USP9X_HUMAN
Evidence for PS localization
Functions
Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes Lys-48-, Lys-29- and Lys-33-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed, PubMed, PubMed, PubMed). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 1693 | Leu | Trp | Intellectualdevelopmentaldisorder,X-linked99,syndromic,female-restricted(MRXS99F) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in USP9X_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 29.2135 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 28.0899 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.0899 | 4 | no |
| GO:0019900 | kinase binding | 24.7191 | 4 | no |
| GO:0046872 | metal ion binding | 23.5955 | 4 | no |
| GO:0019901 | protein kinase binding | 23.5955 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.4719 | 5 | no |
| GO:0005524 | ATP binding | 21.3483 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.3483 | 5 | no |
| GO:0003723 | RNA binding | 20.2247 | 4 | no |
| GO:0004175 | endopeptidase activity | 3.3708 | 4 | yes |
| GO:0004197 | cysteine-type endopeptidase activity | 2.2472 | 5 | yes |
| GO:0004843 | cysteine-type deubiquitinase activity | 2.2472 | 5 | yes |
| GO:0008234 | cysteine-type peptidase activity | 2.2472 | 4 | yes |
| GO:0019783 | ubiquitin-like protein peptidase activity | 2.2472 | 4 | yes |
| GO:0070410 | co-SMAD binding | 2.2472 | 4 | yes |
| GO:0101005 | deubiquitinase activity | 2.2472 | 5 | yes |
| GO:1990380 | Lys48-specific deubiquitinase activity | 2.2472 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in USP9X_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.2921 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 61.7978 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 59.5506 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 57.3034 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 55.0562 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 55.0562 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.5618 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 47.1910 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 47.1910 | 5 | yes |
| GO:0010646 | regulation of cell communication | 47.1910 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.9438 | 4 | no |
| GO:0010468 | regulation of gene expression | 43.8202 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 42.6966 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 40.4494 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 39.3258 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 39.3258 | 4 | yes |
| GO:0036211 | protein modification process | 38.2022 | 4 | yes |
| GO:0043412 | macromolecule modification | 38.2022 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 37.0787 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 37.0787 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.9551 | 5 | yes |
| GO:0006996 | organelle organization | 35.9551 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.9551 | 4 | no |
| GO:0051049 | regulation of transport | 33.7079 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 32.5843 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 31.4607 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 31.4607 | 4 | no |
| GO:0022607 | cellular component assembly | 30.3371 | 4 | no |
| GO:0030030 | cell projection organization | 30.3371 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.2135 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 28.0899 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.0899 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.0899 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 28.0899 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.9663 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 26.9663 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.9663 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.8427 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.8427 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 25.8427 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 25.8427 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.8427 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.8427 | 5 | no |
| GO:0010941 | regulation of cell death | 25.8427 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.8427 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.8427 | 6 | yes |
| GO:0008104 | protein localization | 25.8427 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 24.7191 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.7191 | 4 | no |
| GO:0071310 | cellular response to organic substance | 24.7191 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.5955 | 5 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 23.5955 | 6 | yes |
| GO:0042127 | regulation of cell population proliferation | 23.5955 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.5955 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.5955 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.5955 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.5955 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.5955 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.4719 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.4719 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.4719 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.4719 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 22.4719 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.4719 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.4719 | 7 | no |
| GO:0051338 | regulation of transferase activity | 22.4719 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.4719 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.3483 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 21.3483 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.3483 | 7 | no |
| GO:0031329 | regulation of cellular catabolic process | 21.3483 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 21.3483 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.3483 | 6 | no |
| GO:0032880 | regulation of protein localization | 21.3483 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.2247 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.2247 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.2247 | 4 | no |
| GO:0007010 | cytoskeleton organization | 20.2247 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 17.9775 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 16.8539 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 16.8539 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 16.8539 | 7 | yes |
| GO:0032446 | protein modification by small protein conjugation | 15.7303 | 6 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 15.7303 | 5 | yes |
| GO:0006508 | proteolysis | 15.7303 | 4 | yes |
| GO:0016567 | protein ubiquitination | 14.6067 | 7 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 14.6067 | 5 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 13.4831 | 6 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 13.4831 | 6 | yes |
| GO:0097435 | supramolecular fiber organization | 13.4831 | 4 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 12.3596 | 7 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 12.3596 | 7 | yes |
| GO:1903507 | negative regulation of nucleic acid-templated transcription | 12.3596 | 8 | yes |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 11.2360 | 8 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 11.2360 | 4 | yes |
| GO:0050821 | protein stabilization | 10.1124 | 4 | yes |
| GO:0051052 | regulation of DNA metabolic process | 8.9888 | 5 | yes |
| GO:0051054 | positive regulation of DNA metabolic process | 8.9888 | 6 | yes |
| GO:0001764 | neuron migration | 7.8652 | 4 | yes |
| GO:1990138 | neuron projection extension | 5.6180 | 4 | yes |
| GO:1990000 | amyloid fibril formation | 3.3708 | 4 | yes |
| GO:0016579 | protein deubiquitination | 2.2472 | 6 | yes |
| GO:0030509 | BMP signaling pathway | 2.2472 | 6 | yes |
| GO:0048675 | axon extension | 2.2472 | 5 | yes |
| GO:0070646 | protein modification by small protein removal | 2.2472 | 5 | yes |
| GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process | 2.2472 | 6 | yes |
| GO:1901535 | regulation of DNA demethylation | 2.2472 | 6 | yes |
| GO:1901537 | positive regulation of DNA demethylation | 2.2472 | 7 | yes |
| GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 2.2472 | 5 | yes |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | 2.2472 | 6 | yes |
| GO:0007292 | female gamete generation | 2.2472 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in USP9X_HUMAN |
|---|---|---|---|---|
| DOID:0060038 | specific developmental disorder | 3.3708 | 3 | yes |
| DOID:1059 | intellectual disability | 3.3708 | 4 | yes |
| DOID:0050686 | organ system cancer | 3.3708 | 3 | no |
| DOID:0050776 | non-syndromic X-linked intellectual disability | 2.2472 | 6 | yes |
| DOID:0050888 | syndromic intellectual disability | 2.2472 | 5 | yes |
| DOID:0050889 | non-syndromic intellectual disability | 2.2472 | 5 | yes |
| DOID:0060309 | syndromic X-linked intellectual disability | 2.2472 | 6 | yes |
| DOID:0112025 | female-restricted syndromic X-linked intellectual disability 99 | 2.2472 | 7 | yes |
| DOID:0112026 | non-syndromic X-linked intellectual disability 99 | 2.2472 | 7 | yes |
| DOID:120 | female reproductive organ cancer | 2.2472 | 5 | no |
| DOID:193 | reproductive organ cancer | 2.2472 | 4 | no |
| DOID:331 | central nervous system disease | 2.2472 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DCX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AFAD_HUMAN | [view interactions] | Low throughput | no | yes |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| USP9X_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIRC5_HUMAN | [view interactions] | Low throughput | no | no |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| PSD4_HUMAN | [view interactions] | Low throughput | no | yes |
| GPSM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SMAD1_HUMAN | [view interactions] | Low throughput | no | yes |
| RICTR_HUMAN | [view interactions] | Low throughput | no | yes |
| MARH7_HUMAN | [view interactions] | Low throughput | no | yes |
| SMUF1_HUMAN | [view interactions] | Low throughput | no | yes |
| BCL10_HUMAN | [view interactions] | Low throughput | no | yes |
| MALT1_HUMAN | [view interactions] | Low throughput | no | no |
| ERG_HUMAN | [view interactions] | Low throughput | no | yes |
| AMOL2_HUMAN | [view interactions] | Low throughput | no | no |
| YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NANOG_HUMAN | [view interactions] | Low throughput | no | no |
| SMN_HUMAN | [view interactions] | Low throughput | no | yes |
| TDRD3_HUMAN | [view interactions] | Low throughput | no | yes |
| AMOT_HUMAN | [view interactions] | Low throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LAT_HUMAN | [view interactions] | Low throughput | no | no |
| KPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LATS1_HUMAN | [view interactions] | Low throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | Low throughput | no | no |
| ZN598_HUMAN | [view interactions] | Low throughput | no | no |
| EGLN3_HUMAN | [view interactions] | Low throughput | no | no |
| PCM1_HUMAN | [view interactions] | Low throughput | no | yes |
| CEP55_HUMAN | [view interactions] | Low throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TTK_HUMAN | [view interactions] | Low throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | Low throughput | no | yes |
| ZBT38_HUMAN | [view interactions] | Low throughput | no | no |
| PD1L1_HUMAN | [view interactions] | Low throughput | no | no |
| IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IRS2_HUMAN | [view interactions] | Low throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CE290_HUMAN | [view interactions] | Low throughput | no | no |
| ATX10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CE170_HUMAN | [view interactions] | Low throughput | no | yes |
| RN115_HUMAN | [view interactions] | Low throughput | no | yes |
| AL1A3_HUMAN | [view interactions] | Low throughput | no | yes |
| PBX1_HUMAN | [view interactions] | Low throughput | no | yes |
| BCL9_HUMAN | [view interactions] | Low throughput | no | yes |
| SFI1_HUMAN | [view interactions] | Low throughput | no | no |
| STIL_HUMAN | [view interactions] | Low throughput | no | no |
| PTGES_HUMAN | [view interactions] | Low throughput | no | no |
| DVL2_HUMAN | [view interactions] | Low throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | Low throughput | no | yes |
| ANK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NF2L2_HUMAN | [view interactions] | Low throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARK4_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
| LATS2_HUMAN | [view interactions] | Low throughput | no | yes |
| KLF4_HUMAN | [view interactions] | Low throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
| MCL1_HUMAN | [view interactions] | Low throughput | no | yes |
| SOX2_HUMAN | [view interactions] | Low throughput | no | yes |
| PSD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PEX5_HUMAN | [view interactions] | Low throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NUAK1_HUMAN | [view interactions] | Low throughput | no | no |
| UB2D1_HUMAN | [view interactions] | Low throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | Low throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB8_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| NFKB2_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| RELB_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| MK67I_HUMAN | [view interactions] | High throughput | no | yes |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD4_HUMAN | [view interactions] | High throughput | no | no |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| PJA1_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASB15_HUMAN | [view interactions] | High throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| PEG10_HUMAN | [view interactions] | High throughput | no | no |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PRIC1_HUMAN | [view interactions] | High throughput | no | yes |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRY1_HUMAN | [view interactions] | High throughput | no | yes |
| CRY2_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| ALKB3_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
| PCGF1_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA4_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX20_HUMAN | [view interactions] | High throughput | no | no |
| GEMI4_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI5_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI8_HUMAN | [view interactions] | High throughput | no | yes |
| RSMB_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| ZNHI2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| KIBRA_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL1_HUMAN | [view interactions] | High throughput | no | no |
| SAV1_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| MINY4_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| ARRD3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| AL1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXNIP_HUMAN | [view interactions] | High throughput | no | no |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| KDM6B_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWP1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| RBM45_HUMAN | [view interactions] | High throughput | no | yes |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNE2_HUMAN | [view interactions] | High throughput | no | yes |
| PLCD4_HUMAN | [view interactions] | High throughput | no | no |
| F168A_HUMAN | [view interactions] | High throughput | no | yes |
| DGKG_HUMAN | [view interactions] | High throughput | no | no |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| WDR54_HUMAN | [view interactions] | High throughput | no | no |
| SALL4_HUMAN | [view interactions] | High throughput | no | no |
| ABT1_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| MZF1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ZN764_HUMAN | [view interactions] | High throughput | no | no |
| RASFA_HUMAN | [view interactions] | High throughput | no | no |
| IKBL1_HUMAN | [view interactions] | High throughput | no | no |
| BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR3_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ZN363_HUMAN | [view interactions] | High throughput | no | yes |
| IRS4_HUMAN | [view interactions] | High throughput | no | no |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| KDM4C_HUMAN | [view interactions] | High throughput | no | no |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OXND1_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| ATP7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KSR2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN408_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN263_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| SUV3_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXI2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUV91_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| TCF25_HUMAN | [view interactions] | High throughput | no | yes |
| CNR2_HUMAN | [view interactions] | High throughput | no | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| ZN516_HUMAN | [view interactions] | High throughput | no | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| PTPC1_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN21_HUMAN | [view interactions] | High throughput | no | yes |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| GATA3_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ITB2_HUMAN | [view interactions] | High throughput | no | no |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HG2A_HUMAN | [view interactions] | High throughput | no | yes |
| DDX60_HUMAN | [view interactions] | High throughput | no | no |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCH1_HUMAN | [view interactions] | High throughput | no | no |
| UBE2B_HUMAN | [view interactions] | High throughput | no | no |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| CLK3_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| JAK3_HUMAN | [view interactions] | High throughput | no | no |
| UBE2C_HUMAN | [view interactions] | High throughput | no | yes |
| M3K10_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNK1_HUMAN | [view interactions] | High throughput | no | yes |
| SRXN1_HUMAN | [view interactions] | High throughput | no | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRSK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UFC1_HUMAN | [view interactions] | High throughput | no | yes |
| MYO3B_HUMAN | [view interactions] | High throughput | no | yes |
| UBE4B_HUMAN | [view interactions] | High throughput | no | yes |
| NUAK2_HUMAN | [view interactions] | High throughput | no | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| MAST1_HUMAN | [view interactions] | High throughput | no | yes |
| PSB4_HUMAN | [view interactions] | High throughput | no | yes |
| NEK6_HUMAN | [view interactions] | High throughput | no | yes |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| UBL7_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| UBP34_HUMAN | [view interactions] | High throughput | no | yes |
| AXIN1_HUMAN | [view interactions] | High throughput | no | yes |
| U520_HUMAN | [view interactions] | High throughput | no | yes |
| IGBP1_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANCHR_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IF1AX_HUMAN | [view interactions] | Computational | no | yes |
| EPN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ZFX_HUMAN | [view interactions] | Computational | no | yes |