SLK_HUMAN
Evidence for PS localization
Functions
Mediates apoptosis and actin stress fiber dissolution. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SLK_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 37.9310 | 4 | yes |
| GO:0000166 | nucleotide binding | 36.2069 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 34.4828 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 34.4828 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.4828 | 4 | yes |
| GO:0003723 | RNA binding | 31.0345 | 4 | no |
| GO:0005524 | ATP binding | 29.3103 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 29.3103 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 29.3103 | 5 | yes |
| GO:0045296 | cadherin binding | 22.4138 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 22.4138 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.4138 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.4138 | 6 | no |
| GO:0004674 | protein serine/threonine kinase activity | 8.6207 | 4 | yes |
| GO:0016301 | kinase activity | 8.6207 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 8.6207 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 8.6207 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 5.1724 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SLK_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.7931 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 62.0690 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 60.3448 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 58.6207 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 56.8966 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 48.2759 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 48.2759 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 48.2759 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 44.8276 | 4 | yes |
| GO:0006996 | organelle organization | 44.8276 | 4 | yes |
| GO:0010468 | regulation of gene expression | 43.1034 | 6 | no |
| GO:0008104 | protein localization | 39.6552 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.6552 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 37.9310 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.9310 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 36.2069 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.2069 | 5 | no |
| GO:0022607 | cellular component assembly | 36.2069 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 34.4828 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.7586 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 32.7586 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.0345 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 31.0345 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.3103 | 5 | no |
| GO:0031399 | regulation of protein modification process | 29.3103 | 6 | no |
| GO:0071702 | organic substance transport | 29.3103 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 27.5862 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 27.5862 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 27.5862 | 5 | no |
| GO:0060341 | regulation of cellular localization | 27.5862 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.5862 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.5862 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.8621 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.8621 | 6 | no |
| GO:0051049 | regulation of transport | 25.8621 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.8621 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.8621 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.8621 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.1379 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.1379 | 6 | no |
| GO:0032880 | regulation of protein localization | 24.1379 | 5 | no |
| GO:0051726 | regulation of cell cycle | 24.1379 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.1379 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 24.1379 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.1379 | 4 | no |
| GO:0015031 | protein transport | 22.4138 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.4138 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.4138 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.4138 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.4138 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.4138 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.4138 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.4138 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.6897 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 20.6897 | 7 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.6897 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.6897 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 20.6897 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.6897 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 20.6897 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 18.9655 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 17.2414 | 4 | yes |
| GO:0036211 | protein modification process | 17.2414 | 4 | yes |
| GO:0043412 | macromolecule modification | 17.2414 | 4 | yes |
| GO:0030334 | regulation of cell migration | 15.5172 | 5 | yes |
| GO:2000145 | regulation of cell motility | 15.5172 | 4 | yes |
| GO:0006915 | apoptotic process | 12.0690 | 4 | yes |
| GO:0016310 | phosphorylation | 10.3448 | 5 | yes |
| GO:0006468 | protein phosphorylation | 10.3448 | 5 | yes |
| GO:0031122 | cytoplasmic microtubule organization | 8.6207 | 4 | yes |
| GO:1901888 | regulation of cell junction assembly | 8.6207 | 5 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 6.8966 | 5 | yes |
| GO:0051893 | regulation of focal adhesion assembly | 5.1724 | 7 | yes |
| GO:0090109 | regulation of cell-substrate junction assembly | 5.1724 | 6 | yes |
| GO:0150116 | regulation of cell-substrate junction organization | 5.1724 | 5 | yes |
| GO:0001952 | regulation of cell-matrix adhesion | 5.1724 | 6 | yes |
| GO:0046777 | protein autophosphorylation | 3.4483 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SLK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KEAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| NHRF3_HUMAN | [view interactions] | Low throughput | no | no |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PITH1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAT1_HUMAN | [view interactions] | High throughput | no | yes |
| OGA_HUMAN | [view interactions] | High throughput | no | yes |
| PSD10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| GNS_HUMAN | [view interactions] | High throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBMX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F10A1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| SPSY_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| PURA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5A_HUMAN | [view interactions] | High throughput | no | yes |
| ELOB_HUMAN | [view interactions] | High throughput | no | no |
| ADRM1_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD4_HUMAN | [view interactions] | High throughput | no | yes |
| WDR44_HUMAN | [view interactions] | High throughput | no | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD50_HUMAN | [view interactions] | High throughput | no | yes |
| TOPK_HUMAN | [view interactions] | High throughput | no | no |
| IPO9_HUMAN | [view interactions] | High throughput | no | no |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| RPAP3_HUMAN | [view interactions] | High throughput | no | yes |
| RRAGC_HUMAN | [view interactions] | High throughput | no | yes |
| NRBP_HUMAN | [view interactions] | High throughput | no | yes |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| RBGP1_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| CSTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| KCC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENSA_HUMAN | [view interactions] | High throughput | no | yes |
| GYS1_HUMAN | [view interactions] | High throughput | no | yes |
| RIR2_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| GLYG_HUMAN | [view interactions] | High throughput | no | yes |
| TCP4_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS2_HUMAN | [view interactions] | High throughput | no | yes |
| MISSL_HUMAN | [view interactions] | High throughput | no | yes |
| DDX27_HUMAN | [view interactions] | High throughput | no | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| RBM28_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK2_HUMAN | [view interactions] | High throughput | no | no |
| PAX7_HUMAN | [view interactions] | High throughput | no | no |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| RM43_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| SAP18_HUMAN | [view interactions] | High throughput | no | yes |
| ANR39_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZIM2_HUMAN | [view interactions] | High throughput | no | no |
| MILR1_HUMAN | [view interactions] | High throughput | no | no |
| BBS1_HUMAN | [view interactions] | High throughput | no | no |
| CH076_HUMAN | [view interactions] | High throughput | no | yes |
| MOB1B_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| DNJC8_HUMAN | [view interactions] | High throughput | no | yes |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| BORC8_HUMAN | [view interactions] | High throughput | no | yes |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| TBCD9_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| MED17_HUMAN | [view interactions] | High throughput | no | no |
| SUV92_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CYTSB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| RBL2A_HUMAN | [view interactions] | High throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HGH1_HUMAN | [view interactions] | High throughput | no | no |
| TTC4_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPP2_HUMAN | [view interactions] | High throughput | no | no |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |