Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRD2I_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRD2I_HUMAN
GO:0003779 actin binding 28.5714 4 no
GO:0005159 insulin-like growth factor receptor binding 28.5714 4 no
GO:0004860 protein kinase inhibitor activity 28.5714 5 no
GO:0019210 kinase inhibitor activity 28.5714 4 no
GO:0019887 protein kinase regulator activity 28.5714 4 no
GO:0045309 protein phosphorylated amino acid binding 28.5714 4 no
GO:0050815 phosphoserine residue binding 28.5714 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in GRD2I_HUMAN
GO:0010646 regulation of cell communication 85.7143 4 yes
GO:0048523 negative regulation of cellular process 71.4286 4 yes
GO:0010648 negative regulation of cell communication 57.1429 5 yes
GO:0023057 negative regulation of signaling 57.1429 4 yes
GO:0050804 modulation of chemical synaptic transmission 57.1429 5 yes
GO:0099177 regulation of trans-synaptic signaling 57.1429 4 yes
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0048585 negative regulation of response to stimulus 57.1429 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0008104 protein localization 57.1429 4 no
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0009968 negative regulation of signal transduction 42.8571 5 no
GO:0010605 negative regulation of macromolecule metabolic process 42.8571 5 no
GO:0045595 regulation of cell differentiation 42.8571 4 no
GO:0048522 positive regulation of cellular process 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0051248 negative regulation of protein metabolic process 42.8571 6 no
GO:0006355 regulation of DNA-templated transcription 28.5714 7 no
GO:0007268 chemical synaptic transmission 28.5714 7 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0032006 regulation of TOR signaling 28.5714 6 no
GO:0032007 negative regulation of TOR signaling 28.5714 7 no
GO:0042981 regulation of apoptotic process 28.5714 5 no
GO:0043067 regulation of programmed cell death 28.5714 4 no
GO:0043086 negative regulation of catalytic activity 28.5714 4 no
GO:0045893 positive regulation of DNA-templated transcription 28.5714 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:0051254 positive regulation of RNA metabolic process 28.5714 6 no
GO:0098916 anterograde trans-synaptic signaling 28.5714 6 no
GO:0099536 synaptic signaling 28.5714 4 no
GO:0099537 trans-synaptic signaling 28.5714 5 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:1902532 negative regulation of intracellular signal transduction 28.5714 6 no
GO:1902680 positive regulation of RNA biosynthetic process 28.5714 7 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0010975 regulation of neuron projection development 28.5714 7 no
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0045664 regulation of neuron differentiation 28.5714 5 no
GO:0051960 regulation of nervous system development 28.5714 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no
GO:0006605 protein targeting 28.5714 4 no
GO:0010563 negative regulation of phosphorus metabolic process 28.5714 6 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0031400 negative regulation of protein modification process 28.5714 7 no
GO:0045936 negative regulation of phosphate metabolic process 28.5714 7 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BI2L1_HUMAN [view interactions] Low throughput no yes
GRID2_HUMAN [view entry] [view interactions] Low throughput yes no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A1_HUMAN [view entry] [view interactions] High throughput yes yes
FHDC1_HUMAN [view interactions] High throughput no no
FMNL1_HUMAN [view entry] [view interactions] High throughput yes no