GDN_HUMAN
Evidence for PS localization
Functions
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GDN_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 30.7692 | 4 | no |
| GO:0019900 | kinase binding | 23.0769 | 4 | no |
| GO:0019901 | protein kinase binding | 23.0769 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GDN_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 76.9231 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 69.2308 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 69.2308 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 61.5385 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 61.5385 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 61.5385 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 53.8462 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 53.8462 | 4 | yes |
| GO:0010468 | regulation of gene expression | 46.1538 | 5 | yes |
| GO:0010646 | regulation of cell communication | 46.1538 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 38.4615 | 6 | yes |
| GO:0031323 | regulation of cellular metabolic process | 38.4615 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 38.4615 | 5 | no |
| GO:0008104 | protein localization | 38.4615 | 4 | no |
| GO:0071702 | organic substance transport | 38.4615 | 4 | no |
| GO:0071705 | nitrogen compound transport | 38.4615 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.4615 | 4 | yes |
| GO:0010629 | negative regulation of gene expression | 38.4615 | 6 | yes |
| GO:0051128 | regulation of cellular component organization | 38.4615 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 30.7692 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 30.7692 | 4 | yes |
| GO:2000145 | regulation of cell motility | 30.7692 | 4 | yes |
| GO:0006508 | proteolysis | 30.7692 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 30.7692 | 4 | no |
| GO:0036211 | protein modification process | 30.7692 | 4 | no |
| GO:0043412 | macromolecule modification | 30.7692 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.7692 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.7692 | 5 | no |
| GO:0015031 | protein transport | 30.7692 | 4 | no |
| GO:0009894 | regulation of catabolic process | 30.7692 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 30.7692 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 30.7692 | 4 | yes |
| GO:0030334 | regulation of cell migration | 30.7692 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 30.7692 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 30.7692 | 4 | yes |
| GO:0051049 | regulation of transport | 30.7692 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | yes |
| GO:0030336 | negative regulation of cell migration | 23.0769 | 6 | no |
| GO:0040013 | negative regulation of locomotion | 23.0769 | 4 | no |
| GO:2000146 | negative regulation of cell motility | 23.0769 | 5 | no |
| GO:0009057 | macromolecule catabolic process | 23.0769 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.0769 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0071310 | cellular response to organic substance | 23.0769 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 23.0769 | 4 | no |
| GO:1901652 | response to peptide | 23.0769 | 4 | no |
| GO:1901653 | cellular response to peptide | 23.0769 | 5 | no |
| GO:1901699 | cellular response to nitrogen compound | 23.0769 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 23.0769 | 4 | no |
| GO:0006886 | intracellular protein transport | 23.0769 | 4 | no |
| GO:0022607 | cellular component assembly | 23.0769 | 4 | no |
| GO:0006996 | organelle organization | 23.0769 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 23.0769 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 23.0769 | 6 | yes |
| GO:0042127 | regulation of cell population proliferation | 23.0769 | 4 | yes |
| GO:0042176 | regulation of protein catabolic process | 23.0769 | 5 | yes |
| GO:0045861 | negative regulation of proteolysis | 23.0769 | 7 | yes |
| GO:0051051 | negative regulation of transport | 23.0769 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 15.3846 | 4 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 15.3846 | 5 | yes |
| GO:0052547 | regulation of peptidase activity | 15.3846 | 5 | yes |
| GO:0061041 | regulation of wound healing | 15.3846 | 6 | yes |
| GO:0061045 | negative regulation of wound healing | 15.3846 | 6 | yes |
| GO:0080134 | regulation of response to stress | 15.3846 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 15.3846 | 4 | yes |
| GO:1900047 | negative regulation of hemostasis | 15.3846 | 4 | yes |
| GO:1903034 | regulation of response to wounding | 15.3846 | 5 | yes |
| GO:1903035 | negative regulation of response to wounding | 15.3846 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 15.3846 | 4 | yes |
| GO:0001558 | regulation of cell growth | 15.3846 | 4 | yes |
| GO:0007162 | negative regulation of cell adhesion | 15.3846 | 5 | yes |
| GO:0007599 | hemostasis | 15.3846 | 4 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 15.3846 | 5 | yes |
| GO:0009895 | negative regulation of catabolic process | 15.3846 | 5 | yes |
| GO:0010466 | negative regulation of peptidase activity | 15.3846 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 15.3846 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 15.3846 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 15.3846 | 4 | yes |
| GO:0030193 | regulation of blood coagulation | 15.3846 | 4 | yes |
| GO:0030195 | negative regulation of blood coagulation | 15.3846 | 5 | yes |
| GO:0030308 | negative regulation of cell growth | 15.3846 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 15.3846 | 4 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 15.3846 | 5 | yes |
| GO:0043086 | negative regulation of catalytic activity | 15.3846 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 15.3846 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 15.3846 | 5 | yes |
| GO:0045926 | negative regulation of growth | 15.3846 | 4 | yes |
| GO:0046903 | secretion | 15.3846 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 15.3846 | 5 | yes |
| GO:0050818 | regulation of coagulation | 15.3846 | 4 | yes |
| GO:0050819 | negative regulation of coagulation | 15.3846 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 15.3846 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GDN_HUMAN |
|---|---|---|---|---|
| DOID:1697 | ichthyosis | 15.3846 | 4 | no |
| DOID:37 | skin disease | 15.3846 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| THRB_HUMAN | [view interactions] | Low throughput | no | no |
| UROK_HUMAN | [view interactions] | Low throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| HBD_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ACPH_HUMAN | [view interactions] | High throughput | no | yes |
| BCAT1_HUMAN | [view interactions] | High throughput | no | no |
| DUS3L_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| SP100_HUMAN | [view interactions] | High throughput | no | no |
| XPO5_HUMAN | [view interactions] | High throughput | no | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9B_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLK2_HUMAN | [view interactions] | High throughput | no | no |
| KLK13_HUMAN | [view interactions] | High throughput | no | no |
| RTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| PMEL_HUMAN | [view interactions] | High throughput | no | no |
| TPA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APOD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| C1T9B_HUMAN | [view interactions] | High throughput | no | no |
| KCNE1_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| ST14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVOPL_HUMAN | [view interactions] | High throughput | no | no |
| CAD23_HUMAN | [view interactions] | High throughput | no | yes |
| CCL3_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| CA054_HUMAN | [view interactions] | High throughput | no | yes |
| TSN16_HUMAN | [view interactions] | High throughput | no | no |
| C1QT7_HUMAN | [view interactions] | High throughput | no | no |
| KCMB3_HUMAN | [view interactions] | High throughput | no | no |
| LCN6_HUMAN | [view interactions] | High throughput | no | no |
| NAT8B_HUMAN | [view interactions] | High throughput | no | no |
| VWF_HUMAN | [view interactions] | Computational | no | no |
| FA8_HUMAN | [view interactions] | Computational | no | yes |
| PAI1_HUMAN | [view interactions] | Computational | no | no |
| F13A_HUMAN | [view interactions] | Computational | no | no |
| LRP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GPV_HUMAN | [view interactions] | Computational | no | no |
| DRC4_HUMAN | [view interactions] | Computational | no | yes |
| DRC2_HUMAN | [view interactions] | Computational | no | no |
| GP1BB_HUMAN | [view interactions] | Computational | no | no |
| FA11_HUMAN | [view interactions] | Computational | no | no |
| FA5_HUMAN | [view interactions] | Computational | no | no |
| GPIX_HUMAN | [view interactions] | Computational | no | no |
| GP1BA_HUMAN | [view interactions] | Computational | no | no |
| SNX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| F13B_HUMAN | [view interactions] | Computational | no | no |
| UPAR_HUMAN | [view interactions] | Computational | no | yes |