Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CYH2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP . The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed). Involved in neurite growth . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CYH2_HUMAN
GO:0043168 anion binding 29.6296 4 yes
GO:0019900 kinase binding 29.6296 4 no
GO:0000166 nucleotide binding 25.9259 4 no
GO:0017076 purine nucleotide binding 25.9259 5 no
GO:0032555 purine ribonucleotide binding 25.9259 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.9259 4 no
GO:0019901 protein kinase binding 25.9259 5 no
GO:0030695 GTPase regulator activity 22.2222 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 7.4074 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CYH2_HUMAN
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0048522 positive regulation of cellular process 62.9630 4 no
GO:0048523 negative regulation of cellular process 62.9630 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:0009966 regulation of signal transduction 55.5556 4 yes
GO:0051049 regulation of transport 51.8519 4 no
GO:0051128 regulation of cellular component organization 51.8519 4 no
GO:0008104 protein localization 44.4444 4 no
GO:0048584 positive regulation of response to stimulus 40.7407 4 no
GO:0051246 regulation of protein metabolic process 37.0370 5 no
GO:1902531 regulation of intracellular signal transduction 37.0370 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0060627 regulation of vesicle-mediated transport 33.3333 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009967 positive regulation of signal transduction 29.6296 5 no
GO:0010468 regulation of gene expression 29.6296 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.6296 5 no
GO:0010604 positive regulation of macromolecule metabolic process 29.6296 5 no
GO:0015031 protein transport 29.6296 4 no
GO:0051248 negative regulation of protein metabolic process 29.6296 6 no
GO:0071702 organic substance transport 29.6296 4 no
GO:0071705 nitrogen compound transport 29.6296 4 no
GO:0050804 modulation of chemical synaptic transmission 29.6296 5 no
GO:0099177 regulation of trans-synaptic signaling 29.6296 4 no
GO:0048585 negative regulation of response to stimulus 29.6296 4 no
GO:0051050 positive regulation of transport 29.6296 4 no
GO:0019220 regulation of phosphate metabolic process 29.6296 6 no
GO:0051130 positive regulation of cellular component organization 29.6296 5 no
GO:0051174 regulation of phosphorus metabolic process 29.6296 5 no
GO:0006996 organelle organization 29.6296 4 yes
GO:0009894 regulation of catabolic process 25.9259 4 no
GO:0042981 regulation of apoptotic process 25.9259 5 no
GO:0043067 regulation of programmed cell death 25.9259 4 no
GO:0051252 regulation of RNA metabolic process 25.9259 5 no
GO:0051223 regulation of protein transport 25.9259 5 no
GO:0070201 regulation of establishment of protein localization 25.9259 6 no
GO:0030100 regulation of endocytosis 25.9259 5 no
GO:0031400 negative regulation of protein modification process 25.9259 7 no
GO:0010648 negative regulation of cell communication 25.9259 5 no
GO:0023057 negative regulation of signaling 25.9259 4 no
GO:1903829 positive regulation of protein localization 25.9259 5 no
GO:0001932 regulation of protein phosphorylation 25.9259 7 no
GO:0031324 negative regulation of cellular metabolic process 25.9259 5 no
GO:0042325 regulation of phosphorylation 25.9259 7 no
GO:0098657 import into cell 25.9259 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0043066 negative regulation of apoptotic process 22.2222 6 no
GO:0043069 negative regulation of programmed cell death 22.2222 5 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0044089 positive regulation of cellular component biogenesis 22.2222 5 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0048259 regulation of receptor-mediated endocytosis 22.2222 6 no
GO:0006915 apoptotic process 22.2222 4 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0141124 intracellular signaling cassette 22.2222 4 no
GO:0006355 regulation of DNA-templated transcription 22.2222 7 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 no
GO:0007010 cytoskeleton organization 18.5185 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 14.8148 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
VPP2_HUMAN [view interactions] Low throughput no yes
AA2AR_HUMAN [view entry] [view interactions] Low throughput yes yes
MYD88_HUMAN [view interactions] Low throughput no yes
INAVA_HUMAN [view interactions] Low throughput no yes
SODC_HUMAN [view interactions] Low throughput no yes
INSR_HUMAN [view interactions] Low throughput no yes
IRS1_HUMAN [view entry] [view interactions] Low throughput yes yes
CNKR2_HUMAN [view entry] [view interactions] Low throughput yes no
ARF1_HUMAN [view entry] [view interactions] Low throughput yes yes
CC120_HUMAN [view interactions] Low throughput no no
ICEF1_HUMAN [view interactions] Low throughput no yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
PLPL2_HUMAN [view interactions] Low throughput no no
ARL4D_HUMAN [view interactions] Low throughput no no
ARL4A_HUMAN [view interactions] Low throughput no no
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
DOCK1_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI23_HUMAN [view interactions] Low throughput no yes
GGA3_HUMAN [view entry] [view interactions] Low throughput yes yes
ALDOA_HUMAN [view entry] [view interactions] Low throughput yes no
VPP1_HUMAN [view entry] [view interactions] Low throughput yes yes
VPP3_HUMAN [view interactions] Low throughput no no
VPP4_HUMAN [view interactions] Low throughput no no
PK3CA_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
MK06_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
TRI55_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CNKR1_HUMAN [view interactions] High throughput no no
APC_HUMAN [view entry] [view interactions] High throughput yes no
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
CYTIP_HUMAN [view interactions] High throughput no yes
FOSL2_HUMAN [view interactions] High throughput no yes
MTMR7_HUMAN [view interactions] High throughput no no
CCD40_HUMAN [view interactions] High throughput no no
APEX1_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
STRP2_HUMAN [view interactions] High throughput no yes
TX1B3_HUMAN [view interactions] High throughput no no
CYH1_HUMAN [view interactions] High throughput no no
KCNE3_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
P5CR3_HUMAN [view interactions] High throughput no no
ZNRD2_HUMAN [view interactions] High throughput no yes
VAC14_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SPPL3_HUMAN [view interactions] High throughput no no
ARFG1_HUMAN [view interactions] High throughput no no
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
KPCG_HUMAN [view entry] [view interactions] High throughput yes yes
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes