Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AQP4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Forms a water-specific channel (PubMed, PubMed, PubMed). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004253 TRG_DiLeu_BaEn_1 TRG 288 293 -
ELMI004253 TRG_DiLeu_BaEn_1 TRG 288 293 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AQP4_HUMAN
GO:0015267 channel activity 23.5294 4 yes
GO:0002020 protease binding 23.5294 4 no
GO:0043169 cation binding 23.5294 4 no
GO:0046872 metal ion binding 23.5294 5 no
GO:0005372 water transmembrane transporter activity 11.7647 4 yes
GO:0015250 water channel activity 11.7647 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AQP4_HUMAN
GO:0048522 positive regulation of cellular process 64.7059 4 no
GO:0010646 regulation of cell communication 58.8235 4 no
GO:0051128 regulation of cellular component organization 52.9412 4 no
GO:0009966 regulation of signal transduction 47.0588 4 no
GO:0050804 modulation of chemical synaptic transmission 41.1765 5 no
GO:0099177 regulation of trans-synaptic signaling 41.1765 4 no
GO:0008104 protein localization 41.1765 4 no
GO:0022607 cellular component assembly 35.2941 4 yes
GO:0048523 negative regulation of cellular process 35.2941 4 no
GO:0051130 positive regulation of cellular component organization 35.2941 5 no
GO:0009967 positive regulation of signal transduction 29.4118 5 no
GO:0010647 positive regulation of cell communication 29.4118 5 no
GO:0023056 positive regulation of signaling 29.4118 4 no
GO:0048584 positive regulation of response to stimulus 29.4118 4 no
GO:0060255 regulation of macromolecule metabolic process 29.4118 4 no
GO:0030030 cell projection organization 29.4118 4 no
GO:0031323 regulation of cellular metabolic process 29.4118 4 no
GO:0032880 regulation of protein localization 29.4118 5 no
GO:0050807 regulation of synapse organization 29.4118 5 no
GO:0050890 cognition 29.4118 4 no
GO:0051049 regulation of transport 29.4118 4 no
GO:0060341 regulation of cellular localization 29.4118 4 no
GO:0120036 plasma membrane bounded cell projection organization 29.4118 5 no
GO:0044087 regulation of cellular component biogenesis 29.4118 4 no
GO:0071702 organic substance transport 29.4118 4 no
GO:0071705 nitrogen compound transport 29.4118 4 no
GO:0032535 regulation of cellular component size 23.5294 4 yes
GO:0043933 protein-containing complex organization 23.5294 4 yes
GO:0065003 protein-containing complex assembly 23.5294 5 yes
GO:0071310 cellular response to organic substance 23.5294 4 yes
GO:0051246 regulation of protein metabolic process 23.5294 5 no
GO:0080090 regulation of primary metabolic process 23.5294 4 no
GO:0031344 regulation of cell projection organization 23.5294 5 no
GO:0048585 negative regulation of response to stimulus 23.5294 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.5294 6 no
GO:1902531 regulation of intracellular signal transduction 23.5294 5 no
GO:0099536 synaptic signaling 23.5294 4 no
GO:0099537 trans-synaptic signaling 23.5294 5 no
GO:0007612 learning 23.5294 4 no
GO:0022603 regulation of anatomical structure morphogenesis 23.5294 4 no
GO:0031175 neuron projection development 23.5294 6 no
GO:0044057 regulation of system process 23.5294 4 no
GO:0051050 positive regulation of transport 23.5294 4 no
GO:0051094 positive regulation of developmental process 23.5294 4 no
GO:0051240 positive regulation of multicellular organismal process 23.5294 4 no
GO:0051960 regulation of nervous system development 23.5294 5 no
GO:0051962 positive regulation of nervous system development 23.5294 5 no
GO:2000026 regulation of multicellular organismal development 23.5294 4 no
GO:0015031 protein transport 23.5294 4 no
GO:0044089 positive regulation of cellular component biogenesis 23.5294 5 no
GO:0061024 membrane organization 23.5294 4 no
GO:0008361 regulation of cell size 17.6471 5 yes
GO:0051259 protein complex oligomerization 17.6471 6 yes
GO:0051260 protein homooligomerization 17.6471 7 yes
GO:0003091 renal water homeostasis 11.7647 4 yes
GO:0003341 cilium movement 11.7647 4 yes
GO:0003351 epithelial cilium movement involved in extracellular fluid movement 11.7647 5 yes
GO:0006833 water transport 11.7647 5 yes
GO:0006858 extracellular transport 11.7647 4 yes
GO:0009992 intracellular water homeostasis 11.7647 4 yes
GO:0034097 response to cytokine 11.7647 4 yes
GO:0034341 response to type II interferon 11.7647 5 yes
GO:0042044 fluid transport 11.7647 4 yes
GO:0050891 multicellular organismal-level water homeostasis 11.7647 4 yes
GO:0051262 protein tetramerization 11.7647 7 yes
GO:0051289 protein homotetramerization 11.7647 8 yes
GO:0071345 cellular response to cytokine stimulus 11.7647 5 yes
GO:0071346 cellular response to type II interferon 11.7647 6 yes
GO:0090660 cerebrospinal fluid circulation 11.7647 4 yes
GO:0099111 microtubule-based transport 11.7647 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AQP4_HUMAN [view entry] [view interactions] Low throughput yes no
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
PSMD4_HUMAN [view interactions] Low throughput no yes
WLS_HUMAN [view entry] [view interactions] High throughput yes no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV4_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
HPCL4_HUMAN [view interactions] High throughput no no
CXA8_HUMAN [view interactions] High throughput no no
CREB3_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
OXDA_HUMAN [view interactions] High throughput no no
UBP1_HUMAN [view interactions] High throughput no yes
WDR48_HUMAN [view entry] [view interactions] High throughput yes yes
PHLP1_HUMAN [view interactions] High throughput no yes
FOXO3_HUMAN [view interactions] High throughput no yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
HECAM_HUMAN [view interactions] High throughput no no
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
DAG1_HUMAN [view entry] [view interactions] High throughput yes no
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
NRX1A_HUMAN [view entry] [view interactions] High throughput yes no
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SSR3_HUMAN [view interactions] High throughput no yes