SC6A1_HUMAN
Evidence for PS localization
Functions
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SC6A1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 32.8125 | 4 | yes |
| GO:0046872 | metal ion binding | 31.2500 | 5 | yes |
| GO:0000166 | nucleotide binding | 20.3125 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.3125 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 15.6250 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 14.0625 | 4 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 10.9375 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 9.3750 | 5 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 7.8125 | 4 | yes |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 6.2500 | 4 | yes |
| GO:0015081 | sodium ion transmembrane transporter activity | 6.2500 | 6 | yes |
| GO:0015291 | secondary active transmembrane transporter activity | 6.2500 | 4 | yes |
| GO:0015293 | symporter activity | 6.2500 | 5 | yes |
| GO:0015294 | solute:monoatomic cation symporter activity | 6.2500 | 5 | yes |
| GO:0015370 | solute:sodium symporter activity | 6.2500 | 6 | yes |
| GO:0005283 | amino acid:sodium symporter activity | 4.6875 | 5 | yes |
| GO:0005343 | organic acid:sodium symporter activity | 4.6875 | 4 | yes |
| GO:0005416 | amino acid:monoatomic cation symporter activity | 4.6875 | 4 | yes |
| GO:0008028 | monocarboxylic acid transmembrane transporter activity | 4.6875 | 5 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 4.6875 | 4 | yes |
| GO:0005332 | gamma-aminobutyric acid:sodium:chloride symporter activity | 3.1250 | 5 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 3.1250 | 5 | yes |
| GO:0015185 | gamma-aminobutyric acid transmembrane transporter activity | 3.1250 | 4 | yes |
| GO:0015296 | monoatomic anion:monoatomic cation symporter activity | 3.1250 | 5 | yes |
| GO:0015355 | secondary active monocarboxylate transmembrane transporter activity | 3.1250 | 5 | yes |
| GO:0015373 | monoatomic anion:sodium symporter activity | 3.1250 | 6 | yes |
| GO:0015377 | chloride:monoatomic cation symporter activity | 3.1250 | 6 | yes |
| GO:0015378 | sodium:chloride symporter activity | 3.1250 | 7 | yes |
| GO:0140161 | monocarboxylate:sodium symporter activity | 3.1250 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SC6A1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 43.7500 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.1875 | 4 | yes |
| GO:0051049 | regulation of transport | 39.0625 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 32.8125 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 31.2500 | 4 | no |
| GO:0051050 | positive regulation of transport | 29.6875 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 28.1250 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 28.1250 | 4 | yes |
| GO:0022607 | cellular component assembly | 28.1250 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 26.5625 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.5625 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 26.5625 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | yes |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0008104 | protein localization | 23.4375 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 23.4375 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.8750 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 21.8750 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 21.8750 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 20.3125 | 5 | no |
| GO:0030030 | cell projection organization | 20.3125 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.3125 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 20.3125 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 20.3125 | 4 | no |
| GO:0051046 | regulation of secretion | 18.7500 | 5 | yes |
| GO:0010038 | response to metal ion | 17.1875 | 4 | yes |
| GO:0098657 | import into cell | 15.6250 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 15.6250 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 15.6250 | 4 | yes |
| GO:0034330 | cell junction organization | 14.0625 | 4 | yes |
| GO:0050890 | cognition | 14.0625 | 4 | yes |
| GO:0051047 | positive regulation of secretion | 14.0625 | 5 | yes |
| GO:0050808 | synapse organization | 12.5000 | 5 | yes |
| GO:0051592 | response to calcium ion | 12.5000 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 12.5000 | 6 | yes |
| GO:0099536 | synaptic signaling | 12.5000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 12.5000 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 12.5000 | 7 | yes |
| GO:0007613 | memory | 12.5000 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 12.5000 | 4 | yes |
| GO:0007612 | learning | 10.9375 | 4 | yes |
| GO:0033993 | response to lipid | 9.3750 | 4 | yes |
| GO:0051952 | regulation of amine transport | 9.3750 | 5 | yes |
| GO:0003018 | vascular process in circulatory system | 9.3750 | 4 | yes |
| GO:0006836 | neurotransmitter transport | 9.3750 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 9.3750 | 4 | yes |
| GO:0015711 | organic anion transport | 9.3750 | 5 | yes |
| GO:0046942 | carboxylic acid transport | 7.8125 | 6 | yes |
| GO:0051954 | positive regulation of amine transport | 7.8125 | 5 | yes |
| GO:0001504 | neurotransmitter uptake | 7.8125 | 5 | yes |
| GO:0006811 | monoatomic ion transport | 7.8125 | 4 | yes |
| GO:0008306 | associative learning | 7.8125 | 5 | yes |
| GO:0015849 | organic acid transport | 7.8125 | 5 | yes |
| GO:0042220 | response to cocaine | 6.2500 | 4 | yes |
| GO:0043279 | response to alkaloid | 6.2500 | 5 | yes |
| GO:0050805 | negative regulation of synaptic transmission | 6.2500 | 5 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 6.2500 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 6.2500 | 4 | yes |
| GO:0098810 | neurotransmitter reuptake | 6.2500 | 4 | yes |
| GO:0150104 | transport across blood-brain barrier | 6.2500 | 5 | yes |
| GO:0006812 | monoatomic cation transport | 6.2500 | 5 | yes |
| GO:0009743 | response to carbohydrate | 6.2500 | 4 | yes |
| GO:0010232 | vascular transport | 6.2500 | 4 | yes |
| GO:0030001 | metal ion transport | 6.2500 | 6 | yes |
| GO:0032890 | regulation of organic acid transport | 4.6875 | 5 | yes |
| GO:0032892 | positive regulation of organic acid transport | 4.6875 | 5 | yes |
| GO:0035725 | sodium ion transmembrane transport | 4.6875 | 5 | yes |
| GO:0051955 | regulation of amino acid transport | 4.6875 | 6 | yes |
| GO:0051957 | positive regulation of amino acid transport | 4.6875 | 6 | yes |
| GO:0006814 | sodium ion transport | 4.6875 | 7 | yes |
| GO:0006865 | amino acid transport | 4.6875 | 5 | yes |
| GO:0010288 | response to lead ion | 4.6875 | 5 | yes |
| GO:0014052 | regulation of gamma-aminobutyric acid secretion | 4.6875 | 6 | yes |
| GO:0015800 | acidic amino acid transport | 4.6875 | 6 | yes |
| GO:0032228 | regulation of synaptic transmission, GABAergic | 4.6875 | 6 | yes |
| GO:0032229 | negative regulation of synaptic transmission, GABAergic | 3.1250 | 6 | yes |
| GO:0032355 | response to estradiol | 3.1250 | 4 | yes |
| GO:0034285 | response to disaccharide | 3.1250 | 5 | yes |
| GO:0051933 | amino acid neurotransmitter reuptake | 3.1250 | 5 | yes |
| GO:0051936 | gamma-aminobutyric acid reuptake | 3.1250 | 6 | yes |
| GO:0051939 | gamma-aminobutyric acid import | 3.1250 | 6 | yes |
| GO:0098656 | monoatomic anion transmembrane transport | 3.1250 | 4 | yes |
| GO:0098658 | inorganic anion import across plasma membrane | 3.1250 | 5 | yes |
| GO:0098659 | inorganic cation import across plasma membrane | 3.1250 | 5 | yes |
| GO:0098661 | inorganic anion transmembrane transport | 3.1250 | 4 | yes |
| GO:0098719 | sodium ion import across plasma membrane | 3.1250 | 6 | yes |
| GO:0099587 | inorganic ion import across plasma membrane | 3.1250 | 4 | yes |
| GO:1902476 | chloride transmembrane transport | 3.1250 | 5 | yes |
| GO:0006820 | monoatomic anion transport | 3.1250 | 5 | yes |
| GO:0006821 | chloride transport | 3.1250 | 5 | yes |
| GO:0009744 | response to sucrose | 3.1250 | 6 | yes |
| GO:0014054 | positive regulation of gamma-aminobutyric acid secretion | 3.1250 | 6 | yes |
| GO:0014074 | response to purine-containing compound | 3.1250 | 5 | yes |
| GO:0015698 | inorganic anion transport | 3.1250 | 4 | yes |
| GO:0015812 | gamma-aminobutyric acid transport | 3.1250 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARFG1_HUMAN | [view interactions] | Low throughput | no | no |
| HUNK_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| T4S4_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| 5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
| AT11C_HUMAN | [view interactions] | High throughput | no | no |
| TRI29_HUMAN | [view interactions] | High throughput | no | no |
| VTNC_HUMAN | [view interactions] | High throughput | no | no |
| FIBG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VA0D2_HUMAN | [view interactions] | High throughput | no | no |
| TM242_HUMAN | [view interactions] | High throughput | no | yes |
| ERN1_HUMAN | [view interactions] | High throughput | no | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FIBA_HUMAN | [view interactions] | High throughput | no | no |
| PLMN_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASGL1_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYDC_HUMAN | [view interactions] | High throughput | no | yes |
| DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGKG_HUMAN | [view interactions] | High throughput | no | no |
| EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| FADS1_HUMAN | [view interactions] | High throughput | no | yes |
| F120C_HUMAN | [view interactions] | High throughput | no | yes |
| F1712_HUMAN | [view interactions] | High throughput | no | no |
| F171B_HUMAN | [view interactions] | High throughput | no | yes |
| GABR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P66B_HUMAN | [view interactions] | High throughput | no | yes |
| GLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H15_HUMAN | [view interactions] | High throughput | no | no |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNB2_HUMAN | [view interactions] | High throughput | no | no |
| KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCALD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PITM2_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RALY_HUMAN | [view interactions] | High throughput | no | yes |
| RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUFY3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S4A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUB_HUMAN | [view interactions] | High throughput | no | yes |
| RU2A_HUMAN | [view interactions] | High throughput | no | yes |
| SPKAP_HUMAN | [view interactions] | High throughput | no | yes |
| STX1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNC18_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| DRD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |