Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GDN_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GDN_HUMAN
GO:0019900 kinase binding 28.5714 4 no
GO:0003723 RNA binding 21.4286 4 no
GO:0019901 protein kinase binding 21.4286 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in GDN_HUMAN
GO:0048523 negative regulation of cellular process 64.2857 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.2857 4 yes
GO:0010646 regulation of cell communication 57.1429 4 yes
GO:0080090 regulation of primary metabolic process 57.1429 4 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 yes
GO:0009889 regulation of biosynthetic process 42.8571 4 yes
GO:0009890 negative regulation of biosynthetic process 42.8571 5 yes
GO:0010468 regulation of gene expression 42.8571 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 42.8571 6 yes
GO:0031324 negative regulation of cellular metabolic process 42.8571 5 yes
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 42.8571 6 yes
GO:0006996 organelle organization 35.7143 4 yes
GO:0009057 macromolecule catabolic process 35.7143 4 yes
GO:0009966 regulation of signal transduction 35.7143 4 yes
GO:0010629 negative regulation of gene expression 35.7143 7 yes
GO:0010648 negative regulation of cell communication 35.7143 5 yes
GO:0023057 negative regulation of signaling 35.7143 4 yes
GO:0050804 modulation of chemical synaptic transmission 35.7143 5 yes
GO:0051049 regulation of transport 35.7143 4 yes
GO:0051128 regulation of cellular component organization 35.7143 4 yes
GO:0099177 regulation of trans-synaptic signaling 35.7143 4 yes
GO:0022607 cellular component assembly 35.7143 4 no
GO:0042127 regulation of cell population proliferation 28.5714 4 yes
GO:0048522 positive regulation of cellular process 28.5714 4 yes
GO:0048585 negative regulation of response to stimulus 28.5714 4 yes
GO:0051051 negative regulation of transport 28.5714 4 yes
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 yes
GO:0051248 negative regulation of protein metabolic process 28.5714 6 yes
GO:0006508 proteolysis 28.5714 4 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0008285 negative regulation of cell population proliferation 21.4286 5 yes
GO:0009894 regulation of catabolic process 21.4286 4 yes
GO:0009968 negative regulation of signal transduction 21.4286 5 yes
GO:0010647 positive regulation of cell communication 21.4286 5 yes
GO:0023056 positive regulation of signaling 21.4286 4 yes
GO:0030163 protein catabolic process 21.4286 4 yes
GO:0030334 regulation of cell migration 21.4286 5 yes
GO:0032101 regulation of response to external stimulus 21.4286 4 yes
GO:0032102 negative regulation of response to external stimulus 21.4286 5 yes
GO:0051094 positive regulation of developmental process 21.4286 4 yes
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 yes
GO:0080134 regulation of response to stress 21.4286 4 yes
GO:1901565 organonitrogen compound catabolic process 21.4286 4 yes
GO:1902531 regulation of intracellular signal transduction 21.4286 5 yes
GO:2000145 regulation of cell motility 21.4286 4 yes
GO:0008104 protein localization 21.4286 4 no
GO:0009893 positive regulation of metabolic process 21.4286 4 no
GO:0010604 positive regulation of macromolecule metabolic process 21.4286 5 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0048584 positive regulation of response to stimulus 21.4286 4 no
GO:0099536 synaptic signaling 21.4286 4 no
GO:0099537 trans-synaptic signaling 21.4286 5 no
GO:0071702 organic substance transport 21.4286 4 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:0001558 regulation of cell growth 14.2857 4 yes
GO:0007162 negative regulation of cell adhesion 14.2857 5 yes
GO:0009895 negative regulation of catabolic process 14.2857 5 yes
GO:0010755 regulation of plasminogen activation 14.2857 8 yes
GO:0010757 negative regulation of plasminogen activation 14.2857 9 yes
GO:0010955 negative regulation of protein processing 14.2857 8 yes
GO:0016050 vesicle organization 14.2857 5 yes
GO:0030155 regulation of cell adhesion 14.2857 4 yes
GO:0030162 regulation of proteolysis 14.2857 6 yes
GO:0030193 regulation of blood coagulation 14.2857 4 yes
GO:0030195 negative regulation of blood coagulation 14.2857 5 yes
GO:0030308 negative regulation of cell growth 14.2857 5 yes
GO:0042176 regulation of protein catabolic process 14.2857 5 yes
GO:0045595 regulation of cell differentiation 14.2857 4 yes
GO:0045597 positive regulation of cell differentiation 14.2857 5 yes
GO:0045861 negative regulation of proteolysis 14.2857 7 yes
GO:0045926 negative regulation of growth 14.2857 4 yes
GO:0046903 secretion 14.2857 4 yes
GO:0050806 positive regulation of synaptic transmission 14.2857 5 yes
GO:0050818 regulation of coagulation 14.2857 4 yes
GO:0050819 negative regulation of coagulation 14.2857 5 yes
GO:0061041 regulation of wound healing 14.2857 6 yes
GO:0061045 negative regulation of wound healing 14.2857 6 yes
GO:0070613 regulation of protein processing 14.2857 7 yes
GO:1900047 negative regulation of hemostasis 14.2857 4 yes
GO:1902532 negative regulation of intracellular signal transduction 14.2857 6 yes
GO:1903034 regulation of response to wounding 14.2857 5 yes
GO:1903035 negative regulation of response to wounding 14.2857 5 yes
GO:1903317 regulation of protein maturation 14.2857 6 yes
GO:1903318 negative regulation of protein maturation 14.2857 7 yes
GO:2000026 regulation of multicellular organismal development 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UROK_HUMAN [view interactions] Low throughput no no
THRB_HUMAN [view interactions] Low throughput no no
SOST_HUMAN [view interactions] High throughput no no
HDAC4_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
FAM9B_HUMAN [view interactions] High throughput no no
ETS2_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
KLK2_HUMAN [view interactions] High throughput no no
KLK13_HUMAN [view interactions] High throughput no no
RTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SG2A2_HUMAN [view interactions] High throughput no no
PMEL_HUMAN [view interactions] High throughput no no
TPA_HUMAN [view entry] [view interactions] High throughput yes no
APOD_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP2_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
C1T9B_HUMAN [view interactions] High throughput no no
KCNE1_HUMAN [view interactions] High throughput no no
S22A4_HUMAN [view interactions] High throughput no yes
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
SVOPL_HUMAN [view interactions] High throughput no no
CAD23_HUMAN [view interactions] High throughput no yes
CCL3_HUMAN [view interactions] High throughput no no
FURIN_HUMAN [view interactions] High throughput no yes
CA054_HUMAN [view interactions] High throughput no yes
TSN16_HUMAN [view interactions] High throughput no no
C1QT7_HUMAN [view interactions] High throughput no no
KCMB3_HUMAN [view interactions] High throughput no no
LCN6_HUMAN [view interactions] High throughput no no
NAT8B_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
HBD_HUMAN [view interactions] High throughput no no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
B3GN2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
GDE_HUMAN [view entry] [view interactions] High throughput yes no
NCBP1_HUMAN [view interactions] High throughput no yes
ACPH_HUMAN [view interactions] High throughput no yes
BCAT1_HUMAN [view interactions] High throughput no no
DUS3L_HUMAN [view interactions] High throughput no yes
HNRL1_HUMAN [view interactions] High throughput no yes
SP100_HUMAN [view interactions] High throughput no no
XPO5_HUMAN [view interactions] High throughput no yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes