Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IRS1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
1043 Ser Tyr Diabetesmellitus,non-insulin-dependent(NIDDM) -
1095 Cys Tyr Diabetesmellitus,non-insulin-dependent(NIDDM) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI003065 DOC_MAPK_JIP1_4 DOC 857 863 -
ELMI002011 DOC_WW_Pin1_4 DOC 431 436 -
ELMI003692 LIG_SH2_GRB2like LIG 896 899 -
ELMI000927 MOD_CK2_1 MOD 85 91 -
ELMI000928 MOD_CK2_1 MOD 96 102 -
ELMI000926 MOD_CK2_1 MOD 327 333 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IRS1_HUMAN
GO:0017076 purine nucleotide binding 37.6471 4 no
GO:0032555 purine ribonucleotide binding 37.6471 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.6471 4 no
GO:0005524 ATP binding 31.7647 5 no
GO:0030554 adenyl nucleotide binding 31.7647 5 no
GO:0032559 adenyl ribonucleotide binding 31.7647 5 no
GO:0016301 kinase activity 30.5882 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 30.5882 4 no
GO:0019900 kinase binding 29.4118 4 yes
GO:0019901 protein kinase binding 29.4118 5 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 28.2353 4 no
GO:0045309 protein phosphorylated amino acid binding 16.4706 4 yes
GO:0001784 phosphotyrosine residue binding 12.9412 5 yes
GO:0030159 signaling receptor complex adaptor activity 9.4118 4 yes
GO:0030971 receptor tyrosine kinase binding 9.4118 4 yes
GO:0042169 SH2 domain binding 9.4118 4 yes
GO:1990782 protein tyrosine kinase binding 9.4118 6 yes
GO:0005159 insulin-like growth factor receptor binding 8.2353 4 yes
GO:0005080 protein kinase C binding 4.7059 6 yes
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3.5294 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IRS1_HUMAN
GO:0048522 positive regulation of cellular process 81.1765 4 yes
GO:0060255 regulation of macromolecule metabolic process 77.6471 4 yes
GO:0080090 regulation of primary metabolic process 76.4706 4 yes
GO:0031323 regulation of cellular metabolic process 75.2941 4 yes
GO:0048523 negative regulation of cellular process 74.1176 4 yes
GO:0010646 regulation of cell communication 71.7647 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 71.7647 4 no
GO:0009966 regulation of signal transduction 69.4118 4 yes
GO:0009893 positive regulation of metabolic process 64.7059 4 yes
GO:0051246 regulation of protein metabolic process 61.1765 5 no
GO:0010604 positive regulation of macromolecule metabolic process 60.0000 5 yes
GO:0031325 positive regulation of cellular metabolic process 58.8235 5 yes
GO:0010468 regulation of gene expression 56.4706 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 55.2941 5 no
GO:0031326 regulation of cellular biosynthetic process 54.1176 5 yes
GO:0051128 regulation of cellular component organization 54.1176 4 no
GO:0009889 regulation of biosynthetic process 54.1176 4 yes
GO:0036211 protein modification process 52.9412 4 no
GO:0043412 macromolecule modification 52.9412 4 no
GO:0019220 regulation of phosphate metabolic process 51.7647 6 yes
GO:0051174 regulation of phosphorus metabolic process 51.7647 5 yes
GO:0009892 negative regulation of metabolic process 51.7647 4 no
GO:1902531 regulation of intracellular signal transduction 51.7647 5 no
GO:0010556 regulation of macromolecule biosynthetic process 51.7647 5 yes
GO:0031399 regulation of protein modification process 50.5882 6 no
GO:0010605 negative regulation of macromolecule metabolic process 49.4118 5 no
GO:0051247 positive regulation of protein metabolic process 48.2353 6 no
GO:0042325 regulation of phosphorylation 47.0588 7 yes
GO:0048584 positive regulation of response to stimulus 47.0588 4 yes
GO:0010647 positive regulation of cell communication 45.8824 5 yes
GO:0023056 positive regulation of signaling 45.8824 4 yes
GO:0031324 negative regulation of cellular metabolic process 45.8824 5 no
GO:0051049 regulation of transport 44.7059 4 yes
GO:0071310 cellular response to organic substance 44.7059 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.7059 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 44.7059 5 no
GO:0009967 positive regulation of signal transduction 44.7059 5 yes
GO:0010941 regulation of cell death 41.1765 4 no
GO:0006796 phosphate-containing compound metabolic process 41.1765 4 no
GO:0042127 regulation of cell population proliferation 40.0000 4 yes
GO:0043085 positive regulation of catalytic activity 40.0000 4 yes
GO:0001932 regulation of protein phosphorylation 40.0000 7 no
GO:0031401 positive regulation of protein modification process 40.0000 7 no
GO:0051252 regulation of RNA metabolic process 40.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 38.8235 7 yes
GO:0060341 regulation of cellular localization 38.8235 4 yes
GO:0043067 regulation of programmed cell death 38.8235 5 no
GO:0010562 positive regulation of phosphorus metabolic process 38.8235 6 yes
GO:0042327 positive regulation of phosphorylation 37.6471 8 yes
GO:0042981 regulation of apoptotic process 37.6471 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 37.6471 4 yes
GO:0051338 regulation of transferase activity 36.4706 4 yes
GO:0006355 regulation of DNA-templated transcription 36.4706 6 no
GO:1903506 regulation of nucleic acid-templated transcription 36.4706 7 no
GO:2001141 regulation of RNA biosynthetic process 36.4706 6 no
GO:0048585 negative regulation of response to stimulus 35.2941 4 yes
GO:0045595 regulation of cell differentiation 35.2941 4 no
GO:1902533 positive regulation of intracellular signal transduction 35.2941 6 no
GO:0010648 negative regulation of cell communication 34.1176 5 yes
GO:0023057 negative regulation of signaling 34.1176 4 yes
GO:0032880 regulation of protein localization 34.1176 5 yes
GO:1901701 cellular response to oxygen-containing compound 34.1176 4 yes
GO:0051248 negative regulation of protein metabolic process 34.1176 6 no
GO:0008284 positive regulation of cell population proliferation 34.1176 5 yes
GO:0010243 response to organonitrogen compound 34.1176 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 32.9412 6 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 32.9412 5 yes
GO:0009891 positive regulation of biosynthetic process 32.9412 5 yes
GO:0043549 regulation of kinase activity 31.7647 5 yes
GO:0001934 positive regulation of protein phosphorylation 31.7647 8 no
GO:0060548 negative regulation of cell death 31.7647 5 no
GO:0016310 phosphorylation 31.7647 5 no
GO:0009968 negative regulation of signal transduction 31.7647 5 yes
GO:0051050 positive regulation of transport 30.5882 4 yes
GO:0051347 positive regulation of transferase activity 30.5882 5 yes
GO:0043408 regulation of MAPK cascade 30.5882 6 no
GO:0006468 protein phosphorylation 30.5882 5 no
GO:0006996 organelle organization 30.5882 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.5882 6 yes
GO:0010628 positive regulation of gene expression 29.4118 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 29.4118 6 no
GO:0051336 regulation of hydrolase activity 29.4118 4 no
GO:0009894 regulation of catabolic process 29.4118 4 yes
GO:0043066 negative regulation of apoptotic process 28.2353 7 no
GO:0043069 negative regulation of programmed cell death 28.2353 6 no
GO:0051130 positive regulation of cellular component organization 28.2353 5 no
GO:0080134 regulation of response to stress 28.2353 4 no
GO:0071417 cellular response to organonitrogen compound 27.0588 4 yes
GO:1901699 cellular response to nitrogen compound 27.0588 4 yes
GO:0030155 regulation of cell adhesion 27.0588 4 no
GO:0033043 regulation of organelle organization 27.0588 5 no
GO:0018193 peptidyl-amino acid modification 27.0588 5 no
GO:0033674 positive regulation of kinase activity 25.8824 6 yes
GO:0002684 positive regulation of immune system process 25.8824 4 no
GO:0030334 regulation of cell migration 25.8824 5 no
GO:0045859 regulation of protein kinase activity 25.8824 6 no
GO:2000145 regulation of cell motility 25.8824 4 no
GO:0051223 regulation of protein transport 24.7059 5 yes
GO:0070201 regulation of establishment of protein localization 24.7059 6 yes
GO:1901652 response to peptide 24.7059 4 yes
GO:0043410 positive regulation of MAPK cascade 24.7059 7 no
GO:0051240 positive regulation of multicellular organismal process 24.7059 4 no
GO:0051726 regulation of cell cycle 24.7059 4 no
GO:0022607 cellular component assembly 24.7059 4 no
GO:0044087 regulation of cellular component biogenesis 24.7059 4 no
GO:0031344 regulation of cell projection organization 24.7059 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 24.7059 6 no
GO:0031329 regulation of cellular catabolic process 23.5294 5 yes
GO:0030335 positive regulation of cell migration 23.5294 6 no
GO:0040017 positive regulation of locomotion 23.5294 4 no
GO:0051094 positive regulation of developmental process 23.5294 4 no
GO:1903829 positive regulation of protein localization 23.5294 5 no
GO:2000147 positive regulation of cell motility 23.5294 5 no
GO:0051345 positive regulation of hydrolase activity 23.5294 5 no
GO:2000112 regulation of cellular macromolecule biosynthetic process 22.3529 6 yes
GO:0051254 positive regulation of RNA metabolic process 22.3529 6 no
GO:0008104 protein localization 22.3529 4 no
GO:0030030 cell projection organization 22.3529 4 no
GO:0031400 negative regulation of protein modification process 22.3529 7 no
GO:0050776 regulation of immune response 22.3529 4 no
GO:0016192 vesicle-mediated transport 22.3529 4 no
GO:0032870 cellular response to hormone stimulus 21.1765 4 yes
GO:1901653 cellular response to peptide 21.1765 5 yes
GO:0045785 positive regulation of cell adhesion 21.1765 5 no
GO:0009890 negative regulation of biosynthetic process 21.1765 5 no
GO:0031327 negative regulation of cellular biosynthetic process 21.1765 6 no
GO:0006915 apoptotic process 21.1765 4 no
GO:0032386 regulation of intracellular transport 21.1765 5 no
GO:0033993 response to lipid 18.8235 4 yes
GO:0034762 regulation of transmembrane transport 18.8235 4 yes
GO:0043434 response to peptide hormone 18.8235 4 yes
GO:0009896 positive regulation of catabolic process 17.6471 5 yes
GO:0071396 cellular response to lipid 16.4706 5 yes
GO:0019216 regulation of lipid metabolic process 15.2941 5 yes
GO:0031331 positive regulation of cellular catabolic process 15.2941 6 yes
GO:0032868 response to insulin 15.2941 5 yes
GO:0071375 cellular response to peptide hormone stimulus 15.2941 5 yes
GO:0045834 positive regulation of lipid metabolic process 14.1176 5 yes
GO:0048878 chemical homeostasis 14.1176 4 yes
GO:0006109 regulation of carbohydrate metabolic process 14.1176 5 yes
GO:0008286 insulin receptor signaling pathway 14.1176 6 yes
GO:0010675 regulation of cellular carbohydrate metabolic process 12.9412 5 yes
GO:0043467 regulation of generation of precursor metabolites and energy 12.9412 5 yes
GO:0051051 negative regulation of transport 12.9412 4 yes
GO:0032869 cellular response to insulin stimulus 11.7647 6 yes
GO:0046626 regulation of insulin receptor signaling pathway 11.7647 5 yes
GO:0048015 phosphatidylinositol-mediated signaling 11.7647 5 yes
GO:0048017 inositol lipid-mediated signaling 11.7647 4 yes
GO:0051046 regulation of secretion 11.7647 5 yes
GO:0062012 regulation of small molecule metabolic process 11.7647 4 yes
GO:1903530 regulation of secretion by cell 11.7647 4 yes
GO:0010827 regulation of glucose transmembrane transport 10.5882 5 yes
GO:0043255 regulation of carbohydrate biosynthetic process 10.5882 5 yes
GO:0045913 positive regulation of carbohydrate metabolic process 10.5882 5 yes
GO:0046324 regulation of glucose import 10.5882 6 yes
GO:0062013 positive regulation of small molecule metabolic process 10.5882 5 yes
GO:1900076 regulation of cellular response to insulin stimulus 10.5882 4 yes
GO:0010676 positive regulation of cellular carbohydrate metabolic process 9.4118 6 yes
GO:0010906 regulation of glucose metabolic process 9.4118 5 yes
GO:0010962 regulation of glucan biosynthetic process 9.4118 6 yes
GO:0014065 phosphatidylinositol 3-kinase signaling 9.4118 6 yes
GO:0032881 regulation of polysaccharide metabolic process 9.4118 5 yes
GO:0032885 regulation of polysaccharide biosynthetic process 9.4118 6 yes
GO:0034764 positive regulation of transmembrane transport 9.4118 5 yes
GO:0070873 regulation of glycogen metabolic process 9.4118 6 yes
GO:0005979 regulation of glycogen biosynthetic process 9.4118 7 yes
GO:0010828 positive regulation of glucose transmembrane transport 8.2353 6 yes
GO:0010907 positive regulation of glucose metabolic process 8.2353 6 yes
GO:0046326 positive regulation of glucose import 8.2353 7 yes
GO:0050994 regulation of lipid catabolic process 8.2353 5 yes
GO:1903828 negative regulation of protein localization 8.2353 5 yes
GO:0033500 carbohydrate homeostasis 7.0588 5 yes
GO:0042593 glucose homeostasis 7.0588 6 yes
GO:0045725 positive regulation of glycogen biosynthetic process 7.0588 7 yes
GO:0046627 negative regulation of insulin receptor signaling pathway 7.0588 6 yes
GO:0046628 positive regulation of insulin receptor signaling pathway 7.0588 6 yes
GO:0048009 insulin-like growth factor receptor signaling pathway 7.0588 6 yes
GO:0050708 regulation of protein secretion 7.0588 5 yes
GO:0070875 positive regulation of glycogen metabolic process 7.0588 6 yes
GO:1900077 negative regulation of cellular response to insulin stimulus 7.0588 5 yes
GO:1900078 positive regulation of cellular response to insulin stimulus 7.0588 5 yes
GO:0043550 regulation of lipid kinase activity 5.8824 6 yes
GO:0043551 regulation of phosphatidylinositol 3-kinase activity 5.8824 7 yes
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 5.8824 7 yes
GO:0046883 regulation of hormone secretion 5.8824 4 yes
GO:0050796 regulation of insulin secretion 5.8824 6 yes
GO:0050996 positive regulation of lipid catabolic process 5.8824 6 yes
GO:0090087 regulation of peptide transport 5.8824 5 yes
GO:0090218 positive regulation of lipid kinase activity 5.8824 6 yes
GO:0090276 regulation of peptide hormone secretion 5.8824 5 yes
GO:0002791 regulation of peptide secretion 5.8824 6 yes
GO:0010565 regulation of cellular ketone metabolic process 5.8824 5 yes
GO:0019217 regulation of fatty acid metabolic process 4.7059 6 yes
GO:0031998 regulation of fatty acid beta-oxidation 4.7059 6 yes
GO:0046320 regulation of fatty acid oxidation 4.7059 7 yes
GO:0070542 response to fatty acid 4.7059 4 yes
GO:0032000 positive regulation of fatty acid beta-oxidation 3.5294 7 yes
GO:0045923 positive regulation of fatty acid metabolic process 3.5294 6 yes
GO:0046321 positive regulation of fatty acid oxidation 3.5294 7 yes
GO:0046676 negative regulation of insulin secretion 3.5294 7 yes
GO:0046888 negative regulation of hormone secretion 3.5294 5 yes
GO:0050709 negative regulation of protein secretion 3.5294 6 yes
GO:0051048 negative regulation of secretion 3.5294 5 yes
GO:0051224 negative regulation of protein transport 3.5294 5 yes
GO:0071398 cellular response to fatty acid 3.5294 5 yes
GO:0090278 negative regulation of peptide hormone secretion 3.5294 6 yes
GO:1903531 negative regulation of secretion by cell 3.5294 5 yes
GO:1904950 negative regulation of establishment of protein localization 3.5294 6 yes
GO:0002792 negative regulation of peptide secretion 3.5294 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in IRS1_HUMAN
DOID:0050686 organ system cancer 4.7059 3 no
DOID:0081062 diabetes 3.5294 5 yes
DOID:2978 carbohydrate metabolic disorder 3.5294 3 yes
DOID:4194 glucose metabolism disease 3.5294 4 yes
DOID:9351 diabetes mellitus 3.5294 6 yes
DOID:9352 type 2 diabetes mellitus 3.5294 7 yes
DOID:120 female reproductive organ cancer 2.3529 5 no
DOID:193 reproductive organ cancer 2.3529 4 no
DOID:6457 Cowden syndrome 2.3529 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
P55G_HUMAN [view interactions] Low throughput no yes
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] Low throughput yes yes
INSR_HUMAN [view interactions] Low throughput no yes
NUCL_HUMAN [view interactions] Low throughput no yes
PHIP_HUMAN [view interactions] Low throughput no yes
ASPP2_HUMAN [view interactions] Low throughput no yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
SIR1_HUMAN [view interactions] Low throughput no yes
PK3CA_HUMAN [view entry] [view interactions] Low throughput yes yes
PABP1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI72_HUMAN [view interactions] Low throughput no no
CRK_HUMAN [view entry] [view interactions] Low throughput yes no
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
H10_HUMAN [view interactions] Low throughput no yes
2AAA_HUMAN [view entry] [view interactions] Low throughput yes no
PHB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN1_HUMAN [view interactions] Low throughput no yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
MK08_HUMAN [view interactions] Low throughput no yes
MK09_HUMAN [view interactions] Low throughput no yes
GRB14_HUMAN [view interactions] Low throughput no yes
E2AK2_HUMAN [view entry] [view interactions] Low throughput yes yes
IF4E_HUMAN [view entry] [view interactions] Low throughput yes yes
CYH3_HUMAN [view entry] [view interactions] Low throughput yes yes
CYH2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
RS27A_HUMAN [view entry] [view interactions] Low throughput yes yes
RL40_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCT_HUMAN [view interactions] Low throughput no no
IL4RA_HUMAN [view interactions] Low throughput no no
VIME_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRA_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC2_HUMAN [view interactions] Low throughput no yes
SOCS1_HUMAN [view interactions] Low throughput no yes
KHDR1_HUMAN [view interactions] Low throughput no yes
IKKA_HUMAN [view interactions] Low throughput no yes
IKKB_HUMAN [view interactions] Low throughput no yes
BCL2_HUMAN [view interactions] Low throughput no no
B2CL1_HUMAN [view interactions] Low throughput no yes
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
RPTOR_HUMAN [view interactions] Low throughput no yes
JAK3_HUMAN [view interactions] Low throughput no no
JAK1_HUMAN [view interactions] Low throughput no yes
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
NISCH_HUMAN [view interactions] Low throughput no yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
UBF1_HUMAN [view interactions] Low throughput no yes
CBLB_HUMAN [view interactions] Low throughput no yes
ESR1_HUMAN [view interactions] Low throughput no no
CBL_HUMAN [view interactions] Low throughput no yes
GRB10_HUMAN [view entry] [view interactions] Low throughput yes yes
SOCS3_HUMAN [view interactions] Low throughput no yes
P85B_HUMAN [view interactions] Low throughput no yes
PK3CB_HUMAN [view interactions] Low throughput no yes
IRS2_HUMAN [view interactions] Low throughput no yes
SQSTM_HUMAN [view interactions] Low throughput no yes
DVL2_HUMAN [view interactions] Low throughput no yes
RBX1_HUMAN [view entry] [view interactions] Low throughput yes no
FBX40_HUMAN [view interactions] Low throughput no no
UBP7_HUMAN [view interactions] Low throughput no yes
PTEN_HUMAN [view entry] [view interactions] Low throughput yes yes
FBXW8_HUMAN [view interactions] Low throughput no yes
CUL7_HUMAN [view interactions] Low throughput no yes
CAV2_HUMAN [view interactions] Low throughput no no
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
CD36_HUMAN [view interactions] Low throughput no no
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
SH2B1_HUMAN [view interactions] Low throughput no yes
CD2AP_HUMAN [view interactions] Low throughput no no
USP9X_HUMAN [view entry] [view interactions] Low throughput yes yes
RAD51_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
MDM2_HUMAN [view interactions] Low throughput no yes
KLHL9_HUMAN [view interactions] Low throughput no no
KLH13_HUMAN [view interactions] Low throughput no no
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF4_HUMAN [view interactions] Low throughput no yes
AP3S1_HUMAN [view entry] [view interactions] Low throughput yes no
NCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRU_HUMAN [view interactions] Low throughput no yes
SIK2_HUMAN [view interactions] Low throughput no yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
PASK_HUMAN [view interactions] Low throughput no yes
IRS1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
PEX14_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR3_HUMAN [view interactions] High throughput no yes
PELI1_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA2_HUMAN [view interactions] High throughput no no
IPO8_HUMAN [view interactions] High throughput no no
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
RAN_HUMAN [view entry] [view interactions] High throughput yes no
PDIP3_HUMAN [view interactions] High throughput no no
RFC3_HUMAN [view interactions] High throughput no yes
AFF3_HUMAN [view interactions] High throughput no yes
HNRPU_HUMAN [view interactions] High throughput no yes
YBOX1_HUMAN [view interactions] High throughput no yes
RAB6B_HUMAN [view entry] [view interactions] High throughput yes yes
SYRC_HUMAN [view interactions] High throughput no yes
TEN3_HUMAN [view interactions] High throughput no yes
IPO9_HUMAN [view interactions] High throughput no no
CNOT9_HUMAN [view interactions] High throughput no yes
UNG_HUMAN [view interactions] High throughput no yes
LIPB1_HUMAN [view interactions] High throughput no yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
RLA0_HUMAN [view entry] [view interactions] High throughput yes yes
CAVN2_HUMAN [view interactions] High throughput no no
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD3_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
PTPRD_HUMAN [view entry] [view interactions] High throughput yes no
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
CUL1_HUMAN [view interactions] High throughput no yes
FBW1A_HUMAN [view interactions] High throughput no yes
FBW1B_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
KC1A_HUMAN [view interactions] High throughput no yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ZDH18_HUMAN [view interactions] High throughput no yes
ZDH23_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX25_HUMAN [view interactions] High throughput no no
PLCG2_HUMAN [view interactions] High throughput no yes
MEMO1_HUMAN [view interactions] Computational no yes
PDPK1_HUMAN [view entry] [view interactions] Computational yes yes
SOMA_HUMAN [view interactions] Computational no no
PRLR_HUMAN [view interactions] Computational no no
SOCS4_HUMAN [view interactions] Computational no yes
MK01_HUMAN [view entry] [view interactions] Computational yes yes
IGF1_HUMAN [view entry] [view interactions] Computational yes no
FINC_HUMAN [view interactions] Computational no yes
NEMO_HUMAN [view interactions] Computational no yes
KPCD1_HUMAN [view interactions] Computational no yes
YAP1_HUMAN [view interactions] Computational no yes
NTRK3_HUMAN [view entry] [view interactions] Computational yes yes
LEP_HUMAN [view interactions] Computational no no
IGF2_HUMAN [view interactions] Computational no no
RET_HUMAN [view interactions] Computational no yes
OGT1_HUMAN [view entry] [view interactions] Computational yes yes
GFRA1_HUMAN [view interactions] Computational no no
NCK1_HUMAN [view interactions] Computational no yes
PK3CD_HUMAN [view interactions] Computational no no
INSRR_HUMAN [view interactions] Computational no no
BCAR1_HUMAN [view interactions] Computational no yes
ERBB3_HUMAN [view interactions] Computational no yes
MET_HUMAN [view interactions] Computational no yes
BECN1_HUMAN [view interactions] Computational no yes
IL2_HUMAN [view interactions] Computational no no
RASK_HUMAN [view entry] [view interactions] Computational yes no
ARBK1_HUMAN [view entry] [view interactions] Computational yes yes
RASN_HUMAN [view entry] [view interactions] Computational yes no
LST8_HUMAN [view interactions] Computational no yes
CRKL_HUMAN [view entry] [view interactions] Computational yes yes
IL2RB_HUMAN [view interactions] Computational no no
SH2B2_HUMAN [view interactions] Computational no no
RASH_HUMAN [view entry] [view interactions] Computational yes no
MYPT1_HUMAN [view entry] [view interactions] Computational yes yes
KPCE_HUMAN [view entry] [view interactions] Computational yes yes
SOM2_HUMAN [view interactions] Computational no no
GDNF_HUMAN [view interactions] Computational no yes
IL2RA_HUMAN [view interactions] Computational no no
AKT2_HUMAN [view entry] [view interactions] Computational yes yes
KS6B2_HUMAN [view interactions] Computational no yes
IL2RG_HUMAN [view interactions] Computational no no
PAXI_HUMAN [view interactions] Computational no yes
LEPR_HUMAN [view interactions] Computational no no
IL4_HUMAN [view interactions] Computational no no
PI3R5_HUMAN [view interactions] Computational no no
ITAV_HUMAN [view interactions] Computational no yes
GRAP2_HUMAN [view interactions] Computational no no
INS_HUMAN [view interactions] Computational no no
KLOT_HUMAN [view interactions] Computational no no
CAV1_HUMAN [view interactions] Computational no no
GPR83_HUMAN [view interactions] Computational no no
PK3CG_HUMAN [view interactions] Computational no yes
LCK_HUMAN [view entry] [view interactions] Computational yes no
PI3R6_HUMAN [view interactions] Computational no yes
SHIP1_HUMAN [view interactions] Computational no no
NTRK2_HUMAN [view entry] [view interactions] Computational yes yes
PTN6_HUMAN [view interactions] Computational no no
GLUT4_HUMAN [view interactions] Computational no no
FOXO3_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
NTRK1_HUMAN [view interactions] Computational no yes
SRBS1_HUMAN [view entry] [view interactions] Computational yes yes
RACK1_HUMAN [view interactions] Computational no yes