Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRASP_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRASP_HUMAN
GO:0043168 anion binding 29.1667 4 no
GO:0000166 nucleotide binding 20.8333 4 no
GO:0005524 ATP binding 20.8333 5 no
GO:0016301 kinase activity 20.8333 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 20.8333 4 no
GO:0017076 purine nucleotide binding 20.8333 5 no
GO:0030554 adenyl nucleotide binding 20.8333 6 no
GO:0032555 purine ribonucleotide binding 20.8333 4 no
GO:0032559 adenyl ribonucleotide binding 20.8333 5 no
GO:0035639 purine ribonucleoside triphosphate binding 20.8333 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 20.8333 5 no
GO:0030695 GTPase regulator activity 20.8333 4 no
GO:0019900 kinase binding 20.8333 4 no
GO:0030165 PDZ domain binding 12.5000 4 yes
GO:0031267 small GTPase binding 12.5000 5 yes
GO:0051020 GTPase binding 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRASP_HUMAN
GO:0010646 regulation of cell communication 66.6667 4 no
GO:0048522 positive regulation of cellular process 58.3333 4 no
GO:0009966 regulation of signal transduction 54.1667 4 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:0048523 negative regulation of cellular process 45.8333 4 no
GO:0051049 regulation of transport 41.6667 4 yes
GO:0031323 regulation of cellular metabolic process 41.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:0080090 regulation of primary metabolic process 41.6667 4 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0050804 modulation of chemical synaptic transmission 37.5000 5 no
GO:0099177 regulation of trans-synaptic signaling 37.5000 4 no
GO:0007268 chemical synaptic transmission 33.3333 7 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0098916 anterograde trans-synaptic signaling 33.3333 6 no
GO:0099536 synaptic signaling 33.3333 4 no
GO:0099537 trans-synaptic signaling 33.3333 5 no
GO:0060627 regulation of vesicle-mediated transport 29.1667 4 yes
GO:0010648 negative regulation of cell communication 29.1667 5 no
GO:0023057 negative regulation of signaling 29.1667 4 no
GO:0048585 negative regulation of response to stimulus 29.1667 4 no
GO:0009967 positive regulation of signal transduction 29.1667 5 no
GO:0010647 positive regulation of cell communication 29.1667 5 no
GO:0023056 positive regulation of signaling 29.1667 4 no
GO:0048584 positive regulation of response to stimulus 29.1667 4 no
GO:0010562 positive regulation of phosphorus metabolic process 29.1667 6 no
GO:0019220 regulation of phosphate metabolic process 29.1667 6 no
GO:0031399 regulation of protein modification process 29.1667 6 no
GO:0031401 positive regulation of protein modification process 29.1667 7 no
GO:0043085 positive regulation of catalytic activity 29.1667 4 no
GO:0045937 positive regulation of phosphate metabolic process 29.1667 7 no
GO:0051174 regulation of phosphorus metabolic process 29.1667 5 no
GO:0051247 positive regulation of protein metabolic process 29.1667 6 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0030155 regulation of cell adhesion 25.0000 4 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 25.0000 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 25.0000 9 no
GO:0032880 regulation of protein localization 20.8333 5 yes
GO:0060341 regulation of cellular localization 20.8333 4 yes
GO:0070201 regulation of establishment of protein localization 20.8333 6 yes
GO:0009968 negative regulation of signal transduction 20.8333 5 no
GO:0010605 negative regulation of macromolecule metabolic process 20.8333 5 no
GO:0016310 phosphorylation 20.8333 5 no
GO:0043086 negative regulation of catalytic activity 20.8333 4 no
GO:0051240 positive regulation of multicellular organismal process 20.8333 4 no
GO:0051336 regulation of hydrolase activity 20.8333 4 no
GO:0045785 positive regulation of cell adhesion 20.8333 5 no
GO:0051056 regulation of small GTPase mediated signal transduction 20.8333 6 no
GO:0006996 organelle organization 20.8333 4 no
GO:0010243 response to organonitrogen compound 20.8333 4 no
GO:0022603 regulation of anatomical structure morphogenesis 20.8333 4 no
GO:0030334 regulation of cell migration 20.8333 5 no
GO:0031324 negative regulation of cellular metabolic process 20.8333 5 no
GO:0031344 regulation of cell projection organization 20.8333 5 no
GO:0032101 regulation of response to external stimulus 20.8333 4 no
GO:0034330 cell junction organization 20.8333 4 no
GO:0051050 positive regulation of transport 20.8333 4 no
GO:0051130 positive regulation of cellular component organization 20.8333 5 no
GO:0071310 cellular response to organic substance 20.8333 4 no
GO:0080134 regulation of response to stress 20.8333 4 no
GO:2000145 regulation of cell motility 20.8333 4 no
GO:0032386 regulation of intracellular transport 16.6667 5 yes
GO:0051223 regulation of protein transport 16.6667 5 yes
GO:0033157 regulation of intracellular protein transport 12.5000 6 yes
GO:1905475 regulation of protein localization to membrane 12.5000 6 yes
GO:1902473 regulation of protein localization to synapse 8.3333 6 yes
GO:1902683 regulation of receptor localization to synapse 8.3333 4 yes
GO:1903076 regulation of protein localization to plasma membrane 8.3333 7 yes
GO:1904375 regulation of protein localization to cell periphery 8.3333 6 yes
GO:1905749 regulation of endosome to plasma membrane protein transport 8.3333 6 yes
GO:2001135 regulation of endocytic recycling 8.3333 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CYH2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP3_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
APBA2_HUMAN [view interactions] Low throughput no yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM3_HUMAN [view entry] [view interactions] Low throughput yes no
GBRB2_HUMAN [view entry] [view interactions] Low throughput yes no
CYH3_HUMAN [view entry] [view interactions] Low throughput yes yes
PSD1_HUMAN [view entry] [view interactions] Low throughput yes no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
KSYK_HUMAN [view interactions] Low throughput no no
DOCK1_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
GLU2B_HUMAN [view interactions] High throughput no yes
FCSD2_HUMAN [view interactions] High throughput no no
ZHX1_HUMAN [view interactions] High throughput no no
ZBTB5_HUMAN [view interactions] High throughput no yes
CEP83_HUMAN [view interactions] High throughput no yes
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
AFF1_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ACE2_HUMAN [view interactions] High throughput no no
FRY_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
AFF2_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A1_HUMAN [view entry] [view interactions] High throughput yes yes