WDR48_HUMAN
(Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in WDR48_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 28.0000 | 4 | no |
GO:0043168 | anion binding | 28.0000 | 4 | no |
GO:0003723 | RNA binding | 28.0000 | 4 | no |
GO:0005524 | ATP binding | 26.0000 | 5 | no |
GO:0017076 | purine nucleotide binding | 26.0000 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 26.0000 | 6 | no |
GO:0032555 | purine ribonucleotide binding | 26.0000 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 26.0000 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 26.0000 | 4 | no |
GO:0003677 | DNA binding | 6.0000 | 4 | yes |
GO:0003690 | double-stranded DNA binding | 6.0000 | 5 | yes |
GO:0016504 | peptidase activator activity | 6.0000 | 4 | yes |
GO:0035800 | deubiquitinase activator activity | 6.0000 | 5 | yes |
GO:0003697 | single-stranded DNA binding | 4.0000 | 5 | yes |
GO:0043130 | ubiquitin binding | 4.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in WDR48_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 58.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 54.0000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 52.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 48.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 42.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.0000 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 38.0000 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 38.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 38.0000 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 38.0000 | 5 | yes |
GO:0022607 | cellular component assembly | 36.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 36.0000 | 4 | yes |
GO:0036211 | protein modification process | 32.0000 | 4 | no |
GO:0043412 | macromolecule modification | 32.0000 | 4 | no |
GO:0033043 | regulation of organelle organization | 32.0000 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | yes |
GO:0032880 | regulation of protein localization | 30.0000 | 5 | no |
GO:0060341 | regulation of cellular localization | 30.0000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 28.0000 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 28.0000 | 5 | no |
GO:1903829 | positive regulation of protein localization | 28.0000 | 5 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 26.0000 | 5 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 26.0000 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 26.0000 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 26.0000 | 5 | no |
GO:0006996 | organelle organization | 26.0000 | 4 | no |
GO:0008104 | protein localization | 26.0000 | 4 | no |
GO:0031399 | regulation of protein modification process | 24.0000 | 6 | yes |
GO:0051052 | regulation of DNA metabolic process | 24.0000 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 24.0000 | 5 | no |
GO:0050821 | protein stabilization | 24.0000 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 24.0000 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.0000 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 24.0000 | 6 | no |
GO:0042127 | regulation of cell population proliferation | 22.0000 | 4 | yes |
GO:0051054 | positive regulation of DNA metabolic process | 22.0000 | 6 | yes |
GO:0009968 | negative regulation of signal transduction | 22.0000 | 5 | no |
GO:0010468 | regulation of gene expression | 22.0000 | 6 | no |
GO:0010648 | negative regulation of cell communication | 22.0000 | 5 | no |
GO:0023057 | negative regulation of signaling | 22.0000 | 4 | no |
GO:0051726 | regulation of cell cycle | 22.0000 | 4 | no |
GO:0070201 | regulation of establishment of protein localization | 22.0000 | 6 | no |
GO:1904951 | positive regulation of establishment of protein localization | 22.0000 | 6 | no |
GO:0023056 | positive regulation of signaling | 20.0000 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 20.0000 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 20.0000 | 5 | yes |
GO:0080134 | regulation of response to stress | 18.0000 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 18.0000 | 5 | yes |
GO:0090304 | nucleic acid metabolic process | 14.0000 | 4 | yes |
GO:0008284 | positive regulation of cell population proliferation | 14.0000 | 5 | yes |
GO:0031396 | regulation of protein ubiquitination | 12.0000 | 9 | yes |
GO:1901873 | regulation of post-translational protein modification | 12.0000 | 7 | yes |
GO:1903320 | regulation of protein modification by small protein conjugation or removal | 12.0000 | 8 | yes |
GO:0006259 | DNA metabolic process | 8.0000 | 5 | yes |
GO:0006281 | DNA repair | 8.0000 | 5 | yes |
GO:0006302 | double-strand break repair | 8.0000 | 6 | yes |
GO:0006974 | DNA damage response | 8.0000 | 4 | yes |
GO:0048232 | male gamete generation | 6.0000 | 4 | yes |
GO:0048568 | embryonic organ development | 6.0000 | 4 | yes |
GO:0050678 | regulation of epithelial cell proliferation | 6.0000 | 5 | yes |
GO:0050679 | positive regulation of epithelial cell proliferation | 6.0000 | 6 | yes |
GO:0072520 | seminiferous tubule development | 6.0000 | 4 | yes |
GO:0080135 | regulation of cellular response to stress | 6.0000 | 4 | yes |
GO:1902525 | regulation of protein monoubiquitination | 6.0000 | 10 | yes |
GO:0000018 | regulation of DNA recombination | 6.0000 | 6 | yes |
GO:0043588 | skin development | 4.0000 | 4 | yes |
GO:0045739 | positive regulation of DNA repair | 4.0000 | 5 | yes |
GO:0045911 | positive regulation of DNA recombination | 4.0000 | 7 | yes |
GO:0046425 | regulation of receptor signaling pathway via JAK-STAT | 4.0000 | 6 | yes |
GO:0046427 | positive regulation of receptor signaling pathway via JAK-STAT | 4.0000 | 7 | yes |
GO:0048705 | skeletal system morphogenesis | 4.0000 | 4 | yes |
GO:1904892 | regulation of receptor signaling pathway via STAT | 4.0000 | 5 | yes |
GO:1904894 | positive regulation of receptor signaling pathway via STAT | 4.0000 | 6 | yes |
GO:1905168 | positive regulation of double-strand break repair via homologous recombination | 4.0000 | 7 | yes |
GO:2000779 | regulation of double-strand break repair | 4.0000 | 6 | yes |
GO:2000781 | positive regulation of double-strand break repair | 4.0000 | 6 | yes |
GO:0000724 | double-strand break repair via homologous recombination | 4.0000 | 7 | yes |
GO:0000725 | recombinational repair | 4.0000 | 6 | yes |
GO:0006282 | regulation of DNA repair | 4.0000 | 5 | yes |
GO:0006310 | DNA recombination | 4.0000 | 6 | yes |
GO:0010569 | regulation of double-strand break repair via homologous recombination | 4.0000 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FANCI_HUMAN | [view interactions] | Low throughput | no | yes |
ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
ANDR_HUMAN | [view interactions] | Low throughput | no | no |
TBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RIPK1_HUMAN | [view interactions] | Low throughput | no | yes |
ULK1_HUMAN | [view interactions] | Low throughput | no | no |
NFAT5_HUMAN | [view interactions] | Low throughput | no | yes |
NMRL1_HUMAN | [view interactions] | Low throughput | no | yes |
ID1_HUMAN | [view interactions] | Low throughput | no | yes |
MYC_HUMAN | [view interactions] | Low throughput | no | yes |
PCNA_HUMAN | [view interactions] | Low throughput | no | no |
RAD51_HUMAN | [view interactions] | Low throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FACD2_HUMAN | [view interactions] | Low throughput | no | no |
UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RL40_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBP12_HUMAN | [view interactions] | Low throughput | no | yes |
UBP46_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBP1_HUMAN | [view interactions] | Low throughput | no | yes |
PHLP2_HUMAN | [view interactions] | Low throughput | no | yes |
PHLP1_HUMAN | [view interactions] | Low throughput | no | yes |
WDR20_HUMAN | [view interactions] | Low throughput | no | no |
R51A1_HUMAN | [view interactions] | Low throughput | no | no |
ATAD5_HUMAN | [view interactions] | Low throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSA3_HUMAN | [view interactions] | High throughput | no | no |
FBXL7_HUMAN | [view interactions] | High throughput | no | no |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VSX2_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
H33_HUMAN | [view interactions] | High throughput | no | yes |
NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
RASF8_HUMAN | [view interactions] | High throughput | no | yes |
ORC3_HUMAN | [view interactions] | High throughput | no | yes |
NFAC1_HUMAN | [view interactions] | High throughput | no | no |
NFAC2_HUMAN | [view interactions] | High throughput | no | yes |
JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
SOCS6_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
WAPL_HUMAN | [view interactions] | High throughput | no | yes |
BRD2_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
DAB2_HUMAN | [view interactions] | High throughput | no | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARI1A_HUMAN | [view interactions] | High throughput | no | yes |
CNOT7_HUMAN | [view interactions] | High throughput | no | no |
U2AF4_HUMAN | [view interactions] | High throughput | no | yes |
CSTF1_HUMAN | [view interactions] | High throughput | no | yes |
NEST_HUMAN | [view interactions] | High throughput | no | no |
RPP30_HUMAN | [view interactions] | High throughput | no | yes |
SF3B5_HUMAN | [view interactions] | High throughput | no | yes |
AQP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAHM5_HUMAN | [view interactions] | High throughput | no | no |
MCU_HUMAN | [view interactions] | High throughput | no | yes |
ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
FETUA_HUMAN | [view interactions] | High throughput | no | no |
SKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SOAT1_HUMAN | [view interactions] | High throughput | no | no |
ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMTL2_HUMAN | [view interactions] | High throughput | no | no |
WDR48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSD13_HUMAN | [view interactions] | High throughput | no | yes |
FOXO3_HUMAN | [view interactions] | High throughput | no | yes |
TULP3_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GORS1_HUMAN | [view interactions] | High throughput | no | yes |
SGO1_HUMAN | [view interactions] | High throughput | no | no |
FAXC_HUMAN | [view interactions] | High throughput | no | no |
OPALI_HUMAN | [view interactions] | High throughput | no | yes |
SPSB2_HUMAN | [view interactions] | High throughput | no | no |
HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
DACT2_HUMAN | [view interactions] | High throughput | no | yes |
GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
IGDC4_HUMAN | [view interactions] | High throughput | no | yes |
VSIG4_HUMAN | [view interactions] | High throughput | no | no |
TR19L_HUMAN | [view interactions] | High throughput | no | no |
PGES2_HUMAN | [view interactions] | High throughput | no | yes |
PFD3_HUMAN | [view interactions] | High throughput | no | yes |
ASIC4_HUMAN | [view interactions] | High throughput | no | no |
PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
DDB1_HUMAN | [view interactions] | High throughput | no | yes |
CLAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
H2AZ_HUMAN | [view interactions] | High throughput | no | yes |
H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MSS4_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
DVL2_HUMAN | [view interactions] | High throughput | no | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDLR_HUMAN | [view interactions] | High throughput | no | yes |
BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYYC_HUMAN | [view interactions] | High throughput | no | yes |
C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMGN2_HUMAN | [view interactions] | High throughput | no | no |
MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S10A2_HUMAN | [view interactions] | High throughput | no | no |
AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XRCC4_HUMAN | [view interactions] | High throughput | no | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SSR3_HUMAN | [view interactions] | High throughput | no | yes |
UIMC1_HUMAN | [view interactions] | High throughput | no | no |
P53_HUMAN | [view interactions] | High throughput | no | no |
SPT6H_HUMAN | [view interactions] | High throughput | no | yes |
NEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WRN_HUMAN | [view interactions] | High throughput | no | yes |
NELFE_HUMAN | [view interactions] | High throughput | no | yes |
CRTAP_HUMAN | [view interactions] | High throughput | no | yes |
GPN3_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IWS1_HUMAN | [view interactions] | High throughput | no | yes |
PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KAISO_HUMAN | [view interactions] | High throughput | no | yes |
KDM4A_HUMAN | [view interactions] | High throughput | no | yes |
CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPN1_HUMAN | [view interactions] | High throughput | no | yes |
TRM11_HUMAN | [view interactions] | High throughput | no | no |
TARB1_HUMAN | [view interactions] | High throughput | no | no |
DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARHGA_HUMAN | [view interactions] | High throughput | no | yes |
RPB7_HUMAN | [view interactions] | High throughput | no | yes |
SAHH3_HUMAN | [view interactions] | High throughput | no | yes |
UBR5_HUMAN | [view interactions] | High throughput | no | no |
EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
NOP10_HUMAN | [view interactions] | High throughput | no | yes |
EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BOP1_HUMAN | [view interactions] | High throughput | no | yes |
TCOF_HUMAN | [view interactions] | High throughput | no | yes |
ZN639_HUMAN | [view interactions] | High throughput | no | yes |
CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
AP3M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WDR70_HUMAN | [view interactions] | High throughput | no | no |
DKC1_HUMAN | [view interactions] | High throughput | no | yes |
YLPM1_HUMAN | [view interactions] | High throughput | no | yes |
CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SET_HUMAN | [view interactions] | High throughput | no | yes |
CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NHP2_HUMAN | [view interactions] | High throughput | no | yes |
SHQ1_HUMAN | [view interactions] | High throughput | no | no |
PSME3_HUMAN | [view interactions] | High throughput | no | yes |
STK11_HUMAN | [view interactions] | High throughput | no | yes |
SMAP_HUMAN | [view interactions] | High throughput | no | yes |
PBIR2_HUMAN | [view interactions] | High throughput | no | yes |
NAF1_HUMAN | [view interactions] | High throughput | no | yes |
P3H1_HUMAN | [view interactions] | High throughput | no | yes |
MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
RPB9_HUMAN | [view interactions] | High throughput | no | yes |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
RIPK4_HUMAN | [view interactions] | High throughput | no | no |
TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ILKAP_HUMAN | [view interactions] | High throughput | no | yes |
TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CE350_HUMAN | [view interactions] | High throughput | no | yes |
BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK10_HUMAN | [view interactions] | High throughput | no | no |
NPTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPAM1_HUMAN | [view interactions] | High throughput | no | yes |
ARID2_HUMAN | [view interactions] | High throughput | no | no |
GUAA_HUMAN | [view interactions] | High throughput | no | no |
TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
KSR2_HUMAN | [view interactions] | High throughput | no | yes |
RN19B_HUMAN | [view interactions] | High throughput | no | yes |
TSYL6_HUMAN | [view interactions] | High throughput | no | no |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
KI67_HUMAN | [view interactions] | High throughput | no | no |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
VSX1_HUMAN | [view interactions] | High throughput | no | no |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
PTBP3_HUMAN | [view interactions] | High throughput | no | no |
CIRBP_HUMAN | [view interactions] | High throughput | no | no |
DDX54_HUMAN | [view interactions] | High throughput | no | yes |
NOP16_HUMAN | [view interactions] | High throughput | no | yes |
CENPV_HUMAN | [view interactions] | High throughput | no | yes |
USH1C_HUMAN | [view interactions] | High throughput | no | yes |
PAXI1_HUMAN | [view interactions] | High throughput | no | no |
BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
UN13B_HUMAN | [view interactions] | High throughput | no | no |