Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TPA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI000225 MOD_OFUCOSY MOD 91 97 -
ELMI000226 MOD_OFUCOSY MOD 291 296 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TPA_HUMAN
GO:0046872 metal ion binding 31.2500 4 no
GO:0003723 RNA binding 31.2500 4 no
GO:0005216 ion channel activity 25.0000 4 no
GO:0005509 calcium ion binding 25.0000 5 no
GO:0015267 channel activity 25.0000 4 no
GO:0004175 endopeptidase activity 18.7500 4 yes
GO:0004252 serine-type endopeptidase activity 18.7500 5 yes
GO:0008236 serine-type peptidase activity 18.7500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TPA_HUMAN
GO:0060255 regulation of macromolecule metabolic process 68.7500 4 yes
GO:0080090 regulation of primary metabolic process 68.7500 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 68.7500 4 yes
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0010646 regulation of cell communication 62.5000 4 yes
GO:0051246 regulation of protein metabolic process 56.2500 5 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0010243 response to organonitrogen compound 50.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 yes
GO:0099177 regulation of trans-synaptic signaling 43.7500 4 yes
GO:0031325 positive regulation of cellular metabolic process 43.7500 5 no
GO:0048523 negative regulation of cellular process 43.7500 4 no
GO:0009894 regulation of catabolic process 43.7500 4 no
GO:0009892 negative regulation of metabolic process 43.7500 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 43.7500 5 yes
GO:0030162 regulation of proteolysis 43.7500 6 yes
GO:0050804 modulation of chemical synaptic transmission 43.7500 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 43.7500 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0033043 regulation of organelle organization 37.5000 5 no
GO:0051130 positive regulation of cellular component organization 37.5000 5 no
GO:0006508 proteolysis 37.5000 4 yes
GO:0032101 regulation of response to external stimulus 37.5000 4 yes
GO:0036211 protein modification process 37.5000 4 yes
GO:0043412 macromolecule modification 37.5000 4 yes
GO:0048585 negative regulation of response to stimulus 37.5000 4 yes
GO:0071310 cellular response to organic substance 31.2500 4 yes
GO:0071417 cellular response to organonitrogen compound 31.2500 4 yes
GO:0080134 regulation of response to stress 31.2500 4 yes
GO:1901699 cellular response to nitrogen compound 31.2500 4 yes
GO:1901701 cellular response to oxygen-containing compound 31.2500 4 yes
GO:0006355 regulation of DNA-templated transcription 31.2500 6 no
GO:0009889 regulation of biosynthetic process 31.2500 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.2500 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.2500 5 no
GO:0031326 regulation of cellular biosynthetic process 31.2500 5 no
GO:0043269 regulation of ion transport 31.2500 5 no
GO:0051252 regulation of RNA metabolic process 31.2500 5 no
GO:1903506 regulation of nucleic acid-templated transcription 31.2500 7 no
GO:2001141 regulation of RNA biosynthetic process 31.2500 6 no
GO:0010647 positive regulation of cell communication 31.2500 5 no
GO:0051247 positive regulation of protein metabolic process 31.2500 6 no
GO:0060341 regulation of cellular localization 31.2500 4 no
GO:0010941 regulation of cell death 31.2500 4 no
GO:0009896 positive regulation of catabolic process 31.2500 5 no
GO:0031329 regulation of cellular catabolic process 31.2500 5 no
GO:0051241 negative regulation of multicellular organismal process 31.2500 4 yes
GO:0051248 negative regulation of protein metabolic process 31.2500 6 yes
GO:0071407 cellular response to organic cyclic compound 25.0000 5 yes
GO:0098916 anterograde trans-synaptic signaling 25.0000 5 yes
GO:0099537 trans-synaptic signaling 25.0000 4 yes
GO:1901652 response to peptide 25.0000 4 yes
GO:1901653 cellular response to peptide 25.0000 5 yes
GO:0008104 protein localization 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of ion transmembrane transport 25.0000 5 no
GO:0045893 positive regulation of DNA-templated transcription 25.0000 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 6 no
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 no
GO:1902680 positive regulation of RNA biosynthetic process 25.0000 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 25.0000 8 no
GO:1904062 regulation of cation transmembrane transport 25.0000 6 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 7 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0052547 regulation of peptidase activity 25.0000 5 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0006897 endocytosis 25.0000 5 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0043393 regulation of protein binding 25.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0031331 positive regulation of cellular catabolic process 25.0000 6 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 yes
GO:0007268 chemical synaptic transmission 25.0000 6 yes
GO:0014070 response to organic cyclic compound 25.0000 4 yes
GO:0032102 negative regulation of response to external stimulus 25.0000 5 yes
GO:0045861 negative regulation of proteolysis 25.0000 7 yes
GO:0051591 response to cAMP 18.7500 4 yes
GO:0061041 regulation of wound healing 18.7500 6 yes
GO:0061045 negative regulation of wound healing 18.7500 6 yes
GO:1900047 negative regulation of hemostasis 18.7500 4 yes
GO:1903034 regulation of response to wounding 18.7500 5 yes
GO:1903035 negative regulation of response to wounding 18.7500 5 yes
GO:0007599 hemostasis 18.7500 4 yes
GO:0014074 response to purine-containing compound 18.7500 5 yes
GO:0030193 regulation of blood coagulation 18.7500 4 yes
GO:0030195 negative regulation of blood coagulation 18.7500 5 yes
GO:0035249 synaptic transmission, glutamatergic 18.7500 7 yes
GO:0046683 response to organophosphorus 18.7500 4 yes
GO:0050818 regulation of coagulation 18.7500 4 yes
GO:0050819 negative regulation of coagulation 18.7500 5 yes
GO:0051604 protein maturation 12.5000 4 yes
GO:0060278 regulation of ovulation 12.5000 4 yes
GO:0060279 positive regulation of ovulation 12.5000 5 yes
GO:0060467 negative regulation of fertilization 12.5000 5 yes
GO:0070542 response to fatty acid 12.5000 4 yes
GO:0071371 cellular response to gonadotropin stimulus 12.5000 5 yes
GO:0071372 cellular response to follicle-stimulating hormone stimulus 12.5000 6 yes
GO:0071373 cellular response to luteinizing hormone stimulus 12.5000 6 yes
GO:0071375 cellular response to peptide hormone stimulus 12.5000 5 yes
GO:0071383 cellular response to steroid hormone stimulus 12.5000 5 yes
GO:0071384 cellular response to corticosteroid stimulus 12.5000 6 yes
GO:0071385 cellular response to glucocorticoid stimulus 12.5000 7 yes
GO:0071396 cellular response to lipid 12.5000 5 yes
GO:0071548 response to dexamethasone 12.5000 5 yes
GO:0071549 cellular response to dexamethasone stimulus 12.5000 6 yes
GO:0080154 regulation of fertilization 12.5000 4 yes
GO:0099183 trans-synaptic signaling by BDNF, modulating synaptic transmission 12.5000 6 yes
GO:0099191 trans-synaptic signaling by BDNF 12.5000 5 yes
GO:0099550 trans-synaptic signaling, modulating synaptic transmission 12.5000 5 yes
GO:1901654 response to ketone 12.5000 4 yes
GO:1901655 cellular response to ketone 12.5000 5 yes
GO:2000242 negative regulation of reproductive process 12.5000 4 yes
GO:2000243 positive regulation of reproductive process 12.5000 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 12.5000 5 yes
GO:0014812 muscle cell migration 12.5000 4 yes
GO:0014909 smooth muscle cell migration 12.5000 5 yes
GO:0016485 protein processing 12.5000 5 yes
GO:0031638 zymogen activation 12.5000 6 yes
GO:0031639 plasminogen activation 12.5000 7 yes
GO:0031960 response to corticosteroid 12.5000 5 yes
GO:0032354 response to follicle-stimulating hormone 12.5000 5 yes
GO:0032870 cellular response to hormone stimulus 12.5000 4 yes
GO:0033993 response to lipid 12.5000 4 yes
GO:0034698 response to gonadotropin 12.5000 4 yes
GO:0034699 response to luteinizing hormone 12.5000 5 yes
GO:0036293 response to decreased oxygen levels 12.5000 4 yes
GO:0042730 fibrinolysis 12.5000 6 yes
GO:0043434 response to peptide hormone 12.5000 4 yes
GO:0048008 platelet-derived growth factor receptor signaling pathway 12.5000 6 yes
GO:0048545 response to steroid hormone 12.5000 4 yes
GO:0051384 response to glucocorticoid 12.5000 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in TPA_HUMAN
DOID:1697 ichthyosis 12.5000 4 no
DOID:37 skin disease 12.5000 3 no
DOID:1289 neurodegenerative disease 12.5000 4 no
DOID:331 central nervous system disease 12.5000 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PLRKT_HUMAN [view interactions] Low throughput no yes
TPA_HUMAN [view entry] [view interactions] Low throughput yes no
PAI1_HUMAN [view interactions] Low throughput no no
TETN_HUMAN [view interactions] Low throughput no no
CALR_HUMAN [view interactions] Low throughput no yes
UROK_HUMAN [view interactions] Low throughput no no
K2C8_HUMAN [view interactions] Low throughput no no
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
NEUS_HUMAN [view interactions] Low throughput no yes
IPSP_HUMAN [view interactions] Low throughput no no
FIBA_HUMAN [view interactions] Low throughput no no
LRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
FA10_HUMAN [view interactions] Low throughput no no
FINC_HUMAN [view interactions] Low throughput no yes
LAMA1_HUMAN [view interactions] Low throughput no no
LAMA3_HUMAN [view interactions] Low throughput no no
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] Low throughput yes yes
PDGFC_HUMAN [view interactions] Low throughput no no
THRB_HUMAN [view interactions] Low throughput no no
HMGB1_HUMAN [view interactions] Low throughput no yes
GRID2_HUMAN [view entry] [view interactions] High throughput yes no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
TERF2_HUMAN [view interactions] High throughput no yes
POTE1_HUMAN [view interactions] High throughput no no
FGL1_HUMAN [view interactions] High throughput no no
PGS2_HUMAN [view interactions] High throughput no no
TMM25_HUMAN [view interactions] High throughput no yes
PTPRK_HUMAN [view interactions] High throughput no no
IFN14_HUMAN [view interactions] High throughput no no
PAI2_HUMAN [view interactions] High throughput no no
IC1_HUMAN [view interactions] High throughput no no
ZPI_HUMAN [view interactions] High throughput no no
PA2GX_HUMAN [view interactions] High throughput no no
SPB6_HUMAN [view interactions] High throughput no yes
GDN_HUMAN [view entry] [view interactions] High throughput yes no
IBP1_HUMAN [view interactions] High throughput no no
DEF1_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
FBX6_HUMAN [view interactions] High throughput no yes
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
MSMB_HUMAN [view interactions] High throughput no no
A2AP_HUMAN [view interactions] High throughput no no
IGFL3_HUMAN [view interactions] High throughput no no
HEPS_HUMAN [view interactions] High throughput no yes
TMPSD_HUMAN [view interactions] High throughput no no
NOTC2_HUMAN [view interactions] High throughput no yes
SLUR1_HUMAN [view interactions] High throughput no no
CL3L1_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
CAH9_HUMAN [view interactions] High throughput no no
S10AA_HUMAN [view interactions] Computational no no
ITB2_HUMAN [view interactions] Computational no no
TF_HUMAN [view interactions] Computational no no
MRC1_HUMAN [view interactions] Computational no no
ANT3_HUMAN [view interactions] Computational no no
NMDZ1_HUMAN [view entry] [view interactions] Computational yes yes
ITAM_HUMAN [view interactions] Computational no no
VTNC_HUMAN [view interactions] Computational no no
UBA1_HUMAN [view entry] [view interactions] Computational yes yes
UBE2A_HUMAN [view interactions] Computational no no
PDGFD_HUMAN [view interactions] Computational no no
PLMN_HUMAN [view interactions] Computational no no
UPAR_HUMAN [view interactions] Computational no yes