KPCB_HUMAN
Evidence for PS localization
Functions
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at Ser-180, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates Ser-36 of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A (PubMed). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis . Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002185 | DOC_AGCK_PIF_1 | DOC | 656 | 661 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KPCB_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 34.1463 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.4878 | 4 | yes |
| GO:0019901 | protein kinase binding | 30.4878 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 29.2683 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 28.0488 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.0488 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 26.8293 | 5 | yes |
| GO:0005524 | ATP binding | 25.6098 | 5 | yes |
| GO:0003723 | RNA binding | 23.1707 | 4 | no |
| GO:0016301 | kinase activity | 20.7317 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 20.7317 | 4 | yes |
| GO:0046872 | metal ion binding | 20.7317 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 18.2927 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 17.0732 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 15.8537 | 4 | yes |
| GO:0005080 | protein kinase C binding | 9.7561 | 6 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 9.7561 | 4 | yes |
| GO:0004697 | protein kinase C activity | 7.3171 | 5 | yes |
| GO:0004698 | calcium-dependent protein kinase C activity | 7.3171 | 6 | yes |
| GO:0008270 | zinc ion binding | 7.3171 | 6 | yes |
| GO:0009931 | calcium-dependent protein serine/threonine kinase activity | 7.3171 | 5 | yes |
| GO:0010857 | calcium-dependent protein kinase activity | 7.3171 | 4 | yes |
| GO:0046914 | transition metal ion binding | 7.3171 | 5 | yes |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 7.3171 | 5 | yes |
| GO:0016922 | nuclear receptor binding | 4.8780 | 6 | yes |
| GO:0035173 | histone kinase activity | 4.8780 | 4 | yes |
| GO:0035184 | histone threonine kinase activity | 4.8780 | 5 | yes |
| GO:0030374 | nuclear receptor coactivator activity | 3.6585 | 4 | yes |
| GO:0035403 | histone kinase activity (H3-T6 specific) | 3.6585 | 6 | yes |
| GO:0050681 | nuclear androgen receptor binding | 3.6585 | 7 | yes |
| GO:0005246 | calcium channel regulator activity | 2.4390 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KPCB_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 58.5366 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 56.0976 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 56.0976 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 53.6585 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.4390 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 52.4390 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 51.2195 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.3415 | 4 | yes |
| GO:0010468 | regulation of gene expression | 42.6829 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.2439 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 37.8049 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.5854 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.5854 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.3659 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 35.3659 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.3659 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 35.3659 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.3659 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 35.3659 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 34.1463 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 34.1463 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 32.9268 | 5 | yes |
| GO:0051049 | regulation of transport | 32.9268 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.9268 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.9268 | 5 | no |
| GO:0031399 | regulation of protein modification process | 31.7073 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 30.4878 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 29.2683 | 4 | yes |
| GO:0010941 | regulation of cell death | 29.2683 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.2683 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.0488 | 5 | yes |
| GO:0036211 | protein modification process | 28.0488 | 4 | yes |
| GO:0043412 | macromolecule modification | 28.0488 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 28.0488 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 28.0488 | 4 | yes |
| GO:0006996 | organelle organization | 28.0488 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.0488 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.0488 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.0488 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.0488 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 28.0488 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 26.8293 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 26.8293 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 26.8293 | 7 | no |
| GO:0022607 | cellular component assembly | 25.6098 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.6098 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.6098 | 6 | no |
| GO:0008104 | protein localization | 25.6098 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.3902 | 4 | yes |
| GO:0023057 | negative regulation of signaling | 24.3902 | 4 | yes |
| GO:0071702 | organic substance transport | 24.3902 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 24.3902 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 24.3902 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 24.3902 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 24.3902 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 23.1707 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 23.1707 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 23.1707 | 4 | no |
| GO:0051338 | regulation of transferase activity | 23.1707 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.9512 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 21.9512 | 5 | no |
| GO:2000145 | regulation of cell motility | 21.9512 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.9512 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.9512 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 20.7317 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 20.7317 | 4 | yes |
| GO:0030030 | cell projection organization | 20.7317 | 4 | no |
| GO:0030334 | regulation of cell migration | 20.7317 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 20.7317 | 5 | no |
| GO:0043086 | negative regulation of catalytic activity | 20.7317 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 20.7317 | 4 | no |
| GO:0016310 | phosphorylation | 19.5122 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 19.5122 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 19.5122 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 19.5122 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 19.5122 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 19.5122 | 6 | yes |
| GO:0006468 | protein phosphorylation | 19.5122 | 5 | yes |
| GO:0009968 | negative regulation of signal transduction | 19.5122 | 5 | yes |
| GO:0051046 | regulation of secretion | 18.2927 | 5 | yes |
| GO:0018193 | peptidyl-amino acid modification | 17.0732 | 5 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 17.0732 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 17.0732 | 4 | yes |
| GO:0015031 | protein transport | 15.8537 | 4 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 15.8537 | 6 | yes |
| GO:0018209 | peptidyl-serine modification | 15.8537 | 6 | yes |
| GO:0050776 | regulation of immune response | 15.8537 | 4 | yes |
| GO:0061024 | membrane organization | 15.8537 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 15.8537 | 7 | yes |
| GO:0034762 | regulation of transmembrane transport | 14.6341 | 4 | yes |
| GO:0051051 | negative regulation of transport | 14.6341 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 14.6341 | 4 | yes |
| GO:0006811 | ion transport | 14.6341 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 12.1951 | 5 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 12.1951 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 12.1951 | 6 | yes |
| GO:0048878 | chemical homeostasis | 10.9756 | 4 | yes |
| GO:0006812 | cation transport | 10.9756 | 5 | yes |
| GO:0030001 | metal ion transport | 9.7561 | 6 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 9.7561 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 9.7561 | 5 | yes |
| GO:0006915 | apoptotic process | 9.7561 | 4 | yes |
| GO:0022411 | cellular component disassembly | 8.5366 | 4 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 8.5366 | 5 | yes |
| GO:0050801 | ion homeostasis | 8.5366 | 5 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 8.5366 | 4 | yes |
| GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling | 7.3171 | 6 | yes |
| GO:0045765 | regulation of angiogenesis | 7.3171 | 5 | yes |
| GO:0055080 | cation homeostasis | 7.3171 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 7.3171 | 6 | yes |
| GO:1901342 | regulation of vasculature development | 7.3171 | 5 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 7.3171 | 5 | yes |
| GO:0006816 | calcium ion transport | 7.3171 | 7 | yes |
| GO:0030003 | cellular cation homeostasis | 6.0976 | 5 | yes |
| GO:0045766 | positive regulation of angiogenesis | 6.0976 | 6 | yes |
| GO:0055065 | metal ion homeostasis | 6.0976 | 7 | yes |
| GO:0055074 | calcium ion homeostasis | 6.0976 | 8 | yes |
| GO:0072507 | divalent inorganic cation homeostasis | 6.0976 | 7 | yes |
| GO:1904018 | positive regulation of vasculature development | 6.0976 | 5 | yes |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 6.0976 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 6.0976 | 4 | yes |
| GO:0006873 | cellular ion homeostasis | 6.0976 | 4 | yes |
| GO:0050851 | antigen receptor-mediated signaling pathway | 4.8780 | 5 | yes |
| GO:0050853 | B cell receptor signaling pathway | 4.8780 | 6 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 4.8780 | 4 | yes |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 4.8780 | 6 | yes |
| GO:0006874 | cellular calcium ion homeostasis | 4.8780 | 7 | yes |
| GO:0006875 | cellular metal ion homeostasis | 4.8780 | 6 | yes |
| GO:0030397 | membrane disassembly | 3.6585 | 5 | yes |
| GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway | 3.6585 | 5 | yes |
| GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | 3.6585 | 6 | yes |
| GO:0042113 | B cell activation | 3.6585 | 4 | yes |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 3.6585 | 7 | yes |
| GO:0046626 | regulation of insulin receptor signaling pathway | 3.6585 | 5 | yes |
| GO:0046627 | negative regulation of insulin receptor signaling pathway | 3.6585 | 6 | yes |
| GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 3.6585 | 5 | yes |
| GO:0050855 | regulation of B cell receptor signaling pathway | 3.6585 | 6 | yes |
| GO:0051081 | nuclear membrane disassembly | 3.6585 | 6 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 3.6585 | 5 | yes |
| GO:0071763 | nuclear membrane organization | 3.6585 | 5 | yes |
| GO:0099171 | presynaptic modulation of chemical synaptic transmission | 3.6585 | 6 | yes |
| GO:1900076 | regulation of cellular response to insulin stimulus | 3.6585 | 4 | yes |
| GO:1900077 | negative regulation of cellular response to insulin stimulus | 3.6585 | 5 | yes |
| GO:0006325 | chromatin organization | 3.6585 | 4 | yes |
| GO:0007077 | mitotic nuclear membrane disassembly | 3.6585 | 4 | yes |
| GO:0009743 | response to carbohydrate | 3.6585 | 4 | yes |
| GO:0010827 | regulation of glucose transmembrane transport | 3.6585 | 5 | yes |
| GO:0010829 | negative regulation of glucose transmembrane transport | 2.4390 | 6 | yes |
| GO:0042953 | lipoprotein transport | 2.4390 | 5 | yes |
| GO:0044872 | lipoprotein localization | 2.4390 | 5 | yes |
| GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway | 2.4390 | 6 | yes |
| GO:0050861 | positive regulation of B cell receptor signaling pathway | 2.4390 | 7 | yes |
| GO:0071322 | cellular response to carbohydrate stimulus | 2.4390 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KPCB_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 2.4390 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PDLI5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LDB3_HUMAN | [view interactions] | Low throughput | no | no |
| KDM1A_HUMAN | [view interactions] | Low throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | Low throughput | no | no |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| C1QBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| RACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| NCF1_HUMAN | [view interactions] | Low throughput | no | no |
| IF6_HUMAN | [view interactions] | Low throughput | no | yes |
| GLRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRA_HUMAN | [view interactions] | Low throughput | no | yes |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| HOIL1_HUMAN | [view interactions] | Low throughput | no | no |
| NCAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IL3RB_HUMAN | [view interactions] | Low throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | Low throughput | no | no |
| TRI41_HUMAN | [view interactions] | Low throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DDX58_HUMAN | [view interactions] | Low throughput | no | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RNF31_HUMAN | [view interactions] | Low throughput | no | yes |
| IBTK_HUMAN | [view interactions] | Low throughput | no | yes |
| KCNA5_HUMAN | [view interactions] | Low throughput | no | no |
| LSP1_HUMAN | [view interactions] | Low throughput | no | no |
| CISH_HUMAN | [view interactions] | Low throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | Low throughput | no | yes |
| CAR11_HUMAN | [view interactions] | Low throughput | no | no |
| TNR1A_HUMAN | [view interactions] | Low throughput | no | yes |
| RB_HUMAN | [view interactions] | Low throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| USP9X_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DRD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BTK_HUMAN | [view interactions] | Low throughput | no | no |
| PDPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AFAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIEA_HUMAN | [view interactions] | Low throughput | no | yes |
| PKCB1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRP3_HUMAN | [view interactions] | Low throughput | no | no |
| GNA12_HUMAN | [view interactions] | Low throughput | no | no |
| GNA13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS2_HUMAN | [view interactions] | Low throughput | no | no |
| TIAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HMGB1_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| H11_HUMAN | [view interactions] | Low throughput | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TOP2A_HUMAN | [view interactions] | Low throughput | no | no |
| PEBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEUM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H10_HUMAN | [view interactions] | Low throughput | no | yes |
| CD5_HUMAN | [view interactions] | Low throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDC2_HUMAN | [view interactions] | Low throughput | no | yes |
| ITB2_HUMAN | [view interactions] | Low throughput | no | no |
| PTPA_HUMAN | [view interactions] | Low throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | Low throughput | no | yes |
| CASR_HUMAN | [view interactions] | Low throughput | no | no |
| SYT6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| H15_HUMAN | [view interactions] | Low throughput | no | no |
| NUMB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| DAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| DNLI1_HUMAN | [view interactions] | Low throughput | no | yes |
| SHCBP_HUMAN | [view interactions] | High throughput | no | no |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| HNRDL_HUMAN | [view interactions] | High throughput | no | yes |
| ICMT_HUMAN | [view interactions] | High throughput | no | no |
| H2B1K_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1D_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1N_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1M_HUMAN | [view interactions] | High throughput | no | yes |
| H2BFS_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1L_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A4_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2B1J_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AZ_HUMAN | [view interactions] | High throughput | no | yes |
| H2AV_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1H_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1J_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1D_HUMAN | [view interactions] | High throughput | no | yes |
| H2AJ_HUMAN | [view interactions] | High throughput | no | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| ARL2_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT05_HUMAN | [view interactions] | High throughput | no | yes |
| RT06_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF2_HUMAN | [view interactions] | High throughput | no | yes |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LBR_HUMAN | [view interactions] | High throughput | no | yes |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| H2A2A_HUMAN | [view interactions] | High throughput | no | yes |
| H2A2C_HUMAN | [view interactions] | High throughput | no | yes |
| H32_HUMAN | [view interactions] | High throughput | no | yes |
| DDX46_HUMAN | [view interactions] | High throughput | no | yes |
| DDX42_HUMAN | [view interactions] | High throughput | no | yes |
| CCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| SRBD1_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI5_HUMAN | [view interactions] | High throughput | no | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2A1C_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| H2A3_HUMAN | [view interactions] | High throughput | no | yes |
| TAM41_HUMAN | [view interactions] | High throughput | no | no |
| PURB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UHRF1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX50_HUMAN | [view interactions] | High throughput | no | yes |
| PELO_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
| DHX33_HUMAN | [view interactions] | High throughput | no | yes |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| DDX18_HUMAN | [view interactions] | High throughput | no | yes |
| HPF1_HUMAN | [view interactions] | High throughput | no | no |
| TV23B_HUMAN | [view interactions] | High throughput | no | no |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| STK39_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCF2_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL5_HUMAN | [view interactions] | High throughput | no | yes |
| MTO1_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CN37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B_HUMAN | [view interactions] | High throughput | no | yes |
| DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT1_HUMAN | [view interactions] | High throughput | no | no |
| RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERF1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMAL3_HUMAN | [view interactions] | High throughput | no | no |
| CARL1_HUMAN | [view interactions] | High throughput | no | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPA_HUMAN | [view interactions] | High throughput | no | yes |
| DOPP1_HUMAN | [view interactions] | High throughput | no | yes |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| RHPN1_HUMAN | [view interactions] | High throughput | no | yes |
| GDF15_HUMAN | [view interactions] | High throughput | no | no |
| SEN34_HUMAN | [view interactions] | High throughput | no | yes |
| MAGT1_HUMAN | [view interactions] | High throughput | no | yes |
| ABC3C_HUMAN | [view interactions] | High throughput | no | no |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| DIC_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF3_HUMAN | [view interactions] | High throughput | no | yes |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| BMPR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ8B_HUMAN | [view interactions] | High throughput | no | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| IKKB_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBD4_HUMAN | [view interactions] | High throughput | no | yes |
| SOGA3_HUMAN | [view interactions] | High throughput | no | no |
| RDH14_HUMAN | [view interactions] | High throughput | no | yes |
| DEC1_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM2_HUMAN | [view interactions] | High throughput | no | yes |
| HABP4_HUMAN | [view interactions] | High throughput | no | yes |
| CYH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |