Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WDR48_HUMAN

(Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in WDR48_HUMAN
GO:0000166 nucleotide binding 28.0000 4 no
GO:0043168 anion binding 28.0000 4 no
GO:0003723 RNA binding 28.0000 4 no
GO:0005524 ATP binding 26.0000 5 no
GO:0017076 purine nucleotide binding 26.0000 5 no
GO:0030554 adenyl nucleotide binding 26.0000 6 no
GO:0032555 purine ribonucleotide binding 26.0000 4 no
GO:0032559 adenyl ribonucleotide binding 26.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 26.0000 4 no
GO:0003677 DNA binding 6.0000 4 yes
GO:0003690 double-stranded DNA binding 6.0000 5 yes
GO:0016504 peptidase activator activity 6.0000 4 yes
GO:0035800 deubiquitinase activator activity 6.0000 5 yes
GO:0003697 single-stranded DNA binding 4.0000 5 yes
GO:0043130 ubiquitin binding 4.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in WDR48_HUMAN
GO:0048522 positive regulation of cellular process 58.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.0000 4 yes
GO:0080090 regulation of primary metabolic process 52.0000 4 yes
GO:0031323 regulation of cellular metabolic process 48.0000 4 no
GO:0010646 regulation of cell communication 42.0000 4 yes
GO:0048523 negative regulation of cellular process 40.0000 4 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.0000 5 yes
GO:0009889 regulation of biosynthetic process 38.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 38.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 38.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 38.0000 5 yes
GO:0022607 cellular component assembly 36.0000 4 no
GO:0009966 regulation of signal transduction 36.0000 4 yes
GO:0036211 protein modification process 32.0000 4 no
GO:0043412 macromolecule modification 32.0000 4 no
GO:0033043 regulation of organelle organization 32.0000 5 no
GO:0051246 regulation of protein metabolic process 30.0000 5 yes
GO:0032880 regulation of protein localization 30.0000 5 no
GO:0060341 regulation of cellular localization 30.0000 4 no
GO:0009892 negative regulation of metabolic process 28.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 28.0000 5 no
GO:1903829 positive regulation of protein localization 28.0000 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.0000 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 26.0000 5 no
GO:0048585 negative regulation of response to stimulus 26.0000 4 no
GO:0051130 positive regulation of cellular component organization 26.0000 5 no
GO:0006996 organelle organization 26.0000 4 no
GO:0008104 protein localization 26.0000 4 no
GO:0031399 regulation of protein modification process 24.0000 6 yes
GO:0051052 regulation of DNA metabolic process 24.0000 5 yes
GO:0031324 negative regulation of cellular metabolic process 24.0000 5 no
GO:0050821 protein stabilization 24.0000 4 no
GO:0009891 positive regulation of biosynthetic process 24.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 24.0000 6 no
GO:0042127 regulation of cell population proliferation 22.0000 4 yes
GO:0051054 positive regulation of DNA metabolic process 22.0000 6 yes
GO:0009968 negative regulation of signal transduction 22.0000 5 no
GO:0010468 regulation of gene expression 22.0000 6 no
GO:0010648 negative regulation of cell communication 22.0000 5 no
GO:0023057 negative regulation of signaling 22.0000 4 no
GO:0051726 regulation of cell cycle 22.0000 4 no
GO:0070201 regulation of establishment of protein localization 22.0000 6 no
GO:1904951 positive regulation of establishment of protein localization 22.0000 6 no
GO:0023056 positive regulation of signaling 20.0000 4 yes
GO:0048584 positive regulation of response to stimulus 20.0000 4 yes
GO:0010647 positive regulation of cell communication 20.0000 5 yes
GO:0080134 regulation of response to stress 18.0000 4 yes
GO:0009967 positive regulation of signal transduction 18.0000 5 yes
GO:0090304 nucleic acid metabolic process 14.0000 4 yes
GO:0008284 positive regulation of cell population proliferation 14.0000 5 yes
GO:0031396 regulation of protein ubiquitination 12.0000 9 yes
GO:1901873 regulation of post-translational protein modification 12.0000 7 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 12.0000 8 yes
GO:0006259 DNA metabolic process 8.0000 5 yes
GO:0006281 DNA repair 8.0000 5 yes
GO:0006302 double-strand break repair 8.0000 6 yes
GO:0006974 DNA damage response 8.0000 4 yes
GO:0048232 male gamete generation 6.0000 4 yes
GO:0048568 embryonic organ development 6.0000 4 yes
GO:0050678 regulation of epithelial cell proliferation 6.0000 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 6.0000 6 yes
GO:0072520 seminiferous tubule development 6.0000 4 yes
GO:0080135 regulation of cellular response to stress 6.0000 4 yes
GO:1902525 regulation of protein monoubiquitination 6.0000 10 yes
GO:0000018 regulation of DNA recombination 6.0000 6 yes
GO:0043588 skin development 4.0000 4 yes
GO:0045739 positive regulation of DNA repair 4.0000 5 yes
GO:0045911 positive regulation of DNA recombination 4.0000 7 yes
GO:0046425 regulation of receptor signaling pathway via JAK-STAT 4.0000 6 yes
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 4.0000 7 yes
GO:0048705 skeletal system morphogenesis 4.0000 4 yes
GO:1904892 regulation of receptor signaling pathway via STAT 4.0000 5 yes
GO:1904894 positive regulation of receptor signaling pathway via STAT 4.0000 6 yes
GO:1905168 positive regulation of double-strand break repair via homologous recombination 4.0000 7 yes
GO:2000779 regulation of double-strand break repair 4.0000 6 yes
GO:2000781 positive regulation of double-strand break repair 4.0000 6 yes
GO:0000724 double-strand break repair via homologous recombination 4.0000 7 yes
GO:0000725 recombinational repair 4.0000 6 yes
GO:0006282 regulation of DNA repair 4.0000 5 yes
GO:0006310 DNA recombination 4.0000 6 yes
GO:0010569 regulation of double-strand break repair via homologous recombination 4.0000 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FANCI_HUMAN [view interactions] Low throughput no yes
ITCH_HUMAN [view interactions] Low throughput no yes
ANDR_HUMAN [view interactions] Low throughput no no
TBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
RIPK1_HUMAN [view interactions] Low throughput no yes
ULK1_HUMAN [view interactions] Low throughput no no
NFAT5_HUMAN [view interactions] Low throughput no yes
NMRL1_HUMAN [view interactions] Low throughput no yes
ID1_HUMAN [view interactions] Low throughput no yes
MYC_HUMAN [view interactions] Low throughput no yes
PCNA_HUMAN [view interactions] Low throughput no no
RAD51_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
FACD2_HUMAN [view interactions] Low throughput no no
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
RL40_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP12_HUMAN [view interactions] Low throughput no yes
UBP46_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP1_HUMAN [view interactions] Low throughput no yes
PHLP2_HUMAN [view interactions] Low throughput no yes
PHLP1_HUMAN [view interactions] Low throughput no yes
WDR20_HUMAN [view interactions] Low throughput no no
R51A1_HUMAN [view interactions] Low throughput no no
ATAD5_HUMAN [view interactions] Low throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
PSA3_HUMAN [view interactions] High throughput no no
FBXL7_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
VSX2_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
NOLC1_HUMAN [view interactions] High throughput no yes
RASF8_HUMAN [view interactions] High throughput no yes
ORC3_HUMAN [view interactions] High throughput no yes
NFAC1_HUMAN [view interactions] High throughput no no
NFAC2_HUMAN [view interactions] High throughput no yes
JMJD6_HUMAN [view interactions] High throughput no yes
SOCS6_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
WAPL_HUMAN [view interactions] High throughput no yes
BRD2_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
DAB2_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
ARI1A_HUMAN [view interactions] High throughput no yes
CNOT7_HUMAN [view interactions] High throughput no no
U2AF4_HUMAN [view interactions] High throughput no yes
CSTF1_HUMAN [view interactions] High throughput no yes
NEST_HUMAN [view interactions] High throughput no no
RPP30_HUMAN [view interactions] High throughput no yes
SF3B5_HUMAN [view interactions] High throughput no yes
AQP4_HUMAN [view entry] [view interactions] High throughput yes no
ESYT1_HUMAN [view entry] [view interactions] High throughput yes yes
CAHM5_HUMAN [view interactions] High throughput no no
MCU_HUMAN [view interactions] High throughput no yes
ATP5I_HUMAN [view interactions] High throughput no yes
FCHO2_HUMAN [view interactions] High throughput no yes
FETUA_HUMAN [view interactions] High throughput no no
SKT_HUMAN [view entry] [view interactions] High throughput yes yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
SOAT1_HUMAN [view interactions] High throughput no no
ARHG7_HUMAN [view entry] [view interactions] High throughput yes yes
SMTL2_HUMAN [view interactions] High throughput no no
WDR48_HUMAN [view entry] [view interactions] High throughput yes yes
PSD13_HUMAN [view interactions] High throughput no yes
FOXO3_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
IMA5_HUMAN [view entry] [view interactions] High throughput yes yes
GORS1_HUMAN [view interactions] High throughput no yes
SGO1_HUMAN [view interactions] High throughput no no
FAXC_HUMAN [view interactions] High throughput no no
OPALI_HUMAN [view interactions] High throughput no yes
SPSB2_HUMAN [view interactions] High throughput no no
HUMMR_HUMAN [view interactions] High throughput no yes
DACT2_HUMAN [view interactions] High throughput no yes
GPBL1_HUMAN [view interactions] High throughput no yes
IGDC4_HUMAN [view interactions] High throughput no yes
VSIG4_HUMAN [view interactions] High throughput no no
TR19L_HUMAN [view interactions] High throughput no no
PGES2_HUMAN [view interactions] High throughput no yes
PFD3_HUMAN [view interactions] High throughput no yes
ASIC4_HUMAN [view interactions] High throughput no no
PNMA2_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
DDB1_HUMAN [view interactions] High throughput no yes
CLAP2_HUMAN [view entry] [view interactions] High throughput yes no
H2AZ_HUMAN [view interactions] High throughput no yes
H2B2E_HUMAN [view interactions] High throughput no yes
IMB1_HUMAN [view entry] [view interactions] High throughput yes yes
MSS4_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
DVL2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
LDLR_HUMAN [view interactions] High throughput no yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
SYYC_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
HMGN2_HUMAN [view interactions] High throughput no no
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
S10A2_HUMAN [view interactions] High throughput no no
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC4_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes
UIMC1_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
SPT6H_HUMAN [view interactions] High throughput no yes
NEB1_HUMAN [view entry] [view interactions] High throughput yes yes
WRN_HUMAN [view interactions] High throughput no yes
NELFE_HUMAN [view interactions] High throughput no yes
CRTAP_HUMAN [view interactions] High throughput no yes
GPN3_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
IWS1_HUMAN [view interactions] High throughput no yes
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
KAISO_HUMAN [view interactions] High throughput no yes
KDM4A_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
GPN1_HUMAN [view interactions] High throughput no yes
TRM11_HUMAN [view interactions] High throughput no no
TARB1_HUMAN [view interactions] High throughput no no
DMWD_HUMAN [view entry] [view interactions] High throughput yes no
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
ARHGA_HUMAN [view interactions] High throughput no yes
RPB7_HUMAN [view interactions] High throughput no yes
SAHH3_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
EIF3H_HUMAN [view interactions] High throughput no yes
NOP10_HUMAN [view interactions] High throughput no yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
BOP1_HUMAN [view interactions] High throughput no yes
TCOF_HUMAN [view interactions] High throughput no yes
ZN639_HUMAN [view interactions] High throughput no yes
CUL4B_HUMAN [view interactions] High throughput no yes
AP3M1_HUMAN [view entry] [view interactions] High throughput yes yes
WDR70_HUMAN [view interactions] High throughput no no
DKC1_HUMAN [view interactions] High throughput no yes
YLPM1_HUMAN [view interactions] High throughput no yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
SET_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
NHP2_HUMAN [view interactions] High throughput no yes
SHQ1_HUMAN [view interactions] High throughput no no
PSME3_HUMAN [view interactions] High throughput no yes
STK11_HUMAN [view interactions] High throughput no yes
SMAP_HUMAN [view interactions] High throughput no yes
PBIR2_HUMAN [view interactions] High throughput no yes
NAF1_HUMAN [view interactions] High throughput no yes
P3H1_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
ZBTB2_HUMAN [view interactions] High throughput no yes
RPB9_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
ILKAP_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
CE350_HUMAN [view interactions] High throughput no yes
BIRC6_HUMAN [view entry] [view interactions] High throughput yes yes
CDK10_HUMAN [view interactions] High throughput no no
NPTX1_HUMAN [view entry] [view interactions] High throughput yes yes
GPAM1_HUMAN [view interactions] High throughput no yes
ARID2_HUMAN [view interactions] High throughput no no
GUAA_HUMAN [view interactions] High throughput no no
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
KSR1_HUMAN [view interactions] High throughput no yes
KSR2_HUMAN [view interactions] High throughput no yes
RN19B_HUMAN [view interactions] High throughput no yes
TSYL6_HUMAN [view interactions] High throughput no no
HERC2_HUMAN [view interactions] High throughput no yes
KI67_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
DCAF4_HUMAN [view interactions] High throughput no yes
VSX1_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
CIRBP_HUMAN [view interactions] High throughput no no
DDX54_HUMAN [view interactions] High throughput no yes
NOP16_HUMAN [view interactions] High throughput no yes
CENPV_HUMAN [view interactions] High throughput no yes
USH1C_HUMAN [view interactions] High throughput no yes
PAXI1_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
EIF3F_HUMAN [view interactions] High throughput no yes
UN13B_HUMAN [view interactions] High throughput no no