Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MARE3_HUMAN

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed). May play a role in cell migration . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MARE3_HUMAN
GO:0015631 tubulin binding 36.0000 4 yes
GO:0008017 microtubule binding 34.6667 5 yes
GO:0017076 purine nucleotide binding 24.0000 4 no
GO:0032555 purine ribonucleotide binding 24.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.0000 4 no
GO:0019900 kinase binding 22.6667 4 yes
GO:0019901 protein kinase binding 21.3333 5 yes
GO:0051010 microtubule plus-end binding 18.6667 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MARE3_HUMAN
GO:0006996 organelle organization 60.0000 4 yes
GO:0048522 positive regulation of cellular process 58.6667 4 yes
GO:0007010 cytoskeleton organization 56.0000 5 yes
GO:0051128 regulation of cellular component organization 56.0000 4 yes
GO:0048523 negative regulation of cellular process 44.0000 4 no
GO:0022607 cellular component assembly 38.6667 4 yes
GO:0033043 regulation of organelle organization 38.6667 5 yes
GO:0010646 regulation of cell communication 38.6667 4 no
GO:0051130 positive regulation of cellular component organization 36.0000 5 no
GO:0051493 regulation of cytoskeleton organization 34.6667 6 yes
GO:0060255 regulation of macromolecule metabolic process 34.6667 4 yes
GO:0009893 positive regulation of metabolic process 33.3333 4 yes
GO:0008104 protein localization 32.0000 4 yes
GO:0031323 regulation of cellular metabolic process 32.0000 4 yes
GO:0044087 regulation of cellular component biogenesis 32.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 32.0000 4 yes
GO:0080090 regulation of primary metabolic process 32.0000 4 yes
GO:0030030 cell projection organization 32.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 30.6667 5 yes
GO:0032886 regulation of microtubule-based process 30.6667 4 yes
GO:0051246 regulation of protein metabolic process 29.3333 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 28.0000 5 yes
GO:0009966 regulation of signal transduction 28.0000 4 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 yes
GO:0070507 regulation of microtubule cytoskeleton organization 26.6667 5 yes
GO:1902903 regulation of supramolecular fiber organization 26.6667 5 yes
GO:0045595 regulation of cell differentiation 26.6667 4 no
GO:0031325 positive regulation of cellular metabolic process 24.0000 5 yes
GO:0031399 regulation of protein modification process 24.0000 6 yes
GO:0120036 plasma membrane bounded cell projection organization 24.0000 5 no
GO:0031110 regulation of microtubule polymerization or depolymerization 22.6667 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 22.6667 4 no
GO:0030334 regulation of cell migration 22.6667 5 no
GO:2000145 regulation of cell motility 22.6667 4 no
GO:0051049 regulation of transport 22.6667 4 no
GO:0010468 regulation of gene expression 21.3333 5 yes
GO:0019220 regulation of phosphate metabolic process 21.3333 6 yes
GO:0042325 regulation of phosphorylation 21.3333 7 yes
GO:0051174 regulation of phosphorus metabolic process 21.3333 5 yes
GO:0070925 organelle assembly 21.3333 5 yes
GO:0051129 negative regulation of cellular component organization 21.3333 5 no
GO:0071702 organic substance transport 21.3333 4 no
GO:0071705 nitrogen compound transport 21.3333 4 no
GO:0031344 regulation of cell projection organization 21.3333 5 no
GO:0044089 positive regulation of cellular component biogenesis 21.3333 5 no
GO:0097435 supramolecular fiber organization 21.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.3333 6 no
GO:0001932 regulation of protein phosphorylation 20.0000 7 yes
GO:0031401 positive regulation of protein modification process 20.0000 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 18.6667 6 yes
GO:0032271 regulation of protein polymerization 18.6667 6 yes
GO:0042327 positive regulation of phosphorylation 18.6667 8 yes
GO:0043254 regulation of protein-containing complex assembly 18.6667 5 yes
GO:0045937 positive regulation of phosphate metabolic process 18.6667 7 yes
GO:0051726 regulation of cell cycle 18.6667 4 yes
GO:0001934 positive regulation of protein phosphorylation 17.3333 8 yes
GO:0031113 regulation of microtubule polymerization 16.0000 6 yes
GO:0009889 regulation of biosynthetic process 14.6667 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 14.6667 5 yes
GO:0031326 regulation of cellular biosynthetic process 14.6667 5 yes
GO:0043085 positive regulation of catalytic activity 14.6667 4 yes
GO:0140694 non-membrane-bounded organelle assembly 14.6667 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 13.3333 5 yes
GO:0033365 protein localization to organelle 13.3333 5 yes
GO:0009891 positive regulation of biosynthetic process 12.0000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 12.0000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 12.0000 6 yes
GO:0051225 spindle assembly 12.0000 4 yes
GO:0051252 regulation of RNA metabolic process 12.0000 5 yes
GO:0051338 regulation of transferase activity 12.0000 4 yes
GO:0043393 regulation of protein binding 10.6667 4 yes
GO:0043549 regulation of kinase activity 10.6667 5 yes
GO:0044380 protein localization to cytoskeleton 10.6667 6 yes
GO:0045787 positive regulation of cell cycle 9.3333 5 yes
GO:0045859 regulation of protein kinase activity 9.3333 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 9.3333 6 yes
GO:0051347 positive regulation of transferase activity 9.3333 5 yes
GO:0072698 protein localization to microtubule cytoskeleton 9.3333 7 yes
GO:0006355 regulation of DNA-templated transcription 8.0000 6 yes
GO:0033674 positive regulation of kinase activity 8.0000 6 yes
GO:0051254 positive regulation of RNA metabolic process 8.0000 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 8.0000 7 yes
GO:2001141 regulation of RNA biosynthetic process 8.0000 6 yes
GO:0035372 protein localization to microtubule 6.6667 8 yes
GO:0045860 positive regulation of protein kinase activity 6.6667 7 yes
GO:0045893 positive regulation of DNA-templated transcription 6.6667 7 yes
GO:1902680 positive regulation of RNA biosynthetic process 6.6667 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 6.6667 8 yes
GO:1904526 regulation of microtubule binding 6.6667 5 yes
GO:0051099 positive regulation of binding 5.3333 4 yes
GO:1904825 protein localization to microtubule plus-end 5.3333 10 yes
GO:1905725 protein localization to microtubule end 5.3333 9 yes
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 4.0000 6 yes
GO:0032092 positive regulation of protein binding 4.0000 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 4.0000 7 yes
GO:1903031 regulation of microtubule plus-end binding 4.0000 6 yes
GO:1903033 positive regulation of microtubule plus-end binding 4.0000 7 yes
GO:1904029 regulation of cyclin-dependent protein kinase activity 4.0000 5 yes
GO:1904528 positive regulation of microtubule binding 4.0000 6 yes
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 2.6667 6 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 2.6667 8 yes
GO:1904031 positive regulation of cyclin-dependent protein kinase activity 2.6667 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in MARE3_HUMAN
DOID:331 central nervous system disease 2.6667 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TBA1B_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
ADNP_HUMAN [view interactions] Low throughput no yes
APCL_HUMAN [view entry] [view interactions] Low throughput yes no
MARE1_HUMAN [view entry] [view interactions] Low throughput yes yes
DREB_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1B_HUMAN [view entry] [view interactions] Low throughput yes yes
ANK3_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PSRC1_HUMAN [view interactions] Low throughput no no
DCTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SIAH1_HUMAN [view interactions] Low throughput no yes
AURKA_HUMAN [view entry] [view interactions] Low throughput yes no
AURKB_HUMAN [view interactions] Low throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
TTBK1_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
FCHO1_HUMAN [view interactions] High throughput no yes
CALR_HUMAN [view interactions] High throughput no yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
TEBP_HUMAN [view interactions] High throughput no yes
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
CF132_HUMAN [view interactions] High throughput no no
CAMP1_HUMAN [view interactions] High throughput no yes
CAMP2_HUMAN [view interactions] High throughput no yes
CAMP3_HUMAN [view interactions] High throughput no no
CBL_HUMAN [view interactions] High throughput no yes
CCD66_HUMAN [view interactions] High throughput no yes
GRDN_HUMAN [view interactions] High throughput no no
CP110_HUMAN [view interactions] High throughput no yes
CCSE2_HUMAN [view interactions] High throughput no yes
CDC27_HUMAN [view interactions] High throughput no yes
CK5P2_HUMAN [view interactions] High throughput no yes
CENPJ_HUMAN [view interactions] High throughput no no
CE104_HUMAN [view interactions] High throughput no yes
CE162_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
C170B_HUMAN [view interactions] High throughput no yes
CE350_HUMAN [view interactions] High throughput no yes
CEP44_HUMAN [view interactions] High throughput no yes
CFA97_HUMAN [view interactions] High throughput no yes
CKAP2_HUMAN [view interactions] High throughput no yes
CKP2L_HUMAN [view interactions] High throughput no yes
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
COBL_HUMAN [view interactions] High throughput no yes
CTTB2_HUMAN [view entry] [view interactions] High throughput yes yes
DCDC2_HUMAN [view interactions] High throughput no yes
DCLK1_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP3_HUMAN [view interactions] High throughput no no
DIP2B_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
EMAL4_HUMAN [view interactions] High throughput no yes
F161A_HUMAN [view interactions] High throughput no no
FA83B_HUMAN [view interactions] High throughput no no
CEP43_HUMAN [view interactions] High throughput no no
FLIP1_HUMAN [view entry] [view interactions] High throughput yes no
GA2L3_HUMAN [view interactions] High throughput no no
GEN_HUMAN [view interactions] High throughput no yes
HAUS8_HUMAN [view interactions] High throughput no yes
HMMR_HUMAN [view interactions] High throughput no yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
K1107_HUMAN [view interactions] High throughput no yes
SKT_HUMAN [view entry] [view interactions] High throughput yes yes
K1671_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF15_HUMAN [view interactions] High throughput no no
KIF1B_HUMAN [view interactions] High throughput no yes
KIF1C_HUMAN [view interactions] High throughput no yes
KIF24_HUMAN [view interactions] High throughput no no
KIF2A_HUMAN [view entry] [view interactions] High throughput yes yes
KIF7_HUMAN [view interactions] High throughput no yes
LMO7_HUMAN [view entry] [view interactions] High throughput yes yes
LUZP1_HUMAN [view interactions] High throughput no yes
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
MACOI_HUMAN [view interactions] High throughput no no
MAP1A_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1S_HUMAN [view interactions] High throughput no no
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
MAP7_HUMAN [view interactions] High throughput no yes
MA7D1_HUMAN [view entry] [view interactions] High throughput yes no
MA7D2_HUMAN [view interactions] High throughput no yes
MA7D3_HUMAN [view interactions] High throughput no no
MAP9_HUMAN [view interactions] High throughput no no
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
MAST4_HUMAN [view interactions] High throughput no no
MCM10_HUMAN [view interactions] High throughput no no
MINK1_HUMAN [view entry] [view interactions] High throughput yes yes
MTUS1_HUMAN [view interactions] High throughput no no
NAV1_HUMAN [view interactions] High throughput no yes
NAV2_HUMAN [view interactions] High throughput no yes
NCKP5_HUMAN [view interactions] High throughput no no
NCK5L_HUMAN [view interactions] High throughput no yes
NDC80_HUMAN [view interactions] High throughput no no
NEDD1_HUMAN [view interactions] High throughput no yes
NEK1_HUMAN [view interactions] High throughput no yes
NEK4_HUMAN [view interactions] High throughput no yes
PATL1_HUMAN [view interactions] High throughput no yes
PCNT_HUMAN [view interactions] High throughput no yes
PI3R4_HUMAN [view interactions] High throughput no yes
PKHA5_HUMAN [view entry] [view interactions] High throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
PRSR2_HUMAN [view interactions] High throughput no yes
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
RPAP2_HUMAN [view interactions] High throughput no yes
SEBP2_HUMAN [view interactions] High throughput no yes
SENP2_HUMAN [view interactions] High throughput no yes
SH319_HUMAN [view interactions] High throughput no no
SPD2B_HUMAN [view interactions] High throughput no no
SI1L3_HUMAN [view interactions] High throughput no yes
SLAI2_HUMAN [view interactions] High throughput no no
SOGA1_HUMAN [view interactions] High throughput no yes
SPAG5_HUMAN [view interactions] High throughput no yes
CYTSB_HUMAN [view entry] [view interactions] High throughput yes yes
CYTSA_HUMAN [view interactions] High throughput no yes
SPICE_HUMAN [view interactions] High throughput no yes
STIM1_HUMAN [view interactions] High throughput no yes
SYBU_HUMAN [view interactions] High throughput no yes
SYNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
TACC1_HUMAN [view entry] [view interactions] High throughput yes yes
TACC2_HUMAN [view interactions] High throughput no yes
TANC1_HUMAN [view entry] [view interactions] High throughput yes yes
TDRD3_HUMAN [view interactions] High throughput no yes
TM131_HUMAN [view interactions] High throughput no yes
TRI36_HUMAN [view interactions] High throughput no no
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TTBK2_HUMAN [view interactions] High throughput no yes
TTF2_HUMAN [view interactions] High throughput no yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
TUT7_HUMAN [view interactions] High throughput no yes
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
CENPC_HUMAN [view interactions] High throughput no no
CENPF_HUMAN [view interactions] High throughput no no
CP131_HUMAN [view interactions] High throughput no no
CEP55_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
DDX20_HUMAN [view interactions] High throughput no no
DLG5_HUMAN [view entry] [view interactions] High throughput yes no
DLGP5_HUMAN [view interactions] High throughput no no
DNMBP_HUMAN [view interactions] High throughput no no
DVL1_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC4_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
HAUS7_HUMAN [view interactions] High throughput no no
IBTK_HUMAN [view interactions] High throughput no yes
IFT74_HUMAN [view interactions] High throughput no yes
KIF11_HUMAN [view interactions] High throughput no yes
KI21A_HUMAN [view entry] [view interactions] High throughput yes yes
LAR4B_HUMAN [view interactions] High throughput no yes
M4K4_HUMAN [view interactions] High throughput no yes
MARF1_HUMAN [view interactions] High throughput no yes
MYO9B_HUMAN [view interactions] High throughput no yes
PRC2A_HUMAN [view interactions] High throughput no yes
RASF8_HUMAN [view interactions] High throughput no yes
SKA3_HUMAN [view interactions] High throughput no no
STIM2_HUMAN [view interactions] High throughput no yes
TTC28_HUMAN [view interactions] High throughput no no
ZN598_HUMAN [view interactions] High throughput no no
RBTN2_HUMAN [view interactions] High throughput no yes
PSA1_HUMAN [view interactions] High throughput no yes
TROAP_HUMAN [view interactions] High throughput no yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP2_HUMAN [view entry] [view interactions] High throughput yes no
CLIP2_HUMAN [view entry] [view interactions] High throughput yes yes
DP13B_HUMAN [view entry] [view interactions] High throughput yes yes
DOK4_HUMAN [view interactions] High throughput no yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4E2_HUMAN [view interactions] High throughput no no
PSB1_HUMAN [view interactions] High throughput no yes
THIOM_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
GA2L2_HUMAN [view interactions] High throughput no no
SPDE6_HUMAN [view interactions] High throughput no no
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
MARE2_HUMAN [view entry] [view interactions] High throughput yes yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
MARH7_HUMAN [view interactions] High throughput no yes
CRAC1_HUMAN [view entry] [view interactions] High throughput yes yes
KLD7B_HUMAN [view interactions] High throughput no no
ZN526_HUMAN [view interactions] High throughput no yes
LHX4_HUMAN [view interactions] High throughput no no
F161B_HUMAN [view interactions] High throughput no yes
DDT4L_HUMAN [view interactions] High throughput no no
FX4L1_HUMAN [view interactions] High throughput no no
SKAP_HUMAN [view interactions] High throughput no yes
FX4L4_HUMAN [view interactions] High throughput no no
CD045_HUMAN [view interactions] High throughput no no
ANKR1_HUMAN [view interactions] High throughput no no
ZC21A_HUMAN [view interactions] High throughput no yes
AMPL_HUMAN [view entry] [view interactions] High throughput yes no
PO4F1_HUMAN [view interactions] High throughput no no
T2FB_HUMAN [view interactions] High throughput no yes
RM12_HUMAN [view interactions] High throughput no yes
TRAIP_HUMAN [view interactions] High throughput no yes
TEX43_HUMAN [view interactions] High throughput no no
ZN547_HUMAN [view interactions] High throughput no no
CT202_HUMAN [view interactions] High throughput no no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
KIF2C_HUMAN [view entry] [view interactions] High throughput yes no
KI18B_HUMAN [view interactions] High throughput no no
SLAI1_HUMAN [view interactions] High throughput no no
GTSE1_HUMAN [view interactions] High throughput no no
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
KIF19_HUMAN [view interactions] High throughput no yes
YAF2_HUMAN [view interactions] High throughput no yes
CRDL2_HUMAN [view interactions] High throughput no yes
TLE5_HUMAN [view interactions] High throughput no no
MEOX2_HUMAN [view interactions] High throughput no no
ZC21C_HUMAN [view interactions] High throughput no yes
HROB_HUMAN [view interactions] High throughput no yes
REL_HUMAN [view interactions] High throughput no yes
SPE2B_HUMAN [view interactions] High throughput no no
MYOME_HUMAN [view interactions] High throughput no no
CCSE1_HUMAN [view interactions] High throughput no no
IKZF1_HUMAN [view interactions] High throughput no no
SPDE2_HUMAN [view interactions] High throughput no no
PRP6_HUMAN [view interactions] High throughput no yes
NXF1_HUMAN [view interactions] High throughput no yes
EXOS7_HUMAN [view interactions] High throughput no yes
ESS2_HUMAN [view interactions] High throughput no yes
MGN_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
GA2L1_HUMAN [view interactions] High throughput no yes
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
IASPP_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MARK3_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
LIS1_HUMAN [view entry] [view interactions] Computational yes yes
CENPE_HUMAN [view interactions] Computational no no
SPEF1_HUMAN [view interactions] Computational no no
DYHC1_HUMAN [view entry] [view interactions] Computational yes yes
DOCK1_HUMAN [view entry] [view interactions] Computational yes yes