Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PURA_HUMAN

This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination. [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
89 Ala Pro Neurodevelopmentaldisorderwithneonatalrespiratoryinsufficiency,hypotonia,andfeedingdifficulties(NEDRIHF) -
97 Lys Glu Neurodevelopmentaldisorderwithneonatalrespiratoryinsufficiency,hypotonia,andfeedingdifficulties(NEDRIHF) -
100 Leu Pro Neurodevelopmentaldisorderwithneonatalrespiratoryinsufficiency,hypotonia,andfeedingdifficulties(NEDRIHF) -
157 Met Lys Neurodevelopmentaldisorderwithneonatalrespiratoryinsufficiency,hypotonia,andfeedingdifficulties(NEDRIHF) -
199 Arg Pro Neurodevelopmentaldisorderwithneonatalrespiratoryinsufficiency,hypotonia,andfeedingdifficulties(NEDRIHF) -
206 Ile Phe Neurodevelopmentaldisorderwithneonatalrespiratoryinsufficiency,hypotonia,andfeedingdifficulties(NEDRIHF) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PURA_HUMAN
GO:0003723 RNA binding 51.2195 4 yes
GO:0003677 DNA binding 10.9756 4 yes
GO:0140297 DNA-binding transcription factor binding 8.5366 4 yes
GO:0003690 double-stranded DNA binding 7.3171 5 yes
GO:0043565 sequence-specific DNA binding 7.3171 5 yes
GO:0003697 single-stranded DNA binding 6.0976 5 yes
GO:0000976 transcription cis-regulatory region binding 4.8780 5 yes
GO:0001067 transcription regulatory region nucleic acid binding 4.8780 4 yes
GO:1990837 sequence-specific double-stranded DNA binding 4.8780 6 yes
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 3.6585 6 yes
GO:0032422 purine-rich negative regulatory element binding 3.6585 6 yes
GO:0042162 telomeric DNA binding 3.6585 6 yes
GO:0003691 double-stranded telomeric DNA binding 2.4390 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PURA_HUMAN
GO:0031323 regulation of cellular metabolic process 54.8780 4 yes
GO:0048522 positive regulation of cellular process 54.8780 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.8780 4 yes
GO:0080090 regulation of primary metabolic process 51.2195 4 yes
GO:0048523 negative regulation of cellular process 45.1220 4 yes
GO:0009889 regulation of biosynthetic process 43.9024 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 43.9024 5 yes
GO:0031326 regulation of cellular biosynthetic process 43.9024 5 yes
GO:0022607 cellular component assembly 42.6829 4 no
GO:0010468 regulation of gene expression 41.4634 6 yes
GO:0051128 regulation of cellular component organization 40.2439 4 no
GO:0009893 positive regulation of metabolic process 39.0244 4 no
GO:0051246 regulation of protein metabolic process 36.5854 5 no
GO:0009892 negative regulation of metabolic process 35.3659 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 35.3659 5 no
GO:0010605 negative regulation of macromolecule metabolic process 34.1463 5 yes
GO:0010646 regulation of cell communication 34.1463 4 no
GO:0031325 positive regulation of cellular metabolic process 34.1463 5 no
GO:0006996 organelle organization 32.9268 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.7073 5 yes
GO:0051252 regulation of RNA metabolic process 31.7073 5 yes
GO:0031324 negative regulation of cellular metabolic process 30.4878 5 yes
GO:0009966 regulation of signal transduction 28.0488 4 no
GO:0043933 protein-containing complex organization 28.0488 4 no
GO:0009059 macromolecule biosynthetic process 28.0488 4 no
GO:0009890 negative regulation of biosynthetic process 26.8293 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 26.8293 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 26.8293 6 yes
GO:0031399 regulation of protein modification process 26.8293 6 no
GO:0044087 regulation of cellular component biogenesis 25.6098 4 no
GO:0006412 translation 25.6098 4 no
GO:1901566 organonitrogen compound biosynthetic process 25.6098 4 no
GO:0019220 regulation of phosphate metabolic process 24.3902 6 no
GO:0036211 protein modification process 24.3902 4 no
GO:0043412 macromolecule modification 24.3902 4 no
GO:0051174 regulation of phosphorus metabolic process 24.3902 5 no
GO:0051247 positive regulation of protein metabolic process 24.3902 6 no
GO:0009891 positive regulation of biosynthetic process 24.3902 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.3902 6 no
GO:0031328 positive regulation of cellular biosynthetic process 24.3902 6 no
GO:0051248 negative regulation of protein metabolic process 24.3902 6 no
GO:0009894 regulation of catabolic process 24.3902 4 no
GO:0006355 regulation of DNA-templated transcription 23.1707 7 yes
GO:0042127 regulation of cell population proliferation 23.1707 4 yes
GO:0090304 nucleic acid metabolic process 23.1707 4 yes
GO:2001141 regulation of RNA biosynthetic process 23.1707 6 yes
GO:0048584 positive regulation of response to stimulus 23.1707 4 no
GO:0043067 regulation of programmed cell death 23.1707 4 no
GO:0065003 protein-containing complex assembly 23.1707 5 no
GO:0008104 protein localization 21.9512 4 no
GO:1902531 regulation of intracellular signal transduction 21.9512 5 no
GO:0042981 regulation of apoptotic process 21.9512 5 no
GO:0002181 cytoplasmic translation 21.9512 5 no
GO:0010647 positive regulation of cell communication 20.7317 5 no
GO:0023056 positive regulation of signaling 20.7317 4 no
GO:0030030 cell projection organization 20.7317 4 no
GO:0042325 regulation of phosphorylation 20.7317 7 no
GO:0006357 regulation of transcription by RNA polymerase II 15.8537 8 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 13.4146 5 yes
GO:0008284 positive regulation of cell population proliferation 12.1951 5 yes
GO:0051253 negative regulation of RNA metabolic process 10.9756 6 yes
GO:0045892 negative regulation of DNA-templated transcription 8.5366 8 yes
GO:1902679 negative regulation of RNA biosynthetic process 8.5366 7 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 7.3171 9 yes
GO:0006259 DNA metabolic process 4.8780 5 yes
GO:0007399 nervous system development 4.8780 4 yes
GO:0008088 axo-dendritic transport 3.6585 5 yes
GO:0010970 transport along microtubule 3.6585 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 3.6585 4 yes
GO:0099111 microtubule-based transport 3.6585 4 yes
GO:0006268 DNA unwinding involved in DNA replication 2.4390 9 yes
GO:0006270 DNA replication initiation 2.4390 6 yes
GO:0032392 DNA geometric change 2.4390 7 yes
GO:0032508 DNA duplex unwinding 2.4390 8 yes
GO:0032943 mononuclear cell proliferation 2.4390 4 yes
GO:0046651 lymphocyte proliferation 2.4390 4 yes
GO:0051276 chromosome organization 2.4390 5 yes
GO:0071103 DNA conformation change 2.4390 6 yes
GO:0098935 dendritic transport 2.4390 6 yes
GO:0098963 dendritic transport of messenger ribonucleoprotein complex 2.4390 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RB_HUMAN [view interactions] Low throughput no yes
SP1_HUMAN [view interactions] Low throughput no yes
E2F1_HUMAN [view interactions] Low throughput no yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
H11_HUMAN [view interactions] Low throughput no no
CCNT1_HUMAN [view interactions] Low throughput no yes
CCNA2_HUMAN [view interactions] Low throughput no no
CCNE1_HUMAN [view interactions] Low throughput no no
CCNB1_HUMAN [view interactions] Low throughput no no
CCND1_HUMAN [view interactions] Low throughput no yes
CCNH_HUMAN [view interactions] Low throughput no yes
CDK1_HUMAN [view interactions] Low throughput no no
CDK4_HUMAN [view interactions] Low throughput no no
PURA_HUMAN [view entry] [view interactions] Low throughput yes no
CDK2_HUMAN [view interactions] Low throughput no yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
E2AK2_HUMAN [view entry] [view interactions] High throughput yes yes
H14_HUMAN [view interactions] High throughput no yes
RRS1_HUMAN [view interactions] High throughput no yes
ZCRB1_HUMAN [view interactions] High throughput no no
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
KI67_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
MOT11_HUMAN [view interactions] High throughput no no
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
CTCF_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
OASL_HUMAN [view interactions] High throughput no no
P2RY6_HUMAN [view interactions] High throughput no no
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
KPSH1_HUMAN [view interactions] High throughput no yes
KSYK_HUMAN [view interactions] High throughput no no
FAK1_HUMAN [view entry] [view interactions] High throughput yes yes
SCYL2_HUMAN [view interactions] High throughput no yes
PACE1_HUMAN [view interactions] High throughput no yes
DYRK2_HUMAN [view interactions] High throughput no yes
SGK3_HUMAN [view interactions] High throughput no yes
PLK3_HUMAN [view interactions] High throughput no no
SRPK3_HUMAN [view interactions] High throughput no no
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
MAST1_HUMAN [view interactions] High throughput no yes
CPEB1_HUMAN [view entry] [view interactions] High throughput yes no
CNBP_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
LN28A_HUMAN [view interactions] High throughput no no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CUL1_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
VGFR1_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
MEPCE_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
PO5F1_HUMAN [view interactions] High throughput no yes
RARA_HUMAN [view interactions] High throughput no no
IGSF8_HUMAN [view entry] [view interactions] High throughput yes no
ICAM1_HUMAN [view interactions] High throughput no no
TADBP_HUMAN [view interactions] High throughput no yes
LN28B_HUMAN [view interactions] High throughput no no
SURF2_HUMAN [view interactions] High throughput no yes
ZC3H3_HUMAN [view interactions] High throughput no yes
RS8_HUMAN [view entry] [view interactions] High throughput yes no
PRR11_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
WDR46_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
RIOK1_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view entry] [view interactions] High throughput yes yes
SNAI1_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
HABP4_HUMAN [view interactions] High throughput no yes
SERB1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
CGAS_HUMAN [view interactions] High throughput no yes
WDR76_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
H2B1B_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
RC3H1_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
TIA1_HUMAN [view interactions] High throughput no no
RU17_HUMAN [view interactions] High throughput no yes
ZBT7B_HUMAN [view interactions] High throughput no no
BRD7_HUMAN [view interactions] High throughput no yes
ARI2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
ZN263_HUMAN [view interactions] High throughput no yes
MAFB_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RBM39_HUMAN [view interactions] High throughput no yes
MKRN1_HUMAN [view interactions] High throughput no no
IF16_HUMAN [view interactions] High throughput no no
NHP2_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF5_HUMAN [view interactions] High throughput no yes
F120A_HUMAN [view interactions] High throughput no yes
NEIL1_HUMAN [view interactions] High throughput no yes
RL19_HUMAN [view entry] [view interactions] High throughput yes yes
ABT1_HUMAN [view interactions] High throughput no no
H2A1_HUMAN [view interactions] High throughput no yes
RL17_HUMAN [view entry] [view interactions] High throughput yes yes
RED1_HUMAN [view interactions] High throughput no no
MAGB2_HUMAN [view interactions] High throughput no no
H12_HUMAN [view interactions] High throughput no yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
LLPH_HUMAN [view interactions] High throughput no no
H2AB2_HUMAN [view interactions] High throughput no no
H15_HUMAN [view interactions] High throughput no no
MBB1A_HUMAN [view interactions] High throughput no yes
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
PRR3_HUMAN [view interactions] High throughput no no
SRSF3_HUMAN [view interactions] High throughput no yes
H2A2C_HUMAN [view interactions] High throughput no yes
RBM19_HUMAN [view interactions] High throughput no yes
DDX21_HUMAN [view interactions] High throughput no yes
LYAR_HUMAN [view interactions] High throughput no no
SRSF6_HUMAN [view interactions] High throughput no yes
RL1D1_HUMAN [view interactions] High throughput no yes
RS19_HUMAN [view entry] [view interactions] High throughput yes no
FGF8_HUMAN [view interactions] High throughput no no
REXO4_HUMAN [view interactions] High throughput no yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
H13_HUMAN [view interactions] High throughput no no
YBOX2_HUMAN [view interactions] High throughput no no
KRR1_HUMAN [view interactions] High throughput no yes
RL15_HUMAN [view entry] [view interactions] High throughput yes no
RBMS2_HUMAN [view interactions] High throughput no yes
SRSF4_HUMAN [view interactions] High throughput no yes
PURG_HUMAN [view interactions] High throughput no yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
DGCR8_HUMAN [view entry] [view interactions] High throughput yes yes
RL13_HUMAN [view entry] [view interactions] High throughput yes yes
RL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZN668_HUMAN [view interactions] High throughput no yes
RLA0_HUMAN [view entry] [view interactions] High throughput yes yes
SURF6_HUMAN [view interactions] High throughput no yes
RL31_HUMAN [view entry] [view interactions] High throughput yes yes
ZNF71_HUMAN [view interactions] High throughput no no
ZN346_HUMAN [view interactions] High throughput no yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
RL14_HUMAN [view entry] [view interactions] High throughput yes yes
PRKRA_HUMAN [view entry] [view interactions] High throughput yes yes
RSSA_HUMAN [view entry] [view interactions] High throughput yes yes
RN151_HUMAN [view interactions] High throughput no no
RL13A_HUMAN [view entry] [view interactions] High throughput yes yes
U3IP2_HUMAN [view interactions] High throughput no yes
FGFP1_HUMAN [view interactions] High throughput no no
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
MECP2_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
YTDC1_HUMAN [view interactions] High throughput no yes
TRI31_HUMAN [view interactions] High throughput no no
ANM1_HUMAN [view interactions] High throughput no yes
MYCN_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
RNF43_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
DOT1L_HUMAN [view interactions] High throughput no yes
MEN1_HUMAN [view interactions] High throughput no yes
OTU6B_HUMAN [view interactions] High throughput no yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
UBP36_HUMAN [view interactions] High throughput no yes
B3GN2_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
IL7RA_HUMAN [view interactions] High throughput no no
PURB_HUMAN [view entry] [view interactions] High throughput yes no
ZN638_HUMAN [view interactions] High throughput no yes
RFC3_HUMAN [view interactions] High throughput no yes
DDX23_HUMAN [view interactions] High throughput no yes
RFC2_HUMAN [view interactions] High throughput no yes
DPOLA_HUMAN [view interactions] High throughput no yes
SDHF3_HUMAN [view interactions] High throughput no yes
PSD11_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
RINI_HUMAN [view interactions] High throughput no yes
ML12A_HUMAN [view interactions] High throughput no no
TGM2_HUMAN [view interactions] High throughput no no
MCM3_HUMAN [view interactions] High throughput no no
TAF6_HUMAN [view interactions] High throughput no no
LRBA_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
PRS4_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
LIPA1_HUMAN [view entry] [view interactions] High throughput yes yes
DPOA2_HUMAN [view interactions] High throughput no yes
PDCD4_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
LARP1_HUMAN [view interactions] High throughput no yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
CCAR2_HUMAN [view interactions] High throughput no yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
IPO9_HUMAN [view interactions] High throughput no no
SLK_HUMAN [view entry] [view interactions] High throughput yes yes
RPAP3_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
NRBP_HUMAN [view interactions] High throughput no yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
BIG1_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no