Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IF4B_HUMAN

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in IF4B_HUMAN
GO:0003723 RNA binding 60.0000 4 yes
GO:0045296 cadherin binding 20.9524 4 no
GO:0003727 single-stranded RNA binding 7.6190 5 yes
GO:0003743 translation initiation factor activity 7.6190 4 yes
GO:0003725 double-stranded RNA binding 3.8095 5 yes
GO:0033592 RNA strand annealing activity 2.8571 5 yes
GO:0043024 ribosomal small subunit binding 2.8571 4 yes
GO:0140666 annealing activity 2.8571 4 yes
GO:0034057 RNA strand-exchange activity 1.9048 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IF4B_HUMAN
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 56.1905 4 yes
GO:0080090 regulation of primary metabolic process 56.1905 4 yes
GO:0031323 regulation of cellular metabolic process 54.2857 4 yes
GO:0048522 positive regulation of cellular process 53.3333 4 no
GO:0010468 regulation of gene expression 50.4762 5 yes
GO:0048523 negative regulation of cellular process 49.5238 4 no
GO:0009889 regulation of biosynthetic process 43.8095 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 43.8095 5 yes
GO:0031326 regulation of cellular biosynthetic process 43.8095 5 yes
GO:0051246 regulation of protein metabolic process 40.9524 5 yes
GO:0009893 positive regulation of metabolic process 40.9524 4 no
GO:0009892 negative regulation of metabolic process 39.0476 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.0952 5 no
GO:0010605 negative regulation of macromolecule metabolic process 36.1905 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.1905 5 no
GO:0009059 macromolecule biosynthetic process 35.2381 4 no
GO:0051252 regulation of RNA metabolic process 35.2381 5 no
GO:0022607 cellular component assembly 34.2857 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 34.2857 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 34.2857 5 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0034645 cellular macromolecule biosynthetic process 32.3810 4 no
GO:0006412 translation 31.4286 4 no
GO:0006518 peptide metabolic process 31.4286 4 no
GO:0043043 peptide biosynthetic process 31.4286 5 no
GO:0043603 cellular amide metabolic process 31.4286 4 no
GO:0043604 amide biosynthetic process 31.4286 5 no
GO:1901566 organonitrogen compound biosynthetic process 31.4286 4 no
GO:0051128 regulation of cellular component organization 31.4286 4 no
GO:0002181 cytoplasmic translation 30.4762 5 no
GO:0031325 positive regulation of cellular metabolic process 30.4762 5 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:1903506 regulation of nucleic acid-templated transcription 27.6190 7 no
GO:2001141 regulation of RNA biosynthetic process 27.6190 6 no
GO:0010628 positive regulation of gene expression 27.6190 6 no
GO:0051247 positive regulation of protein metabolic process 27.6190 6 no
GO:0006355 regulation of DNA-templated transcription 26.6667 6 no
GO:0090304 nucleic acid metabolic process 25.7143 4 no
GO:0043933 protein-containing complex organization 24.7619 4 yes
GO:0010941 regulation of cell death 24.7619 4 no
GO:0016070 RNA metabolic process 23.8095 5 no
GO:0008104 protein localization 23.8095 4 no
GO:0006996 organelle organization 23.8095 4 no
GO:0042981 regulation of apoptotic process 22.8571 6 no
GO:0043067 regulation of programmed cell death 22.8571 5 no
GO:1902531 regulation of intracellular signal transduction 22.8571 5 no
GO:0065003 protein-containing complex assembly 21.9048 5 yes
GO:0031399 regulation of protein modification process 21.9048 6 no
GO:0048584 positive regulation of response to stimulus 20.9524 4 no
GO:0009891 positive regulation of biosynthetic process 20.9524 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.9524 6 no
GO:0031328 positive regulation of cellular biosynthetic process 20.9524 6 no
GO:0051248 negative regulation of protein metabolic process 20.9524 6 no
GO:0034248 regulation of cellular amide metabolic process 19.0476 5 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 19.0476 6 yes
GO:0006417 regulation of translation 18.0952 6 yes
GO:0010608 post-transcriptional regulation of gene expression 18.0952 6 yes
GO:0022618 ribonucleoprotein complex assembly 12.3810 6 yes
GO:0071826 ribonucleoprotein complex subunit organization 12.3810 5 yes
GO:0006446 regulation of translational initiation 8.5714 7 yes
GO:0001731 formation of translation preinitiation complex 1.9048 7 yes
GO:0097010 eukaryotic translation initiation factor 4F complex assembly 1.9048 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in IF4B_HUMAN
DOID:1289 neurodegenerative disease 2.8571 4 no
DOID:331 central nervous system disease 2.8571 3 no
DOID:231 motor neuron disease 1.9048 5 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
STK11_HUMAN [view interactions] Low throughput no yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
IF4G1_HUMAN [view entry] [view interactions] Low throughput yes yes
OTU6B_HUMAN [view interactions] Low throughput no yes
CSPG4_HUMAN [view interactions] Low throughput no yes
IF4B_HUMAN [view entry] [view interactions] Low throughput yes yes
EIF3A_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP11_HUMAN [view interactions] Low throughput no yes
SMAD3_HUMAN [view interactions] Low throughput no yes
PABP1_HUMAN [view entry] [view interactions] Low throughput yes yes
DDX3X_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6A1_HUMAN [view interactions] Low throughput no yes
KCC2D_HUMAN [view entry] [view interactions] Low throughput yes yes
PLK1_HUMAN [view interactions] Low throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
FBX6_HUMAN [view interactions] High throughput no yes
MGN_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
FBX32_HUMAN [view interactions] High throughput no no
PAN2_HUMAN [view interactions] High throughput no no
PLCB1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ASB2_HUMAN [view interactions] High throughput no no
ZBTB1_HUMAN [view interactions] High throughput no no
FBW1B_HUMAN [view interactions] High throughput no yes
MAEL_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
GAN_HUMAN [view interactions] High throughput no yes
RC3H1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
GRHPR_HUMAN [view entry] [view interactions] High throughput yes no
U5S1_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP2_HUMAN [view interactions] High throughput no yes
RNF31_HUMAN [view interactions] High throughput no yes
SNAI1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
TISD_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
ALBU_HUMAN [view interactions] High throughput no no
ANR53_HUMAN [view interactions] High throughput no no
ARPC5_HUMAN [view interactions] High throughput no yes
BAZ2A_HUMAN [view interactions] High throughput no no
RTRAF_HUMAN [view interactions] High throughput no yes
RTCB_HUMAN [view interactions] High throughput no yes
CDON_HUMAN [view interactions] High throughput no no
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX3Y_HUMAN [view interactions] High throughput no yes
DEN1C_HUMAN [view interactions] High throughput no no
DLEC1_HUMAN [view interactions] High throughput no no
DSG4_HUMAN [view interactions] High throughput no no
EIF3D_HUMAN [view interactions] High throughput no yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3G_HUMAN [view interactions] High throughput no yes
EIF3J_HUMAN [view interactions] High throughput no yes
EIF3K_HUMAN [view interactions] High throughput no yes
EIF3L_HUMAN [view interactions] High throughput no yes
FA98A_HUMAN [view interactions] High throughput no no
FEZF2_HUMAN [view interactions] High throughput no no
FGF11_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPU_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
RT23_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
RB12B_HUMAN [view interactions] High throughput no yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
RL14_HUMAN [view entry] [view interactions] High throughput yes yes
RL18_HUMAN [view entry] [view interactions] High throughput yes yes
RL22_HUMAN [view entry] [view interactions] High throughput yes no
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
RL24_HUMAN [view entry] [view interactions] High throughput yes yes
RL31_HUMAN [view entry] [view interactions] High throughput yes yes
RL9_HUMAN [view entry] [view interactions] High throughput yes yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
RS11_HUMAN [view entry] [view interactions] High throughput yes yes
RS12_HUMAN [view entry] [view interactions] High throughput yes yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
RS14_HUMAN [view entry] [view interactions] High throughput yes yes
RS15A_HUMAN [view entry] [view interactions] High throughput yes yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
RS17_HUMAN [view entry] [view interactions] High throughput yes yes
RS18_HUMAN [view entry] [view interactions] High throughput yes yes
RS19_HUMAN [view entry] [view interactions] High throughput yes no
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
RS23_HUMAN [view entry] [view interactions] High throughput yes yes
RS24_HUMAN [view entry] [view interactions] High throughput yes yes
RS25_HUMAN [view entry] [view interactions] High throughput yes yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
RS3A_HUMAN [view entry] [view interactions] High throughput yes yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
RS5_HUMAN [view entry] [view interactions] High throughput yes yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
RS7_HUMAN [view entry] [view interactions] High throughput yes yes
RS8_HUMAN [view entry] [view interactions] High throughput yes no
RS9_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF3_HUMAN [view interactions] High throughput no yes
S45A3_HUMAN [view interactions] High throughput no no
SMD1_HUMAN [view interactions] High throughput no yes
SMD3_HUMAN [view interactions] High throughput no yes
RSMN_HUMAN [view interactions] High throughput no yes
SRSF9_HUMAN [view interactions] High throughput no yes
TM232_HUMAN [view interactions] High throughput no no
BACD2_HUMAN [view interactions] High throughput no no
TPPC8_HUMAN [view interactions] High throughput no yes
USP9Y_HUMAN [view interactions] High throughput no no
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3M_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
GLUC_HUMAN [view interactions] High throughput no no
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
ZBT7B_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
TRIM6_HUMAN [view interactions] High throughput no no
CHM4C_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
INS_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CIC_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
F16P1_HUMAN [view interactions] High throughput no no
IF16_HUMAN [view interactions] High throughput no no
GRB7_HUMAN [view interactions] High throughput no no
TXNIP_HUMAN [view interactions] High throughput no no
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
IKKE_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
PAGE4_HUMAN [view interactions] High throughput no no
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
NIF3L_HUMAN [view interactions] High throughput no yes
RBP10_HUMAN [view interactions] High throughput no no
NCOA5_HUMAN [view interactions] High throughput no yes
NALP7_HUMAN [view interactions] High throughput no no
CLU_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP2_HUMAN [view entry] [view interactions] High throughput yes yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MAP2_HUMAN [view interactions] High throughput no yes
PSPC1_HUMAN [view interactions] High throughput no yes
RBM42_HUMAN [view interactions] High throughput no yes
RBM8A_HUMAN [view interactions] High throughput no yes
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
SRP09_HUMAN [view interactions] High throughput no no
ATG12_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RHOU_HUMAN [view interactions] High throughput no no
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
IF4A1_HUMAN [view interactions] High throughput no no
RL29_HUMAN [view entry] [view interactions] High throughput yes yes
PHAX_HUMAN [view interactions] High throughput no yes
IF4G2_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
CSTF2_HUMAN [view interactions] High throughput no yes
NU107_HUMAN [view interactions] High throughput no no
NU153_HUMAN [view interactions] High throughput no yes
NADAP_HUMAN [view interactions] High throughput no yes
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
RPAC1_HUMAN [view interactions] High throughput no no
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4B_HUMAN [view interactions] High throughput no yes
SYNC_HUMAN [view interactions] High throughput no yes
OSBP1_HUMAN [view interactions] High throughput no yes
SAMH1_HUMAN [view interactions] High throughput no yes
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC5_HUMAN [view interactions] High throughput no yes
ANM3_HUMAN [view interactions] High throughput no yes
SF01_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
COF1_HUMAN [view entry] [view interactions] High throughput yes no
PYRG1_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
NELL1_HUMAN [view interactions] High throughput no yes
DOHH_HUMAN [view interactions] High throughput no yes
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
ERF3A_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
IMDH2_HUMAN [view interactions] High throughput no yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
FUBP2_HUMAN [view interactions] High throughput no yes
AGO3_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
AGO4_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3H_HUMAN [view interactions] High throughput no yes
BRSK2_HUMAN [view interactions] High throughput no no
RM45_HUMAN [view interactions] High throughput no no
UBP7_HUMAN [view interactions] High throughput no yes
MYCBP_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
MTM1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
NAA10_HUMAN [view interactions] High throughput no yes
GBF1_HUMAN [view interactions] High throughput no yes
DCA15_HUMAN [view interactions] High throughput no no
TTL12_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
ERC6L_HUMAN [view interactions] High throughput no yes
IF4A2_HUMAN [view entry] [view interactions] High throughput yes yes
MPIP2_HUMAN [view interactions] High throughput no no
RN183_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
PAIRB_HUMAN [view interactions] High throughput no yes
WIZ_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
TMEDA_HUMAN [view interactions] High throughput no yes
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
IFT88_HUMAN [view interactions] High throughput no no
SLN11_HUMAN [view interactions] High throughput no yes
MTA70_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
SAP_HUMAN [view interactions] High throughput no yes
CRY1_HUMAN [view interactions] High throughput no yes
DOK2_HUMAN [view interactions] High throughput no no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
CRCDL_HUMAN [view interactions] High throughput no yes
PHAR1_HUMAN [view entry] [view interactions] High throughput yes yes
P66A_HUMAN [view interactions] High throughput no yes
TINF2_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
PCNA_HUMAN [view interactions] High throughput no no
P85A_HUMAN [view interactions] High throughput no yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3I_HUMAN [view interactions] High throughput no yes
EIF3B_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
CRYAA_HUMAN [view interactions] High throughput no no
KLK6_HUMAN [view interactions] High throughput no no
CCD15_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
PLK4_HUMAN [view interactions] High throughput no yes
PRD13_HUMAN [view interactions] High throughput no no
TDRD5_HUMAN [view interactions] High throughput no no
TIFAB_HUMAN [view interactions] High throughput no no
LTOR5_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
ACD_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
CPSF7_HUMAN [view interactions] High throughput no yes
EIF3F_HUMAN [view interactions] High throughput no yes