Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AQP4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Forms a water-specific channel (PubMed, PubMed, PubMed). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004253 TRG_DiLeu_BaEn_1 TRG 288 293 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AQP4_HUMAN
GO:0015267 channel activity 23.5294 4 yes
GO:0046872 metal ion binding 23.5294 4 no
GO:0005372 water transmembrane transporter activity 11.7647 4 yes
GO:0015250 water channel activity 11.7647 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AQP4_HUMAN
GO:0060255 regulation of macromolecule metabolic process 70.5882 4 yes
GO:0048522 positive regulation of cellular process 64.7059 4 no
GO:0051049 regulation of transport 52.9412 4 no
GO:0010468 regulation of gene expression 47.0588 5 yes
GO:0048523 negative regulation of cellular process 47.0588 4 yes
GO:0071310 cellular response to organic substance 41.1765 4 yes
GO:0071702 organic substance transport 41.1765 4 yes
GO:1901701 cellular response to oxygen-containing compound 41.1765 4 yes
GO:0031323 regulation of cellular metabolic process 41.1765 4 no
GO:0051171 regulation of nitrogen compound metabolic process 41.1765 4 no
GO:0080090 regulation of primary metabolic process 41.1765 4 no
GO:0009892 negative regulation of metabolic process 35.2941 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 35.2941 5 yes
GO:0022607 cellular component assembly 35.2941 4 yes
GO:0009966 regulation of signal transduction 35.2941 4 no
GO:0010646 regulation of cell communication 35.2941 4 no
GO:0051050 positive regulation of transport 35.2941 4 no
GO:0051128 regulation of cellular component organization 35.2941 4 no
GO:0051246 regulation of protein metabolic process 35.2941 5 no
GO:0009893 positive regulation of metabolic process 35.2941 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.2941 5 no
GO:0043933 protein-containing complex organization 29.4118 4 yes
GO:0048878 chemical homeostasis 29.4118 4 yes
GO:0065003 protein-containing complex assembly 29.4118 5 yes
GO:0010648 negative regulation of cell communication 29.4118 5 no
GO:0023057 negative regulation of signaling 29.4118 4 no
GO:0032880 regulation of protein localization 29.4118 5 no
GO:0060341 regulation of cellular localization 29.4118 4 no
GO:0010243 response to organonitrogen compound 29.4118 4 no
GO:0031325 positive regulation of cellular metabolic process 29.4118 5 no
GO:0031399 regulation of protein modification process 29.4118 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.4118 5 no
GO:1902531 regulation of intracellular signal transduction 29.4118 5 no
GO:0034762 regulation of transmembrane transport 29.4118 4 no
GO:0048584 positive regulation of response to stimulus 29.4118 4 no
GO:0008104 protein localization 29.4118 4 no
GO:0071705 nitrogen compound transport 29.4118 4 no
GO:0001817 regulation of cytokine production 23.5294 4 yes
GO:0010629 negative regulation of gene expression 23.5294 6 yes
GO:0014070 response to organic cyclic compound 23.5294 4 yes
GO:0051241 negative regulation of multicellular organismal process 23.5294 4 yes
GO:0051259 protein complex oligomerization 23.5294 6 yes
GO:0051260 protein homooligomerization 23.5294 7 yes
GO:0071407 cellular response to organic cyclic compound 23.5294 5 yes
GO:0009968 negative regulation of signal transduction 23.5294 5 no
GO:0036211 protein modification process 23.5294 4 no
GO:0043412 macromolecule modification 23.5294 4 no
GO:0048585 negative regulation of response to stimulus 23.5294 4 no
GO:0031401 positive regulation of protein modification process 23.5294 7 no
GO:0043085 positive regulation of catalytic activity 23.5294 4 no
GO:0044057 regulation of system process 23.5294 4 no
GO:0051094 positive regulation of developmental process 23.5294 4 no
GO:0051240 positive regulation of multicellular organismal process 23.5294 4 no
GO:0051247 positive regulation of protein metabolic process 23.5294 6 no
GO:1901652 response to peptide 23.5294 4 no
GO:2000026 regulation of multicellular organismal development 23.5294 4 no
GO:0034330 cell junction organization 23.5294 4 no
GO:0034765 regulation of ion transmembrane transport 23.5294 5 no
GO:0043269 regulation of ion transport 23.5294 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.5294 5 no
GO:0071417 cellular response to organonitrogen compound 23.5294 4 no
GO:1901699 cellular response to nitrogen compound 23.5294 4 no
GO:0006811 ion transport 23.5294 4 no
GO:0001818 negative regulation of cytokine production 17.6471 5 yes
GO:0032535 regulation of cellular component size 17.6471 4 yes
GO:0033993 response to lipid 17.6471 4 yes
GO:0071396 cellular response to lipid 17.6471 5 yes
GO:0099111 microtubule-based transport 17.6471 4 yes
GO:0001678 cellular glucose homeostasis 11.7647 4 yes
GO:0003091 renal water homeostasis 11.7647 4 yes
GO:0003341 cilium movement 11.7647 4 yes
GO:0003351 epithelial cilium movement involved in extracellular fluid movement 11.7647 5 yes
GO:0006833 water transport 11.7647 5 yes
GO:0006858 extracellular transport 11.7647 4 yes
GO:0006972 hyperosmotic response 11.7647 4 yes
GO:0008361 regulation of cell size 11.7647 5 yes
GO:0009651 response to salt stress 11.7647 4 yes
GO:0009743 response to carbohydrate 11.7647 4 yes
GO:0009746 response to hexose 11.7647 6 yes
GO:0009749 response to glucose 11.7647 7 yes
GO:0009992 cellular water homeostasis 11.7647 4 yes
GO:0010574 regulation of vascular endothelial growth factor production 11.7647 5 yes
GO:0015669 gas transport 11.7647 4 yes
GO:0015670 carbon dioxide transport 11.7647 5 yes
GO:0019755 one-carbon compound transport 11.7647 5 yes
GO:0030104 water homeostasis 11.7647 5 yes
GO:0031960 response to corticosteroid 11.7647 5 yes
GO:0032355 response to estradiol 11.7647 4 yes
GO:0032651 regulation of interleukin-1 beta production 11.7647 6 yes
GO:0032652 regulation of interleukin-1 production 11.7647 5 yes
GO:0032675 regulation of interleukin-6 production 11.7647 5 yes
GO:0032691 negative regulation of interleukin-1 beta production 11.7647 7 yes
GO:0032692 negative regulation of interleukin-1 production 11.7647 6 yes
GO:0032715 negative regulation of interleukin-6 production 11.7647 6 yes
GO:0033500 carbohydrate homeostasis 11.7647 5 yes
GO:0034097 response to cytokine 11.7647 4 yes
GO:0034284 response to monosaccharide 11.7647 5 yes
GO:0034341 response to interferon-gamma 11.7647 5 yes
GO:0042044 fluid transport 11.7647 4 yes
GO:0042538 hyperosmotic salinity response 11.7647 5 yes
GO:0042593 glucose homeostasis 11.7647 6 yes
GO:0048545 response to steroid hormone 11.7647 4 yes
GO:0051262 protein tetramerization 11.7647 7 yes
GO:0051289 protein homotetramerization 11.7647 8 yes
GO:0051384 response to glucocorticoid 11.7647 6 yes
GO:0060353 regulation of cell adhesion molecule production 11.7647 4 yes
GO:0060354 negative regulation of cell adhesion molecule production 11.7647 5 yes
GO:0070555 response to interleukin-1 11.7647 5 yes
GO:0070741 response to interleukin-6 11.7647 5 yes
GO:0071322 cellular response to carbohydrate stimulus 11.7647 5 yes
GO:0071326 cellular response to monosaccharide stimulus 11.7647 6 yes
GO:0071331 cellular response to hexose stimulus 11.7647 7 yes
GO:0071333 cellular response to glucose stimulus 11.7647 5 yes
GO:0071345 cellular response to cytokine stimulus 11.7647 5 yes
GO:0071346 cellular response to interferon-gamma 11.7647 6 yes
GO:0071347 cellular response to interleukin-1 11.7647 6 yes
GO:0071354 cellular response to interleukin-6 11.7647 6 yes
GO:0071392 cellular response to estradiol stimulus 11.7647 5 yes
GO:0090660 cerebrospinal fluid circulation 11.7647 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AQP4_HUMAN [view entry] [view interactions] Low throughput yes no
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
PSMD4_HUMAN [view interactions] Low throughput no yes
WLS_HUMAN [view entry] [view interactions] High throughput yes no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV4_HUMAN [view interactions] High throughput no yes
HPCL4_HUMAN [view interactions] High throughput no no
CXA8_HUMAN [view interactions] High throughput no no
CREB3_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
OXDA_HUMAN [view interactions] High throughput no no
UBP1_HUMAN [view interactions] High throughput no yes
WDR48_HUMAN [view entry] [view interactions] High throughput yes yes
PHLP1_HUMAN [view interactions] High throughput no yes
FOXO3_HUMAN [view interactions] High throughput no yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
HECAM_HUMAN [view interactions] High throughput no no
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
DAG1_HUMAN [view entry] [view interactions] High throughput yes no
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
TRPM4_HUMAN [view interactions] Computational no no
SNTA1_HUMAN [view entry] [view interactions] Computational yes no
AQP11_HUMAN [view interactions] Computational no no
CXA1_HUMAN [view entry] [view interactions] Computational yes yes
GRM5_HUMAN [view entry] [view interactions] Computational yes no
MOG_HUMAN [view entry] [view interactions] Computational yes no
EAA2_HUMAN [view entry] [view interactions] Computational yes no
ABCC8_HUMAN [view interactions] Computational no yes