SLK_HUMAN
Evidence for PS localization
Functions
Mediates apoptosis and actin stress fiber dissolution. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SLK_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 42.8571 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 39.2857 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 39.2857 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 35.7143 | 5 | yes |
| GO:0005524 | ATP binding | 32.1429 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 32.1429 | 5 | yes |
| GO:0045296 | cadherin binding | 28.5714 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 25.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.0000 | 6 | no |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 25.0000 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 21.4286 | 5 | no |
| GO:0004674 | protein serine/threonine kinase activity | 14.2857 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 14.2857 | 4 | yes |
| GO:0016301 | kinase activity | 14.2857 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 14.2857 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 14.2857 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 7.1429 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SLK_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 71.4286 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 64.2857 | 4 | no |
| GO:0006996 | organelle organization | 57.1429 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 57.1429 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 42.8571 | 4 | yes |
| GO:0008104 | protein localization | 42.8571 | 4 | no |
| GO:0051049 | regulation of transport | 39.2857 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.2857 | 5 | no |
| GO:0010941 | regulation of cell death | 39.2857 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 39.2857 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 39.2857 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 39.2857 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.2857 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.2857 | 5 | no |
| GO:0022607 | cellular component assembly | 39.2857 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.7143 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 35.7143 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.7143 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.7143 | 4 | no |
| GO:0010468 | regulation of gene expression | 35.7143 | 5 | no |
| GO:0071310 | cellular response to organic substance | 32.1429 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 32.1429 | 4 | yes |
| GO:0015031 | protein transport | 32.1429 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 32.1429 | 4 | no |
| GO:0071702 | organic substance transport | 32.1429 | 4 | no |
| GO:0071705 | nitrogen compound transport | 32.1429 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.1429 | 5 | no |
| GO:0031399 | regulation of protein modification process | 32.1429 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 32.1429 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
| GO:0051726 | regulation of cell cycle | 28.5714 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 28.5714 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.5714 | 6 | no |
| GO:0060341 | regulation of cellular localization | 28.5714 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 28.5714 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 28.5714 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 28.5714 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.5714 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.5714 | 5 | no |
| GO:0033043 | regulation of organelle organization | 28.5714 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0060548 | negative regulation of cell death | 25.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0006886 | intracellular protein transport | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 25.0000 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.0000 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.0000 | 6 | no |
| GO:0045597 | positive regulation of cell differentiation | 25.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.4286 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.4286 | 6 | no |
| GO:0061024 | membrane organization | 21.4286 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.4286 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 21.4286 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 21.4286 | 4 | yes |
| GO:0030334 | regulation of cell migration | 21.4286 | 5 | yes |
| GO:0036211 | protein modification process | 21.4286 | 4 | yes |
| GO:0043412 | macromolecule modification | 21.4286 | 4 | yes |
| GO:2000145 | regulation of cell motility | 21.4286 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 21.4286 | 5 | no |
| GO:0008285 | negative regulation of cell population proliferation | 21.4286 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 21.4286 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.4286 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 21.4286 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.4286 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.4286 | 4 | no |
| GO:0023057 | negative regulation of signaling | 21.4286 | 4 | no |
| GO:0030162 | regulation of proteolysis | 21.4286 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.4286 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 21.4286 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.4286 | 4 | no |
| GO:0006468 | protein phosphorylation | 17.8571 | 5 | yes |
| GO:0016310 | phosphorylation | 17.8571 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 17.8571 | 4 | yes |
| GO:0006915 | apoptotic process | 14.2857 | 4 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 14.2857 | 5 | yes |
| GO:0031122 | cytoplasmic microtubule organization | 14.2857 | 4 | yes |
| GO:1901888 | regulation of cell junction assembly | 14.2857 | 5 | yes |
| GO:0001952 | regulation of cell-matrix adhesion | 10.7143 | 6 | yes |
| GO:0046777 | protein autophosphorylation | 10.7143 | 6 | yes |
| GO:0051893 | regulation of focal adhesion assembly | 10.7143 | 7 | yes |
| GO:0090109 | regulation of cell-substrate junction assembly | 10.7143 | 6 | yes |
| GO:0150116 | regulation of cell-substrate junction organization | 10.7143 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| NHRF3_HUMAN | [view interactions] | Low throughput | no | no |
| SLK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KEAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| RBM28_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| DDX27_HUMAN | [view interactions] | High throughput | no | no |
| MISSL_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS2_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYG_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RIR2_HUMAN | [view interactions] | High throughput | no | no |
| GYS1_HUMAN | [view interactions] | High throughput | no | yes |
| ENSA_HUMAN | [view interactions] | High throughput | no | yes |
| PAX7_HUMAN | [view interactions] | High throughput | no | no |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| RM43_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| SAP18_HUMAN | [view interactions] | High throughput | no | yes |
| ANR39_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZIM2_HUMAN | [view interactions] | High throughput | no | no |
| MILR1_HUMAN | [view interactions] | High throughput | no | no |
| BBS1_HUMAN | [view interactions] | High throughput | no | no |
| CH076_HUMAN | [view interactions] | High throughput | no | yes |
| MOB1B_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| DNJC8_HUMAN | [view interactions] | High throughput | no | yes |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| BORC8_HUMAN | [view interactions] | High throughput | no | yes |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| TBCD9_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| MED17_HUMAN | [view interactions] | High throughput | no | no |
| SUV92_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| RBL2A_HUMAN | [view interactions] | High throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HGH1_HUMAN | [view interactions] | High throughput | no | no |
| TTC4_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPP2_HUMAN | [view interactions] | High throughput | no | no |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PITH1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP3_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| CSTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| KCC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCP4_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK2_HUMAN | [view interactions] | High throughput | no | no |
| GEMI6_HUMAN | [view interactions] | Computational | no | yes |
| CDK1_HUMAN | [view interactions] | Computational | no | no |
| PLK1_HUMAN | [view interactions] | Computational | no | yes |
| CCNB2_HUMAN | [view interactions] | Computational | no | yes |