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KPCG_HUMAN

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress . Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in KPCG_HUMAN
GO:0043168 anion binding 35.5263 4 yes
GO:0019900 kinase binding 34.2105 4 no
GO:0000166 nucleotide binding 31.5789 4 yes
GO:0017076 purine nucleotide binding 30.2632 5 yes
GO:0030554 adenyl nucleotide binding 30.2632 6 yes
GO:0032555 purine ribonucleotide binding 28.9474 4 yes
GO:0032559 adenyl ribonucleotide binding 28.9474 5 yes
GO:0043169 cation binding 28.9474 4 yes
GO:0019901 protein kinase binding 28.9474 5 no
GO:0005524 ATP binding 27.6316 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 27.6316 4 yes
GO:0046872 metal ion binding 27.6316 5 yes
GO:0003723 RNA binding 27.6316 4 no
GO:0031625 ubiquitin protein ligase binding 21.0526 5 no
GO:0044389 ubiquitin-like protein ligase binding 21.0526 4 no
GO:0046914 transition metal ion binding 14.4737 6 yes
GO:0008270 zinc ion binding 13.1579 7 yes
GO:0016301 kinase activity 13.1579 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 11.8421 4 yes
GO:0004674 protein serine/threonine kinase activity 10.5263 4 yes
GO:0106310 protein serine kinase activity 10.5263 4 yes
GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 6.5789 5 yes
GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3.9474 6 yes
GO:0009931 calcium-dependent protein serine/threonine kinase activity 3.9474 5 yes
GO:0010857 calcium-dependent protein kinase activity 3.9474 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 2.6316 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KPCG_HUMAN
GO:0060255 regulation of macromolecule metabolic process 61.8421 4 yes
GO:0048522 positive regulation of cellular process 60.5263 4 yes
GO:0048523 negative regulation of cellular process 60.5263 4 yes
GO:0010646 regulation of cell communication 59.2105 4 yes
GO:0080090 regulation of primary metabolic process 57.8947 4 yes
GO:0031323 regulation of cellular metabolic process 55.2632 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 yes
GO:0009966 regulation of signal transduction 48.6842 4 no
GO:0051128 regulation of cellular component organization 46.0526 4 yes
GO:0022607 cellular component assembly 43.4211 4 no
GO:0031399 regulation of protein modification process 40.7895 6 yes
GO:0006996 organelle organization 40.7895 4 no
GO:0009892 negative regulation of metabolic process 39.4737 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 39.4737 5 yes
GO:0048584 positive regulation of response to stimulus 39.4737 4 yes
GO:0051049 regulation of transport 39.4737 4 yes
GO:0009893 positive regulation of metabolic process 38.1579 4 yes
GO:0010647 positive regulation of cell communication 35.5263 5 yes
GO:0023056 positive regulation of signaling 35.5263 4 yes
GO:0042981 regulation of apoptotic process 35.5263 5 yes
GO:0043067 regulation of programmed cell death 35.5263 4 yes
GO:0009889 regulation of biosynthetic process 35.5263 4 no
GO:0010556 regulation of macromolecule biosynthetic process 35.5263 5 no
GO:0031326 regulation of cellular biosynthetic process 35.5263 5 no
GO:0010604 positive regulation of macromolecule metabolic process 34.2105 5 yes
GO:0008104 protein localization 34.2105 4 no
GO:0010468 regulation of gene expression 34.2105 6 no
GO:0009894 regulation of catabolic process 30.2632 4 yes
GO:0031325 positive regulation of cellular metabolic process 30.2632 5 no
GO:1902531 regulation of intracellular signal transduction 30.2632 5 no
GO:0031324 negative regulation of cellular metabolic process 30.2632 5 no
GO:0050804 modulation of chemical synaptic transmission 28.9474 5 yes
GO:0051248 negative regulation of protein metabolic process 28.9474 6 yes
GO:0099177 regulation of trans-synaptic signaling 28.9474 4 yes
GO:0071310 cellular response to organic substance 28.9474 4 no
GO:0019220 regulation of phosphate metabolic process 28.9474 6 no
GO:0051174 regulation of phosphorus metabolic process 28.9474 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.6316 5 yes
GO:0043066 negative regulation of apoptotic process 27.6316 6 yes
GO:0043069 negative regulation of programmed cell death 27.6316 5 yes
GO:0009967 positive regulation of signal transduction 27.6316 5 no
GO:0051247 positive regulation of protein metabolic process 27.6316 6 no
GO:0010648 negative regulation of cell communication 27.6316 5 no
GO:0023057 negative regulation of signaling 27.6316 4 no
GO:0042325 regulation of phosphorylation 26.3158 7 no
GO:0051094 positive regulation of developmental process 26.3158 4 no
GO:0044087 regulation of cellular component biogenesis 26.3158 4 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 yes
GO:0036211 protein modification process 25.0000 4 yes
GO:0043412 macromolecule modification 25.0000 4 yes
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0031400 negative regulation of protein modification process 23.6842 7 yes
GO:0009968 negative regulation of signal transduction 23.6842 5 no
GO:0048585 negative regulation of response to stimulus 23.6842 4 no
GO:0071705 nitrogen compound transport 23.6842 4 no
GO:0060341 regulation of cellular localization 23.6842 4 no
GO:0010243 response to organonitrogen compound 22.3684 4 yes
GO:0051338 regulation of transferase activity 22.3684 4 no
GO:2000026 regulation of multicellular organismal development 22.3684 4 no
GO:0032880 regulation of protein localization 22.3684 5 no
GO:0007268 chemical synaptic transmission 21.0526 7 yes
GO:0014070 response to organic cyclic compound 21.0526 4 yes
GO:0080134 regulation of response to stress 21.0526 4 yes
GO:0098916 anterograde trans-synaptic signaling 21.0526 6 yes
GO:0099536 synaptic signaling 21.0526 4 yes
GO:0099537 trans-synaptic signaling 21.0526 5 yes
GO:0009890 negative regulation of biosynthetic process 21.0526 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.0526 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.0526 6 no
GO:0051252 regulation of RNA metabolic process 21.0526 5 no
GO:0065003 protein-containing complex assembly 21.0526 5 no
GO:0050890 cognition 19.7368 4 yes
GO:0030162 regulation of proteolysis 18.4211 6 yes
GO:0016310 phosphorylation 17.1053 5 yes
GO:0042176 regulation of protein catabolic process 17.1053 5 yes
GO:0050806 positive regulation of synaptic transmission 17.1053 5 yes
GO:1901873 regulation of post-translational protein modification 17.1053 7 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 17.1053 8 yes
GO:0006468 protein phosphorylation 15.7895 5 yes
GO:0031396 regulation of protein ubiquitination 15.7895 9 yes
GO:0051046 regulation of secretion 14.4737 5 yes
GO:1903530 regulation of secretion by cell 14.4737 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 13.1579 5 yes
GO:0060627 regulation of vesicle-mediated transport 13.1579 4 yes
GO:0043523 regulation of neuron apoptotic process 11.8421 6 yes
GO:1901874 negative regulation of post-translational protein modification 11.8421 8 yes
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 11.8421 9 yes
GO:0031397 negative regulation of protein ubiquitination 10.5263 10 yes
GO:0051588 regulation of neurotransmitter transport 10.5263 5 yes
GO:0061136 regulation of proteasomal protein catabolic process 10.5263 6 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 10.5263 7 yes
GO:0009895 negative regulation of catabolic process 9.2105 5 yes
GO:0030100 regulation of endocytosis 9.2105 5 yes
GO:0043524 negative regulation of neuron apoptotic process 9.2105 7 yes
GO:0046928 regulation of neurotransmitter secretion 9.2105 5 yes
GO:0017157 regulation of exocytosis 7.8947 5 yes
GO:0043279 response to alkaloid 7.8947 5 yes
GO:0051052 regulation of DNA metabolic process 7.8947 5 yes
GO:0080135 regulation of cellular response to stress 7.8947 4 yes
GO:0042177 negative regulation of protein catabolic process 6.5789 6 yes
GO:0045861 negative regulation of proteolysis 6.5789 7 yes
GO:0051054 positive regulation of DNA metabolic process 6.5789 6 yes
GO:0060291 long-term synaptic potentiation 6.5789 4 yes
GO:1903305 regulation of regulated secretory pathway 6.5789 6 yes
GO:0014072 response to isoquinoline alkaloid 5.2632 5 yes
GO:0043278 response to morphine 5.2632 6 yes
GO:2000300 regulation of synaptic vesicle exocytosis 5.2632 6 yes
GO:0099171 presynaptic modulation of chemical synaptic transmission 3.9474 6 yes
GO:1901799 negative regulation of proteasomal protein catabolic process 3.9474 7 yes
GO:1903051 negative regulation of proteolysis involved in protein catabolic process 3.9474 8 yes
GO:0006282 regulation of DNA repair 2.6316 5 yes
GO:0032095 regulation of response to food 2.6316 5 yes
GO:0032107 regulation of response to nutrient levels 2.6316 4 yes
GO:0032423 regulation of mismatch repair 2.6316 6 yes
GO:0032425 positive regulation of mismatch repair 2.6316 6 yes
GO:0045739 positive regulation of DNA repair 2.6316 5 yes
GO:0050764 regulation of phagocytosis 2.6316 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CLOCK_HUMAN [view interactions] Low throughput no yes
GLRB_HUMAN [view entry] [view interactions] Low throughput yes no
TRPC3_HUMAN [view interactions] Low throughput no no
PTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA4_HUMAN [view entry] [view interactions] Low throughput yes no
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
GBRA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRA4_HUMAN [view entry] [view interactions] Low throughput yes no
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
IBTK_HUMAN [view interactions] Low throughput no yes
RBP10_HUMAN [view interactions] Low throughput no no
RANB9_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
AFAP1_HUMAN [view interactions] Low throughput no yes
RGS2_HUMAN [view interactions] Low throughput no no
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
HMGB1_HUMAN [view interactions] Low throughput no yes
GBRR1_HUMAN [view entry] [view interactions] Low throughput yes no
RIGI_HUMAN [view interactions] Low throughput no yes
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
TOP2A_HUMAN [view interactions] Low throughput no no
PEBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CD5_HUMAN [view interactions] Low throughput no no
GBRB1_HUMAN [view entry] [view interactions] Low throughput yes no
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
CXA1_HUMAN [view entry] [view interactions] Low throughput yes yes
MARCS_HUMAN [view entry] [view interactions] Low throughput yes yes
SDC2_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB2_HUMAN [view interactions] Low throughput no no
GSK3A_HUMAN [view interactions] Low throughput no yes
CASR_HUMAN [view interactions] Low throughput no no
ANXA7_HUMAN [view entry] [view interactions] Low throughput yes yes
BCL2_HUMAN [view interactions] Low throughput no no
DAB2_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DNJC5_HUMAN [view interactions] Low throughput no yes
ARHG7_HUMAN [view entry] [view interactions] Low throughput yes yes
LDB3_HUMAN [view interactions] Low throughput no no
LIMK1_HUMAN [view entry] [view interactions] Low throughput yes yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
K1C19_HUMAN [view interactions] High throughput no no
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
F167A_HUMAN [view interactions] High throughput no yes
TCP1L_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
OXDA_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TIA1_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
KPCG_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ARHGP_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
EPHB1_HUMAN [view interactions] High throughput no no
SCN3A_HUMAN [view interactions] High throughput no yes
TRIM5_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
UBE2T_HUMAN [view interactions] High throughput no no
FBX7_HUMAN [view interactions] High throughput no yes
TIAM2_HUMAN [view interactions] High throughput no yes
HABP4_HUMAN [view interactions] High throughput no yes
MARK4_HUMAN [view interactions] High throughput no yes
NEUG_HUMAN [view entry] [view interactions] High throughput yes yes
PP14A_HUMAN [view interactions] High throughput no yes
CYH2_HUMAN [view entry] [view interactions] High throughput yes yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
NOXA1_HUMAN [view interactions] High throughput no yes
EXOC5_HUMAN [view entry] [view interactions] High throughput yes yes
CCHCR_HUMAN [view interactions] High throughput no no
DACT1_HUMAN [view entry] [view interactions] High throughput yes yes
DACT2_HUMAN [view interactions] High throughput no yes
DACT3_HUMAN [view interactions] High throughput no yes
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
NS1BP_HUMAN [view interactions] High throughput no yes
TCF25_HUMAN [view interactions] High throughput no yes
H90B2_HUMAN [view interactions] High throughput no no
PCKGM_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
KPRA_HUMAN [view interactions] High throughput no no
RCN2_HUMAN [view interactions] High throughput no yes
S25A3_HUMAN [view entry] [view interactions] High throughput yes no
TBB4B_HUMAN [view interactions] High throughput no yes
PRPS1_HUMAN [view entry] [view interactions] High throughput yes no
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP77_HUMAN [view interactions] High throughput no no
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
PRPS2_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
KPRB_HUMAN [view interactions] High throughput no yes
LTBP1_HUMAN [view interactions] High throughput no no
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1B_HUMAN [view interactions] High throughput no yes
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
DJC10_HUMAN [view interactions] High throughput no yes
DMXL2_HUMAN [view entry] [view interactions] High throughput yes yes