Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NPTX1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NPTX1_HUMAN
GO:0046872 metal ion binding 47.6190 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NPTX1_HUMAN
GO:0048523 negative regulation of cellular process 71.4286 4 no
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0009966 regulation of signal transduction 66.6667 4 yes
GO:0009893 positive regulation of metabolic process 61.9048 4 no
GO:0010604 positive regulation of macromolecule metabolic process 61.9048 5 no
GO:0060255 regulation of macromolecule metabolic process 61.9048 4 no
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0031325 positive regulation of cellular metabolic process 57.1429 5 no
GO:0051171 regulation of nitrogen compound metabolic process 57.1429 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 57.1429 5 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0051246 regulation of protein metabolic process 52.3810 5 no
GO:0051247 positive regulation of protein metabolic process 52.3810 6 no
GO:0010468 regulation of gene expression 47.6190 5 no
GO:0071310 cellular response to organic substance 47.6190 4 yes
GO:0010648 negative regulation of cell communication 42.8571 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.8571 5 no
GO:0023057 negative regulation of signaling 42.8571 4 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:1902531 regulation of intracellular signal transduction 42.8571 5 no
GO:1901701 cellular response to oxygen-containing compound 42.8571 4 yes
GO:0009889 regulation of biosynthetic process 38.0952 4 no
GO:0009968 negative regulation of signal transduction 38.0952 5 no
GO:0010556 regulation of macromolecule biosynthetic process 38.0952 5 no
GO:0031326 regulation of cellular biosynthetic process 38.0952 5 no
GO:0031401 positive regulation of protein modification process 38.0952 7 no
GO:0045595 regulation of cell differentiation 38.0952 4 no
GO:0048585 negative regulation of response to stimulus 38.0952 4 no
GO:0051093 negative regulation of developmental process 38.0952 4 no
GO:0051241 negative regulation of multicellular organismal process 38.0952 4 no
GO:0051252 regulation of RNA metabolic process 38.0952 5 no
GO:0010941 regulation of cell death 38.0952 4 no
GO:0008104 protein localization 38.0952 4 yes
GO:0030030 cell projection organization 38.0952 4 yes
GO:0050804 modulation of chemical synaptic transmission 38.0952 5 yes
GO:0099177 regulation of trans-synaptic signaling 38.0952 4 yes
GO:0006355 regulation of DNA-templated transcription 33.3333 6 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:1903506 regulation of nucleic acid-templated transcription 33.3333 7 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:2000026 regulation of multicellular organismal development 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0042981 regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 5 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 yes
GO:0050807 regulation of synapse organization 33.3333 5 yes
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0045596 negative regulation of cell differentiation 28.5714 5 no
GO:0045926 negative regulation of growth 28.5714 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0010243 response to organonitrogen compound 28.5714 4 no
GO:0031175 neuron projection development 28.5714 6 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0048638 regulation of developmental growth 28.5714 4 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0080134 regulation of response to stress 28.5714 4 no
GO:0080135 regulation of cellular response to stress 28.5714 4 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 28.5714 6 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0043066 negative regulation of apoptotic process 28.5714 7 no
GO:0043069 negative regulation of programmed cell death 28.5714 6 no
GO:0060548 negative regulation of cell death 28.5714 5 no
GO:0010038 response to metal ion 28.5714 4 yes
GO:0031644 regulation of nervous system process 28.5714 5 yes
GO:0044057 regulation of system process 28.5714 4 yes
GO:0099175 regulation of postsynapse organization 28.5714 6 yes
GO:0030155 regulation of cell adhesion 23.8095 4 no
GO:0036211 protein modification process 23.8095 4 no
GO:0043412 macromolecule modification 23.8095 4 no
GO:0045859 regulation of protein kinase activity 23.8095 6 no
GO:0045860 positive regulation of protein kinase activity 23.8095 7 no
GO:0006508 proteolysis 23.8095 4 no
GO:0014070 response to organic cyclic compound 23.8095 4 no
GO:0022603 regulation of anatomical structure morphogenesis 23.8095 4 no
GO:0033993 response to lipid 23.8095 4 no
GO:0043408 regulation of MAPK cascade 23.8095 6 no
GO:0050767 regulation of neurogenesis 23.8095 6 no
GO:0051240 positive regulation of multicellular organismal process 23.8095 4 no
GO:0051960 regulation of nervous system development 23.8095 5 no
GO:0060284 regulation of cell development 23.8095 5 no
GO:1902473 regulation of protein localization to synapse 23.8095 6 no
GO:0010975 regulation of neuron projection development 23.8095 7 no
GO:0043933 protein-containing complex organization 23.8095 4 no
GO:0065003 protein-containing complex assembly 23.8095 5 no
GO:1903829 positive regulation of protein localization 23.8095 5 no
GO:0006357 regulation of transcription by RNA polymerase II 23.8095 7 no
GO:0045893 positive regulation of DNA-templated transcription 23.8095 7 no
GO:0048640 negative regulation of developmental growth 23.8095 5 no
GO:0051050 positive regulation of transport 23.8095 4 no
GO:0051254 positive regulation of RNA metabolic process 23.8095 6 no
GO:1902680 positive regulation of RNA biosynthetic process 23.8095 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 23.8095 8 no
GO:0033043 regulation of organelle organization 23.8095 5 yes
GO:1901888 regulation of cell junction assembly 19.0476 5 yes
GO:0006996 organelle organization 19.0476 4 yes
GO:0048878 chemical homeostasis 19.0476 4 yes
GO:0051963 regulation of synapse assembly 19.0476 6 yes
GO:0071241 cellular response to inorganic substance 19.0476 4 yes
GO:0071248 cellular response to metal ion 19.0476 5 yes
GO:0099601 regulation of neurotransmitter receptor activity 19.0476 4 yes
GO:1990778 protein localization to cell periphery 14.2857 5 yes
GO:0007005 mitochondrion organization 14.2857 5 yes
GO:0072657 protein localization to membrane 14.2857 4 yes
GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 14.2857 5 yes
GO:0099537 trans-synaptic signaling 14.2857 4 yes
GO:1902414 protein localization to cell junction 9.5238 5 yes
GO:1904889 regulation of excitatory synapse assembly 9.5238 7 yes
GO:0007268 chemical synaptic transmission 9.5238 6 yes
GO:0007409 axonogenesis 9.5238 8 yes
GO:0032990 cell part morphogenesis 9.5238 4 yes
GO:0033365 protein localization to organelle 9.5238 5 yes
GO:0033500 carbohydrate homeostasis 9.5238 5 yes
GO:0042593 glucose homeostasis 9.5238 6 yes
GO:0048812 neuron projection morphogenesis 9.5238 7 yes
GO:0048858 cell projection morphogenesis 9.5238 5 yes
GO:0098916 anterograde trans-synaptic signaling 9.5238 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 9.5238 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIA4_HUMAN [view entry] [view interactions] Low throughput yes no
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
MKRN3_HUMAN [view interactions] Low throughput no yes
NPTXR_HUMAN [view entry] [view interactions] Low throughput yes yes
NPTX2_HUMAN [view entry] [view interactions] Low throughput yes yes
THSD4_HUMAN [view interactions] High throughput no no
DAG1_HUMAN [view entry] [view interactions] High throughput yes no
FGF19_HUMAN [view interactions] High throughput no yes
IDUA_HUMAN [view interactions] High throughput no yes
TMPS4_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
OSBP1_HUMAN [view interactions] High throughput no yes
NAKD2_HUMAN [view interactions] High throughput no yes
NIT2_HUMAN [view interactions] High throughput no yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
TCOF_HUMAN [view interactions] High throughput no yes
RCN2_HUMAN [view interactions] High throughput no yes
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
T132A_HUMAN [view interactions] High throughput no yes
WDR48_HUMAN [view entry] [view interactions] High throughput yes yes
NEUFC_HUMAN [view interactions] High throughput no yes
DEF1_HUMAN [view interactions] High throughput no no
TM2D3_HUMAN [view interactions] High throughput no yes
CHSTA_HUMAN [view interactions] High throughput no yes
GILT_HUMAN [view interactions] High throughput no no
GDF3_HUMAN [view interactions] High throughput no no
LIPG_HUMAN [view interactions] High throughput no no
MMP10_HUMAN [view interactions] High throughput no no
WNT7A_HUMAN [view entry] [view interactions] High throughput yes no
NAPSA_HUMAN [view interactions] High throughput no no
DHI1_HUMAN [view interactions] High throughput no no
MIME_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
ASF1A_HUMAN [view interactions] High throughput no no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
FCG3B_HUMAN [view interactions] High throughput no no
ZPBP2_HUMAN [view interactions] High throughput no no
NECT3_HUMAN [view entry] [view interactions] High throughput yes yes
SIAE_HUMAN [view interactions] High throughput no yes
TACT_HUMAN [view interactions] High throughput no no
BMP7_HUMAN [view interactions] High throughput no no
TECT1_HUMAN [view interactions] High throughput no yes
LYZL2_HUMAN [view interactions] High throughput no no
LYPD4_HUMAN [view interactions] High throughput no no
LYPD1_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
LIPR1_HUMAN [view interactions] High throughput no no
LYZL1_HUMAN [view interactions] High throughput no no
I12R1_HUMAN [view interactions] High throughput no no
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
WNT5A_HUMAN [view entry] [view interactions] High throughput yes no
TAZ_HUMAN [view interactions] High throughput no yes
GXLT1_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
LRP2_HUMAN [view interactions] High throughput no no
C1QA_HUMAN [view interactions] High throughput no no
LCN9_HUMAN [view interactions] High throughput no no
AB17B_HUMAN [view entry] [view interactions] High throughput yes no
CST9L_HUMAN [view interactions] High throughput no no
BY55_HUMAN [view interactions] High throughput no no
CCL3_HUMAN [view interactions] High throughput no no
NGLY1_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
EFNA2_HUMAN [view interactions] High throughput no no
OS9_HUMAN [view interactions] High throughput no yes
CD8A_HUMAN [view interactions] High throughput no no
DB136_HUMAN [view interactions] High throughput no no
LY86_HUMAN [view interactions] High throughput no no
HDBP1_HUMAN [view interactions] High throughput no no
IL25_HUMAN [view interactions] High throughput no no
ESPB1_HUMAN [view interactions] High throughput no no
PXDC2_HUMAN [view interactions] High throughput no yes
IGFL1_HUMAN [view interactions] High throughput no no
FUT8_HUMAN [view interactions] High throughput no yes
TRIM7_HUMAN [view interactions] High throughput no yes