Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGS14_HUMAN

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RGS14_HUMAN
GO:0043168 anion binding 30.2326 4 no
GO:0000166 nucleotide binding 27.3256 4 no
GO:0043169 cation binding 26.7442 4 no
GO:0046872 metal ion binding 26.7442 5 no
GO:0017076 purine nucleotide binding 25.5814 5 no
GO:0032555 purine ribonucleotide binding 25.5814 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.5814 4 no
GO:0003723 RNA binding 22.0930 4 no
GO:0003779 actin binding 21.5116 4 no
GO:0019900 kinase binding 16.2791 4 yes
GO:0016462 pyrophosphatase activity 14.5349 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 14.5349 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 14.5349 6 yes
GO:0019901 protein kinase binding 13.9535 5 yes
GO:0003924 GTPase activity 12.2093 7 yes
GO:0030695 GTPase regulator activity 5.8140 4 yes
GO:0015631 tubulin binding 3.4884 4 yes
GO:0005096 GTPase activator activity 2.9070 4 yes
GO:0008017 microtubule binding 2.9070 5 yes
GO:0030159 signaling receptor complex adaptor activity 2.9070 4 yes
GO:0005092 GDP-dissociation inhibitor activity 1.1628 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RGS14_HUMAN
GO:0048522 positive regulation of cellular process 48.8372 4 yes
GO:0051128 regulation of cellular component organization 38.9535 4 no
GO:0006996 organelle organization 37.7907 4 yes
GO:0048523 negative regulation of cellular process 34.8837 4 yes
GO:0022607 cellular component assembly 34.3023 4 no
GO:0010646 regulation of cell communication 32.5581 4 yes
GO:0031323 regulation of cellular metabolic process 30.8140 4 yes
GO:0060255 regulation of macromolecule metabolic process 29.0698 4 yes
GO:0080090 regulation of primary metabolic process 26.1628 4 yes
GO:0051049 regulation of transport 25.0000 4 no
GO:0008104 protein localization 24.4186 4 no
GO:0007010 cytoskeleton organization 23.8372 5 yes
GO:0009966 regulation of signal transduction 22.0930 4 yes
GO:0033043 regulation of organelle organization 20.3488 5 no
GO:0044087 regulation of cellular component biogenesis 20.3488 4 no
GO:0051246 regulation of protein metabolic process 19.1860 5 yes
GO:0010647 positive regulation of cell communication 15.6977 5 yes
GO:0023056 positive regulation of signaling 15.6977 4 yes
GO:0050804 modulation of chemical synaptic transmission 15.6977 5 yes
GO:0099177 regulation of trans-synaptic signaling 15.6977 4 yes
GO:1902531 regulation of intracellular signal transduction 15.1163 5 yes
GO:0051240 positive regulation of multicellular organismal process 14.5349 4 yes
GO:0009892 negative regulation of metabolic process 13.9535 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 13.9535 5 yes
GO:0031324 negative regulation of cellular metabolic process 13.3721 5 yes
GO:0031399 regulation of protein modification process 13.3721 6 yes
GO:0051094 positive regulation of developmental process 13.3721 4 yes
GO:0019220 regulation of phosphate metabolic process 12.7907 6 yes
GO:0051174 regulation of phosphorus metabolic process 12.7907 5 yes
GO:0001932 regulation of protein phosphorylation 12.2093 7 yes
GO:0042325 regulation of phosphorylation 12.2093 7 yes
GO:0045595 regulation of cell differentiation 11.6279 4 yes
GO:0051248 negative regulation of protein metabolic process 10.4651 6 yes
GO:0043549 regulation of kinase activity 9.8837 5 yes
GO:0045859 regulation of protein kinase activity 9.8837 6 yes
GO:0051338 regulation of transferase activity 9.8837 4 yes
GO:2000026 regulation of multicellular organismal development 9.3023 4 yes
GO:0043408 regulation of MAPK cascade 9.3023 6 yes
GO:0045597 positive regulation of cell differentiation 8.7209 5 yes
GO:0048585 negative regulation of response to stimulus 8.1395 4 yes
GO:0031400 negative regulation of protein modification process 7.5581 7 yes
GO:0060284 regulation of cell development 7.5581 5 yes
GO:0010648 negative regulation of cell communication 6.9767 5 yes
GO:0023057 negative regulation of signaling 6.9767 4 yes
GO:0043086 negative regulation of catalytic activity 6.9767 4 yes
GO:0050767 regulation of neurogenesis 6.9767 6 yes
GO:0051960 regulation of nervous system development 6.9767 5 yes
GO:0001933 negative regulation of protein phosphorylation 6.3953 8 yes
GO:0009968 negative regulation of signal transduction 6.3953 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 6.3953 6 yes
GO:0010720 positive regulation of cell development 6.3953 6 yes
GO:0042326 negative regulation of phosphorylation 6.3953 8 yes
GO:0045936 negative regulation of phosphate metabolic process 6.3953 7 yes
GO:0009416 response to light stimulus 5.8140 4 yes
GO:0050769 positive regulation of neurogenesis 5.8140 6 yes
GO:0050890 cognition 5.8140 4 yes
GO:0051962 positive regulation of nervous system development 5.8140 5 yes
GO:0007612 learning 5.2326 4 yes
GO:0071900 regulation of protein serine/threonine kinase activity 5.2326 7 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 4.6512 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 4.6512 7 yes
GO:1902532 negative regulation of intracellular signal transduction 4.0698 6 yes
GO:0006469 negative regulation of protein kinase activity 4.0698 7 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 4.0698 4 yes
GO:0033673 negative regulation of kinase activity 4.0698 6 yes
GO:0051348 negative regulation of transferase activity 4.0698 5 yes
GO:0006913 nucleocytoplasmic transport 3.4884 5 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 3.4884 5 yes
GO:0008306 associative learning 3.4884 5 yes
GO:0050806 positive regulation of synaptic transmission 3.4884 5 yes
GO:0051169 nuclear transport 3.4884 4 yes
GO:0007613 memory 2.9070 4 yes
GO:0008542 visual learning 2.9070 4 yes
GO:0043405 regulation of MAP kinase activity 2.9070 8 yes
GO:0043409 negative regulation of MAPK cascade 2.3256 7 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 2.3256 8 yes
GO:0007616 long-term memory 1.7442 5 yes
GO:0043407 negative regulation of MAP kinase activity 1.7442 8 yes
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 1.7442 6 yes
GO:0010070 zygote asymmetric cell division 1.1628 4 yes
GO:0031914 negative regulation of synaptic plasticity 1.1628 4 yes
GO:0048008 platelet-derived growth factor receptor signaling pathway 1.1628 6 yes
GO:0060291 long-term synaptic potentiation 1.1628 4 yes
GO:0070373 negative regulation of ERK1 and ERK2 cascade 1.1628 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP2A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] Low throughput yes no
GNA11_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] Low throughput yes yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] Low throughput yes yes
RUFY3_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRF1_HUMAN [view interactions] High throughput no yes
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
RL9_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
ADDG_HUMAN [view entry] [view interactions] High throughput yes yes
MYPT1_HUMAN [view entry] [view interactions] High throughput yes yes
LIMC1_HUMAN [view entry] [view interactions] High throughput yes no
CALB2_HUMAN [view entry] [view interactions] High throughput yes yes
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
SYT3_HUMAN [view entry] [view interactions] High throughput yes no
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
ABLM2_HUMAN [view entry] [view interactions] High throughput yes yes
ARC1A_HUMAN [view entry] [view interactions] High throughput yes yes
ARP5L_HUMAN [view entry] [view interactions] High throughput yes yes
MYL10_HUMAN [view interactions] High throughput no no
CSKI1_HUMAN [view entry] [view interactions] High throughput yes yes
PSD3_HUMAN [view entry] [view interactions] High throughput yes yes
PCLO_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA6_HUMAN [view interactions] High throughput no no
NDUS6_HUMAN [view entry] [view interactions] High throughput yes yes
RL15_HUMAN [view entry] [view interactions] High throughput yes no
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
RLA1_HUMAN [view entry] [view interactions] High throughput yes no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
MYPT2_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
DLG2_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP2_HUMAN [view entry] [view interactions] High throughput yes yes
GBG5_HUMAN [view interactions] High throughput no no
RS18_HUMAN [view entry] [view interactions] High throughput yes yes
ATP8_HUMAN [view interactions] High throughput no no
IDH3G_HUMAN [view entry] [view interactions] High throughput yes yes
IPO7_HUMAN [view entry] [view interactions] High throughput yes yes
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
COR2A_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
HPCL4_HUMAN [view interactions] High throughput no no
KCAB2_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
RL7_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP3_HUMAN [view entry] [view interactions] High throughput yes yes
GBG4_HUMAN [view interactions] High throughput no no
COF2_HUMAN [view entry] [view interactions] High throughput yes yes
IMB1_HUMAN [view entry] [view interactions] High throughput yes yes
TB10B_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PSB5_HUMAN [view interactions] High throughput no yes
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
QCR9_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4A_HUMAN [view interactions] High throughput no yes
RS11_HUMAN [view entry] [view interactions] High throughput yes yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC4_HUMAN [view entry] [view interactions] High throughput yes no
DR4L2_HUMAN [view interactions] High throughput no no
DHRS4_HUMAN [view entry] [view interactions] High throughput yes no
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
RS28_HUMAN [view entry] [view interactions] High throughput yes yes
PUR6_HUMAN [view entry] [view interactions] High throughput yes yes
FARP1_HUMAN [view entry] [view interactions] High throughput yes no
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN1_HUMAN [view entry] [view interactions] High throughput yes yes
MICA1_HUMAN [view interactions] High throughput no yes
LRRC7_HUMAN [view entry] [view interactions] High throughput yes no
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
LY6H_HUMAN [view entry] [view interactions] High throughput yes no
TRIM3_HUMAN [view entry] [view interactions] High throughput yes no
CADH2_HUMAN [view entry] [view interactions] High throughput yes no
MLC1_HUMAN [view interactions] High throughput no no
NFH_HUMAN [view entry] [view interactions] High throughput yes yes
NHRF1_HUMAN [view interactions] High throughput no no
RS3A_HUMAN [view entry] [view interactions] High throughput yes yes
UN13A_HUMAN [view entry] [view interactions] High throughput yes no
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
ERIP6_HUMAN [view interactions] High throughput no no
ZC21A_HUMAN [view interactions] High throughput no yes
IP3KA_HUMAN [view entry] [view interactions] High throughput yes no
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
ACTY_HUMAN [view entry] [view interactions] High throughput yes no
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
RL18_HUMAN [view entry] [view interactions] High throughput yes yes
KCJ10_HUMAN [view interactions] High throughput no no
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
AL3A2_HUMAN [view entry] [view interactions] High throughput yes yes
IF2A_HUMAN [view entry] [view interactions] High throughput yes yes
PKP4_HUMAN [view entry] [view interactions] High throughput yes yes
AOFB_HUMAN [view entry] [view interactions] High throughput yes yes
CA198_HUMAN [view interactions] High throughput no yes
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
ACO11_HUMAN [view interactions] High throughput no yes
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
PYGM_HUMAN [view entry] [view interactions] High throughput yes no
LIN7A_HUMAN [view entry] [view interactions] High throughput yes yes
GTR14_HUMAN [view interactions] High throughput no no
GTR3_HUMAN [view interactions] High throughput no yes
TBB4B_HUMAN [view interactions] High throughput no yes
GAPR1_HUMAN [view entry] [view interactions] High throughput yes yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
ATX10_HUMAN [view entry] [view interactions] High throughput yes yes
BORG4_HUMAN [view entry] [view interactions] High throughput yes yes
CADM4_HUMAN [view interactions] High throughput no yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
MMSA_HUMAN [view entry] [view interactions] High throughput yes no
HIBCH_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
SV2C_HUMAN [view interactions] High throughput no no
RFIP2_HUMAN [view entry] [view interactions] High throughput yes yes
SYAC_HUMAN [view interactions] High throughput no yes
T22D4_HUMAN [view entry] [view interactions] High throughput yes no
RL18A_HUMAN [view entry] [view interactions] High throughput yes yes
ETHE1_HUMAN [view interactions] High throughput no yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
GHC1_HUMAN [view entry] [view interactions] High throughput yes yes
RL22_HUMAN [view entry] [view interactions] High throughput yes no
THYG_HUMAN [view interactions] High throughput no no
CDIPT_HUMAN [view entry] [view interactions] High throughput yes yes
ELMO2_HUMAN [view entry] [view interactions] High throughput yes no
SYT1_HUMAN [view entry] [view interactions] High throughput yes no
H14_HUMAN [view interactions] High throughput no yes
SERB1_HUMAN [view interactions] High throughput no yes
RN214_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
PRS4_HUMAN [view entry] [view interactions] High throughput yes yes
HDHD2_HUMAN [view interactions] High throughput no yes
IPKA_HUMAN [view interactions] High throughput no yes
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
RGS12_HUMAN [view entry] [view interactions] High throughput yes no
WASP_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4B_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CSF1_HUMAN [view interactions] High throughput no no
TINF2_HUMAN [view interactions] High throughput no no
NFKB1_HUMAN [view interactions] High throughput no yes
TRAF2_HUMAN [view interactions] High throughput no yes
VIPR2_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
MYL6_HUMAN [view entry] [view interactions] High throughput yes no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
NP1L1_HUMAN [view entry] [view interactions] High throughput yes yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO5A_HUMAN [view entry] [view interactions] High throughput yes yes
COR2B_HUMAN [view entry] [view interactions] High throughput yes yes
ML12B_HUMAN [view interactions] High throughput no no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRB_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
MYL6B_HUMAN [view entry] [view interactions] High throughput yes no
FLII_HUMAN [view entry] [view interactions] High throughput yes yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
NP1L4_HUMAN [view entry] [view interactions] High throughput yes yes
BSN_HUMAN [view entry] [view interactions] High throughput yes yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD2_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC2_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
ASB9_HUMAN [view interactions] High throughput no no
MYL9_HUMAN [view interactions] High throughput no no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
ERC2_HUMAN [view entry] [view interactions] High throughput yes yes
SYT7_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
SH3L2_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
MPRIP_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
APOB_HUMAN [view interactions] High throughput no no
LRRF2_HUMAN [view interactions] High throughput no yes
ADDB_HUMAN [view entry] [view interactions] High throughput yes yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes