Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRD2I_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRD2I_HUMAN
GO:0003779 actin binding 33.3333 4 no
GO:0005159 insulin-like growth factor receptor binding 33.3333 4 no
GO:0004860 protein kinase inhibitor activity 33.3333 5 no
GO:0019210 kinase inhibitor activity 33.3333 4 no
GO:0019887 protein kinase regulator activity 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GRD2I_HUMAN
GO:0010646 regulation of cell communication 83.3333 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0050804 modulation of chemical synaptic transmission 66.6667 5 yes
GO:0099177 regulation of trans-synaptic signaling 66.6667 4 yes
GO:0008104 protein localization 66.6667 4 no
GO:0071705 nitrogen compound transport 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0006886 intracellular protein transport 50.0000 4 no
GO:0015031 protein transport 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0071702 organic substance transport 50.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:2000026 regulation of multicellular organismal development 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0006605 protein targeting 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0010975 regulation of neuron projection development 33.3333 7 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0045664 regulation of neuron differentiation 33.3333 5 no
GO:0048522 positive regulation of cellular process 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0051960 regulation of nervous system development 33.3333 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BI2L1_HUMAN [view interactions] Low throughput no yes
GRID2_HUMAN [view entry] [view interactions] Low throughput yes no
ZMY11_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A1_HUMAN [view interactions] High throughput no yes
FHDC1_HUMAN [view interactions] High throughput no no
FMNL1_HUMAN [view entry] [view interactions] High throughput yes no