LIMC1_HUMAN
Evidence for PS localization
Functions
Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LIMC1_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 34.4828 | 4 | yes |
| GO:0019900 | kinase binding | 34.4828 | 4 | no |
| GO:0019901 | protein kinase binding | 34.4828 | 5 | no |
| GO:0046872 | metal ion binding | 31.0345 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.0345 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 31.0345 | 5 | no |
| GO:0003723 | RNA binding | 27.5862 | 4 | no |
| GO:0005524 | ATP binding | 27.5862 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.5862 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.5862 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.5862 | 4 | no |
| GO:0045296 | cadherin binding | 24.1379 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LIMC1_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 72.4138 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 72.4138 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 68.9655 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 65.5172 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 62.0690 | 4 | yes |
| GO:0010468 | regulation of gene expression | 55.1724 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 55.1724 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 51.7241 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 51.7241 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 51.7241 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 48.2759 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 48.2759 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 44.8276 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 44.8276 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 44.8276 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 44.8276 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 41.3793 | 5 | no |
| GO:0006996 | organelle organization | 41.3793 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 41.3793 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 37.9310 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 37.9310 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 37.9310 | 6 | no |
| GO:0051049 | regulation of transport | 37.9310 | 4 | no |
| GO:0008104 | protein localization | 37.9310 | 4 | no |
| GO:0022607 | cellular component assembly | 37.9310 | 4 | no |
| GO:0007010 | cytoskeleton organization | 37.9310 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 37.9310 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 34.4828 | 4 | no |
| GO:0032880 | regulation of protein localization | 34.4828 | 5 | no |
| GO:0060341 | regulation of cellular localization | 34.4828 | 4 | no |
| GO:0031399 | regulation of protein modification process | 34.4828 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.0345 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 31.0345 | 5 | no |
| GO:0010646 | regulation of cell communication | 31.0345 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.0345 | 5 | no |
| GO:0071310 | cellular response to organic substance | 31.0345 | 4 | no |
| GO:0033043 | regulation of organelle organization | 31.0345 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 27.5862 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 27.5862 | 7 | no |
| GO:0009966 | regulation of signal transduction | 27.5862 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.5862 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.5862 | 6 | no |
| GO:0051050 | positive regulation of transport | 27.5862 | 4 | no |
| GO:0071702 | organic substance transport | 27.5862 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 27.5862 | 7 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 27.5862 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 27.5862 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 27.5862 | 5 | yes |
| GO:0036211 | protein modification process | 24.1379 | 4 | no |
| GO:0043412 | macromolecule modification | 24.1379 | 4 | no |
| GO:0034330 | cell junction organization | 24.1379 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.1379 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 24.1379 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.1379 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 24.1379 | 4 | no |
| GO:0010941 | regulation of cell death | 24.1379 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 24.1379 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 24.1379 | 5 | no |
| GO:0071705 | nitrogen compound transport | 24.1379 | 4 | no |
| GO:0051223 | regulation of protein transport | 24.1379 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 24.1379 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 24.1379 | 7 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 24.1379 | 4 | yes |
| GO:2000145 | regulation of cell motility | 20.6897 | 4 | yes |
| GO:0030030 | cell projection organization | 20.6897 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 20.6897 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.6897 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.6897 | 4 | no |
| GO:0051338 | regulation of transferase activity | 20.6897 | 4 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.6897 | 7 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 20.6897 | 6 | no |
| GO:0080134 | regulation of response to stress | 20.6897 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.6897 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 20.6897 | 8 | no |
| GO:0010243 | response to organonitrogen compound | 20.6897 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 20.6897 | 4 | no |
| GO:0051726 | regulation of cell cycle | 20.6897 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 20.6897 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 20.6897 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 20.6897 | 4 | no |
| GO:0015031 | protein transport | 20.6897 | 4 | no |
| GO:0051222 | positive regulation of protein transport | 20.6897 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 20.6897 | 5 | no |
| GO:1904951 | positive regulation of establishment of protein localization | 20.6897 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 20.6897 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.6897 | 4 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 20.6897 | 6 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 20.6897 | 6 | no |
| GO:0030334 | regulation of cell migration | 20.6897 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 20.6897 | 6 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 17.2414 | 8 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 17.2414 | 6 | yes |
| GO:0030155 | regulation of cell adhesion | 17.2414 | 4 | yes |
| GO:0032970 | regulation of actin filament-based process | 17.2414 | 4 | yes |
| GO:0042327 | positive regulation of phosphorylation | 17.2414 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 17.2414 | 7 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 13.7931 | 5 | yes |
| GO:0031032 | actomyosin structure organization | 13.7931 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 13.7931 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 13.7931 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 10.3448 | 6 | yes |
| GO:1901888 | regulation of cell junction assembly | 10.3448 | 5 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 10.3448 | 6 | yes |
| GO:0010638 | positive regulation of organelle organization | 10.3448 | 6 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 6.8966 | 7 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 6.8966 | 6 | yes |
| GO:2000146 | negative regulation of cell motility | 6.8966 | 5 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 6.8966 | 5 | yes |
| GO:0030336 | negative regulation of cell migration | 6.8966 | 6 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 6.8966 | 5 | yes |
| GO:0032233 | positive regulation of actin filament bundle assembly | 6.8966 | 6 | yes |
| GO:0040013 | negative regulation of locomotion | 6.8966 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 6.8966 | 5 | yes |
| GO:0051492 | regulation of stress fiber assembly | 6.8966 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HUWE1_HUMAN | [view interactions] | Low throughput | no | yes |
| LRIG3_HUMAN | [view interactions] | Low throughput | no | yes |
| LRIG1_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| ACK1_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABRA_HUMAN | [view interactions] | High throughput | no | no |
| FRPD2_HUMAN | [view interactions] | High throughput | no | no |
| MAGE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K6_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| S43A3_HUMAN | [view interactions] | High throughput | no | yes |
| IFNG_HUMAN | [view interactions] | High throughput | no | no |
| BIRC8_HUMAN | [view interactions] | High throughput | no | no |
| SYTL5_HUMAN | [view interactions] | High throughput | no | no |
| TNNI2_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUTC_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| GABPA_HUMAN | [view interactions] | High throughput | no | no |
| IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRM61_HUMAN | [view interactions] | High throughput | no | no |
| DCX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| MAGT1_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF3C_HUMAN | [view interactions] | High throughput | no | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| CE120_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| OTU6B_HUMAN | [view interactions] | High throughput | no | yes |
| KLH15_HUMAN | [view interactions] | High throughput | no | yes |
| RFC2_HUMAN | [view interactions] | High throughput | no | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAGK_HUMAN | [view interactions] | High throughput | no | no |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| SMAG1_HUMAN | [view interactions] | High throughput | no | yes |