PURA_HUMAN
This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination. [View more on UniProt]
Interacting region for partners were not defined.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PURA_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 56.6667 | 4 | yes |
GO:0003677 | DNA binding | 10.0000 | 4 | yes |
GO:0140297 | DNA-binding transcription factor binding | 8.3333 | 4 | yes |
GO:0003690 | double-stranded DNA binding | 6.6667 | 5 | yes |
GO:0003697 | single-stranded DNA binding | 6.6667 | 5 | yes |
GO:0043565 | sequence-specific DNA binding | 6.6667 | 5 | yes |
GO:0000976 | transcription cis-regulatory region binding | 3.3333 | 5 | yes |
GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 3.3333 | 6 | yes |
GO:0001067 | transcription regulatory region nucleic acid binding | 3.3333 | 4 | yes |
GO:0032422 | purine-rich negative regulatory element binding | 3.3333 | 6 | yes |
GO:0042162 | telomeric DNA binding | 3.3333 | 6 | yes |
GO:1990837 | sequence-specific double-stranded DNA binding | 3.3333 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PURA_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 55.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 48.3333 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 48.3333 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 46.6667 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 46.6667 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 43.3333 | 4 | yes |
GO:0010468 | regulation of gene expression | 40.0000 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 38.3333 | 4 | yes |
GO:0022607 | cellular component assembly | 38.3333 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 36.6667 | 5 | yes |
GO:0010646 | regulation of cell communication | 36.6667 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 35.0000 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 35.0000 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 35.0000 | 5 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 35.0000 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 35.0000 | 5 | no |
GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.6667 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 31.6667 | 5 | yes |
GO:0051252 | regulation of RNA metabolic process | 31.6667 | 5 | yes |
GO:0006412 | translation | 31.6667 | 4 | no |
GO:0006518 | peptide metabolic process | 31.6667 | 4 | no |
GO:0009059 | macromolecule biosynthetic process | 31.6667 | 4 | no |
GO:0034645 | cellular macromolecule biosynthetic process | 31.6667 | 4 | no |
GO:0043043 | peptide biosynthetic process | 31.6667 | 5 | no |
GO:0043603 | cellular amide metabolic process | 31.6667 | 4 | no |
GO:0043604 | amide biosynthetic process | 31.6667 | 5 | no |
GO:0044271 | cellular nitrogen compound biosynthetic process | 31.6667 | 4 | no |
GO:1901566 | organonitrogen compound biosynthetic process | 31.6667 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 31.6667 | 5 | no |
GO:0009966 | regulation of signal transduction | 31.6667 | 4 | no |
GO:0002181 | cytoplasmic translation | 30.0000 | 5 | no |
GO:0010941 | regulation of cell death | 30.0000 | 4 | no |
GO:0006996 | organelle organization | 28.3333 | 4 | yes |
GO:0036211 | protein modification process | 28.3333 | 4 | no |
GO:0043412 | macromolecule modification | 28.3333 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.3333 | 5 | no |
GO:0090304 | nucleic acid metabolic process | 26.6667 | 4 | yes |
GO:0043933 | protein-containing complex organization | 26.6667 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 26.6667 | 6 | no |
GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
GO:0043067 | regulation of programmed cell death | 26.6667 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | yes |
GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
GO:0042981 | regulation of apoptotic process | 25.0000 | 6 | no |
GO:0006355 | regulation of DNA-templated transcription | 23.3333 | 6 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 23.3333 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 23.3333 | 6 | yes |
GO:0016070 | RNA metabolic process | 23.3333 | 5 | no |
GO:0031329 | regulation of cellular catabolic process | 23.3333 | 5 | no |
GO:0042325 | regulation of phosphorylation | 23.3333 | 7 | no |
GO:1902531 | regulation of intracellular signal transduction | 23.3333 | 5 | no |
GO:0006396 | RNA processing | 21.6667 | 6 | no |
GO:0044087 | regulation of cellular component biogenesis | 21.6667 | 4 | no |
GO:0065003 | protein-containing complex assembly | 21.6667 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 21.6667 | 6 | no |
GO:0080134 | regulation of response to stress | 21.6667 | 4 | no |
GO:0009890 | negative regulation of biosynthetic process | 20.0000 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.0000 | 6 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 20.0000 | 6 | yes |
GO:0006357 | regulation of transcription by RNA polymerase II | 16.6667 | 7 | yes |
GO:0008284 | positive regulation of cell population proliferation | 15.0000 | 5 | yes |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 13.3333 | 6 | yes |
GO:0051253 | negative regulation of RNA metabolic process | 10.0000 | 6 | yes |
GO:0045892 | negative regulation of DNA-templated transcription | 6.6667 | 7 | yes |
GO:1902679 | negative regulation of RNA biosynthetic process | 6.6667 | 7 | yes |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 6.6667 | 8 | yes |
GO:0000122 | negative regulation of transcription by RNA polymerase II | 5.0000 | 8 | yes |
GO:0006259 | DNA metabolic process | 5.0000 | 4 | yes |
GO:0007399 | nervous system development | 5.0000 | 4 | yes |
GO:0008088 | axo-dendritic transport | 3.3333 | 5 | yes |
GO:0010970 | transport along microtubule | 3.3333 | 4 | yes |
GO:0030705 | cytoskeleton-dependent intracellular transport | 3.3333 | 4 | yes |
GO:0032943 | mononuclear cell proliferation | 3.3333 | 4 | yes |
GO:0046651 | lymphocyte proliferation | 3.3333 | 4 | yes |
GO:0099111 | microtubule-based transport | 3.3333 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in PURA_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 3.3333 | 3 | no |
DOID:480 | movement disease | 3.3333 | 5 | no |
DOID:936 | brain disease | 3.3333 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
H11_HUMAN | [view interactions] | Low throughput | no | no |
CCNT1_HUMAN | [view interactions] | Low throughput | no | yes |
CCNA2_HUMAN | [view interactions] | Low throughput | no | no |
CCNE1_HUMAN | [view interactions] | Low throughput | no | no |
CCNB1_HUMAN | [view interactions] | Low throughput | no | no |
CCND1_HUMAN | [view interactions] | Low throughput | no | yes |
CCNH_HUMAN | [view interactions] | Low throughput | no | yes |
CDK1_HUMAN | [view interactions] | Low throughput | no | no |
CDK4_HUMAN | [view interactions] | Low throughput | no | no |
CDK2_HUMAN | [view interactions] | Low throughput | no | yes |
RB_HUMAN | [view interactions] | Low throughput | no | yes |
SP1_HUMAN | [view interactions] | Low throughput | no | yes |
E2F1_HUMAN | [view interactions] | Low throughput | no | yes |
CDK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RL14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRKRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RN151_HUMAN | [view interactions] | High throughput | no | no |
RL13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
U3IP2_HUMAN | [view interactions] | High throughput | no | yes |
FGFP1_HUMAN | [view interactions] | High throughput | no | no |
RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MECP2_HUMAN | [view interactions] | High throughput | no | yes |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IL7RA_HUMAN | [view interactions] | High throughput | no | no |
PURB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZN638_HUMAN | [view interactions] | High throughput | no | yes |
RFC3_HUMAN | [view interactions] | High throughput | no | yes |
DDX23_HUMAN | [view interactions] | High throughput | no | yes |
RFC2_HUMAN | [view interactions] | High throughput | no | yes |
DPOLA_HUMAN | [view interactions] | High throughput | no | yes |
SDHF3_HUMAN | [view interactions] | High throughput | no | yes |
TRI14_HUMAN | [view interactions] | High throughput | no | yes |
TM11B_HUMAN | [view interactions] | High throughput | no | no |
TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E2AK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H14_HUMAN | [view interactions] | High throughput | no | yes |
RRS1_HUMAN | [view interactions] | High throughput | no | yes |
ZCRB1_HUMAN | [view interactions] | High throughput | no | no |
XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KI67_HUMAN | [view interactions] | High throughput | no | no |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MOT11_HUMAN | [view interactions] | High throughput | no | no |
LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTCF_HUMAN | [view interactions] | High throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OASL_HUMAN | [view interactions] | High throughput | no | no |
P2RY6_HUMAN | [view interactions] | High throughput | no | no |
FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPSH1_HUMAN | [view interactions] | High throughput | no | yes |
KSYK_HUMAN | [view interactions] | High throughput | no | no |
FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
PACE1_HUMAN | [view interactions] | High throughput | no | yes |
DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
SGK3_HUMAN | [view interactions] | High throughput | no | yes |
PLK3_HUMAN | [view interactions] | High throughput | no | no |
SRPK3_HUMAN | [view interactions] | High throughput | no | no |
SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAST1_HUMAN | [view interactions] | High throughput | no | yes |
CPEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CNBP_HUMAN | [view interactions] | High throughput | no | no |
SNW1_HUMAN | [view interactions] | High throughput | no | yes |
VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CUL1_HUMAN | [view interactions] | High throughput | no | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VGFR1_HUMAN | [view interactions] | High throughput | no | no |
VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
RARA_HUMAN | [view interactions] | High throughput | no | no |
IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ICAM1_HUMAN | [view interactions] | High throughput | no | no |
TADBP_HUMAN | [view interactions] | High throughput | no | yes |
LN28A_HUMAN | [view interactions] | High throughput | no | no |
LN28B_HUMAN | [view interactions] | High throughput | no | no |
SURF2_HUMAN | [view interactions] | High throughput | no | yes |
ZC3H3_HUMAN | [view interactions] | High throughput | no | yes |
RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PRR11_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
WDR46_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
LARP7_HUMAN | [view interactions] | High throughput | no | yes |
AGO2_HUMAN | [view interactions] | High throughput | no | yes |
SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HABP4_HUMAN | [view interactions] | High throughput | no | yes |
PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CGAS_HUMAN | [view interactions] | High throughput | no | yes |
WDR76_HUMAN | [view interactions] | High throughput | no | no |
H4_HUMAN | [view interactions] | High throughput | no | yes |
H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
RU17_HUMAN | [view interactions] | High throughput | no | yes |
ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
BRD7_HUMAN | [view interactions] | High throughput | no | yes |
ARI2_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
ZN263_HUMAN | [view interactions] | High throughput | no | yes |
MAFB_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
MKRN1_HUMAN | [view interactions] | High throughput | no | no |
IF16_HUMAN | [view interactions] | High throughput | no | no |
NHP2_HUMAN | [view interactions] | High throughput | no | yes |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
FZR1_HUMAN | [view interactions] | High throughput | no | no |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
F120A_HUMAN | [view interactions] | High throughput | no | yes |
NEIL1_HUMAN | [view interactions] | High throughput | no | yes |
RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABT1_HUMAN | [view interactions] | High throughput | no | no |
H2A1_HUMAN | [view interactions] | High throughput | no | yes |
RL17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RED1_HUMAN | [view interactions] | High throughput | no | no |
MAGB2_HUMAN | [view interactions] | High throughput | no | no |
H12_HUMAN | [view interactions] | High throughput | no | yes |
RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LLPH_HUMAN | [view interactions] | High throughput | no | no |
H2AB2_HUMAN | [view interactions] | High throughput | no | no |
H15_HUMAN | [view interactions] | High throughput | no | no |
MBB1A_HUMAN | [view interactions] | High throughput | no | yes |
RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRR3_HUMAN | [view interactions] | High throughput | no | no |
SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
H2A2C_HUMAN | [view interactions] | High throughput | no | yes |
RBM19_HUMAN | [view interactions] | High throughput | no | yes |
DDX21_HUMAN | [view interactions] | High throughput | no | yes |
LYAR_HUMAN | [view interactions] | High throughput | no | no |
SRSF6_HUMAN | [view interactions] | High throughput | no | yes |
RL1D1_HUMAN | [view interactions] | High throughput | no | yes |
RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FGF8_HUMAN | [view interactions] | High throughput | no | no |
REXO4_HUMAN | [view interactions] | High throughput | no | yes |
RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H13_HUMAN | [view interactions] | High throughput | no | no |
YBOX2_HUMAN | [view interactions] | High throughput | no | no |
KRR1_HUMAN | [view interactions] | High throughput | no | yes |
RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RBMS2_HUMAN | [view interactions] | High throughput | no | yes |
SRSF4_HUMAN | [view interactions] | High throughput | no | yes |
PURG_HUMAN | [view interactions] | High throughput | no | yes |
RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DGCR8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZN668_HUMAN | [view interactions] | High throughput | no | yes |
RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SURF6_HUMAN | [view interactions] | High throughput | no | yes |
RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZNF71_HUMAN | [view interactions] | High throughput | no | no |
ZN346_HUMAN | [view interactions] | High throughput | no | yes |
RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MDHM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MCM3_HUMAN | [view interactions] | Computational | no | no |
YBOX1_HUMAN | [view interactions] | Computational | no | yes |
MCM8_HUMAN | [view interactions] | Computational | no | no |
GNPTA_HUMAN | [view interactions] | Computational | no | yes |