Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LASP1_HUMAN

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in LASP1_HUMAN
GO:0003723 RNA binding 35.8491 4 no
GO:0019900 kinase binding 35.8491 4 no
GO:0019901 protein kinase binding 33.9623 5 no
GO:0046872 metal ion binding 28.3019 4 yes
GO:0017076 purine nucleotide binding 28.3019 4 no
GO:0032555 purine ribonucleotide binding 26.4151 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.5283 4 no
GO:0030554 adenyl nucleotide binding 24.5283 5 no
GO:0032559 adenyl ribonucleotide binding 22.6415 5 no
GO:0045296 cadherin binding 22.6415 4 yes
GO:0005524 ATP binding 20.7547 5 no
GO:0003779 actin binding 18.8679 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LASP1_HUMAN
GO:0048522 positive regulation of cellular process 73.5849 4 no
GO:0060255 regulation of macromolecule metabolic process 67.9245 4 no
GO:0031323 regulation of cellular metabolic process 66.0377 4 no
GO:0051171 regulation of nitrogen compound metabolic process 66.0377 4 no
GO:0080090 regulation of primary metabolic process 66.0377 4 no
GO:0048523 negative regulation of cellular process 62.2642 4 no
GO:0010468 regulation of gene expression 56.6038 5 no
GO:0051128 regulation of cellular component organization 50.9434 4 no
GO:0009889 regulation of biosynthetic process 50.9434 4 no
GO:0010556 regulation of macromolecule biosynthetic process 50.9434 5 no
GO:0031326 regulation of cellular biosynthetic process 49.0566 5 no
GO:0010646 regulation of cell communication 47.1698 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 47.1698 5 no
GO:0009893 positive regulation of metabolic process 47.1698 4 no
GO:0051252 regulation of RNA metabolic process 45.2830 5 no
GO:0071310 cellular response to organic substance 43.3962 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.5094 5 no
GO:0051246 regulation of protein metabolic process 41.5094 5 no
GO:0006996 organelle organization 41.5094 4 no
GO:0031325 positive regulation of cellular metabolic process 39.6226 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 39.6226 5 no
GO:0009966 regulation of signal transduction 39.6226 4 no
GO:0008104 protein localization 39.6226 4 no
GO:1903506 regulation of nucleic acid-templated transcription 37.7358 7 no
GO:2001141 regulation of RNA biosynthetic process 37.7358 6 no
GO:0022607 cellular component assembly 37.7358 4 no
GO:0044087 regulation of cellular component biogenesis 37.7358 4 no
GO:0006355 regulation of DNA-templated transcription 37.7358 6 no
GO:0009892 negative regulation of metabolic process 37.7358 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.8491 5 no
GO:0051049 regulation of transport 35.8491 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.9623 5 no
GO:0031324 negative regulation of cellular metabolic process 32.0755 5 no
GO:0010243 response to organonitrogen compound 32.0755 4 no
GO:0051050 positive regulation of transport 30.1887 4 no
GO:1901701 cellular response to oxygen-containing compound 30.1887 4 no
GO:0033043 regulation of organelle organization 30.1887 5 no
GO:0051129 negative regulation of cellular component organization 28.3019 5 no
GO:0009894 regulation of catabolic process 28.3019 4 no
GO:0031328 positive regulation of cellular biosynthetic process 26.4151 6 no
GO:0032880 regulation of protein localization 26.4151 5 no
GO:0048584 positive regulation of response to stimulus 26.4151 4 no
GO:0060341 regulation of cellular localization 26.4151 4 no
GO:0031399 regulation of protein modification process 26.4151 6 no
GO:0014070 response to organic cyclic compound 26.4151 4 no
GO:0048585 negative regulation of response to stimulus 26.4151 4 no
GO:0009891 positive regulation of biosynthetic process 26.4151 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.5283 6 no
GO:0010628 positive regulation of gene expression 24.5283 6 no
GO:0045595 regulation of cell differentiation 24.5283 4 no
GO:0071702 organic substance transport 24.5283 4 no
GO:2000026 regulation of multicellular organismal development 24.5283 4 no
GO:0071417 cellular response to organonitrogen compound 24.5283 4 no
GO:1901699 cellular response to nitrogen compound 24.5283 4 no
GO:0022603 regulation of anatomical structure morphogenesis 22.6415 4 no
GO:0031344 regulation of cell projection organization 22.6415 5 no
GO:0036211 protein modification process 22.6415 4 no
GO:0043412 macromolecule modification 22.6415 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.6415 6 no
GO:0071705 nitrogen compound transport 22.6415 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.6415 6 no
GO:0007010 cytoskeleton organization 22.6415 5 no
GO:0051247 positive regulation of protein metabolic process 22.6415 6 no
GO:1902531 regulation of intracellular signal transduction 22.6415 5 no
GO:0071407 cellular response to organic cyclic compound 22.6415 5 no
GO:0051094 positive regulation of developmental process 22.6415 4 no
GO:0019220 regulation of phosphate metabolic process 22.6415 6 no
GO:0042325 regulation of phosphorylation 22.6415 7 no
GO:0051174 regulation of phosphorus metabolic process 22.6415 5 no
GO:0006357 regulation of transcription by RNA polymerase II 22.6415 7 no
GO:0010648 negative regulation of cell communication 20.7547 5 no
GO:0023057 negative regulation of signaling 20.7547 4 no
GO:0030334 regulation of cell migration 20.7547 5 no
GO:0051130 positive regulation of cellular component organization 20.7547 5 no
GO:0051254 positive regulation of RNA metabolic process 20.7547 6 no
GO:0080134 regulation of response to stress 20.7547 4 no
GO:2000145 regulation of cell motility 20.7547 4 no
GO:0051493 regulation of cytoskeleton organization 20.7547 6 no
GO:0016192 vesicle-mediated transport 20.7547 4 no
GO:0031329 regulation of cellular catabolic process 20.7547 5 no
GO:0030030 cell projection organization 20.7547 4 no
GO:0006796 phosphate-containing compound metabolic process 20.7547 4 no
GO:0006811 ion transport 11.3208 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in LASP1_HUMAN
DOID:612 primary immunodeficiency disease 3.7736 3 no
DOID:0111198 autosomal dominant distal hereditary motor neuronopathy 3.7736 7 no
DOID:12377 spinal muscular atrophy 3.7736 6 no
DOID:1289 neurodegenerative disease 3.7736 4 no
DOID:231 motor neuron disease 3.7736 5 no
DOID:331 central nervous system disease 3.7736 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ZO2_HUMAN [view entry] [view interactions] Low throughput yes no
ZYX_HUMAN [view interactions] Low throughput no no
LPP_HUMAN [view interactions] Low throughput no yes
PP2BA_HUMAN [view entry] [view interactions] Low throughput yes yes
CSN5_HUMAN [view interactions] Low throughput no yes
UHRF1_HUMAN [view interactions] Low throughput no yes
DNMT1_HUMAN [view interactions] Low throughput no no
EHMT2_HUMAN [view entry] [view interactions] Low throughput yes yes
SNAI1_HUMAN [view interactions] Low throughput no yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
VASP_HUMAN [view interactions] Low throughput no yes
KGP1_HUMAN [view interactions] Low throughput no yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTA_HUMAN [view interactions] Low throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
PCH2_HUMAN [view interactions] High throughput no no
ILK_HUMAN [view interactions] High throughput no no
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
SNR27_HUMAN [view interactions] High throughput no yes
UIF_HUMAN [view interactions] High throughput no yes
ZN764_HUMAN [view interactions] High throughput no no
MFTC_HUMAN [view interactions] High throughput no yes
T2R41_HUMAN [view interactions] High throughput no no
RDH12_HUMAN [view interactions] High throughput no no
S2544_HUMAN [view interactions] High throughput no no
THAP8_HUMAN [view interactions] High throughput no yes
O10H3_HUMAN [view interactions] High throughput no no
MFI_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
FINC_HUMAN [view interactions] High throughput no yes
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP2_HUMAN [view entry] [view interactions] High throughput yes no
ERH_HUMAN [view interactions] High throughput no yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
VAV_HUMAN [view interactions] High throughput no no
SHIP2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA7_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
CXCR2_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
DAZP2_HUMAN [view interactions] High throughput no no
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
SH22A_HUMAN [view interactions] High throughput no no
SPY2_HUMAN [view interactions] High throughput no yes
TRI27_HUMAN [view interactions] High throughput no yes
ITF2_HUMAN [view interactions] High throughput no yes
PSA3_HUMAN [view interactions] High throughput no no
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
REL_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
ZBTB9_HUMAN [view interactions] High throughput no no
ZC21A_HUMAN [view interactions] High throughput no yes
RHXF2_HUMAN [view interactions] High throughput no no
LZTS2_HUMAN [view interactions] High throughput no no
KRA42_HUMAN [view interactions] High throughput no no
THAP1_HUMAN [view interactions] High throughput no no
SEPT3_HUMAN [view interactions] High throughput no no
PLS1_HUMAN [view interactions] High throughput no no
FHL3_HUMAN [view interactions] High throughput no no
FANCC_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
TINF2_HUMAN [view interactions] High throughput no no
ACD_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
FBF1_HUMAN [view interactions] High throughput no no
SCLT1_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
FGFR4_HUMAN [view interactions] High throughput no no
ARHGF_HUMAN [view entry] [view interactions] High throughput yes no
ZDH17_HUMAN [view interactions] High throughput no yes
RBPMS_HUMAN [view interactions] High throughput no no
F168A_HUMAN [view interactions] High throughput no yes
DPOD1_HUMAN [view interactions] High throughput no yes
DMRT3_HUMAN [view interactions] High throughput no no
PIT1_HUMAN [view interactions] High throughput no no
ANS1A_HUMAN [view interactions] High throughput no yes
PITX1_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
RFOX1_HUMAN [view interactions] High throughput no yes
CHERP_HUMAN [view interactions] High throughput no no
DTX2_HUMAN [view interactions] High throughput no yes
NTF2_HUMAN [view interactions] High throughput no yes
VAC14_HUMAN [view entry] [view interactions] High throughput yes yes
MED25_HUMAN [view interactions] High throughput no yes
HXA1_HUMAN [view interactions] High throughput no no
CRBA1_HUMAN [view interactions] High throughput no no
TNS2_HUMAN [view interactions] High throughput no no
TFG_HUMAN [view interactions] High throughput no yes
OTX1_HUMAN [view interactions] High throughput no no
GCM2_HUMAN [view interactions] High throughput no no
TEKT3_HUMAN [view interactions] High throughput no no
INT11_HUMAN [view interactions] High throughput no yes
ARHGG_HUMAN [view interactions] High throughput no yes
BHE40_HUMAN [view interactions] High throughput no yes
ZC3HA_HUMAN [view interactions] High throughput no yes
VEZF1_HUMAN [view interactions] High throughput no yes
RNF38_HUMAN [view interactions] High throughput no yes
SPAG8_HUMAN [view interactions] High throughput no no
GUCD1_HUMAN [view interactions] High throughput no no
BAHD1_HUMAN [view interactions] High throughput no no
DRC4_HUMAN [view interactions] High throughput no yes
LMO4_HUMAN [view interactions] High throughput no yes
YTHD1_HUMAN [view interactions] High throughput no no
F168B_HUMAN [view interactions] High throughput no yes
TEKT5_HUMAN [view interactions] High throughput no no
BAG4_HUMAN [view interactions] High throughput no yes
FOXH1_HUMAN [view interactions] High throughput no no
PRR35_HUMAN [view interactions] High throughput no no
PPR32_HUMAN [view interactions] High throughput no no
OXER1_HUMAN [view interactions] High throughput no yes
TEKT4_HUMAN [view interactions] High throughput no no
CRBA2_HUMAN [view interactions] High throughput no no
TLX3_HUMAN [view interactions] High throughput no no
RBPS2_HUMAN [view interactions] High throughput no no
GT253_HUMAN [view interactions] High throughput no yes
LENG8_HUMAN [view interactions] High throughput no yes
MGT5B_HUMAN [view interactions] High throughput no no
VP37C_HUMAN [view interactions] High throughput no yes
HNRPF_HUMAN [view interactions] High throughput no yes
EVX2_HUMAN [view interactions] High throughput no no
CTSR1_HUMAN [view interactions] High throughput no no
YES_HUMAN [view entry] [view interactions] High throughput yes yes
UFSP1_HUMAN [view interactions] High throughput no yes
CSTFT_HUMAN [view interactions] High throughput no yes
MKRN3_HUMAN [view interactions] High throughput no yes
CN119_HUMAN [view interactions] High throughput no yes
CTNA3_HUMAN [view interactions] High throughput no no
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
KR196_HUMAN [view interactions] High throughput no no
KRA62_HUMAN [view interactions] High throughput no no
KR194_HUMAN [view interactions] High throughput no no
KR108_HUMAN [view interactions] High throughput no no
UBQL2_HUMAN [view interactions] High throughput no yes
CS054_HUMAN [view interactions] High throughput no no
NOXA1_HUMAN [view interactions] High throughput no yes
ARI5A_HUMAN [view interactions] High throughput no yes
CRTP1_HUMAN [view interactions] High throughput no yes
KR261_HUMAN [view interactions] High throughput no no
QRIC1_HUMAN [view interactions] High throughput no yes
PR20E_HUMAN [view interactions] High throughput no no
DOK6_HUMAN [view interactions] High throughput no yes
VGLL3_HUMAN [view interactions] High throughput no no
KRA33_HUMAN [view interactions] High throughput no no
KRA32_HUMAN [view interactions] High throughput no no
KR124_HUMAN [view interactions] High throughput no no
KR193_HUMAN [view interactions] High throughput no no
FBX17_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
CCDC8_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
KTU_HUMAN [view interactions] High throughput no yes
NFYA_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
NUCL_HUMAN [view interactions] High throughput no yes
NAT10_HUMAN [view interactions] High throughput no yes
PDIA5_HUMAN [view interactions] High throughput no yes
API5_HUMAN [view interactions] High throughput no no
K1C18_HUMAN [view interactions] High throughput no no
K22E_HUMAN [view interactions] High throughput no no
G3BP2_HUMAN [view entry] [view interactions] High throughput yes yes
AP3M1_HUMAN [view interactions] High throughput no yes
NCOR2_HUMAN [view interactions] High throughput no yes
CDK12_HUMAN [view interactions] High throughput no yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
H31_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
TES_HUMAN [view interactions] High throughput no yes
PPP6_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
REQU_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
FA24B_HUMAN [view interactions] High throughput no no
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
BTF3_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
ITCH_HUMAN [view interactions] High throughput no yes
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
ARFG1_HUMAN [view interactions] High throughput no no
DDB1_HUMAN [view interactions] High throughput no yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
CH10_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
NXF1_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
DCA15_HUMAN [view interactions] High throughput no no
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
CXCR1_HUMAN [view interactions] Computational no yes
KLH41_HUMAN [view interactions] Computational no no
PALLD_HUMAN [view interactions] Computational no yes