Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LASP1_HUMAN

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types . [View more on UniProt]

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Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in LASP1_HUMAN
GO:0003723 RNA binding 33.3333 4 no
GO:0043169 cation binding 30.3030 4 yes
GO:0046872 metal ion binding 30.3030 5 yes
GO:0019900 kinase binding 30.3030 4 no
GO:0043168 anion binding 30.3030 4 no
GO:0019901 protein kinase binding 28.7879 5 no
GO:0000166 nucleotide binding 28.7879 4 no
GO:0017076 purine nucleotide binding 28.7879 5 no
GO:0032555 purine ribonucleotide binding 28.7879 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.2727 4 no
GO:0030554 adenyl nucleotide binding 24.2424 6 no
GO:0032559 adenyl ribonucleotide binding 24.2424 5 no
GO:0005524 ATP binding 22.7273 5 no
GO:0045296 cadherin binding 21.2121 4 yes
GO:0003779 actin binding 19.6970 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LASP1_HUMAN
GO:0048522 positive regulation of cellular process 72.7273 4 no
GO:0031323 regulation of cellular metabolic process 69.6970 4 no
GO:0048523 negative regulation of cellular process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0009889 regulation of biosynthetic process 65.1515 4 no
GO:0080090 regulation of primary metabolic process 65.1515 4 no
GO:0031326 regulation of cellular biosynthetic process 63.6364 5 no
GO:0010556 regulation of macromolecule biosynthetic process 62.1212 5 no
GO:0010468 regulation of gene expression 59.0909 6 no
GO:0051128 regulation of cellular component organization 57.5758 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 51.5152 5 no
GO:0010646 regulation of cell communication 48.4848 4 no
GO:0051252 regulation of RNA metabolic process 48.4848 5 no
GO:0008104 protein localization 46.9697 4 no
GO:0009893 positive regulation of metabolic process 46.9697 4 no
GO:0022607 cellular component assembly 45.4545 4 no
GO:0006996 organelle organization 43.9394 4 no
GO:0031325 positive regulation of cellular metabolic process 43.9394 5 no
GO:0009891 positive regulation of biosynthetic process 42.4242 5 no
GO:0009892 negative regulation of metabolic process 42.4242 4 no
GO:0010604 positive regulation of macromolecule metabolic process 42.4242 5 no
GO:0051246 regulation of protein metabolic process 42.4242 5 no
GO:0006355 regulation of DNA-templated transcription 42.4242 7 no
GO:2001141 regulation of RNA biosynthetic process 42.4242 6 no
GO:0009966 regulation of signal transduction 40.9091 4 no
GO:0031324 negative regulation of cellular metabolic process 40.9091 5 no
GO:0031328 positive regulation of cellular biosynthetic process 39.3939 6 no
GO:0044087 regulation of cellular component biogenesis 37.8788 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.8788 5 no
GO:0071310 cellular response to organic substance 37.8788 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 36.3636 6 no
GO:0043933 protein-containing complex organization 34.8485 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 no
GO:0071705 nitrogen compound transport 31.8182 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 31.8182 6 no
GO:0048584 positive regulation of response to stimulus 31.8182 4 no
GO:0051049 regulation of transport 31.8182 4 no
GO:0032880 regulation of protein localization 30.3030 5 no
GO:0060341 regulation of cellular localization 30.3030 4 no
GO:0033043 regulation of organelle organization 30.3030 5 no
GO:0051129 negative regulation of cellular component organization 30.3030 5 no
GO:0009894 regulation of catabolic process 30.3030 4 no
GO:0031399 regulation of protein modification process 30.3030 6 no
GO:0006357 regulation of transcription by RNA polymerase II 30.3030 8 no
GO:0048585 negative regulation of response to stimulus 30.3030 4 no
GO:0043067 regulation of programmed cell death 28.7879 4 no
GO:0010647 positive regulation of cell communication 28.7879 5 no
GO:0023056 positive regulation of signaling 28.7879 4 no
GO:0042981 regulation of apoptotic process 27.2727 5 no
GO:1901701 cellular response to oxygen-containing compound 25.7576 4 no
GO:0015031 protein transport 25.7576 4 no
GO:0036211 protein modification process 25.7576 4 no
GO:0043412 macromolecule modification 25.7576 4 no
GO:0051247 positive regulation of protein metabolic process 25.7576 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.7576 5 no
GO:0051130 positive regulation of cellular component organization 24.2424 5 no
GO:1902531 regulation of intracellular signal transduction 24.2424 5 no
GO:0065003 protein-containing complex assembly 24.2424 5 no
GO:0030030 cell projection organization 24.2424 4 no
GO:0009967 positive regulation of signal transduction 24.2424 5 no
GO:0010243 response to organonitrogen compound 24.2424 4 no
GO:0019220 regulation of phosphate metabolic process 24.2424 6 no
GO:0051174 regulation of phosphorus metabolic process 24.2424 5 no
GO:0051254 positive regulation of RNA metabolic process 24.2424 6 no
GO:0009968 negative regulation of signal transduction 24.2424 5 no
GO:0010648 negative regulation of cell communication 24.2424 5 no
GO:0023057 negative regulation of signaling 24.2424 4 no
GO:0007010 cytoskeleton organization 22.7273 5 no
GO:0006796 phosphate-containing compound metabolic process 22.7273 4 no
GO:0042127 regulation of cell population proliferation 22.7273 4 no
GO:0045595 regulation of cell differentiation 22.7273 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.7273 5 no
GO:2000026 regulation of multicellular organismal development 22.7273 4 no
GO:0051050 positive regulation of transport 21.2121 4 no
GO:1903829 positive regulation of protein localization 21.2121 5 no
GO:0051493 regulation of cytoskeleton organization 21.2121 6 no
GO:0010628 positive regulation of gene expression 21.2121 7 no
GO:0014070 response to organic cyclic compound 21.2121 4 no
GO:0051094 positive regulation of developmental process 21.2121 4 no
GO:0051253 negative regulation of RNA metabolic process 21.2121 6 no
GO:0006811 monoatomic ion transport 10.6061 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ZO2_HUMAN [view entry] [view interactions] Low throughput yes no
ZYX_HUMAN [view interactions] Low throughput no no
LPP_HUMAN [view interactions] Low throughput no yes
PP2BA_HUMAN [view entry] [view interactions] Low throughput yes yes
CSN5_HUMAN [view interactions] Low throughput no yes
UHRF1_HUMAN [view interactions] Low throughput no yes
DNMT1_HUMAN [view interactions] Low throughput no no
EHMT2_HUMAN [view entry] [view interactions] Low throughput yes yes
SNAI1_HUMAN [view interactions] Low throughput no yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
VASP_HUMAN [view entry] [view interactions] Low throughput yes yes
KGP1_HUMAN [view interactions] Low throughput no yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTA_HUMAN [view interactions] Low throughput no no
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
ARFG1_HUMAN [view interactions] High throughput no no
DDB1_HUMAN [view interactions] High throughput no yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
CH10_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
NXF1_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
CKS1_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
DCA15_HUMAN [view interactions] High throughput no no
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
LNP_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
FOXO1_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
PCH2_HUMAN [view interactions] High throughput no no
ILK_HUMAN [view interactions] High throughput no no
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
SNR27_HUMAN [view interactions] High throughput no yes
UIF_HUMAN [view interactions] High throughput no yes
ZN764_HUMAN [view interactions] High throughput no no
S2532_HUMAN [view interactions] High throughput no yes
T2R41_HUMAN [view interactions] High throughput no no
RDH12_HUMAN [view interactions] High throughput no no
S2544_HUMAN [view interactions] High throughput no no
THAP8_HUMAN [view interactions] High throughput no yes
O10H3_HUMAN [view interactions] High throughput no no
MFI_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SIM26_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP2_HUMAN [view entry] [view interactions] High throughput yes no
ERH_HUMAN [view interactions] High throughput no yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
VAV_HUMAN [view interactions] High throughput no no
SHIP2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA7_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
CXCR2_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
DAZP2_HUMAN [view interactions] High throughput no no
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
SH22A_HUMAN [view interactions] High throughput no no
ARHGF_HUMAN [view entry] [view interactions] High throughput yes no
SPY2_HUMAN [view interactions] High throughput no yes
TRI27_HUMAN [view interactions] High throughput no yes
ITF2_HUMAN [view interactions] High throughput no yes
PSA3_HUMAN [view interactions] High throughput no no
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
REL_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
ZBTB9_HUMAN [view interactions] High throughput no no
ZC21A_HUMAN [view interactions] High throughput no yes
RHXF2_HUMAN [view interactions] High throughput no no
LZTS2_HUMAN [view interactions] High throughput no no
KRA42_HUMAN [view interactions] High throughput no no
THAP1_HUMAN [view interactions] High throughput no no
SEPT3_HUMAN [view interactions] High throughput no no
PLS1_HUMAN [view interactions] High throughput no no
FHL3_HUMAN [view interactions] High throughput no no
FANCC_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
TINF2_HUMAN [view interactions] High throughput no no
ACD_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
FBF1_HUMAN [view interactions] High throughput no no
SCLT1_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
FGFR4_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
ZDH17_HUMAN [view entry] [view interactions] High throughput yes yes
RBPMS_HUMAN [view interactions] High throughput no no
F168A_HUMAN [view interactions] High throughput no yes
DPOD1_HUMAN [view interactions] High throughput no yes
DMRT3_HUMAN [view interactions] High throughput no no
PIT1_HUMAN [view interactions] High throughput no no
ANS1A_HUMAN [view interactions] High throughput no yes
PITX1_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
RFOX1_HUMAN [view interactions] High throughput no yes
CHERP_HUMAN [view interactions] High throughput no no
DTX2_HUMAN [view interactions] High throughput no yes
NTF2_HUMAN [view interactions] High throughput no yes
VAC14_HUMAN [view entry] [view interactions] High throughput yes yes
MED25_HUMAN [view interactions] High throughput no yes
HXA1_HUMAN [view interactions] High throughput no no
CRBA1_HUMAN [view interactions] High throughput no no
TENS2_HUMAN [view interactions] High throughput no no
TFG_HUMAN [view interactions] High throughput no yes
OTX1_HUMAN [view interactions] High throughput no no
GCM2_HUMAN [view interactions] High throughput no no
TEKT3_HUMAN [view interactions] High throughput no no
INT11_HUMAN [view interactions] High throughput no yes
ARHGG_HUMAN [view interactions] High throughput no yes
BHE40_HUMAN [view interactions] High throughput no yes
ZC3HA_HUMAN [view interactions] High throughput no yes
VEZF1_HUMAN [view interactions] High throughput no yes
RNF38_HUMAN [view interactions] High throughput no yes
SPAG8_HUMAN [view interactions] High throughput no no
GUCD1_HUMAN [view interactions] High throughput no no
BAHD1_HUMAN [view interactions] High throughput no no
DRC4_HUMAN [view interactions] High throughput no yes
LMO4_HUMAN [view interactions] High throughput no yes
YTHD1_HUMAN [view interactions] High throughput no no
F168B_HUMAN [view interactions] High throughput no yes
TEKT5_HUMAN [view interactions] High throughput no no
BAG4_HUMAN [view interactions] High throughput no yes
FOXH1_HUMAN [view interactions] High throughput no no
PRR35_HUMAN [view interactions] High throughput no no
SAXO4_HUMAN [view interactions] High throughput no no
OXER1_HUMAN [view interactions] High throughput no yes
TEKT4_HUMAN [view interactions] High throughput no no
CRBA2_HUMAN [view interactions] High throughput no no
TLX3_HUMAN [view interactions] High throughput no no
RBPS2_HUMAN [view interactions] High throughput no no
GT253_HUMAN [view interactions] High throughput no yes
LENG8_HUMAN [view interactions] High throughput no yes
MGT5B_HUMAN [view interactions] High throughput no no
VP37C_HUMAN [view interactions] High throughput no yes
HNRPF_HUMAN [view interactions] High throughput no yes
EVX2_HUMAN [view interactions] High throughput no no
CTSR1_HUMAN [view interactions] High throughput no no
YES_HUMAN [view entry] [view interactions] High throughput yes yes
UFSP1_HUMAN [view interactions] High throughput no yes
CSTFT_HUMAN [view interactions] High throughput no yes
MKRN3_HUMAN [view interactions] High throughput no yes
CN119_HUMAN [view interactions] High throughput no yes
CTNA3_HUMAN [view interactions] High throughput no no
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
KR196_HUMAN [view interactions] High throughput no no
KRA62_HUMAN [view interactions] High throughput no no
KR194_HUMAN [view interactions] High throughput no no
KR108_HUMAN [view interactions] High throughput no no
UBQL2_HUMAN [view interactions] High throughput no yes
ACTMP_HUMAN [view interactions] High throughput no no
NOXA1_HUMAN [view interactions] High throughput no yes
ARI5A_HUMAN [view interactions] High throughput no yes
CRTP1_HUMAN [view interactions] High throughput no yes
KR261_HUMAN [view interactions] High throughput no no
QRIC1_HUMAN [view interactions] High throughput no yes
PR20E_HUMAN [view interactions] High throughput no no
DOK6_HUMAN [view interactions] High throughput no yes
VGLL3_HUMAN [view interactions] High throughput no no
KRA33_HUMAN [view interactions] High throughput no no
KRA32_HUMAN [view interactions] High throughput no no
KR124_HUMAN [view interactions] High throughput no no
KR193_HUMAN [view interactions] High throughput no no
FBX17_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
CCDC8_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
KTU_HUMAN [view interactions] High throughput no yes
NFYA_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
NUCL_HUMAN [view interactions] High throughput no yes
NAT10_HUMAN [view interactions] High throughput no yes
PDIA5_HUMAN [view interactions] High throughput no yes
API5_HUMAN [view interactions] High throughput no no
K1C18_HUMAN [view interactions] High throughput no no
K22E_HUMAN [view interactions] High throughput no no
G3BP2_HUMAN [view entry] [view interactions] High throughput yes yes
AP3M1_HUMAN [view entry] [view interactions] High throughput yes yes
NCOR2_HUMAN [view interactions] High throughput no yes
CDK12_HUMAN [view interactions] High throughput no yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
H31_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
TES_HUMAN [view interactions] High throughput no yes
PPP6_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
REQU_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
FA24B_HUMAN [view interactions] High throughput no no
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
BTF3_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
EZH2_HUMAN [view interactions] High throughput no no
ITCH_HUMAN [view interactions] High throughput no yes