DOCK1_HUMAN
Evidence for PS localization
Functions
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DOCK1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 41.6667 | 4 | no |
| GO:0019900 | kinase binding | 39.5833 | 4 | no |
| GO:0019901 | protein kinase binding | 39.5833 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 39.5833 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.5000 | 4 | no |
| GO:0030695 | GTPase regulator activity | 31.2500 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 22.9167 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.8333 | 5 | no |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 18.7500 | 5 | yes |
| GO:0005096 | GTPase activator activity | 16.6667 | 4 | yes |
| GO:0017124 | SH3 domain binding | 14.5833 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DOCK1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
| GO:0006996 | organelle organization | 56.2500 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 56.2500 | 4 | no |
| GO:0010646 | regulation of cell communication | 56.2500 | 4 | no |
| GO:0009966 | regulation of signal transduction | 52.0833 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.0833 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.9167 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.9167 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.9167 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 47.9167 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.9167 | 4 | no |
| GO:0030030 | cell projection organization | 45.8333 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 45.8333 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 43.7500 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 41.6667 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 39.5833 | 4 | no |
| GO:0022607 | cellular component assembly | 39.5833 | 4 | no |
| GO:0033043 | regulation of organelle organization | 37.5000 | 5 | no |
| GO:0007264 | small GTPase mediated signal transduction | 37.5000 | 4 | yes |
| GO:0030334 | regulation of cell migration | 37.5000 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 37.5000 | 4 | yes |
| GO:2000145 | regulation of cell motility | 37.5000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 37.5000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 35.4167 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 35.4167 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 35.4167 | 4 | yes |
| GO:0010468 | regulation of gene expression | 35.4167 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.4167 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.4167 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 33.3333 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 33.3333 | 5 | yes |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 31.2500 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 31.2500 | 6 | no |
| GO:0031399 | regulation of protein modification process | 31.2500 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 31.2500 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 31.2500 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.2500 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 31.2500 | 6 | no |
| GO:0045785 | positive regulation of cell adhesion | 31.2500 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 31.2500 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 31.2500 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 31.2500 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.1667 | 7 | no |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 29.1667 | 6 | no |
| GO:0031175 | neuron projection development | 29.1667 | 6 | no |
| GO:0030335 | positive regulation of cell migration | 29.1667 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 29.1667 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 29.1667 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 29.1667 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.1667 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.1667 | 6 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 27.0833 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 27.0833 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 27.0833 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.0833 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 25.0000 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0010632 | regulation of epithelial cell migration | 25.0000 | 4 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 25.0000 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0051345 | positive regulation of hydrolase activity | 22.9167 | 5 | no |
| GO:0008104 | protein localization | 22.9167 | 4 | no |
| GO:0030031 | cell projection assembly | 22.9167 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 22.9167 | 8 | no |
| GO:0002684 | positive regulation of immune system process | 22.9167 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 22.9167 | 7 | no |
| GO:0032880 | regulation of protein localization | 22.9167 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 22.9167 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.9167 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 22.9167 | 5 | no |
| GO:0007015 | actin filament organization | 22.9167 | 5 | no |
| GO:0007265 | Ras protein signal transduction | 22.9167 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 22.9167 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.9167 | 6 | no |
| GO:0045597 | positive regulation of cell differentiation | 22.9167 | 5 | yes |
| GO:0060284 | regulation of cell development | 22.9167 | 5 | yes |
| GO:0061024 | membrane organization | 22.9167 | 4 | yes |
| GO:0051050 | positive regulation of transport | 22.9167 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 20.8333 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 20.8333 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.8333 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.8333 | 4 | no |
| GO:0008360 | regulation of cell shape | 20.8333 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 20.8333 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.8333 | 5 | no |
| GO:0010634 | positive regulation of epithelial cell migration | 18.7500 | 5 | yes |
| GO:0010769 | regulation of cell morphogenesis involved in differentiation | 18.7500 | 6 | yes |
| GO:1900024 | regulation of substrate adhesion-dependent cell spreading | 18.7500 | 6 | yes |
| GO:0006915 | apoptotic process | 16.6667 | 4 | yes |
| GO:0010324 | membrane invagination | 16.6667 | 5 | yes |
| GO:0010720 | positive regulation of cell development | 16.6667 | 6 | yes |
| GO:0010770 | positive regulation of cell morphogenesis involved in differentiation | 16.6667 | 7 | yes |
| GO:0010811 | positive regulation of cell-substrate adhesion | 16.6667 | 6 | yes |
| GO:0099024 | plasma membrane invagination | 16.6667 | 6 | yes |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 16.6667 | 7 | yes |
| GO:0006911 | phagocytosis, engulfment | 14.5833 | 7 | yes |
| GO:0007229 | integrin-mediated signaling pathway | 10.4167 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DOCK1_HUMAN |
|---|---|---|---|---|
| DOID:0111962 | combined immunodeficiency | 4.1667 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 4.1667 | 3 | no |
| DOID:0060038 | specific developmental disorder | 4.1667 | 3 | no |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | 4.1667 | 5 | no |
| DOID:1059 | intellectual disability | 4.1667 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ELMO1_HUMAN | [view interactions] | Low throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANR28_HUMAN | [view interactions] | Low throughput | no | no |
| CEBPE_HUMAN | [view interactions] | Low throughput | no | no |
| DOCK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BCAR1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARL4A_HUMAN | [view interactions] | Low throughput | no | no |
| FGFR1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRASP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ICEF1_HUMAN | [view interactions] | Low throughput | no | yes |
| DAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| ELMO3_HUMAN | [view interactions] | High throughput | no | yes |
| ZHX2_HUMAN | [view interactions] | High throughput | no | yes |
| VP37C_HUMAN | [view interactions] | High throughput | no | yes |
| ELMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOCK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOCK9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF4_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| ANR54_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| BRAF_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CHIN_HUMAN | [view interactions] | High throughput | no | no |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| NUAK1_HUMAN | [view interactions] | High throughput | no | no |
| STK16_HUMAN | [view interactions] | High throughput | no | no |
| SDC2_HUMAN | [view interactions] | High throughput | no | yes |
| L2GL2_HUMAN | [view interactions] | High throughput | no | yes |
| INP5K_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| RHG35_HUMAN | [view interactions] | High throughput | no | yes |
| RHG15_HUMAN | [view interactions] | High throughput | no | no |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG42_HUMAN | [view interactions] | High throughput | no | yes |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH17_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIC1_HUMAN | [view interactions] | High throughput | no | yes |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAL_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPGF4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STRP2_HUMAN | [view interactions] | High throughput | no | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PAXI_HUMAN | [view interactions] | Computational | no | yes |
| RPGF1_HUMAN | [view interactions] | Computational | no | yes |
| GULP1_HUMAN | [view interactions] | Computational | no | no |
| AKT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NET1_HUMAN | [view interactions] | Computational | no | no |
| DCC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WDR35_HUMAN | [view interactions] | Computational | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TRIO_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| YES_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |