SKT_HUMAN
Evidence for PS localization
Functions
Required for normal development of intervertebral disks. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SKT_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 34.0426 | 4 | no |
| GO:0019901 | protein kinase binding | 29.7872 | 5 | no |
| GO:0043168 | anion binding | 25.5319 | 4 | no |
| GO:0003723 | RNA binding | 23.4043 | 4 | no |
| GO:0000166 | nucleotide binding | 21.2766 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.2766 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.2766 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.2766 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SKT_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 78.7234 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 63.8298 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 59.5745 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 55.3191 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 55.3191 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 55.3191 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.1915 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 53.1915 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 51.0638 | 5 | no |
| GO:0010646 | regulation of cell communication | 48.9362 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 48.9362 | 5 | no |
| GO:0022607 | cellular component assembly | 46.8085 | 4 | no |
| GO:0008104 | protein localization | 46.8085 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 44.6809 | 5 | no |
| GO:0006996 | organelle organization | 44.6809 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 44.6809 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 44.6809 | 5 | no |
| GO:0010468 | regulation of gene expression | 42.5532 | 6 | no |
| GO:0031399 | regulation of protein modification process | 38.2979 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 38.2979 | 6 | no |
| GO:0009966 | regulation of signal transduction | 38.2979 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 36.1702 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 36.1702 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 36.1702 | 6 | no |
| GO:0030030 | cell projection organization | 34.0426 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 31.9149 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 31.9149 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 31.9149 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 31.9149 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.7872 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 29.7872 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 29.7872 | 5 | no |
| GO:0036211 | protein modification process | 27.6596 | 4 | no |
| GO:0043412 | macromolecule modification | 27.6596 | 4 | no |
| GO:0071702 | organic substance transport | 27.6596 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 27.6596 | 7 | no |
| GO:0007010 | cytoskeleton organization | 27.6596 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.6596 | 4 | no |
| GO:0023056 | positive regulation of signaling | 27.6596 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 25.5319 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 25.5319 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 25.5319 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.5319 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.5319 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.5319 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.5319 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 25.5319 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.5319 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.5319 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 25.5319 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.5319 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.5319 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.5319 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 23.4043 | 8 | no |
| GO:0045595 | regulation of cell differentiation | 23.4043 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.4043 | 7 | no |
| GO:0051049 | regulation of transport | 23.4043 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.4043 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.4043 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.4043 | 5 | no |
| GO:0009894 | regulation of catabolic process | 23.4043 | 4 | no |
| GO:0034330 | cell junction organization | 23.4043 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 23.4043 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.4043 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.4043 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.2766 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.2766 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.2766 | 4 | no |
| GO:0060284 | regulation of cell development | 21.2766 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.2766 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 21.2766 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.2766 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MARE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FHL2_HUMAN | [view interactions] | High throughput | no | yes |
| NANP8_HUMAN | [view interactions] | High throughput | no | no |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS5_HUMAN | [view interactions] | High throughput | no | yes |
| TEX11_HUMAN | [view interactions] | High throughput | no | no |
| GCC1_HUMAN | [view interactions] | High throughput | no | yes |
| K1C15_HUMAN | [view interactions] | High throughput | no | no |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSBP1_HUMAN | [view interactions] | High throughput | no | no |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| PTK6_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALKB7_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| RINT1_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| INCA1_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICU2_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| TRIB2_HUMAN | [view interactions] | High throughput | no | yes |
| WASF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| RMD5A_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| FOXO3_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| ZDH15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE4_HUMAN | [view interactions] | High throughput | no | no |
| CPNE1_HUMAN | [view interactions] | High throughput | no | no |
| HNRLL_HUMAN | [view interactions] | High throughput | no | yes |
| SYNC_HUMAN | [view interactions] | High throughput | no | yes |
| NAL14_HUMAN | [view interactions] | High throughput | no | no |
| NOS3_HUMAN | [view interactions] | High throughput | no | no |
| LICH_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |