Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SC6A1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SC6A1_HUMAN
GO:0046872 metal ion binding 33.3333 4 yes
GO:0008324 cation transmembrane transporter activity 22.2222 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 22.2222 4 yes
GO:0046873 metal ion transmembrane transporter activity 18.5185 5 yes
GO:0008509 anion transmembrane transporter activity 14.8148 4 yes
GO:0022853 active ion transmembrane transporter activity 14.8148 4 yes
GO:0005283 amino acid:sodium symporter activity 11.1111 5 yes
GO:0005343 organic acid:sodium symporter activity 11.1111 4 yes
GO:0005416 amino acid:cation symporter activity 11.1111 6 yes
GO:0008514 organic anion transmembrane transporter activity 11.1111 5 yes
GO:0015081 sodium ion transmembrane transporter activity 11.1111 6 yes
GO:0015103 inorganic anion transmembrane transporter activity 11.1111 4 yes
GO:0015108 chloride transmembrane transporter activity 11.1111 5 yes
GO:0015171 amino acid transmembrane transporter activity 11.1111 5 yes
GO:0015291 secondary active transmembrane transporter activity 11.1111 4 yes
GO:0015293 symporter activity 11.1111 5 yes
GO:0015294 solute:cation symporter activity 11.1111 5 yes
GO:0015370 solute:sodium symporter activity 11.1111 6 yes
GO:0046943 carboxylic acid transmembrane transporter activity 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SC6A1_HUMAN
GO:0048522 positive regulation of cellular process 59.2593 4 no
GO:0051049 regulation of transport 55.5556 4 yes
GO:0010646 regulation of cell communication 48.1481 4 yes
GO:0022607 cellular component assembly 48.1481 4 no
GO:0051050 positive regulation of transport 40.7407 4 yes
GO:0051128 regulation of cellular component organization 40.7407 4 no
GO:0050804 modulation of chemical synaptic transmission 37.0370 5 yes
GO:0099177 regulation of trans-synaptic signaling 37.0370 4 yes
GO:0009966 regulation of signal transduction 37.0370 4 no
GO:0043269 regulation of ion transport 33.3333 5 yes
GO:0048523 negative regulation of cellular process 33.3333 4 yes
GO:0050890 cognition 33.3333 4 yes
GO:0099537 trans-synaptic signaling 33.3333 4 yes
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0007268 chemical synaptic transmission 29.6296 6 yes
GO:0010038 response to metal ion 29.6296 4 yes
GO:0051046 regulation of secretion 29.6296 5 yes
GO:0098916 anterograde trans-synaptic signaling 29.6296 5 yes
GO:0009893 positive regulation of metabolic process 29.6296 4 no
GO:0060255 regulation of macromolecule metabolic process 29.6296 4 no
GO:0070201 regulation of establishment of protein localization 29.6296 6 no
GO:0031344 regulation of cell projection organization 29.6296 5 no
GO:0043933 protein-containing complex organization 29.6296 4 no
GO:0065003 protein-containing complex assembly 29.6296 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.6296 6 no
GO:0030030 cell projection organization 29.6296 4 no
GO:0007612 learning 25.9259 4 yes
GO:0034330 cell junction organization 25.9259 4 yes
GO:0043270 positive regulation of ion transport 25.9259 5 yes
GO:0050808 synapse organization 25.9259 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 25.9259 5 no
GO:0010941 regulation of cell death 25.9259 4 no
GO:0016192 vesicle-mediated transport 25.9259 4 no
GO:0019220 regulation of phosphate metabolic process 25.9259 6 no
GO:0031323 regulation of cellular metabolic process 25.9259 4 no
GO:0031325 positive regulation of cellular metabolic process 25.9259 5 no
GO:0031399 regulation of protein modification process 25.9259 6 no
GO:0042325 regulation of phosphorylation 25.9259 7 no
GO:0051171 regulation of nitrogen compound metabolic process 25.9259 4 no
GO:0051174 regulation of phosphorus metabolic process 25.9259 5 no
GO:0051223 regulation of protein transport 25.9259 5 no
GO:0051240 positive regulation of multicellular organismal process 25.9259 4 no
GO:0051246 regulation of protein metabolic process 25.9259 5 no
GO:0071310 cellular response to organic substance 25.9259 4 no
GO:0080090 regulation of primary metabolic process 25.9259 4 no
GO:1903530 regulation of secretion by cell 25.9259 4 no
GO:0009967 positive regulation of signal transduction 25.9259 5 no
GO:0048584 positive regulation of response to stimulus 25.9259 4 no
GO:0051094 positive regulation of developmental process 25.9259 4 no
GO:0051130 positive regulation of cellular component organization 25.9259 5 no
GO:0120036 plasma membrane bounded cell projection organization 25.9259 5 no
GO:1902531 regulation of intracellular signal transduction 25.9259 5 no
GO:0007613 memory 22.2222 4 yes
GO:0010648 negative regulation of cell communication 22.2222 5 yes
GO:0023057 negative regulation of signaling 22.2222 4 yes
GO:0071702 organic substance transport 22.2222 4 yes
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0044057 regulation of system process 22.2222 4 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0050806 positive regulation of synaptic transmission 22.2222 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0060548 negative regulation of cell death 22.2222 5 no
GO:0006996 organelle organization 22.2222 4 no
GO:0010468 regulation of gene expression 22.2222 5 no
GO:0010720 positive regulation of cell development 22.2222 6 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0060284 regulation of cell development 22.2222 5 no
GO:0017157 regulation of exocytosis 22.2222 5 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0003018 vascular process in circulatory system 18.5185 4 yes
GO:0006811 ion transport 18.5185 4 yes
GO:0006820 anion transport 18.5185 5 yes
GO:0008306 associative learning 18.5185 5 yes
GO:0010243 response to organonitrogen compound 18.5185 4 yes
GO:0051047 positive regulation of secretion 18.5185 5 yes
GO:0071705 nitrogen compound transport 18.5185 4 yes
GO:0006836 neurotransmitter transport 14.8148 4 yes
GO:0014070 response to organic cyclic compound 14.8148 4 yes
GO:0015711 organic anion transport 14.8148 5 yes
GO:0015849 organic acid transport 14.8148 5 yes
GO:0042220 response to cocaine 14.8148 4 yes
GO:0043279 response to alkaloid 14.8148 5 yes
GO:0046942 carboxylic acid transport 14.8148 6 yes
GO:0051592 response to calcium ion 14.8148 5 yes
GO:0051952 regulation of amine transport 14.8148 5 yes
GO:0098656 anion transmembrane transport 14.8148 4 yes
GO:0098657 import into cell 14.8148 4 yes
GO:0098660 inorganic ion transmembrane transport 14.8148 4 yes
GO:0001504 neurotransmitter uptake 11.1111 4 yes
GO:0006812 cation transport 11.1111 5 yes
GO:0006821 chloride transport 11.1111 7 yes
GO:0006865 amino acid transport 11.1111 5 yes
GO:0010232 vascular transport 11.1111 4 yes
GO:0015698 inorganic anion transport 11.1111 6 yes
GO:0015800 acidic amino acid transport 11.1111 6 yes
GO:0030001 metal ion transport 11.1111 6 yes
GO:0051954 positive regulation of amine transport 11.1111 5 yes
GO:0098655 cation transmembrane transport 11.1111 4 yes
GO:0098661 inorganic anion transmembrane transport 11.1111 5 yes
GO:0098662 inorganic cation transmembrane transport 11.1111 5 yes
GO:0150104 transport across blood-brain barrier 11.1111 5 yes
GO:1902476 chloride transmembrane transport 11.1111 6 yes
GO:0010288 response to lead ion 7.4074 5 yes
GO:0032228 regulation of synaptic transmission, GABAergic 7.4074 6 yes
GO:0044070 regulation of anion transport 7.4074 6 yes
GO:0050805 negative regulation of synaptic transmission 7.4074 5 yes
GO:0098810 neurotransmitter reuptake 7.4074 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
ARFG1_HUMAN [view interactions] Low throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
HSF2B_HUMAN [view interactions] High throughput no yes
DRD2_HUMAN [view entry] [view interactions] High throughput yes no
5HT6R_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view interactions] High throughput no yes
LNX2_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
T4S4_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
5NT3A_HUMAN [view interactions] High throughput no yes
AT11C_HUMAN [view interactions] High throughput no no
TRI29_HUMAN [view interactions] High throughput no no
VTNC_HUMAN [view interactions] High throughput no no
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
VA0D2_HUMAN [view interactions] High throughput no no
TM242_HUMAN [view interactions] High throughput no yes
ERN1_HUMAN [view interactions] High throughput no yes
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
FIBA_HUMAN [view interactions] High throughput no no
PLMN_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
CX6A1_HUMAN [view interactions] High throughput no yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
SYPH_HUMAN [view entry] [view interactions] High throughput yes yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
NDUS5_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
CNTN1_HUMAN [view entry] [view interactions] High throughput yes yes
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
QCR6L_HUMAN [view interactions] High throughput no yes
QCR6_HUMAN [view interactions] High throughput no yes
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
DIRA2_HUMAN [view entry] [view interactions] High throughput yes no
EAA2_HUMAN [view entry] [view interactions] Computational yes no
VIAAT_HUMAN [view interactions] Computational no yes
GBRD_HUMAN [view entry] [view interactions] Computational yes yes
DCE1_HUMAN [view entry] [view interactions] Computational yes yes
DCE2_HUMAN [view interactions] Computational no yes
EAA3_HUMAN [view entry] [view interactions] Computational yes yes
SC24D_HUMAN [view interactions] Computational no yes