KPCG_HUMAN
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress . Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock . [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KPCG_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 33.3333 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 32.3232 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 32.3232 | 4 | yes |
GO:0030554 | adenyl nucleotide binding | 30.3030 | 5 | yes |
GO:0019900 | kinase binding | 30.3030 | 4 | no |
GO:0005524 | ATP binding | 29.2929 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 29.2929 | 5 | yes |
GO:0019901 | protein kinase binding | 26.2626 | 5 | no |
GO:0046872 | metal ion binding | 22.2222 | 4 | yes |
GO:0003723 | RNA binding | 20.2020 | 4 | no |
GO:0016301 | kinase activity | 18.1818 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 17.1717 | 4 | yes |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 14.1414 | 4 | yes |
GO:0004674 | protein serine/threonine kinase activity | 13.1313 | 4 | yes |
GO:0106310 | protein serine kinase activity | 10.1010 | 4 | yes |
GO:0046914 | transition metal ion binding | 9.0909 | 5 | yes |
GO:0008270 | zinc ion binding | 7.0707 | 6 | yes |
GO:0004697 | protein kinase C activity | 4.0404 | 5 | yes |
GO:0004698 | calcium-dependent protein kinase C activity | 4.0404 | 6 | yes |
GO:0009931 | calcium-dependent protein serine/threonine kinase activity | 4.0404 | 5 | yes |
GO:0010857 | calcium-dependent protein kinase activity | 4.0404 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KPCG_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 61.6162 | 4 | yes |
GO:0010646 | regulation of cell communication | 58.5859 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 55.5556 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 55.5556 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 53.5354 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 53.5354 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 49.4949 | 4 | yes |
GO:0009966 | regulation of signal transduction | 49.4949 | 4 | no |
GO:0051128 | regulation of cellular component organization | 46.4646 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 43.4343 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 40.4040 | 4 | yes |
GO:0051049 | regulation of transport | 40.4040 | 4 | yes |
GO:0010941 | regulation of cell death | 39.3939 | 4 | yes |
GO:0022607 | cellular component assembly | 39.3939 | 4 | no |
GO:0010468 | regulation of gene expression | 38.3838 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 37.3737 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 36.3636 | 5 | yes |
GO:0023056 | positive regulation of signaling | 36.3636 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 36.3636 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 35.3535 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 35.3535 | 5 | yes |
GO:0008104 | protein localization | 35.3535 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 35.3535 | 5 | no |
GO:0071310 | cellular response to organic substance | 35.3535 | 4 | no |
GO:0031399 | regulation of protein modification process | 34.3434 | 6 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.3434 | 5 | yes |
GO:0006996 | organelle organization | 34.3434 | 4 | no |
GO:0071702 | organic substance transport | 32.3232 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 31.3131 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 31.3131 | 6 | no |
GO:0071705 | nitrogen compound transport | 31.3131 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 30.3030 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.3030 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 30.3030 | 5 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 29.2929 | 5 | yes |
GO:0060548 | negative regulation of cell death | 29.2929 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 29.2929 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 29.2929 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 29.2929 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 29.2929 | 5 | no |
GO:0010648 | negative regulation of cell communication | 29.2929 | 5 | no |
GO:0023057 | negative regulation of signaling | 29.2929 | 4 | no |
GO:0051094 | positive regulation of developmental process | 29.2929 | 4 | no |
GO:0016192 | vesicle-mediated transport | 29.2929 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 28.2828 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 28.2828 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 28.2828 | 4 | no |
GO:0009894 | regulation of catabolic process | 27.2727 | 4 | yes |
GO:0010243 | response to organonitrogen compound | 27.2727 | 4 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.2727 | 5 | yes |
GO:0080134 | regulation of response to stress | 27.2727 | 4 | yes |
GO:0019220 | regulation of phosphate metabolic process | 27.2727 | 6 | no |
GO:0042325 | regulation of phosphorylation | 27.2727 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 27.2727 | 5 | no |
GO:0043066 | negative regulation of apoptotic process | 26.2626 | 7 | yes |
GO:0043069 | negative regulation of programmed cell death | 26.2626 | 6 | yes |
GO:0001932 | regulation of protein phosphorylation | 26.2626 | 7 | no |
GO:0043933 | protein-containing complex organization | 26.2626 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 26.2626 | 4 | no |
GO:0045595 | regulation of cell differentiation | 26.2626 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 26.2626 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 25.2525 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 25.2525 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 25.2525 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 25.2525 | 4 | no |
GO:0036211 | protein modification process | 24.2424 | 4 | yes |
GO:0043412 | macromolecule modification | 24.2424 | 4 | yes |
GO:0015031 | protein transport | 24.2424 | 4 | no |
GO:0065003 | protein-containing complex assembly | 24.2424 | 5 | no |
GO:0031344 | regulation of cell projection organization | 24.2424 | 5 | no |
GO:0033043 | regulation of organelle organization | 24.2424 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 24.2424 | 4 | no |
GO:0014070 | response to organic cyclic compound | 23.2323 | 4 | yes |
GO:0030030 | cell projection organization | 23.2323 | 4 | no |
GO:0051338 | regulation of transferase activity | 23.2323 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 23.2323 | 5 | no |
GO:0009968 | negative regulation of signal transduction | 22.2222 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.2222 | 6 | no |
GO:0060627 | regulation of vesicle-mediated transport | 21.2121 | 4 | yes |
GO:0010628 | positive regulation of gene expression | 21.2121 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 21.2121 | 5 | no |
GO:2000026 | regulation of multicellular organismal development | 21.2121 | 4 | no |
GO:0051050 | positive regulation of transport | 21.2121 | 4 | no |
GO:0006468 | protein phosphorylation | 20.2020 | 5 | yes |
GO:0016310 | phosphorylation | 20.2020 | 5 | yes |
GO:0051248 | negative regulation of protein metabolic process | 20.2020 | 6 | yes |
GO:0080135 | regulation of cellular response to stress | 20.2020 | 4 | yes |
GO:0006886 | intracellular protein transport | 20.2020 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 20.2020 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 20.2020 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 20.2020 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 20.2020 | 7 | no |
GO:0060341 | regulation of cellular localization | 20.2020 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 20.2020 | 6 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 20.2020 | 5 | no |
GO:1901701 | cellular response to oxygen-containing compound | 20.2020 | 4 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 20.2020 | 7 | no |
GO:2000145 | regulation of cell motility | 20.2020 | 4 | no |
GO:2001141 | regulation of RNA biosynthetic process | 20.2020 | 6 | no |
GO:0051129 | negative regulation of cellular component organization | 20.2020 | 5 | no |
GO:0030162 | regulation of proteolysis | 19.1919 | 6 | yes |
GO:0032101 | regulation of response to external stimulus | 19.1919 | 4 | yes |
GO:1901214 | regulation of neuron death | 19.1919 | 5 | yes |
GO:0007268 | chemical synaptic transmission | 18.1818 | 6 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 18.1818 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 18.1818 | 4 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 17.1717 | 6 | yes |
GO:0050890 | cognition | 17.1717 | 4 | yes |
GO:0042176 | regulation of protein catabolic process | 15.1515 | 5 | yes |
GO:0050806 | positive regulation of synaptic transmission | 15.1515 | 5 | yes |
GO:0018193 | peptidyl-amino acid modification | 14.1414 | 5 | yes |
GO:0031400 | negative regulation of protein modification process | 14.1414 | 7 | yes |
GO:0043523 | regulation of neuron apoptotic process | 14.1414 | 6 | yes |
GO:0051046 | regulation of secretion | 14.1414 | 5 | yes |
GO:1901215 | negative regulation of neuron death | 14.1414 | 6 | yes |
GO:1903530 | regulation of secretion by cell | 14.1414 | 4 | yes |
GO:0046777 | protein autophosphorylation | 11.1111 | 6 | yes |
GO:0043524 | negative regulation of neuron apoptotic process | 10.1010 | 7 | yes |
GO:0051052 | regulation of DNA metabolic process | 10.1010 | 5 | yes |
GO:0017157 | regulation of exocytosis | 9.0909 | 5 | yes |
GO:0018105 | peptidyl-serine phosphorylation | 9.0909 | 6 | yes |
GO:0018209 | peptidyl-serine modification | 9.0909 | 6 | yes |
GO:0051054 | positive regulation of DNA metabolic process | 9.0909 | 6 | yes |
GO:1903050 | regulation of proteolysis involved in protein catabolic process | 9.0909 | 7 | yes |
GO:1903320 | regulation of protein modification by small protein conjugation or removal | 9.0909 | 7 | yes |
GO:0009895 | negative regulation of catabolic process | 8.0808 | 5 | yes |
GO:0031396 | regulation of protein ubiquitination | 8.0808 | 8 | yes |
GO:0051588 | regulation of neurotransmitter transport | 8.0808 | 5 | yes |
GO:0060291 | long-term synaptic potentiation | 8.0808 | 4 | yes |
GO:1903305 | regulation of regulated secretory pathway | 8.0808 | 6 | yes |
GO:0046928 | regulation of neurotransmitter secretion | 7.0707 | 4 | yes |
GO:0061136 | regulation of proteasomal protein catabolic process | 7.0707 | 6 | yes |
GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | 7.0707 | 8 | yes |
GO:0031397 | negative regulation of protein ubiquitination | 6.0606 | 9 | yes |
GO:0043279 | response to alkaloid | 6.0606 | 5 | yes |
GO:0045861 | negative regulation of proteolysis | 6.0606 | 7 | yes |
GO:0042177 | negative regulation of protein catabolic process | 5.0505 | 6 | yes |
GO:2000300 | regulation of synaptic vesicle exocytosis | 4.0404 | 5 | yes |
GO:2001020 | regulation of response to DNA damage stimulus | 4.0404 | 5 | yes |
GO:0014072 | response to isoquinoline alkaloid | 3.0303 | 5 | yes |
GO:0043278 | response to morphine | 3.0303 | 6 | yes |
GO:0099171 | presynaptic modulation of chemical synaptic transmission | 3.0303 | 6 | yes |
GO:1901799 | negative regulation of proteasomal protein catabolic process | 3.0303 | 7 | yes |
GO:1903051 | negative regulation of proteolysis involved in protein catabolic process | 3.0303 | 8 | yes |
GO:2001022 | positive regulation of response to DNA damage stimulus | 3.0303 | 5 | yes |
GO:0006282 | regulation of DNA repair | 2.0202 | 6 | yes |
GO:0032095 | regulation of response to food | 2.0202 | 7 | yes |
GO:0032104 | regulation of response to extracellular stimulus | 2.0202 | 5 | yes |
GO:0032107 | regulation of response to nutrient levels | 2.0202 | 6 | yes |
GO:0032423 | regulation of mismatch repair | 2.0202 | 7 | yes |
GO:0032425 | positive regulation of mismatch repair | 2.0202 | 7 | yes |
GO:0045739 | positive regulation of DNA repair | 2.0202 | 6 | yes |
GO:0050764 | regulation of phagocytosis | 2.0202 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KPCG_HUMAN |
---|---|---|---|---|
DOID:10595 | Charcot-Marie-Tooth disease | 3.0303 | 6 | no |
DOID:440 | neuromuscular disease | 3.0303 | 5 | no |
DOID:574 | peripheral nervous system disease | 3.0303 | 3 | no |
DOID:870 | neuropathy | 3.0303 | 4 | no |
DOID:331 | central nervous system disease | 3.0303 | 3 | no |
DOID:0050155 | sensory system disease | 2.0202 | 3 | no |
DOID:0050542 | Charcot-Marie-Tooth disease type X | 2.0202 | 7 | no |
DOID:0050563 | nonsyndromic deafness | 2.0202 | 5 | no |
DOID:0050888 | syndromic intellectual disability | 2.0202 | 5 | no |
DOID:0060038 | specific developmental disorder | 2.0202 | 3 | no |
DOID:0060309 | syndromic X-linked intellectual disability | 2.0202 | 6 | no |
DOID:1059 | intellectual disability | 2.0202 | 4 | no |
DOID:2742 | auditory system disease | 2.0202 | 4 | no |
DOID:936 | brain disease | 2.0202 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
LDB3_HUMAN | [view interactions] | Low throughput | no | no |
LIMK1_HUMAN | [view interactions] | Low throughput | no | yes |
CLOCK_HUMAN | [view interactions] | Low throughput | no | yes |
GLRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
TRPC3_HUMAN | [view interactions] | Low throughput | no | no |
PTN1_HUMAN | [view interactions] | Low throughput | no | yes |
1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRIA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GBRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBRA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
IBTK_HUMAN | [view interactions] | Low throughput | no | yes |
RBP10_HUMAN | [view interactions] | Low throughput | no | no |
RANB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AFAP1_HUMAN | [view interactions] | Low throughput | no | yes |
RGS2_HUMAN | [view interactions] | Low throughput | no | no |
TIAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HMGB1_HUMAN | [view interactions] | Low throughput | no | yes |
GBRR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DDX58_HUMAN | [view interactions] | Low throughput | no | yes |
STXB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TOP2A_HUMAN | [view interactions] | Low throughput | no | no |
PEBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CD5_HUMAN | [view interactions] | Low throughput | no | no |
GBRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CXA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MARCS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SDC2_HUMAN | [view interactions] | Low throughput | no | yes |
ITB2_HUMAN | [view interactions] | Low throughput | no | no |
GSK3A_HUMAN | [view interactions] | Low throughput | no | yes |
CASR_HUMAN | [view interactions] | Low throughput | no | no |
ANXA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BCL2_HUMAN | [view interactions] | Low throughput | no | no |
DAB2_HUMAN | [view interactions] | Low throughput | no | yes |
CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DNJC5_HUMAN | [view interactions] | Low throughput | no | yes |
ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NOXA1_HUMAN | [view interactions] | High throughput | no | yes |
EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCHCR_HUMAN | [view interactions] | High throughput | no | no |
DACT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DACT3_HUMAN | [view interactions] | High throughput | no | yes |
DACT2_HUMAN | [view interactions] | High throughput | no | yes |
KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPRB_HUMAN | [view interactions] | High throughput | no | yes |
BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRPS2_HUMAN | [view interactions] | High throughput | no | no |
HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP77_HUMAN | [view interactions] | High throughput | no | no |
DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RCN2_HUMAN | [view interactions] | High throughput | no | yes |
KPRA_HUMAN | [view interactions] | High throughput | no | no |
CDC37_HUMAN | [view interactions] | High throughput | no | yes |
PCKGM_HUMAN | [view interactions] | High throughput | no | no |
H90B2_HUMAN | [view interactions] | High throughput | no | no |
TCF25_HUMAN | [view interactions] | High throughput | no | yes |
NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LTBP1_HUMAN | [view interactions] | High throughput | no | no |
NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
DJC10_HUMAN | [view interactions] | High throughput | no | yes |
KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
TCP1L_HUMAN | [view interactions] | High throughput | no | no |
F167A_HUMAN | [view interactions] | High throughput | no | yes |
PIAS1_HUMAN | [view interactions] | High throughput | no | yes |
K1C19_HUMAN | [view interactions] | High throughput | no | no |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OXDA_HUMAN | [view interactions] | High throughput | no | no |
LNX1_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARHGP_HUMAN | [view interactions] | High throughput | no | yes |
GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHB1_HUMAN | [view interactions] | High throughput | no | no |
SCN3A_HUMAN | [view interactions] | High throughput | no | yes |
TRIM5_HUMAN | [view interactions] | High throughput | no | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
UBE2T_HUMAN | [view interactions] | High throughput | no | no |
FBX7_HUMAN | [view interactions] | High throughput | no | yes |
TIAM2_HUMAN | [view interactions] | High throughput | no | yes |
HABP4_HUMAN | [view interactions] | High throughput | no | yes |
MARK4_HUMAN | [view interactions] | High throughput | no | yes |
NEUG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP14A_HUMAN | [view interactions] | High throughput | no | yes |
CYH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TTF2_HUMAN | [view interactions] | Computational | no | yes |
STX4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CRK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ITPR3_HUMAN | [view interactions] | Computational | no | yes |
ITPR2_HUMAN | [view interactions] | Computational | no | yes |
SL9A1_HUMAN | [view interactions] | Computational | no | no |
CABIN_HUMAN | [view interactions] | Computational | no | yes |
GRIA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLCG2_HUMAN | [view interactions] | Computational | no | yes |
MTOR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRIP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
FZD4_HUMAN | [view interactions] | Computational | no | yes |
RAF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
EGLN3_HUMAN | [view interactions] | Computational | no | no |
WNT5A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KPCD1_HUMAN | [view interactions] | Computational | no | yes |
PLCD3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLCD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TTF1_HUMAN | [view interactions] | Computational | no | yes |
SC6A3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
VAS1_HUMAN | [view interactions] | Computational | no | yes |
RARA_HUMAN | [view interactions] | Computational | no | no |
AP2S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SPHK1_HUMAN | [view interactions] | Computational | no | yes |
SPHK2_HUMAN | [view interactions] | Computational | no | no |
EGLN2_HUMAN | [view interactions] | Computational | no | no |
RXRG_HUMAN | [view interactions] | Computational | no | no |
EZRI_HUMAN | [view entry] [view interactions] | Computational | yes | no |
AP2A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CASP3_HUMAN | [view interactions] | Computational | no | yes |
PLPL9_HUMAN | [view interactions] | Computational | no | yes |
PLD2_HUMAN | [view interactions] | Computational | no | yes |
EGLN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BCAR1_HUMAN | [view interactions] | Computational | no | yes |
PLCZ1_HUMAN | [view interactions] | Computational | no | no |
RXRA_HUMAN | [view interactions] | Computational | no | yes |
FOS_HUMAN | [view interactions] | Computational | no | yes |
ARBK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RASN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
EF2K_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RXRB_HUMAN | [view interactions] | Computational | no | yes |
AP2M1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TRPV4_HUMAN | [view interactions] | Computational | no | yes |
CAC1A_HUMAN | [view interactions] | Computational | no | no |
KPCD3_HUMAN | [view interactions] | Computational | no | yes |
KPCD2_HUMAN | [view interactions] | Computational | no | yes |
GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NHRF1_HUMAN | [view interactions] | Computational | no | no |
STXB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AP2B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLCE1_HUMAN | [view interactions] | Computational | no | yes |
CD38_HUMAN | [view interactions] | Computational | no | no |
NCF1_HUMAN | [view interactions] | Computational | no | no |
DVL2_HUMAN | [view interactions] | Computational | no | yes |
MK01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AP2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLD1_HUMAN | [view interactions] | Computational | no | no |
TA2R_HUMAN | [view interactions] | Computational | no | no |
FAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLCD4_HUMAN | [view interactions] | Computational | no | no |
CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PAX8_HUMAN | [view interactions] | Computational | no | yes |
MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |