Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DOCK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DOCK1_HUMAN
GO:0043168 anion binding 38.0952 4 no
GO:0030695 GTPase regulator activity 33.3333 4 yes
GO:0000166 nucleotide binding 30.9524 4 no
GO:0017076 purine nucleotide binding 30.9524 5 no
GO:0032555 purine ribonucleotide binding 30.9524 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0019900 kinase binding 28.5714 4 no
GO:0043169 cation binding 23.8095 4 no
GO:0046872 metal ion binding 23.8095 5 no
GO:0031267 small GTPase binding 23.8095 5 yes
GO:0051020 GTPase binding 23.8095 4 yes
GO:0005096 GTPase activator activity 21.4286 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 19.0476 5 yes
GO:0017124 SH3 domain binding 19.0476 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DOCK1_HUMAN
GO:0048522 positive regulation of cellular process 61.9048 4 yes
GO:0010646 regulation of cell communication 59.5238 4 no
GO:0009966 regulation of signal transduction 52.3810 4 no
GO:0031323 regulation of cellular metabolic process 52.3810 4 no
GO:0051128 regulation of cellular component organization 52.3810 4 no
GO:0006996 organelle organization 52.3810 4 no
GO:0141124 intracellular signaling cassette 50.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 47.6190 5 no
GO:0060255 regulation of macromolecule metabolic process 45.2381 4 no
GO:0080090 regulation of primary metabolic process 45.2381 4 no
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0007264 small GTPase-mediated signal transduction 38.0952 5 yes
GO:0009889 regulation of biosynthetic process 38.0952 4 no
GO:0009893 positive regulation of metabolic process 38.0952 4 no
GO:0022607 cellular component assembly 38.0952 4 no
GO:0030030 cell projection organization 38.0952 4 no
GO:0007010 cytoskeleton organization 38.0952 5 no
GO:0030334 regulation of cell migration 35.7143 5 yes
GO:2000145 regulation of cell motility 35.7143 4 yes
GO:0010468 regulation of gene expression 35.7143 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.7143 5 no
GO:0031325 positive regulation of cellular metabolic process 35.7143 5 no
GO:0031326 regulation of cellular biosynthetic process 35.7143 5 no
GO:0022603 regulation of anatomical structure morphogenesis 35.7143 4 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0010604 positive regulation of macromolecule metabolic process 30.9524 5 no
GO:0031399 regulation of protein modification process 30.9524 6 no
GO:0051130 positive regulation of cellular component organization 30.9524 5 no
GO:0120036 plasma membrane bounded cell projection organization 30.9524 5 no
GO:0051056 regulation of small GTPase mediated signal transduction 30.9524 6 no
GO:0030155 regulation of cell adhesion 28.5714 4 yes
GO:0030335 positive regulation of cell migration 28.5714 6 yes
GO:0040017 positive regulation of locomotion 28.5714 4 yes
GO:2000147 positive regulation of cell motility 28.5714 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 28.5714 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 28.5714 5 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0001932 regulation of protein phosphorylation 26.1905 7 no
GO:0042325 regulation of phosphorylation 26.1905 7 no
GO:0051247 positive regulation of protein metabolic process 26.1905 6 no
GO:1902533 positive regulation of intracellular signal transduction 26.1905 6 no
GO:0006915 apoptotic process 23.8095 4 yes
GO:0010632 regulation of epithelial cell migration 23.8095 4 yes
GO:0010810 regulation of cell-substrate adhesion 23.8095 5 yes
GO:0045785 positive regulation of cell adhesion 23.8095 5 yes
GO:0002684 positive regulation of immune system process 23.8095 4 no
GO:0009892 negative regulation of metabolic process 23.8095 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.8095 5 no
GO:0033043 regulation of organelle organization 23.8095 5 no
GO:0042127 regulation of cell population proliferation 23.8095 4 no
GO:0060341 regulation of cellular localization 23.8095 4 no
GO:0051336 regulation of hydrolase activity 23.8095 4 no
GO:0031401 positive regulation of protein modification process 23.8095 7 no
GO:0010634 positive regulation of epithelial cell migration 21.4286 5 yes
GO:0007015 actin filament organization 21.4286 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0031324 negative regulation of cellular metabolic process 21.4286 5 no
GO:0042981 regulation of apoptotic process 21.4286 5 no
GO:0043067 regulation of programmed cell death 21.4286 4 no
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 no
GO:0097435 supramolecular fiber organization 21.4286 4 no
GO:0032880 regulation of protein localization 21.4286 5 no
GO:0008104 protein localization 21.4286 4 no
GO:0010975 regulation of neuron projection development 21.4286 7 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0031175 neuron projection development 21.4286 6 no
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:1900024 regulation of substrate adhesion-dependent cell spreading 19.0476 6 yes
GO:0010811 positive regulation of cell-substrate adhesion 16.6667 6 yes
GO:0061024 membrane organization 16.6667 4 yes
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 16.6667 7 yes
GO:0006911 phagocytosis, engulfment 11.9048 7 yes
GO:0010324 membrane invagination 11.9048 5 yes
GO:0099024 plasma membrane invagination 11.9048 6 yes
GO:0007229 integrin-mediated signaling pathway 9.5238 4 yes
GO:0007520 myoblast fusion 7.1429 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CRK_HUMAN [view entry] [view interactions] Low throughput yes no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
NCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
ELMO1_HUMAN [view entry] [view interactions] Low throughput yes no
RHOG_HUMAN [view entry] [view interactions] Low throughput yes no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
ANR28_HUMAN [view interactions] Low throughput no no
CEBPE_HUMAN [view interactions] Low throughput no no
DOCK1_HUMAN [view entry] [view interactions] Low throughput yes yes
AGRB1_HUMAN [view entry] [view interactions] Low throughput yes no
BCAR1_HUMAN [view interactions] Low throughput no yes
ARL4A_HUMAN [view interactions] Low throughput no no
FGFR1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
CYH2_HUMAN [view entry] [view interactions] Low throughput yes yes
ICEF1_HUMAN [view interactions] Low throughput no yes
DAB1_HUMAN [view interactions] Low throughput no yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
NCK1_HUMAN [view interactions] High throughput no yes
ELMO3_HUMAN [view interactions] High throughput no yes
ZHX2_HUMAN [view interactions] High throughput no yes
VP37C_HUMAN [view interactions] High throughput no yes
ELMO2_HUMAN [view entry] [view interactions] High throughput yes no
MLP3B_HUMAN [view interactions] High throughput no yes
SMN_HUMAN [view interactions] High throughput no yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK5_HUMAN [view entry] [view interactions] High throughput yes no
DOCK9_HUMAN [view entry] [view interactions] High throughput yes yes
ANR54_HUMAN [view interactions] High throughput no yes
FBW1A_HUMAN [view interactions] High throughput no yes
SURF4_HUMAN [view interactions] High throughput no yes
SNW1_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
FAK1_HUMAN [view entry] [view interactions] High throughput yes yes
MEPCE_HUMAN [view interactions] High throughput no yes
FBW1B_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
SPDLY_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
CHIN_HUMAN [view interactions] High throughput no no
LRC31_HUMAN [view interactions] High throughput no no
SMAD4_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
GLPA_HUMAN [view interactions] High throughput no no
NUAK1_HUMAN [view interactions] High throughput no no
STK16_HUMAN [view interactions] High throughput no no
SDC2_HUMAN [view entry] [view interactions] High throughput yes yes
L2GL2_HUMAN [view interactions] High throughput no yes
INP5K_HUMAN [view interactions] High throughput no no
VSIG4_HUMAN [view interactions] High throughput no no
SPSB4_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
RHG35_HUMAN [view interactions] High throughput no yes
RHG15_HUMAN [view interactions] High throughput no no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
RHG42_HUMAN [view interactions] High throughput no yes
CHIO_HUMAN [view interactions] High throughput no yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
EXOC4_HUMAN [view entry] [view interactions] High throughput yes yes
KLH17_HUMAN [view entry] [view interactions] High throughput yes no
PRIC1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
GNAL_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
RPGF4_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP1_HUMAN [view interactions] High throughput no no
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
STRP2_HUMAN [view interactions] High throughput no yes
DIAP2_HUMAN [view interactions] High throughput no yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
ATG9A_HUMAN [view interactions] High throughput no yes