NPTX1_HUMAN
Evidence for PS localization
Functions
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 370 | Gln | Arg | Spinocerebellarataxia50(SCA50) | - |
| 389 | Gly | Arg | Spinocerebellarataxia50(SCA50) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NPTX1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 45.8333 | 4 | yes |
| GO:0046872 | metal ion binding | 41.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NPTX1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 62.5000 | 4 | no |
| GO:0010646 | regulation of cell communication | 58.3333 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 58.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.1667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 45.8333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.8333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.8333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 41.6667 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 41.6667 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 41.6667 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.6667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.6667 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.6667 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 37.5000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 37.5000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 37.5000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 37.5000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 37.5000 | 6 | no |
| GO:0008104 | protein localization | 37.5000 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 33.3333 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 33.3333 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0051093 | negative regulation of developmental process | 33.3333 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 33.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | yes |
| GO:0030030 | cell projection organization | 33.3333 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 33.3333 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 33.3333 | 4 | yes |
| GO:0032880 | regulation of protein localization | 29.1667 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.1667 | 4 | no |
| GO:0060341 | regulation of cellular localization | 29.1667 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 29.1667 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 29.1667 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.1667 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 29.1667 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 29.1667 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
| GO:0031175 | neuron projection development | 25.0000 | 6 | no |
| GO:0050807 | regulation of synapse organization | 25.0000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0045596 | negative regulation of cell differentiation | 25.0000 | 5 | no |
| GO:0045926 | negative regulation of growth | 25.0000 | 4 | no |
| GO:0048638 | regulation of developmental growth | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.8333 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.8333 | 4 | no |
| GO:0080134 | regulation of response to stress | 20.8333 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.8333 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 20.8333 | 4 | no |
| GO:0033993 | response to lipid | 20.8333 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 20.8333 | 6 | no |
| GO:0050767 | regulation of neurogenesis | 20.8333 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.8333 | 4 | no |
| GO:0051960 | regulation of nervous system development | 20.8333 | 5 | no |
| GO:0060284 | regulation of cell development | 20.8333 | 5 | no |
| GO:0071702 | organic substance transport | 20.8333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.8333 | 4 | no |
| GO:1902473 | regulation of protein localization to synapse | 20.8333 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.8333 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.8333 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.8333 | 6 | no |
| GO:0048640 | negative regulation of developmental growth | 20.8333 | 5 | no |
| GO:0051726 | regulation of cell cycle | 20.8333 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.8333 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.8333 | 8 | no |
| GO:0033674 | positive regulation of kinase activity | 20.8333 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.8333 | 4 | no |
| GO:0043549 | regulation of kinase activity | 20.8333 | 5 | no |
| GO:0043933 | protein-containing complex organization | 20.8333 | 4 | no |
| GO:0051338 | regulation of transferase activity | 20.8333 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 20.8333 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 20.8333 | 5 | no |
| GO:0099175 | regulation of postsynapse organization | 20.8333 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 20.8333 | 5 | no |
| GO:0006915 | apoptotic process | 20.8333 | 4 | no |
| GO:0009894 | regulation of catabolic process | 20.8333 | 4 | no |
| GO:0006996 | organelle organization | 20.8333 | 4 | yes |
| GO:0010038 | response to metal ion | 20.8333 | 4 | yes |
| GO:0099536 | synaptic signaling | 16.6667 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 16.6667 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 12.5000 | 5 | yes |
| GO:0007005 | mitochondrion organization | 12.5000 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 12.5000 | 7 | yes |
| GO:0071241 | cellular response to inorganic substance | 12.5000 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 12.5000 | 5 | yes |
| GO:0072657 | protein localization to membrane | 12.5000 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 12.5000 | 6 | yes |
| GO:0007409 | axonogenesis | 8.3333 | 6 | yes |
| GO:0033365 | protein localization to organelle | 8.3333 | 5 | yes |
| GO:0042593 | glucose homeostasis | 8.3333 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 8.3333 | 5 | yes |
| GO:0070925 | organelle assembly | 8.3333 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 8.3333 | 4 | yes |
| GO:1902414 | protein localization to cell junction | 8.3333 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MKRN3_HUMAN | [view interactions] | Low throughput | no | yes |
| NPTXR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NPTX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LYPD4_HUMAN | [view interactions] | High throughput | no | no |
| LYPD1_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPR1_HUMAN | [view interactions] | High throughput | no | no |
| LYZL1_HUMAN | [view interactions] | High throughput | no | no |
| I12R1_HUMAN | [view interactions] | High throughput | no | no |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNT5A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| GXLT1_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRP2_HUMAN | [view interactions] | High throughput | no | no |
| C1QA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LCN9_HUMAN | [view interactions] | High throughput | no | no |
| AB17B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CST9L_HUMAN | [view interactions] | High throughput | no | no |
| BY55_HUMAN | [view interactions] | High throughput | no | no |
| CCL3_HUMAN | [view interactions] | High throughput | no | no |
| NGLY1_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFNA2_HUMAN | [view interactions] | High throughput | no | no |
| OS9_HUMAN | [view interactions] | High throughput | no | yes |
| CD8A_HUMAN | [view interactions] | High throughput | no | no |
| DB136_HUMAN | [view interactions] | High throughput | no | no |
| LY86_HUMAN | [view interactions] | High throughput | no | no |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| IL25_HUMAN | [view interactions] | High throughput | no | no |
| ESPB1_HUMAN | [view interactions] | High throughput | no | no |
| PXDC2_HUMAN | [view interactions] | High throughput | no | yes |
| IGFL1_HUMAN | [view interactions] | High throughput | no | no |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM7_HUMAN | [view interactions] | High throughput | no | yes |
| THSD4_HUMAN | [view interactions] | High throughput | no | no |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGF19_HUMAN | [view interactions] | High throughput | no | yes |
| IDUA_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAKD2_HUMAN | [view interactions] | High throughput | no | yes |
| NIT2_HUMAN | [view interactions] | High throughput | no | yes |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T132A_HUMAN | [view interactions] | High throughput | no | yes |
| WDR48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUFC_HUMAN | [view interactions] | High throughput | no | yes |
| DEF1_HUMAN | [view interactions] | High throughput | no | no |
| TM2D3_HUMAN | [view interactions] | High throughput | no | yes |
| CHSTA_HUMAN | [view interactions] | High throughput | no | yes |
| GILT_HUMAN | [view interactions] | High throughput | no | no |
| GDF3_HUMAN | [view interactions] | High throughput | no | no |
| LIPF_HUMAN | [view interactions] | High throughput | no | no |
| MMP10_HUMAN | [view interactions] | High throughput | no | no |
| WNT7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAPSA_HUMAN | [view interactions] | High throughput | no | no |
| DHI1_HUMAN | [view interactions] | High throughput | no | no |
| MIME_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCG3B_HUMAN | [view interactions] | High throughput | no | no |
| ZPBP2_HUMAN | [view interactions] | High throughput | no | no |
| NECT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIAE_HUMAN | [view interactions] | High throughput | no | yes |
| TACT_HUMAN | [view interactions] | High throughput | no | no |
| BMP7_HUMAN | [view interactions] | High throughput | no | no |
| TECT1_HUMAN | [view interactions] | High throughput | no | yes |
| LYZL2_HUMAN | [view interactions] | High throughput | no | no |