PURB_HUMAN
Evidence for PS localization
Functions
Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PURB_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 71.0526 | 4 | yes |
| GO:0003729 | mRNA binding | 26.3158 | 5 | yes |
| GO:0003677 | DNA binding | 13.1579 | 4 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 13.1579 | 4 | yes |
| GO:0003690 | double-stranded DNA binding | 10.5263 | 5 | yes |
| GO:0003697 | single-stranded DNA binding | 7.8947 | 5 | yes |
| GO:0043565 | sequence-specific DNA binding | 7.8947 | 5 | yes |
| GO:0000976 | transcription cis-regulatory region binding | 5.2632 | 5 | yes |
| GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 5.2632 | 6 | yes |
| GO:0001067 | transcription regulatory region nucleic acid binding | 5.2632 | 4 | yes |
| GO:0032422 | purine-rich negative regulatory element binding | 5.2632 | 6 | yes |
| GO:1990837 | sequence-specific double-stranded DNA binding | 5.2632 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PURB_HUMAN |
|---|---|---|---|---|
| GO:1901566 | organonitrogen compound biosynthetic process | 44.7368 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 44.7368 | 4 | no |
| GO:0002181 | cytoplasmic translation | 44.7368 | 5 | no |
| GO:0006412 | translation | 44.7368 | 4 | no |
| GO:0006518 | peptide metabolic process | 44.7368 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 44.7368 | 4 | no |
| GO:0034645 | cellular macromolecule biosynthetic process | 44.7368 | 4 | no |
| GO:0043043 | peptide biosynthetic process | 44.7368 | 5 | no |
| GO:0043603 | cellular amide metabolic process | 44.7368 | 4 | no |
| GO:0043604 | amide biosynthetic process | 44.7368 | 5 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 44.7368 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.1053 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.1053 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.1053 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 42.1053 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 42.1053 | 4 | yes |
| GO:0022607 | cellular component assembly | 39.4737 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.8421 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.8421 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 36.8421 | 4 | no |
| GO:0043933 | protein-containing complex organization | 34.2105 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 31.5789 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.5789 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 31.5789 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 31.5789 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.5789 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.5789 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 31.5789 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 31.5789 | 5 | yes |
| GO:0016070 | RNA metabolic process | 31.5789 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.9474 | 5 | no |
| GO:0010646 | regulation of cell communication | 28.9474 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.9474 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.9474 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.9474 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.9474 | 4 | no |
| GO:0006396 | RNA processing | 28.9474 | 6 | no |
| GO:0006996 | organelle organization | 26.3158 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.3158 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.3158 | 5 | no |
| GO:0010941 | regulation of cell death | 23.6842 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.6842 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.6842 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 23.6842 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.6842 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.0526 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 21.0526 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.0526 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 21.0526 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 21.0526 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.0526 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.0526 | 5 | no |
| GO:0022618 | ribonucleoprotein complex assembly | 21.0526 | 6 | no |
| GO:0071826 | ribonucleoprotein complex subunit organization | 21.0526 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.0526 | 6 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.0526 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 21.0526 | 6 | yes |
| GO:0034660 | ncRNA metabolic process | 21.0526 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 15.7895 | 7 | yes |
| GO:2000026 | regulation of multicellular organismal development | 15.7895 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 13.1579 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PURB_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 5.2632 | 3 | no |
| DOID:480 | movement disease | 5.2632 | 5 | no |
| DOID:936 | brain disease | 5.2632 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PURG_HUMAN | [view interactions] | High throughput | no | yes |
| UTP23_HUMAN | [view interactions] | High throughput | no | no |
| YBOX2_HUMAN | [view interactions] | High throughput | no | no |
| MAGB2_HUMAN | [view interactions] | High throughput | no | no |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| PRKRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRR1_HUMAN | [view interactions] | High throughput | no | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| NEIL1_HUMAN | [view interactions] | High throughput | no | yes |
| RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| IL7RA_HUMAN | [view interactions] | High throughput | no | no |
| PURA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFC3_HUMAN | [view interactions] | High throughput | no | yes |
| DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
| A16A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUFY2_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPNE7_HUMAN | [view interactions] | High throughput | no | no |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| UVRAG_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| CNOT7_HUMAN | [view interactions] | High throughput | no | no |
| H1T_HUMAN | [view interactions] | High throughput | no | no |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRS1_HUMAN | [view interactions] | High throughput | no | yes |
| H2AW_HUMAN | [view interactions] | High throughput | no | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OASL_HUMAN | [view interactions] | High throughput | no | no |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KSYK_HUMAN | [view interactions] | High throughput | no | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDBE_HUMAN | [view interactions] | High throughput | no | no |
| ZN497_HUMAN | [view interactions] | High throughput | no | no |
| SOSB2_HUMAN | [view interactions] | High throughput | no | no |
| MBD2_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| AKP8L_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| RFOX2_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| RARA_HUMAN | [view interactions] | High throughput | no | no |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| LN28B_HUMAN | [view interactions] | High throughput | no | no |
| STB5L_HUMAN | [view interactions] | High throughput | no | no |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| ABT1_HUMAN | [view interactions] | High throughput | no | no |
| O52K2_HUMAN | [view interactions] | High throughput | no | no |
| FGF13_HUMAN | [view interactions] | High throughput | no | no |
| CD1A_HUMAN | [view interactions] | High throughput | no | no |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| H2AB2_HUMAN | [view interactions] | High throughput | no | no |
| KALM_HUMAN | [view interactions] | High throughput | no | no |
| ZN467_HUMAN | [view interactions] | High throughput | no | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H1FNT_HUMAN | [view interactions] | High throughput | no | yes |
| RL1D1_HUMAN | [view interactions] | High throughput | no | yes |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| RS30_HUMAN | [view interactions] | High throughput | no | yes |
| ZN346_HUMAN | [view interactions] | High throughput | no | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |