Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TPA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI000225 MOD_OFUCOSY MOD 91 97 -
ELMI000225 MOD_OFUCOSY MOD 91 97 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TPA_HUMAN
GO:0043169 cation binding 43.7500 4 no
GO:0046872 metal ion binding 37.5000 5 no
GO:0140297 DNA-binding transcription factor binding 31.2500 4 no
GO:0003723 RNA binding 31.2500 4 no
GO:0005509 calcium ion binding 31.2500 6 no
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 25.0000 5 no
GO:0004175 endopeptidase activity 18.7500 4 yes
GO:0004252 serine-type endopeptidase activity 18.7500 5 yes
GO:0008236 serine-type peptidase activity 18.7500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TPA_HUMAN
GO:0048523 negative regulation of cellular process 81.2500 4 yes
GO:0010646 regulation of cell communication 75.0000 4 yes
GO:0031323 regulation of cellular metabolic process 75.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 yes
GO:0080090 regulation of primary metabolic process 75.0000 4 yes
GO:0009889 regulation of biosynthetic process 68.7500 4 yes
GO:0010468 regulation of gene expression 68.7500 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 68.7500 5 yes
GO:0031326 regulation of cellular biosynthetic process 68.7500 5 yes
GO:0048522 positive regulation of cellular process 68.7500 4 no
GO:0009892 negative regulation of metabolic process 62.5000 4 yes
GO:0031324 negative regulation of cellular metabolic process 62.5000 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 56.2500 5 yes
GO:0051240 positive regulation of multicellular organismal process 56.2500 4 yes
GO:0051128 regulation of cellular component organization 56.2500 4 no
GO:0009893 positive regulation of metabolic process 56.2500 4 no
GO:0009890 negative regulation of biosynthetic process 50.0000 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 50.0000 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 50.0000 6 yes
GO:0032101 regulation of response to external stimulus 50.0000 4 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 yes
GO:0048585 negative regulation of response to stimulus 50.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 yes
GO:0009894 regulation of catabolic process 50.0000 4 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0010629 negative regulation of gene expression 43.7500 7 yes
GO:0080134 regulation of response to stress 43.7500 4 yes
GO:0009966 regulation of signal transduction 43.7500 4 no
GO:0023056 positive regulation of signaling 43.7500 4 no
GO:1902531 regulation of intracellular signal transduction 43.7500 5 no
GO:0006355 regulation of DNA-templated transcription 43.7500 7 no
GO:0010604 positive regulation of macromolecule metabolic process 43.7500 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 43.7500 5 no
GO:0051252 regulation of RNA metabolic process 43.7500 5 no
GO:2001141 regulation of RNA biosynthetic process 43.7500 6 no
GO:0051130 positive regulation of cellular component organization 43.7500 5 no
GO:0051241 negative regulation of multicellular organismal process 37.5000 4 yes
GO:0051248 negative regulation of protein metabolic process 37.5000 6 yes
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0042127 regulation of cell population proliferation 37.5000 4 no
GO:0045595 regulation of cell differentiation 37.5000 4 no
GO:2000026 regulation of multicellular organismal development 37.5000 4 no
GO:0009891 positive regulation of biosynthetic process 37.5000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 37.5000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 37.5000 6 no
GO:0006357 regulation of transcription by RNA polymerase II 37.5000 8 no
GO:0033043 regulation of organelle organization 37.5000 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 31.2500 4 yes
GO:0030162 regulation of proteolysis 31.2500 6 yes
GO:0032102 negative regulation of response to external stimulus 31.2500 5 yes
GO:0032103 positive regulation of response to external stimulus 31.2500 5 yes
GO:0036211 protein modification process 31.2500 4 yes
GO:0043412 macromolecule modification 31.2500 4 yes
GO:0030334 regulation of cell migration 31.2500 5 no
GO:2000145 regulation of cell motility 31.2500 4 no
GO:0008104 protein localization 31.2500 4 no
GO:0045893 positive regulation of DNA-templated transcription 31.2500 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 31.2500 5 no
GO:0051254 positive regulation of RNA metabolic process 31.2500 6 no
GO:1902680 positive regulation of RNA biosynthetic process 31.2500 7 no
GO:0009896 positive regulation of catabolic process 31.2500 5 no
GO:0009967 positive regulation of signal transduction 31.2500 5 no
GO:0031329 regulation of cellular catabolic process 31.2500 5 no
GO:0042981 regulation of apoptotic process 31.2500 5 no
GO:0043067 regulation of programmed cell death 31.2500 4 no
GO:1902533 positive regulation of intracellular signal transduction 31.2500 6 no
GO:0006508 proteolysis 25.0000 4 yes
GO:0010755 regulation of plasminogen activation 25.0000 8 yes
GO:0030193 regulation of blood coagulation 25.0000 4 yes
GO:0030195 negative regulation of blood coagulation 25.0000 5 yes
GO:0045861 negative regulation of proteolysis 25.0000 7 yes
GO:0050818 regulation of coagulation 25.0000 4 yes
GO:0050819 negative regulation of coagulation 25.0000 5 yes
GO:0061041 regulation of wound healing 25.0000 6 yes
GO:0061045 negative regulation of wound healing 25.0000 6 yes
GO:0070613 regulation of protein processing 25.0000 7 yes
GO:0099536 synaptic signaling 25.0000 4 yes
GO:0099537 trans-synaptic signaling 25.0000 5 yes
GO:1900047 negative regulation of hemostasis 25.0000 4 yes
GO:1903034 regulation of response to wounding 25.0000 5 yes
GO:1903035 negative regulation of response to wounding 25.0000 5 yes
GO:1903317 regulation of protein maturation 25.0000 6 yes
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051960 regulation of nervous system development 25.0000 5 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0015031 protein transport 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0031331 positive regulation of cellular catabolic process 25.0000 6 no
GO:0098657 import into cell 25.0000 4 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0045944 positive regulation of transcription by RNA polymerase II 25.0000 9 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 18.7500 5 yes
GO:0010757 negative regulation of plasminogen activation 18.7500 9 yes
GO:0010955 negative regulation of protein processing 18.7500 8 yes
GO:0042730 fibrinolysis 18.7500 6 yes
GO:0051604 protein maturation 18.7500 4 yes
GO:1903318 negative regulation of protein maturation 18.7500 7 yes
GO:2000242 negative regulation of reproductive process 18.7500 4 yes
GO:0007599 hemostasis 12.5000 4 yes
GO:0014812 muscle cell migration 12.5000 4 yes
GO:0014909 smooth muscle cell migration 12.5000 5 yes
GO:0016485 protein processing 12.5000 5 yes
GO:0030194 positive regulation of blood coagulation 12.5000 5 yes
GO:0031638 zymogen activation 12.5000 6 yes
GO:0031639 plasminogen activation 12.5000 7 yes
GO:0036293 response to decreased oxygen levels 12.5000 4 yes
GO:0048008 platelet-derived growth factor receptor signaling pathway 12.5000 6 yes
GO:0050820 positive regulation of coagulation 12.5000 5 yes
GO:0051917 regulation of fibrinolysis 12.5000 5 yes
GO:0051918 negative regulation of fibrinolysis 12.5000 4 yes
GO:0060467 negative regulation of fertilization 12.5000 5 yes
GO:0060468 prevention of polyspermy 12.5000 6 yes
GO:0080154 regulation of fertilization 12.5000 4 yes
GO:0090303 positive regulation of wound healing 12.5000 6 yes
GO:0099183 trans-synaptic signaling by BDNF, modulating synaptic transmission 12.5000 7 yes
GO:0099191 trans-synaptic signaling by BDNF 12.5000 6 yes
GO:0099550 trans-synaptic signaling, modulating synaptic transmission 12.5000 6 yes
GO:1900048 positive regulation of hemostasis 12.5000 4 yes
GO:1903036 positive regulation of response to wounding 12.5000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TETN_HUMAN [view interactions] Low throughput no no
CALR_HUMAN [view entry] [view interactions] Low throughput yes yes
UROK_HUMAN [view interactions] Low throughput no no
K2C8_HUMAN [view interactions] Low throughput no no
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
NEUS_HUMAN [view interactions] Low throughput no yes
IPSP_HUMAN [view interactions] Low throughput no no
FIBA_HUMAN [view interactions] Low throughput no no
LRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
FA10_HUMAN [view interactions] Low throughput no no
FINC_HUMAN [view interactions] Low throughput no yes
LAMA1_HUMAN [view interactions] Low throughput no no
LAMA3_HUMAN [view interactions] Low throughput no no
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] Low throughput yes yes
PDGFC_HUMAN [view interactions] Low throughput no no
THRB_HUMAN [view interactions] Low throughput no no
HMGB1_HUMAN [view interactions] Low throughput no yes
PLRKT_HUMAN [view interactions] Low throughput no yes
TPA_HUMAN [view entry] [view interactions] Low throughput yes no
PAI1_HUMAN [view interactions] Low throughput no no
PTPRK_HUMAN [view interactions] High throughput no no
IFN14_HUMAN [view interactions] High throughput no no
PAI2_HUMAN [view interactions] High throughput no no
IC1_HUMAN [view interactions] High throughput no no
ZPI_HUMAN [view interactions] High throughput no no
PA2GX_HUMAN [view interactions] High throughput no no
SPB6_HUMAN [view interactions] High throughput no yes
GDN_HUMAN [view entry] [view interactions] High throughput yes no
IBP1_HUMAN [view interactions] High throughput no no
DEF1_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
FBX6_HUMAN [view interactions] High throughput no yes
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
MSMB_HUMAN [view interactions] High throughput no no
A2AP_HUMAN [view interactions] High throughput no no
IGFL3_HUMAN [view interactions] High throughput no no
HEPS_HUMAN [view interactions] High throughput no yes
TMPSD_HUMAN [view interactions] High throughput no no
NOTC2_HUMAN [view entry] [view interactions] High throughput yes yes
SLUR1_HUMAN [view interactions] High throughput no no
CL3L1_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
MYCN_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
CAH9_HUMAN [view interactions] High throughput no no
GRID2_HUMAN [view entry] [view interactions] High throughput yes no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
TERF2_HUMAN [view interactions] High throughput no yes
POTE1_HUMAN [view interactions] High throughput no no
FGL1_HUMAN [view interactions] High throughput no no
PGS2_HUMAN [view interactions] High throughput no no
TMM25_HUMAN [view interactions] High throughput no yes