GRID2_HUMAN
Evidence for PS localization
Functions
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 654 | Ala | Asp | Spinocerebellarataxia,autosomalrecessive,18(SCAR18) | - |
| 654 | Ala | Thr | Spinocerebellarataxia,autosomalrecessive,18(SCAR18) | - |
| 656 | Leu | Val | Spinocerebellarataxia,autosomalrecessive,18(SCAR18) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRID2_HUMAN |
|---|---|---|---|---|
| GO:0046943 | carboxylic acid transmembrane transporter activity | 26.5306 | 4 | yes |
| GO:0043169 | cation binding | 22.4490 | 4 | no |
| GO:0046872 | metal ion binding | 22.4490 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 22.4490 | 4 | no |
| GO:0005216 | monoatomic ion channel activity | 20.4082 | 4 | yes |
| GO:0015267 | channel activity | 20.4082 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 20.4082 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 20.4082 | 6 | yes |
| GO:0022836 | gated channel activity | 20.4082 | 5 | yes |
| GO:0004970 | glutamate-gated receptor activity | 18.3673 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 18.3673 | 6 | yes |
| GO:0008066 | glutamate receptor activity | 18.3673 | 4 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 18.3673 | 5 | yes |
| GO:0022835 | transmitter-gated channel activity | 18.3673 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 18.3673 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 18.3673 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 18.3673 | 6 | yes |
| GO:0030165 | PDZ domain binding | 12.2449 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRID2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 65.3061 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 55.1020 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 51.0204 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 48.9796 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 48.9796 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.9796 | 4 | no |
| GO:0099536 | synaptic signaling | 42.8571 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 42.8571 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 40.8163 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 38.7755 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 38.7755 | 6 | yes |
| GO:0031323 | regulation of cellular metabolic process | 34.6939 | 4 | no |
| GO:0051049 | regulation of transport | 34.6939 | 4 | no |
| GO:0008104 | protein localization | 32.6531 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 32.6531 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 32.6531 | 4 | no |
| GO:0022607 | cellular component assembly | 30.6122 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.6122 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 30.6122 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.6122 | 4 | no |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 28.5714 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 26.5306 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 26.5306 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 26.5306 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 26.5306 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 26.5306 | 4 | no |
| GO:0071702 | organic substance transport | 26.5306 | 4 | no |
| GO:0099175 | regulation of postsynapse organization | 24.4898 | 6 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.4898 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.4898 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.4898 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 24.4898 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.4898 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 24.4898 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.4898 | 4 | no |
| GO:0071705 | nitrogen compound transport | 24.4898 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.4490 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 22.4490 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.4490 | 5 | no |
| GO:0044057 | regulation of system process | 22.4490 | 4 | no |
| GO:0050890 | cognition | 22.4490 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 20.4082 | 7 | yes |
| GO:0034330 | cell junction organization | 20.4082 | 4 | yes |
| GO:0035249 | synaptic transmission, glutamatergic | 20.4082 | 8 | yes |
| GO:0051094 | positive regulation of developmental process | 20.4082 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 20.4082 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 20.4082 | 4 | no |
| GO:0010468 | regulation of gene expression | 20.4082 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.4082 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.4082 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.4082 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 18.3673 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 18.3673 | 4 | yes |
| GO:0050808 | synapse organization | 18.3673 | 5 | yes |
| GO:0034329 | cell junction assembly | 16.3265 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 16.3265 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 16.3265 | 4 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 14.2857 | 4 | yes |
| GO:0007416 | synapse assembly | 14.2857 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 12.2449 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 12.2449 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 12.2449 | 5 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 12.2449 | 4 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 10.2041 | 5 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 10.2041 | 6 | yes |
| GO:0051963 | regulation of synapse assembly | 10.2041 | 6 | yes |
| GO:0060079 | excitatory postsynaptic potential | 10.2041 | 5 | yes |
| GO:1901888 | regulation of cell junction assembly | 10.2041 | 5 | yes |
| GO:0021953 | central nervous system neuron differentiation | 8.1633 | 5 | yes |
| GO:0030182 | neuron differentiation | 8.1633 | 4 | yes |
| GO:0051965 | positive regulation of synapse assembly | 8.1633 | 6 | yes |
| GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 8.1633 | 4 | yes |
| GO:0099150 | regulation of postsynaptic specialization assembly | 8.1633 | 6 | yes |
| GO:0099151 | regulation of postsynaptic density assembly | 8.1633 | 7 | yes |
| GO:1900452 | regulation of long-term synaptic depression | 8.1633 | 4 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 8.1633 | 6 | yes |
| GO:1902115 | regulation of organelle assembly | 8.1633 | 5 | yes |
| GO:1904889 | regulation of excitatory synapse assembly | 8.1633 | 7 | yes |
| GO:1905874 | regulation of postsynaptic density organization | 8.1633 | 6 | yes |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | 6.1224 | 5 | yes |
| GO:0021533 | cell differentiation in hindbrain | 6.1224 | 4 | yes |
| GO:0021707 | cerebellar granule cell differentiation | 6.1224 | 5 | yes |
| GO:0099174 | regulation of presynapse organization | 6.1224 | 6 | yes |
| GO:1900454 | positive regulation of long-term synaptic depression | 6.1224 | 4 | yes |
| GO:1905606 | regulation of presynapse assembly | 6.1224 | 7 | yes |
| GO:1905962 | glutamatergic neuron differentiation | 6.1224 | 5 | yes |
| GO:0060134 | prepulse inhibition | 4.0816 | 6 | yes |
| GO:1904861 | excitatory synapse assembly | 4.0816 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CBLN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BECN1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRID2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HOME1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN4_HUMAN | [view interactions] | Low throughput | no | no |
| GOPC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HTRA3_HUMAN | [view interactions] | Low throughput | no | no |
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRD2I_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| ELN_HUMAN | [view interactions] | High throughput | no | no |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAFA_HUMAN | [view interactions] | High throughput | no | no |
| IDH3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IBP5_HUMAN | [view interactions] | High throughput | no | no |
| CN37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAT2_HUMAN | [view interactions] | High throughput | no | no |
| GHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NRX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GHC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C1QB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TTC9B_HUMAN | [view interactions] | High throughput | no | yes |
| BDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFXN5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| GRID1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCAF4_HUMAN | [view interactions] | High throughput | no | yes |