAN | [view interactions] | High throughput | no | no |
| FMNL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRD2I_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTMRC_HUMAN | [view interactions] | High throughput | no | yes |
| PDE6B_HUMAN | [view interactions] | High throughput | no | no |
| PRP18_HUMAN | [view interactions] | High throughput | no | yes |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| GAS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG04_HUMAN | [view interactions] | High throughput | no | no |
| C19L1_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLI1_HUMAN | [view interactions] | High throughput | no | no |
| LSP1_HUMAN | [view interactions] | High throughput | no | no |
| SIPA1_HUMAN | [view interactions] | High throughput | no | yes |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| GEMI5_HUMAN | [view interactions] | High throughput | no | yes |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RALY_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |