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TRPV1_HUMAN

GO
G2C
SynaptomeDB

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TRPV1_HUMAN
GO:0043168 anion binding 39.7260 4 yes
GO:0043169 cation binding 39.7260 4 yes
GO:0046872 metal ion binding 39.7260 5 yes
GO:0000166 nucleotide binding 38.3562 4 yes
GO:0017076 purine nucleotide binding 36.9863 5 yes
GO:0032555 purine ribonucleotide binding 35.6164 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 35.6164 4 yes
GO:0003723 RNA binding 30.1370 4 no
GO:0030554 adenyl nucleotide binding 28.7671 6 yes
GO:0032559 adenyl ribonucleotide binding 27.3973 5 yes
GO:0005524 ATP binding 27.3973 5 yes
GO:0035091 phosphatidylinositol binding 9.5890 4 yes
GO:0099106 ion channel regulator activity 6.8493 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 5.4795 4 yes
GO:0008324 monoatomic cation transmembrane transporter activity 5.4795 4 yes
GO:0046873 metal ion transmembrane transporter activity 4.1096 5 yes
GO:0015085 calcium ion transmembrane transporter activity 4.1096 6 yes
GO:0022836 gated channel activity 2.7397 5 yes
GO:0022843 voltage-gated monoatomic cation channel activity 2.7397 6 yes
GO:0097603 temperature-gated ion channel activity 2.7397 5 yes
GO:0099094 ligand-gated monoatomic cation channel activity 2.7397 6 yes
GO:0099604 ligand-gated calcium channel activity 2.7397 7 yes
GO:0005216 monoatomic ion channel activity 2.7397 4 yes
GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2.7397 6 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2.7397 6 yes
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2.7397 7 yes
GO:0005244 voltage-gated monoatomic ion channel activity 2.7397 5 yes
GO:0005245 voltage-gated calcium channel activity 2.7397 7 yes
GO:0005261 monoatomic cation channel activity 2.7397 5 yes
GO:0005262 calcium channel activity 2.7397 6 yes
GO:0015267 channel activity 2.7397 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 2.7397 5 yes
GO:0015278 intracellularly gated calcium channel activity 2.7397 7 yes
GO:0017081 chloride channel regulator activity 2.7397 5 yes
GO:0022832 voltage-gated channel activity 2.7397 6 yes
GO:0022834 ligand-gated channel activity 2.7397 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TRPV1_HUMAN
GO:0048522 positive regulation of cellular process 45.2055 4 yes
GO:0022607 cellular component assembly 42.4658 4 yes
GO:0048523 negative regulation of cellular process 42.4658 4 yes
GO:0060255 regulation of macromolecule metabolic process 39.7260 4 yes
GO:0031323 regulation of cellular metabolic process 38.3562 4 yes
GO:0080090 regulation of primary metabolic process 38.3562 4 yes
GO:0008104 protein localization 31.5068 4 no
GO:0006996 organelle organization 31.5068 4 no
GO:0051128 regulation of cellular component organization 30.1370 4 no
GO:0009889 regulation of biosynthetic process 26.0274 4 yes
GO:0009893 positive regulation of metabolic process 26.0274 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 26.0274 5 yes
GO:0031326 regulation of cellular biosynthetic process 26.0274 5 yes
GO:0051049 regulation of transport 26.0274 4 no
GO:0051246 regulation of protein metabolic process 26.0274 5 no
GO:0010468 regulation of gene expression 24.6575 6 yes
GO:0043933 protein-containing complex organization 23.2877 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.9178 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 21.9178 5 no
GO:0010646 regulation of cell communication 21.9178 4 no
GO:0007010 cytoskeleton organization 21.9178 5 no
GO:0065003 protein-containing complex assembly 20.5479 5 yes
GO:0031325 positive regulation of cellular metabolic process 20.5479 5 no
GO:0033043 regulation of organelle organization 20.5479 5 no
GO:0044087 regulation of cellular component biogenesis 20.5479 4 no
GO:0009892 negative regulation of metabolic process 19.1781 4 yes
GO:0031324 negative regulation of cellular metabolic process 19.1781 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 17.8082 5 yes
GO:0045595 regulation of cell differentiation 17.8082 4 yes
GO:0071702 organic substance transport 17.8082 4 yes
GO:0051252 regulation of RNA metabolic process 16.4384 5 yes
GO:0071705 nitrogen compound transport 16.4384 4 yes
GO:0009891 positive regulation of biosynthetic process 15.0685 5 yes
GO:0006355 regulation of DNA-templated transcription 13.6986 7 yes
GO:0042981 regulation of apoptotic process 13.6986 5 yes
GO:0043067 regulation of programmed cell death 13.6986 4 yes
GO:0071310 cellular response to organic substance 13.6986 4 yes
GO:2001141 regulation of RNA biosynthetic process 13.6986 6 yes
GO:0006357 regulation of transcription by RNA polymerase II 12.3288 8 yes
GO:0006811 monoatomic ion transport 12.3288 4 yes
GO:0009890 negative regulation of biosynthetic process 12.3288 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 12.3288 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 12.3288 6 yes
GO:0044057 regulation of system process 12.3288 4 yes
GO:0008016 regulation of heart contraction 10.9589 6 yes
GO:0010243 response to organonitrogen compound 10.9589 4 yes
GO:0014070 response to organic cyclic compound 10.9589 4 yes
GO:0051093 negative regulation of developmental process 10.9589 4 yes
GO:0060284 regulation of cell development 10.9589 5 yes
GO:1903522 regulation of blood circulation 10.9589 5 yes
GO:0006812 monoatomic cation transport 9.5890 5 yes
GO:0030001 metal ion transport 9.5890 6 yes
GO:0045596 negative regulation of cell differentiation 9.5890 5 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 9.5890 5 yes
GO:1901701 cellular response to oxygen-containing compound 9.5890 4 yes
GO:0034097 response to cytokine 8.2192 4 yes
GO:0051241 negative regulation of multicellular organismal process 8.2192 4 yes
GO:0051253 negative regulation of RNA metabolic process 8.2192 6 yes
GO:0071345 cellular response to cytokine stimulus 8.2192 5 yes
GO:0071363 cellular response to growth factor stimulus 8.2192 4 yes
GO:1901699 cellular response to nitrogen compound 8.2192 4 yes
GO:0006816 calcium ion transport 6.8493 7 yes
GO:0045892 negative regulation of DNA-templated transcription 6.8493 8 yes
GO:0046903 secretion 6.8493 4 yes
GO:0071407 cellular response to organic cyclic compound 6.8493 5 yes
GO:0071417 cellular response to organonitrogen compound 6.8493 4 yes
GO:0098655 monoatomic cation transmembrane transport 6.8493 4 yes
GO:0098657 import into cell 6.8493 4 yes
GO:0098662 inorganic cation transmembrane transport 6.8493 4 yes
GO:1902679 negative regulation of RNA biosynthetic process 6.8493 7 yes
GO:1990089 response to nerve growth factor 6.8493 4 yes
GO:1990090 cellular response to nerve growth factor stimulus 6.8493 5 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 5.4795 9 yes
GO:0010721 negative regulation of cell development 5.4795 6 yes
GO:0034605 cellular response to heat 5.4795 4 yes
GO:0043065 positive regulation of apoptotic process 5.4795 6 yes
GO:0043068 positive regulation of programmed cell death 5.4795 5 yes
GO:0043434 response to peptide hormone 5.4795 4 yes
GO:0051259 protein complex oligomerization 5.4795 6 yes
GO:0070588 calcium ion transmembrane transport 5.4795 5 yes
GO:0002790 peptide secretion 4.1096 5 yes
GO:0006936 muscle contraction 4.1096 4 yes
GO:0007600 sensory perception 4.1096 4 yes
GO:0010447 response to acidic pH 4.1096 4 yes
GO:0014074 response to purine-containing compound 4.1096 5 yes
GO:0015833 peptide transport 4.1096 5 yes
GO:0034612 response to tumor necrosis factor 4.1096 5 yes
GO:0042886 amide transport 4.1096 5 yes
GO:0043279 response to alkaloid 4.1096 5 yes
GO:0045428 regulation of nitric oxide biosynthetic process 4.1096 5 yes
GO:0045429 positive regulation of nitric oxide biosynthetic process 4.1096 6 yes
GO:0045822 negative regulation of heart contraction 4.1096 6 yes
GO:0046683 response to organophosphorus 4.1096 4 yes
GO:0050954 sensory perception of mechanical stimulus 4.1096 5 yes
GO:0051260 protein homooligomerization 4.1096 7 yes
GO:0051262 protein tetramerization 4.1096 7 yes
GO:0071356 cellular response to tumor necrosis factor 4.1096 6 yes
GO:0071467 cellular response to pH 4.1096 4 yes
GO:0071468 cellular response to acidic pH 4.1096 5 yes
GO:0080164 regulation of nitric oxide metabolic process 4.1096 4 yes
GO:0097553 calcium ion transmembrane import into cytosol 4.1096 6 yes
GO:1903523 negative regulation of blood circulation 4.1096 5 yes
GO:1904407 positive regulation of nitric oxide metabolic process 4.1096 5 yes
GO:0001660 fever generation 2.7397 5 yes
GO:0001774 microglial cell activation 2.7397 4 yes
GO:0002526 acute inflammatory response 2.7397 5 yes
GO:0003085 negative regulation of systemic arterial blood pressure 2.7397 5 yes
GO:0006835 dicarboxylic acid transport 2.7397 7 yes
GO:0006865 amino acid transport 2.7397 5 yes
GO:0006939 smooth muscle contraction 2.7397 5 yes
GO:0006953 acute-phase response 2.7397 6 yes
GO:0006954 inflammatory response 2.7397 4 yes
GO:0010459 negative regulation of heart rate 2.7397 4 yes
GO:0010917 negative regulation of mitochondrial membrane potential 2.7397 5 yes
GO:0014047 glutamate secretion 2.7397 4 yes
GO:0014832 urinary bladder smooth muscle contraction 2.7397 7 yes
GO:0014848 urinary tract smooth muscle contraction 2.7397 6 yes
GO:0015711 organic anion transport 2.7397 5 yes
GO:0015800 acidic amino acid transport 2.7397 6 yes
GO:0015849 organic acid transport 2.7397 5 yes
GO:0016048 detection of temperature stimulus 2.7397 4 yes
GO:0031649 heat generation 2.7397 4 yes
GO:0033198 response to ATP 2.7397 4 yes
GO:0042116 macrophage activation 2.7397 4 yes
GO:0045776 negative regulation of blood pressure 2.7397 4 yes
GO:0045837 negative regulation of membrane potential 2.7397 4 yes
GO:0046942 carboxylic acid transport 2.7397 6 yes
GO:0050907 detection of chemical stimulus involved in sensory perception 2.7397 4 yes
GO:0050951 sensory perception of temperature stimulus 2.7397 5 yes
GO:0050955 thermoception 2.7397 6 yes
GO:0050960 detection of temperature stimulus involved in thermoception 2.7397 5 yes
GO:0050961 detection of temperature stimulus involved in sensory perception 2.7397 4 yes
GO:0050965 detection of temperature stimulus involved in sensory perception of pain 2.7397 5 yes
GO:0050968 detection of chemical stimulus involved in sensory perception of pain 2.7397 5 yes
GO:0051289 protein homotetramerization 2.7397 8 yes
GO:0051881 regulation of mitochondrial membrane potential 2.7397 4 yes
GO:0060083 smooth muscle contraction involved in micturition 2.7397 8 yes
GO:0062149 detection of stimulus involved in sensory perception of pain 2.7397 4 yes
GO:0070509 calcium ion import 2.7397 8 yes
GO:0071312 cellular response to alkaloid 2.7397 5 yes
GO:0071318 cellular response to ATP 2.7397 5 yes
GO:0071502 cellular response to temperature stimulus 2.7397 4 yes
GO:0090210 regulation of establishment of blood-brain barrier 2.7397 6 yes
GO:0090212 negative regulation of establishment of blood-brain barrier 2.7397 7 yes
GO:0098659 inorganic cation import across plasma membrane 2.7397 5 yes
GO:0098703 calcium ion import across plasma membrane 2.7397 6 yes
GO:0099587 inorganic ion import across plasma membrane 2.7397 4 yes
GO:1901594 response to capsazepine 2.7397 4 yes
GO:1902656 calcium ion import into cytosol 2.7397 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SYT9_HUMAN [view interactions] Low throughput no no
SNAPN_HUMAN [view interactions] Low throughput no yes
TRPV1_HUMAN [view entry] [view interactions] Low throughput yes no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
OS9_HUMAN [view interactions] Low throughput no yes
FAF1_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
CBL_HUMAN [view interactions] Low throughput no yes
RFIP3_HUMAN [view entry] [view interactions] Low throughput yes no
AKAP5_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
HRH1_HUMAN [view interactions] Low throughput no no
UBC9_HUMAN [view entry] [view interactions] Low throughput yes yes
SEPT2_HUMAN [view interactions] High throughput no no
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
ARL8A_HUMAN [view interactions] High throughput no no
ATAD1_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
ATX2_HUMAN [view interactions] High throughput no yes
ATX2L_HUMAN [view interactions] High throughput no no
BMP2K_HUMAN [view interactions] High throughput no yes
CATA_HUMAN [view entry] [view interactions] High throughput yes no
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
COEA1_HUMAN [view interactions] High throughput no no
COPB_HUMAN [view interactions] High throughput no yes
COPG1_HUMAN [view interactions] High throughput no yes
CRIP2_HUMAN [view entry] [view interactions] High throughput yes no
CSDE1_HUMAN [view interactions] High throughput no yes
CATB_HUMAN [view interactions] High throughput no yes
DAB2_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX3Y_HUMAN [view interactions] High throughput no yes
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC9_HUMAN [view interactions] High throughput no yes
DOC11_HUMAN [view interactions] High throughput no yes
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
IF2G_HUMAN [view interactions] High throughput no yes
EIF3B_HUMAN [view interactions] High throughput no yes
IF4G3_HUMAN [view interactions] High throughput no yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
ESYT1_HUMAN [view entry] [view interactions] High throughput yes yes
FCHO2_HUMAN [view interactions] High throughput no yes
FKB1C_HUMAN [view interactions] High throughput no no
FKB1A_HUMAN [view interactions] High throughput no yes
FKBP2_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
H2A2A_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
H2A1_HUMAN [view interactions] High throughput no yes
H2A1D_HUMAN [view interactions] High throughput no yes
H2AJ_HUMAN [view interactions] High throughput no yes
H2A1A_HUMAN [view interactions] High throughput no yes
H2A2B_HUMAN [view interactions] High throughput no yes
H2A3_HUMAN [view interactions] High throughput no yes
H2A1J_HUMAN [view interactions] High throughput no yes
H2AX_HUMAN [view interactions] High throughput no yes
H2A1C_HUMAN [view interactions] High throughput no yes
H2A2C_HUMAN [view interactions] High throughput no yes
H2A1H_HUMAN [view interactions] High throughput no yes
H13_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH2_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
ITA6_HUMAN [view interactions] High throughput no yes
K1C28_HUMAN [view interactions] High throughput no no
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
LIMC1_HUMAN [view entry] [view interactions] High throughput yes no
LRRF2_HUMAN [view interactions] High throughput no yes
LSM12_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
MBNL1_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
MYO7A_HUMAN [view interactions] High throughput no yes
NACAM_HUMAN [view interactions] High throughput no no
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NEXN_HUMAN [view interactions] High throughput no yes
NUFP2_HUMAN [view interactions] High throughput no no
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
OSBL3_HUMAN [view interactions] High throughput no yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
PFKAP_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA6_HUMAN [view entry] [view interactions] High throughput yes no
PLLP_HUMAN [view entry] [view interactions] High throughput yes no
PRVA_HUMAN [view interactions] High throughput no yes
PYM1_HUMAN [view interactions] High throughput no yes
RAI14_HUMAN [view interactions] High throughput no yes
RALA_HUMAN [view entry] [view interactions] High throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] High throughput yes no
RBM14_HUMAN [view interactions] High throughput no yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
RL38_HUMAN [view entry] [view interactions] High throughput yes yes
RS27_HUMAN [view entry] [view interactions] High throughput yes no
RS27L_HUMAN [view entry] [view interactions] High throughput yes no
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RUFY3_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1B_HUMAN [view interactions] High throughput no yes
SH3L1_HUMAN [view interactions] High throughput no yes
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
CYTSA_HUMAN [view interactions] High throughput no yes
SRPRB_HUMAN [view entry] [view interactions] High throughput yes no
THY1_HUMAN [view entry] [view interactions] High throughput yes yes
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV2_HUMAN [view interactions] High throughput no yes
T22D4_HUMAN [view entry] [view interactions] High throughput yes no
TBB1_HUMAN [view interactions] High throughput no yes
TBB6_HUMAN [view entry] [view interactions] High throughput yes yes
U2AF2_HUMAN [view interactions] High throughput no yes
UACA_HUMAN [view interactions] High throughput no yes
VINC_HUMAN [view entry] [view interactions] High throughput yes no
ABLM2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTZ_HUMAN [view entry] [view interactions] High throughput yes yes
ADDB_HUMAN [view entry] [view interactions] High throughput yes yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CO6A1_HUMAN [view interactions] High throughput no no
CSRP1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX17_HUMAN [view entry] [view interactions] High throughput yes yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
SYEP_HUMAN [view interactions] High throughput no yes
SYFB_HUMAN [view entry] [view interactions] High throughput yes yes
FPPS_HUMAN [view entry] [view interactions] High throughput yes yes
FIBA_HUMAN [view interactions] High throughput no no
HBE_HUMAN [view interactions] High throughput no no
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
SYIC_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1D_HUMAN [view entry] [view interactions] High throughput yes yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RS2_HUMAN [view entry] [view interactions] High throughput yes yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
TWF1_HUMAN [view entry] [view interactions] High throughput yes no
VMA5A_HUMAN [view interactions] High throughput no no
YBOX3_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no