Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MARE3_HUMAN

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed). May play a role in cell migration . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MARE3_HUMAN
GO:0015631 tubulin binding 33.7500 4 yes
GO:0008017 microtubule binding 32.5000 5 yes
GO:0043168 anion binding 27.5000 4 no
GO:0000166 nucleotide binding 25.0000 4 no
GO:0017076 purine nucleotide binding 25.0000 5 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.7500 4 no
GO:0043169 cation binding 22.5000 4 no
GO:0046872 metal ion binding 22.5000 5 no
GO:0019900 kinase binding 21.2500 4 yes
GO:0019901 protein kinase binding 20.0000 5 yes
GO:0051010 microtubule plus-end binding 15.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MARE3_HUMAN
GO:0006996 organelle organization 57.5000 4 yes
GO:0048522 positive regulation of cellular process 55.0000 4 yes
GO:0051128 regulation of cellular component organization 55.0000 4 yes
GO:0007010 cytoskeleton organization 52.5000 5 yes
GO:0048523 negative regulation of cellular process 42.5000 4 no
GO:0022607 cellular component assembly 40.0000 4 yes
GO:0010646 regulation of cell communication 38.7500 4 no
GO:0008104 protein localization 35.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 35.0000 4 yes
GO:0031323 regulation of cellular metabolic process 33.7500 4 yes
GO:0033043 regulation of organelle organization 33.7500 5 yes
GO:0051130 positive regulation of cellular component organization 33.7500 5 no
GO:0009893 positive regulation of metabolic process 31.2500 4 yes
GO:0080090 regulation of primary metabolic process 31.2500 4 yes
GO:0030030 cell projection organization 31.2500 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.7500 5 yes
GO:0051493 regulation of cytoskeleton organization 28.7500 6 yes
GO:0009966 regulation of signal transduction 28.7500 4 no
GO:0044087 regulation of cellular component biogenesis 27.5000 4 yes
GO:0051246 regulation of protein metabolic process 27.5000 5 yes
GO:0032886 regulation of microtubule-based process 26.2500 4 yes
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 yes
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0009889 regulation of biosynthetic process 23.7500 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 23.7500 5 yes
GO:0031326 regulation of cellular biosynthetic process 23.7500 5 yes
GO:0051247 positive regulation of protein metabolic process 23.7500 6 yes
GO:1902903 regulation of supramolecular fiber organization 23.7500 5 yes
GO:0070507 regulation of microtubule cytoskeleton organization 22.5000 5 yes
GO:0010468 regulation of gene expression 21.2500 6 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 21.2500 6 yes
GO:0031399 regulation of protein modification process 21.2500 6 yes
GO:0030334 regulation of cell migration 21.2500 5 no
GO:0051049 regulation of transport 21.2500 4 no
GO:1902531 regulation of intracellular signal transduction 21.2500 5 no
GO:2000145 regulation of cell motility 21.2500 4 no
GO:0019220 regulation of phosphate metabolic process 20.0000 6 yes
GO:0042325 regulation of phosphorylation 20.0000 7 yes
GO:0051174 regulation of phosphorus metabolic process 20.0000 5 yes
GO:0001932 regulation of protein phosphorylation 17.5000 7 yes
GO:0009891 positive regulation of biosynthetic process 17.5000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 17.5000 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 17.5000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 17.5000 6 yes
GO:0031401 positive regulation of protein modification process 17.5000 7 yes
GO:0042327 positive regulation of phosphorylation 17.5000 8 yes
GO:0045937 positive regulation of phosphate metabolic process 17.5000 7 yes
GO:0051726 regulation of cell cycle 17.5000 4 yes
GO:0070925 organelle assembly 17.5000 5 yes
GO:0032271 regulation of protein polymerization 16.2500 6 yes
GO:0043254 regulation of protein-containing complex assembly 16.2500 5 yes
GO:0001934 positive regulation of protein phosphorylation 15.0000 8 yes
GO:0031113 regulation of microtubule polymerization 15.0000 6 yes
GO:0043085 positive regulation of catalytic activity 15.0000 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 13.7500 5 yes
GO:0033365 protein localization to organelle 13.7500 5 yes
GO:0140694 non-membrane-bounded organelle assembly 13.7500 6 yes
GO:0051252 regulation of RNA metabolic process 12.5000 5 yes
GO:0051225 spindle assembly 11.2500 4 yes
GO:0044380 protein localization to cytoskeleton 10.0000 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 10.0000 5 yes
GO:0051338 regulation of transferase activity 10.0000 4 yes
GO:0006355 regulation of DNA-templated transcription 8.7500 7 yes
GO:0043549 regulation of kinase activity 8.7500 5 yes
GO:0051254 positive regulation of RNA metabolic process 8.7500 6 yes
GO:0051347 positive regulation of transferase activity 8.7500 5 yes
GO:0072698 protein localization to microtubule cytoskeleton 8.7500 7 yes
GO:2001141 regulation of RNA biosynthetic process 8.7500 6 yes
GO:0033674 positive regulation of kinase activity 7.5000 6 yes
GO:0045787 positive regulation of cell cycle 7.5000 5 yes
GO:0045859 regulation of protein kinase activity 7.5000 6 yes
GO:0035372 protein localization to microtubule 6.2500 8 yes
GO:0045860 positive regulation of protein kinase activity 6.2500 7 yes
GO:0045893 positive regulation of DNA-templated transcription 6.2500 8 yes
GO:1902680 positive regulation of RNA biosynthetic process 6.2500 7 yes
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 3.7500 6 yes
GO:0071900 regulation of protein serine/threonine kinase activity 3.7500 7 yes
GO:1904029 regulation of cyclin-dependent protein kinase activity 3.7500 5 yes
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 2.5000 6 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 2.5000 8 yes
GO:1904031 positive regulation of cyclin-dependent protein kinase activity 2.5000 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AURKA_HUMAN [view entry] [view interactions] Low throughput yes no
AURKB_HUMAN [view interactions] Low throughput no yes
TBA1B_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
ADNP_HUMAN [view interactions] Low throughput no yes
APCL_HUMAN [view entry] [view interactions] Low throughput yes no
MARE1_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DREB_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1B_HUMAN [view entry] [view interactions] Low throughput yes yes
ANK3_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PSRC1_HUMAN [view interactions] Low throughput no no
DCTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SIAH1_HUMAN [view interactions] Low throughput no yes
NXF1_HUMAN [view interactions] High throughput no yes
EXOS7_HUMAN [view interactions] High throughput no yes
ESS2_HUMAN [view interactions] High throughput no yes
MGN_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
GA2L1_HUMAN [view interactions] High throughput no yes
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
IASPP_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MARK3_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
TTBK1_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
FCHO1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
CALR_HUMAN [view entry] [view interactions] High throughput yes yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
TEBP_HUMAN [view interactions] High throughput no yes
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B1_HUMAN [view interactions] High throughput no yes
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
CF132_HUMAN [view interactions] High throughput no no
CAMP1_HUMAN [view interactions] High throughput no yes
CAMP2_HUMAN [view interactions] High throughput no yes
CAMP3_HUMAN [view interactions] High throughput no no
CBL_HUMAN [view interactions] High throughput no yes
CCD66_HUMAN [view interactions] High throughput no yes
GRDN_HUMAN [view interactions] High throughput no no
CP110_HUMAN [view interactions] High throughput no yes
CCSE2_HUMAN [view interactions] High throughput no yes
CDC27_HUMAN [view interactions] High throughput no yes
CENPJ_HUMAN [view interactions] High throughput no no
CE104_HUMAN [view interactions] High throughput no yes
CE162_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
C170B_HUMAN [view interactions] High throughput no yes
CE350_HUMAN [view interactions] High throughput no yes
CEP44_HUMAN [view interactions] High throughput no yes
CFA97_HUMAN [view interactions] High throughput no yes
CKAP2_HUMAN [view interactions] High throughput no yes
CKP2L_HUMAN [view interactions] High throughput no yes
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
COBL_HUMAN [view interactions] High throughput no yes
CTTB2_HUMAN [view entry] [view interactions] High throughput yes yes
DCDC2_HUMAN [view interactions] High throughput no yes
DCLK1_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP3_HUMAN [view interactions] High throughput no no
DIP2B_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
EMAL4_HUMAN [view interactions] High throughput no yes
F161A_HUMAN [view interactions] High throughput no no
FA83B_HUMAN [view interactions] High throughput no no
CEP43_HUMAN [view interactions] High throughput no no
FLIP1_HUMAN [view entry] [view interactions] High throughput yes no
GA2L3_HUMAN [view interactions] High throughput no no
GEN_HUMAN [view interactions] High throughput no yes
HAUS8_HUMAN [view interactions] High throughput no yes
HMMR_HUMAN [view interactions] High throughput no yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
BTBD8_HUMAN [view interactions] High throughput no yes
SKT_HUMAN [view entry] [view interactions] High throughput yes yes
K1671_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF15_HUMAN [view interactions] High throughput no no
KIF1B_HUMAN [view entry] [view interactions] High throughput yes yes
KIF1C_HUMAN [view interactions] High throughput no yes
KIF24_HUMAN [view interactions] High throughput no no
KIF2A_HUMAN [view entry] [view interactions] High throughput yes yes
KIF7_HUMAN [view interactions] High throughput no yes
LMO7_HUMAN [view entry] [view interactions] High throughput yes yes
LUZP1_HUMAN [view interactions] High throughput no yes
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
MACOI_HUMAN [view interactions] High throughput no no
MAP1A_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1S_HUMAN [view interactions] High throughput no no
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
MAP7_HUMAN [view interactions] High throughput no yes
MA7D1_HUMAN [view entry] [view interactions] High throughput yes no
MA7D2_HUMAN [view interactions] High throughput no yes
MA7D3_HUMAN [view interactions] High throughput no no
MAP9_HUMAN [view interactions] High throughput no no
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
MAST4_HUMAN [view interactions] High throughput no no
MCM10_HUMAN [view interactions] High throughput no no
MINK1_HUMAN [view entry] [view interactions] High throughput yes yes
MTUS1_HUMAN [view interactions] High throughput no no
NAV1_HUMAN [view interactions] High throughput no yes
NAV2_HUMAN [view interactions] High throughput no yes
NCKP5_HUMAN [view interactions] High throughput no no
NCK5L_HUMAN [view interactions] High throughput no yes
NDC80_HUMAN [view interactions] High throughput no no
NEDD1_HUMAN [view interactions] High throughput no yes
NEK1_HUMAN [view interactions] High throughput no yes
NEK4_HUMAN [view interactions] High throughput no yes
PATL1_HUMAN [view interactions] High throughput no yes
PCNT_HUMAN [view interactions] High throughput no yes
PI3R4_HUMAN [view interactions] High throughput no yes
PKHA5_HUMAN [view entry] [view interactions] High throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
PRSR2_HUMAN [view interactions] High throughput no yes
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
RPAP2_HUMAN [view interactions] High throughput no yes
SEBP2_HUMAN [view interactions] High throughput no yes
SENP2_HUMAN [view interactions] High throughput no yes
SH319_HUMAN [view interactions] High throughput no no
SPD2B_HUMAN [view interactions] High throughput no no
SI1L3_HUMAN [view entry] [view interactions] High throughput yes yes
SLAI2_HUMAN [view interactions] High throughput no no
MTCL2_HUMAN [view interactions] High throughput no yes
SPAG5_HUMAN [view interactions] High throughput no yes
CYTSB_HUMAN [view entry] [view interactions] High throughput yes yes
CYTSA_HUMAN [view interactions] High throughput no yes
SPICE_HUMAN [view interactions] High throughput no yes
STIM1_HUMAN [view interactions] High throughput no yes
SYBU_HUMAN [view interactions] High throughput no yes
SYNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
TACC1_HUMAN [view entry] [view interactions] High throughput yes yes
TACC2_HUMAN [view interactions] High throughput no yes
TANC1_HUMAN [view entry] [view interactions] High throughput yes yes
TDRD3_HUMAN [view interactions] High throughput no yes
TM131_HUMAN [view interactions] High throughput no yes
TRI36_HUMAN [view interactions] High throughput no no
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TTBK2_HUMAN [view interactions] High throughput no yes
TTF2_HUMAN [view interactions] High throughput no yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
TUT7_HUMAN [view interactions] High throughput no yes
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
CENPC_HUMAN [view interactions] High throughput no no
CENPF_HUMAN [view interactions] High throughput no no
CP131_HUMAN [view interactions] High throughput no no
CEP55_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
DDX20_HUMAN [view interactions] High throughput no no
DLG5_HUMAN [view entry] [view interactions] High throughput yes no
DLGP5_HUMAN [view interactions] High throughput no no
DNMBP_HUMAN [view interactions] High throughput no no
DVL1_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC4_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
HAUS7_HUMAN [view interactions] High throughput no no
IBTK_HUMAN [view interactions] High throughput no yes
IFT74_HUMAN [view interactions] High throughput no yes
KIF11_HUMAN [view interactions] High throughput no yes
KI21A_HUMAN [view entry] [view interactions] High throughput yes yes
LAR4B_HUMAN [view interactions] High throughput no yes
M4K4_HUMAN [view interactions] High throughput no yes
MARF1_HUMAN [view interactions] High throughput no yes
MYO9B_HUMAN [view entry] [view interactions] High throughput yes yes
PRC2A_HUMAN [view interactions] High throughput no yes
RASF8_HUMAN [view interactions] High throughput no yes
SKA3_HUMAN [view interactions] High throughput no no
STIM2_HUMAN [view interactions] High throughput no yes
TTC28_HUMAN [view interactions] High throughput no no
ZN598_HUMAN [view interactions] High throughput no no
RBTN2_HUMAN [view interactions] High throughput no yes
PSA1_HUMAN [view interactions] High throughput no yes
TROAP_HUMAN [view interactions] High throughput no yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
CLIP2_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP2_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CK5P2_HUMAN [view interactions] High throughput no yes
DP13B_HUMAN [view entry] [view interactions] High throughput yes yes
DOK4_HUMAN [view interactions] High throughput no yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4E2_HUMAN [view interactions] High throughput no no
PSB1_HUMAN [view interactions] High throughput no yes
THIOM_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
GA2L2_HUMAN [view interactions] High throughput no no
SPDE6_HUMAN [view interactions] High throughput no no
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
MARE2_HUMAN [view entry] [view interactions] High throughput yes yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
MARH7_HUMAN [view interactions] High throughput no yes
CRAC1_HUMAN [view entry] [view interactions] High throughput yes yes
KLD7B_HUMAN [view interactions] High throughput no no
ZN526_HUMAN [view interactions] High throughput no yes
LHX4_HUMAN [view interactions] High throughput no no
F161B_HUMAN [view interactions] High throughput no yes
DDT4L_HUMAN [view interactions] High throughput no no
FX4L1_HUMAN [view interactions] High throughput no no
SKAP_HUMAN [view interactions] High throughput no yes
FX4L4_HUMAN [view interactions] High throughput no no
SMIP2_HUMAN [view interactions] High throughput no no
ANKR1_HUMAN [view interactions] High throughput no no
ZC21A_HUMAN [view interactions] High throughput no yes
AMPL_HUMAN [view entry] [view interactions] High throughput yes no
PO4F1_HUMAN [view interactions] High throughput no no
T2FB_HUMAN [view interactions] High throughput no yes
RM12_HUMAN [view interactions] High throughput no yes
TRAIP_HUMAN [view interactions] High throughput no yes
SMI10_HUMAN [view interactions] High throughput no no
ZN547_HUMAN [view interactions] High throughput no no
CT202_HUMAN [view interactions] High throughput no no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
SOX4_HUMAN [view interactions] High throughput no yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
KI18B_HUMAN [view interactions] High throughput no no
KIF2C_HUMAN [view entry] [view interactions] High throughput yes no
SLAI1_HUMAN [view interactions] High throughput no no
GTSE1_HUMAN [view interactions] High throughput no no
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
KIF19_HUMAN [view interactions] High throughput no yes
YAF2_HUMAN [view interactions] High throughput no yes
CRDL2_HUMAN [view interactions] High throughput no yes
TLE5_HUMAN [view interactions] High throughput no no
MEOX2_HUMAN [view interactions] High throughput no no
ZC21C_HUMAN [view interactions] High throughput no yes
HROB_HUMAN [view interactions] High throughput no yes
REL_HUMAN [view interactions] High throughput no yes
SPE2B_HUMAN [view interactions] High throughput no no
MYOME_HUMAN [view interactions] High throughput no no
CCSE1_HUMAN [view interactions] High throughput no no
IKZF1_HUMAN [view interactions] High throughput no no
SPDE2_HUMAN [view interactions] High throughput no no
PRP6_HUMAN [view interactions] High throughput no yes