KI21A_HUMAN
Evidence for PS localization
Functions
Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KI21A_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 37.9310 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 37.9310 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 37.9310 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.9310 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 37.9310 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 37.9310 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 34.4828 | 7 | yes |
| GO:0030554 | adenyl nucleotide binding | 34.4828 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 34.4828 | 5 | yes |
| GO:0005524 | ATP binding | 34.4828 | 5 | yes |
| GO:0003723 | RNA binding | 27.5862 | 4 | no |
| GO:0019900 | kinase binding | 27.5862 | 4 | no |
| GO:0019901 | protein kinase binding | 27.5862 | 5 | no |
| GO:0046872 | metal ion binding | 20.6897 | 4 | no |
| GO:0015631 | tubulin binding | 13.7931 | 4 | yes |
| GO:0008017 | microtubule binding | 10.3448 | 5 | yes |
| GO:0071532 | ankyrin repeat binding | 6.8966 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KI21A_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 68.9655 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 68.9655 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 62.0690 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 62.0690 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 62.0690 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 55.1724 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 51.7241 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 51.7241 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 51.7241 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 51.7241 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 48.2759 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 48.2759 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 48.2759 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 44.8276 | 5 | no |
| GO:0033043 | regulation of organelle organization | 41.3793 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 37.9310 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 37.9310 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 37.9310 | 6 | no |
| GO:0048523 | negative regulation of cellular process | 37.9310 | 4 | no |
| GO:0032880 | regulation of protein localization | 37.9310 | 5 | no |
| GO:0060341 | regulation of cellular localization | 37.9310 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 34.4828 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 34.4828 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 34.4828 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 34.4828 | 5 | no |
| GO:1904951 | positive regulation of establishment of protein localization | 31.0345 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 31.0345 | 6 | no |
| GO:0022607 | cellular component assembly | 31.0345 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 31.0345 | 6 | no |
| GO:1904814 | regulation of protein localization to chromosome, telomeric region | 27.5862 | 6 | no |
| GO:1904816 | positive regulation of protein localization to chromosome, telomeric region | 27.5862 | 6 | no |
| GO:1904851 | positive regulation of establishment of protein localization to telomere | 27.5862 | 7 | no |
| GO:1904869 | regulation of protein localization to Cajal body | 27.5862 | 7 | no |
| GO:1904871 | positive regulation of protein localization to Cajal body | 27.5862 | 7 | no |
| GO:1904872 | regulation of telomerase RNA localization to Cajal body | 27.5862 | 4 | no |
| GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | 27.5862 | 4 | no |
| GO:2000278 | regulation of DNA biosynthetic process | 27.5862 | 6 | no |
| GO:2000573 | positive regulation of DNA biosynthetic process | 27.5862 | 7 | no |
| GO:2001252 | positive regulation of chromosome organization | 27.5862 | 7 | no |
| GO:0008104 | protein localization | 27.5862 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.5862 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.5862 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.5862 | 5 | no |
| GO:0032204 | regulation of telomere maintenance | 27.5862 | 6 | no |
| GO:0032206 | positive regulation of telomere maintenance | 27.5862 | 7 | no |
| GO:0032210 | regulation of telomere maintenance via telomerase | 27.5862 | 7 | no |
| GO:0032212 | positive regulation of telomere maintenance via telomerase | 27.5862 | 8 | no |
| GO:0033044 | regulation of chromosome organization | 27.5862 | 6 | no |
| GO:0050821 | protein stabilization | 27.5862 | 4 | no |
| GO:0051052 | regulation of DNA metabolic process | 27.5862 | 5 | no |
| GO:0051054 | positive regulation of DNA metabolic process | 27.5862 | 6 | no |
| GO:0051338 | regulation of transferase activity | 27.5862 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 27.5862 | 5 | no |
| GO:0070202 | regulation of establishment of protein localization to chromosome | 27.5862 | 7 | no |
| GO:0070203 | regulation of establishment of protein localization to telomere | 27.5862 | 7 | no |
| GO:1900180 | regulation of protein localization to nucleus | 27.5862 | 6 | no |
| GO:1900182 | positive regulation of protein localization to nucleus | 27.5862 | 6 | no |
| GO:1904356 | regulation of telomere maintenance via telomere lengthening | 27.5862 | 7 | no |
| GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | 27.5862 | 8 | no |
| GO:0009966 | regulation of signal transduction | 24.1379 | 4 | no |
| GO:0010646 | regulation of cell communication | 24.1379 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.1379 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.1379 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 24.1379 | 7 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.1379 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.1379 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.1379 | 6 | no |
| GO:1901998 | toxin transport | 24.1379 | 4 | no |
| GO:0051049 | regulation of transport | 20.6897 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 20.6897 | 4 | no |
| GO:0006996 | organelle organization | 20.6897 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.6897 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.6897 | 8 | no |
| GO:0010468 | regulation of gene expression | 20.6897 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.6897 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 20.6897 | 5 | no |
| GO:0031399 | regulation of protein modification process | 20.6897 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 20.6897 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.6897 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.6897 | 7 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.6897 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.6897 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.6897 | 5 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KI21A_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 6.8966 | 3 | no |
| DOID:2843 | long QT syndrome | 6.8966 | 6 | no |
| DOID:0050700 | cardiomyopathy | 6.8966 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 6.8966 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KI21A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KANK1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIG1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTT3_HUMAN | [view interactions] | Low throughput | no | no |
| KANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ENDD1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM4_HUMAN | [view interactions] | High throughput | no | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD51_HUMAN | [view interactions] | High throughput | no | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| ZN106_HUMAN | [view interactions] | High throughput | no | no |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN668_HUMAN | [view interactions] | High throughput | no | yes |
| NVL_HUMAN | [view interactions] | High throughput | no | no |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| MSI2H_HUMAN | [view interactions] | High throughput | no | yes |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1L_HUMAN | [view interactions] | High throughput | no | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI4KB_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNF24_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K4_HUMAN | [view interactions] | High throughput | no | yes |
| TBX3_HUMAN | [view interactions] | High throughput | no | no |
| NCOA4_HUMAN | [view interactions] | High throughput | no | no |
| LIPB1_HUMAN | [view interactions] | High throughput | no | yes |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| TACC2_HUMAN | [view interactions] | High throughput | no | yes |
| NOL8_HUMAN | [view interactions] | High throughput | no | yes |
| KI21B_HUMAN | [view interactions] | High throughput | no | yes |
| PHRF1_HUMAN | [view interactions] | High throughput | no | no |
| FIP1_HUMAN | [view interactions] | High throughput | no | yes |
| C99L2_HUMAN | [view interactions] | High throughput | no | yes |
| DGKH_HUMAN | [view interactions] | High throughput | no | yes |
| CF136_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA3_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| NCS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP68_HUMAN | [view interactions] | High throughput | no | yes |
| SRP72_HUMAN | [view interactions] | High throughput | no | yes |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| PHX2A_HUMAN | [view interactions] | Computational | no | no |
| TBB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |