Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NEUG_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Acts as a third messenger substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NEUG_HUMAN
GO:0046872 metal ion binding 70.0000 4 no
GO:0019900 kinase binding 50.0000 4 no
GO:0019901 protein kinase binding 50.0000 5 no
GO:0005509 calcium ion binding 40.0000 5 no
GO:0019887 protein kinase regulator activity 40.0000 4 no
GO:0008270 zinc ion binding 40.0000 6 no
GO:0046914 transition metal ion binding 40.0000 5 no
GO:0008179 adenylate cyclase binding 30.0000 4 no
GO:0010856 adenylate cyclase activator activity 30.0000 4 no
GO:0019209 kinase activator activity 30.0000 4 no
GO:0019211 phosphatase activator activity 30.0000 4 no
GO:0019888 protein phosphatase regulator activity 30.0000 4 no
GO:0030295 protein kinase activator activity 30.0000 5 no
GO:0031432 titin binding 30.0000 4 no
GO:0031997 N-terminal myristoylation domain binding 30.0000 4 no
GO:0043539 protein serine/threonine kinase activator activity 30.0000 6 no
GO:0072542 protein phosphatase activator activity 30.0000 5 no
GO:0097718 disordered domain specific binding 30.0000 4 no
GO:0004674 protein serine/threonine kinase activity 30.0000 4 no
GO:0004697 protein kinase C activity 30.0000 5 no
GO:0004698 calcium-dependent protein kinase C activity 30.0000 6 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 30.0000 4 no
GO:0005524 ATP binding 30.0000 5 no
GO:0009931 calcium-dependent protein serine/threonine kinase activity 30.0000 5 no
GO:0010857 calcium-dependent protein kinase activity 30.0000 4 no
GO:0016301 kinase activity 30.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 30.0000 4 no
GO:0017076 purine nucleotide binding 30.0000 4 no
GO:0030554 adenyl nucleotide binding 30.0000 5 no
GO:0032555 purine ribonucleotide binding 30.0000 4 no
GO:0032559 adenyl ribonucleotide binding 30.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 no
GO:0106310 protein serine kinase activity 30.0000 4 no
GO:0005246 calcium channel regulator activity 30.0000 4 no
GO:0035091 phosphatidylinositol binding 20.0000 4 yes
GO:1901981 phosphatidylinositol phosphate binding 20.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NEUG_HUMAN
GO:0010646 regulation of cell communication 90.0000 4 yes
GO:0048522 positive regulation of cellular process 90.0000 4 yes
GO:0031323 regulation of cellular metabolic process 80.0000 4 no
GO:0048523 negative regulation of cellular process 80.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 80.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 80.0000 4 no
GO:0080090 regulation of primary metabolic process 80.0000 4 no
GO:0009966 regulation of signal transduction 70.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 60.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 60.0000 4 yes
GO:0009892 negative regulation of metabolic process 60.0000 4 no
GO:0009893 positive regulation of metabolic process 60.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 60.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 60.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 60.0000 5 no
GO:0031399 regulation of protein modification process 60.0000 6 no
GO:0031400 negative regulation of protein modification process 60.0000 7 no
GO:0036211 protein modification process 60.0000 4 no
GO:0043412 macromolecule modification 60.0000 4 no
GO:0051049 regulation of transport 60.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 60.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 60.0000 5 no
GO:0051246 regulation of protein metabolic process 60.0000 5 no
GO:0051248 negative regulation of protein metabolic process 60.0000 6 no
GO:1902531 regulation of intracellular signal transduction 60.0000 5 no
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0023056 positive regulation of signaling 50.0000 4 yes
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 no
GO:0010038 response to metal ion 50.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 no
GO:0010563 negative regulation of phosphorus metabolic process 50.0000 6 no
GO:0010941 regulation of cell death 50.0000 4 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 no
GO:0033674 positive regulation of kinase activity 50.0000 6 no
GO:0034762 regulation of transmembrane transport 50.0000 4 no
GO:0042325 regulation of phosphorylation 50.0000 7 no
GO:0042326 negative regulation of phosphorylation 50.0000 8 no
GO:0042327 positive regulation of phosphorylation 50.0000 8 no
GO:0043085 positive regulation of catalytic activity 50.0000 4 no
GO:0043549 regulation of kinase activity 50.0000 5 no
GO:0045936 negative regulation of phosphate metabolic process 50.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 no
GO:0051051 negative regulation of transport 50.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0051336 regulation of hydrolase activity 50.0000 4 no
GO:0051338 regulation of transferase activity 50.0000 4 no
GO:0051345 positive regulation of hydrolase activity 50.0000 5 no
GO:0051347 positive regulation of transferase activity 50.0000 5 no
GO:0001932 regulation of protein phosphorylation 40.0000 7 no
GO:0001933 negative regulation of protein phosphorylation 40.0000 8 no
GO:0001934 positive regulation of protein phosphorylation 40.0000 8 no
GO:0006468 protein phosphorylation 40.0000 5 no
GO:0010959 regulation of metal ion transport 40.0000 6 no
GO:0016310 phosphorylation 40.0000 5 no
GO:0017157 regulation of exocytosis 40.0000 5 no
GO:0022898 regulation of transmembrane transporter activity 40.0000 4 no
GO:0031401 positive regulation of protein modification process 40.0000 7 no
GO:0032410 negative regulation of transporter activity 40.0000 4 no
GO:0034763 negative regulation of transmembrane transport 40.0000 5 no
GO:0034764 positive regulation of transmembrane transport 40.0000 5 no
GO:0034765 regulation of ion transmembrane transport 40.0000 5 no
GO:0034767 positive regulation of ion transmembrane transport 40.0000 6 no
GO:0042981 regulation of apoptotic process 40.0000 6 no
GO:0043067 regulation of programmed cell death 40.0000 5 no
GO:0043269 regulation of ion transport 40.0000 5 no
GO:0043270 positive regulation of ion transport 40.0000 5 no
GO:0043271 negative regulation of ion transport 40.0000 5 no
GO:0044057 regulation of system process 40.0000 4 no
GO:0045859 regulation of protein kinase activity 40.0000 6 no
GO:0045860 positive regulation of protein kinase activity 40.0000 7 no
GO:0046928 regulation of neurotransmitter secretion 40.0000 4 no
GO:0050848 regulation of calcium-mediated signaling 40.0000 6 no
GO:0051046 regulation of secretion 40.0000 5 no
GO:0051050 positive regulation of transport 40.0000 4 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 40.0000 5 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 40.0000 6 no
GO:0051282 regulation of sequestering of calcium ion 40.0000 4 no
GO:0051588 regulation of neurotransmitter transport 40.0000 5 no
GO:0051726 regulation of cell cycle 40.0000 4 no
GO:0051924 regulation of calcium ion transport 40.0000 7 no
GO:0051928 positive regulation of calcium ion transport 40.0000 6 no
GO:0060627 regulation of vesicle-mediated transport 40.0000 4 no
GO:0061024 membrane organization 40.0000 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 40.0000 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 40.0000 8 no
GO:0090257 regulation of muscle system process 40.0000 5 no
GO:1903169 regulation of calcium ion transmembrane transport 40.0000 7 no
GO:1903530 regulation of secretion by cell 40.0000 4 no
GO:1904062 regulation of cation transmembrane transport 40.0000 6 no
GO:1904064 positive regulation of cation transmembrane transport 40.0000 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 40.0000 7 no
GO:0009894 regulation of catabolic process 40.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 40.0000 5 no
GO:0048584 positive regulation of response to stimulus 40.0000 4 no
GO:0010468 regulation of gene expression 40.0000 5 no
GO:0050806 positive regulation of synaptic transmission 30.0000 5 yes
GO:0050890 cognition 30.0000 4 yes
GO:0000086 G2/M transition of mitotic cell cycle 30.0000 5 no
GO:0005513 detection of calcium ion 30.0000 4 no
GO:0006811 ion transport 30.0000 4 no
GO:0006812 cation transport 30.0000 5 no
GO:0006937 regulation of muscle contraction 30.0000 6 no
GO:0006942 regulation of striated muscle contraction 30.0000 7 no
GO:0006996 organelle organization 30.0000 4 no
GO:0007005 mitochondrion organization 30.0000 5 no
GO:0008016 regulation of heart contraction 30.0000 6 no
GO:0010243 response to organonitrogen compound 30.0000 4 no
GO:0010564 regulation of cell cycle process 30.0000 5 no
GO:0010649 regulation of cell communication by electrical coupling 30.0000 5 no
GO:0010799 regulation of peptidyl-threonine phosphorylation 30.0000 8 no
GO:0010800 positive regulation of peptidyl-threonine phosphorylation 30.0000 9 no
GO:0010801 negative regulation of peptidyl-threonine phosphorylation 30.0000 9 no
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 30.0000 6 no
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 30.0000 7 no
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 30.0000 6 no
GO:0010921 regulation of phosphatase activity 30.0000 5 no
GO:0010922 positive regulation of phosphatase activity 30.0000 6 no
GO:0010942 positive regulation of cell death 30.0000 5 no
GO:0014070 response to organic cyclic compound 30.0000 4 no
GO:0019722 calcium-mediated signaling 30.0000 5 no
GO:0019932 second-messenger-mediated signaling 30.0000 4 no
GO:0021762 substantia nigra development 30.0000 4 no
GO:0031952 regulation of protein autophosphorylation 30.0000 8 no
GO:0031954 positive regulation of protein autophosphorylation 30.0000 9 no
GO:0032411 positive regulation of transporter activity 30.0000 4 no
GO:0032412 regulation of ion transmembrane transporter activity 30.0000 5 no
GO:0032413 negative regulation of ion transmembrane transporter activity 30.0000 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 30.0000 5 no
GO:0032465 regulation of cytokinesis 30.0000 5 no
GO:0032516 positive regulation of phosphoprotein phosphatase activity 30.0000 7 no
GO:0034766 negative regulation of ion transmembrane transport 30.0000 6 no
GO:0035303 regulation of dephosphorylation 30.0000 7 no
GO:0035304 regulation of protein dephosphorylation 30.0000 7 no
GO:0035306 positive regulation of dephosphorylation 30.0000 8 no
GO:0035307 positive regulation of protein dephosphorylation 30.0000 8 no
GO:0043388 positive regulation of DNA binding 30.0000 5 no
GO:0043666 regulation of phosphoprotein phosphatase activity 30.0000 6 no
GO:0044772 mitotic cell cycle phase transition 30.0000 4 no
GO:0044839 cell cycle G2/M phase transition 30.0000 4 no
GO:0051099 positive regulation of binding 30.0000 4 no
GO:0051101 regulation of DNA binding 30.0000 4 no
GO:0051128 regulation of cellular component organization 30.0000 4 no
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 30.0000 6 no
GO:0051284 positive regulation of sequestering of calcium ion 30.0000 5 no
GO:0051302 regulation of cell division 30.0000 4 no
GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 30.0000 5 no
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity 30.0000 6 no
GO:0051592 response to calcium ion 30.0000 5 no
GO:0051926 negative regulation of calcium ion transport 30.0000 6 no
GO:0055117 regulation of cardiac muscle contraction 30.0000 7 no
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 30.0000 6 no
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 30.0000 7 no
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 30.0000 7 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 30.0000 6 no
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 30.0000 6 no
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 30.0000 6 no
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 30.0000 6 no
GO:1903170 negative regulation of calcium ion transmembrane transport 30.0000 7 no
GO:1903305 regulation of regulated secretory pathway 30.0000 6 no
GO:1903522 regulation of blood circulation 30.0000 5 no
GO:1904063 negative regulation of cation transmembrane transport 30.0000 7 no
GO:1905912 regulation of calcium ion export across plasma membrane 30.0000 8 no
GO:1905913 negative regulation of calcium ion export across plasma membrane 30.0000 8 no
GO:2000300 regulation of synaptic vesicle exocytosis 30.0000 5 no
GO:2001257 regulation of cation channel activity 30.0000 6 no
GO:2001258 negative regulation of cation channel activity 30.0000 6 no
GO:2001259 positive regulation of cation channel activity 30.0000 6 no
GO:0018105 peptidyl-serine phosphorylation 30.0000 6 no
GO:0018193 peptidyl-amino acid modification 30.0000 5 no
GO:0018209 peptidyl-serine modification 30.0000 6 no
GO:0030162 regulation of proteolysis 30.0000 6 no
GO:0032101 regulation of response to external stimulus 30.0000 4 no
GO:0043066 negative regulation of apoptotic process 30.0000 7 no
GO:0043069 negative regulation of programmed cell death 30.0000 6 no
GO:0060548 negative regulation of cell death 30.0000 5 no
GO:0080134 regulation of response to stress 30.0000 4 no
GO:1901214 regulation of neuron death 30.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 30.0000 4 no
GO:0022607 cellular component assembly 30.0000 4 no
GO:0031329 regulation of cellular catabolic process 30.0000 5 no
GO:0034330 cell junction organization 30.0000 4 no
GO:0044087 regulation of cellular component biogenesis 30.0000 4 no
GO:0044089 positive regulation of cellular component biogenesis 30.0000 5 no
GO:0051094 positive regulation of developmental process 30.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 30.0000 4 no
GO:0071310 cellular response to organic substance 30.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 30.0000 4 no
GO:2000026 regulation of multicellular organismal development 30.0000 4 no
GO:0051252 regulation of RNA metabolic process 30.0000 5 no

Disease

Term Name % Distance from top the of the tree Annotated in NEUG_HUMAN
DOID:0050700 cardiomyopathy 20.0000 4 no
DOID:0060036 intrinsic cardiomyopathy 20.0000 5 no
DOID:114 heart disease 20.0000 3 no
DOID:2843 long QT syndrome 20.0000 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PPCE_HUMAN [view interactions] Low throughput no yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
KLH20_HUMAN [view interactions] High throughput no yes
TRI62_HUMAN [view interactions] High throughput no no
NUDT6_HUMAN [view interactions] High throughput no yes
RWD2B_HUMAN [view interactions] High throughput no no
MED9_HUMAN [view interactions] High throughput no no
IF5_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ZN131_HUMAN [view interactions] High throughput no yes
EFCB7_HUMAN [view interactions] High throughput no no
CLU_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
GLP1R_HUMAN [view interactions] High throughput no no
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
KPCG_HUMAN [view entry] [view interactions] High throughput yes yes
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes