GRIA4_HUMAN
Evidence for PS localization
Functions
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 639 | Thr | Ser | Neurodevelopmentaldisorderwithorwithoutseizuresandgaitabnormalities(NEDSGA) | - |
| 641 | Asn | Asp | Neurodevelopmentaldisorderwithorwithoutseizuresandgaitabnormalities(NEDSGA) | - |
| 643 | Ala | Gly | Neurodevelopmentaldisorderwithorwithoutseizuresandgaitabnormalities(NEDSGA) | - |
| 644 | Ala | Val | Neurodevelopmentaldisorderwithorwithoutseizuresandgaitabnormalities(NEDSGA) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRIA4_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.7442 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.7442 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.7442 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 25.5814 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 25.5814 | 4 | yes |
| GO:0005524 | ATP binding | 24.4186 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 24.4186 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.4186 | 5 | no |
| GO:0005216 | ion channel activity | 20.9302 | 4 | yes |
| GO:0005261 | cation channel activity | 20.9302 | 5 | yes |
| GO:0015267 | channel activity | 20.9302 | 4 | yes |
| GO:0022836 | gated channel activity | 20.9302 | 5 | yes |
| GO:0004970 | ionotropic glutamate receptor activity | 13.9535 | 5 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 13.9535 | 6 | yes |
| GO:0008066 | glutamate receptor activity | 13.9535 | 4 | yes |
| GO:0015276 | ligand-gated ion channel activity | 13.9535 | 5 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 13.9535 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 13.9535 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 13.9535 | 4 | yes |
| GO:0099094 | ligand-gated cation channel activity | 12.7907 | 6 | yes |
| GO:0001540 | amyloid-beta binding | 9.3023 | 4 | yes |
| GO:0004971 | AMPA glutamate receptor activity | 5.8140 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRIA4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.9767 | 4 | no |
| GO:0008104 | protein localization | 46.5116 | 4 | no |
| GO:0051049 | regulation of transport | 46.5116 | 4 | no |
| GO:0010646 | regulation of cell communication | 44.1860 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.2093 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 37.2093 | 4 | no |
| GO:0006996 | organelle organization | 36.0465 | 4 | no |
| GO:0071702 | organic substance transport | 34.8837 | 4 | no |
| GO:0071705 | nitrogen compound transport | 34.8837 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.7209 | 4 | no |
| GO:0015031 | protein transport | 32.5581 | 4 | no |
| GO:0043269 | regulation of ion transport | 32.5581 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 32.5581 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 32.5581 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.5581 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.3953 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.0698 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 27.9070 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 27.9070 | 4 | no |
| GO:0006886 | intracellular protein transport | 25.5814 | 4 | no |
| GO:0023056 | positive regulation of signaling | 25.5814 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.5814 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.4186 | 5 | no |
| GO:0051050 | positive regulation of transport | 24.4186 | 4 | no |
| GO:0022607 | cellular component assembly | 23.2558 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 23.2558 | 4 | no |
| GO:0030030 | cell projection organization | 22.0930 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 22.0930 | 4 | no |
| GO:0072657 | protein localization to membrane | 22.0930 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 22.0930 | 5 | no |
| GO:1904062 | regulation of cation transmembrane transport | 22.0930 | 6 | no |
| GO:0060341 | regulation of cellular localization | 20.9302 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.9302 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 20.9302 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 20.9302 | 6 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 20.9302 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 20.9302 | 4 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 20.9302 | 4 | no |
| GO:0044057 | regulation of system process | 20.9302 | 4 | no |
| GO:0010941 | regulation of cell death | 18.6047 | 4 | yes |
| GO:0043067 | regulation of programmed cell death | 16.2791 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 15.1163 | 6 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 11.6279 | 4 | yes |
| GO:0060548 | negative regulation of cell death | 10.4651 | 5 | yes |
| GO:0043069 | negative regulation of programmed cell death | 9.3023 | 6 | yes |
| GO:0043066 | negative regulation of apoptotic process | 8.1395 | 7 | yes |
| GO:0010660 | regulation of muscle cell apoptotic process | 4.6512 | 7 | yes |
| GO:0034392 | negative regulation of smooth muscle cell apoptotic process | 2.3256 | 9 | yes |
| GO:0010656 | negative regulation of muscle cell apoptotic process | 2.3256 | 8 | yes |
| GO:0034391 | regulation of smooth muscle cell apoptotic process | 2.3256 | 8 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GRIA4_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 2.3256 | 3 | no |
| DOID:0050155 | sensory system disease | 2.3256 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 2.3256 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 2.3256 | 6 | no |
| DOID:2742 | auditory system disease | 2.3256 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK08_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KPCG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E41L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPB41_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| E41L3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NPTX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| ABHD5_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IP3KA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CN37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMOD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| CELF1_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AKAP5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TSN7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NMD3A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NMD3B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KIF5C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MDM2_HUMAN | [view interactions] | Computational | no | yes |
| NFL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHSA9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NMDE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CNIH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP2A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CNIH3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NMDE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NOE2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DLG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NSF_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NMDE4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NMDE3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KIF5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG5_HUMAN | [view entry] [view interactions] | Computational | yes | no |