PSD3_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide exchange factor for ARF6. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
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PSD3_HUMAN has binary interactions with 41 proteins
Isoforms
Interacting regions
Canonical [PSD3_HUMAN]
Isoform [Q9NYI0-2] alignment
Isoform [Q9NYI0-3] alignment
Isoform [H0YC20] alignment
Isoform [H0YAQ7] alignment
Isoform [B4DKF8] alignment
Isoform [E5RIH3] alignment
Isoform [E5RJ29] alignment
Isoform [E5RJE4] alignment
Isoform [E5RH02] alignment
Isoform [E5RFG7] alignment
LOADING 70%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
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Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PSD3_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 42.8571 | 4 | no |
GO:0000166 | nucleotide binding | 38.0952 | 4 | no |
GO:0017076 | purine nucleotide binding | 38.0952 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 38.0952 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 38.0952 | 4 | no |
GO:0016462 | pyrophosphatase activity | 33.3333 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 33.3333 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 33.3333 | 6 | no |
GO:0019900 | kinase binding | 30.9524 | 4 | no |
GO:0019901 | protein kinase binding | 30.9524 | 5 | no |
GO:0003924 | GTPase activity | 30.9524 | 7 | no |
GO:0005525 | GTP binding | 28.5714 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 28.5714 | 6 | no |
GO:0032561 | guanyl ribonucleotide binding | 28.5714 | 5 | no |
GO:0030695 | GTPase regulator activity | 4.7619 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PSD3_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 69.0476 | 4 | no |
GO:0051128 | regulation of cellular component organization | 57.1429 | 4 | no |
GO:0010646 | regulation of cell communication | 52.3810 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
GO:0008104 | protein localization | 50.0000 | 4 | no |
GO:0006996 | organelle organization | 45.2381 | 4 | no |
GO:0051049 | regulation of transport | 45.2381 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 45.2381 | 4 | no |
GO:0009966 | regulation of signal transduction | 40.4762 | 4 | yes |
GO:0022607 | cellular component assembly | 40.4762 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 40.4762 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | yes |
GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
GO:0071702 | organic substance transport | 33.3333 | 4 | no |
GO:0071705 | nitrogen compound transport | 33.3333 | 4 | no |
GO:0010647 | positive regulation of cell communication | 30.9524 | 5 | no |
GO:0023056 | positive regulation of signaling | 30.9524 | 4 | no |
GO:0031344 | regulation of cell projection organization | 30.9524 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 30.9524 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.9524 | 6 | no |
GO:0044087 | regulation of cellular component biogenesis | 30.9524 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARAP1_HUMAN | [view interactions] | Low throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CBPZ_HUMAN | [view interactions] | High throughput | no | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTDSL_HUMAN | [view interactions] | High throughput | no | no |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |