Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRB2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed, PubMed, PubMed, PubMed). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed, PubMed). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer . The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (PubMed, PubMed). Functions also as histamine receptor and mediates cellular responses to histamine . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRB2_HUMAN
GO:0016917 GABA receptor activity 56.2500 4 yes
GO:0004890 GABA-A receptor activity 50.0000 5 yes
GO:0005216 ion channel activity 50.0000 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 50.0000 6 yes
GO:0005253 anion channel activity 50.0000 5 yes
GO:0005254 chloride channel activity 50.0000 6 yes
GO:0008509 anion transmembrane transporter activity 50.0000 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 50.0000 4 yes
GO:0015108 chloride transmembrane transporter activity 50.0000 5 yes
GO:0015267 channel activity 50.0000 4 yes
GO:0015276 ligand-gated ion channel activity 50.0000 5 yes
GO:0022824 transmitter-gated ion channel activity 50.0000 5 yes
GO:0022834 ligand-gated channel activity 50.0000 6 yes
GO:0022835 transmitter-gated channel activity 50.0000 4 yes
GO:0022836 gated channel activity 50.0000 5 yes
GO:0022851 GABA-gated chloride ion channel activity 50.0000 5 yes
GO:0099095 ligand-gated anion channel activity 50.0000 6 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 43.7500 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 43.7500 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 43.7500 6 yes
GO:0005237 inhibitory extracellular ligand-gated ion channel activity 37.5000 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GBRB2_HUMAN
GO:0099537 trans-synaptic signaling 62.5000 4 yes
GO:0098916 anterograde trans-synaptic signaling 56.2500 5 yes
GO:0006811 ion transport 56.2500 4 yes
GO:0007268 chemical synaptic transmission 56.2500 6 yes
GO:0098656 anion transmembrane transport 50.0000 4 yes
GO:0098660 inorganic ion transmembrane transport 50.0000 4 yes
GO:0098661 inorganic anion transmembrane transport 50.0000 5 yes
GO:1902476 chloride transmembrane transport 50.0000 6 yes
GO:0006820 anion transport 50.0000 5 yes
GO:0006821 chloride transport 50.0000 7 yes
GO:0015698 inorganic anion transport 50.0000 6 yes
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0007416 synapse assembly 43.7500 6 yes
GO:0034329 cell junction assembly 43.7500 5 yes
GO:0034330 cell junction organization 43.7500 4 yes
GO:0050808 synapse organization 43.7500 5 yes
GO:1904862 inhibitory synapse assembly 37.5000 7 yes
GO:0010243 response to organonitrogen compound 37.5000 4 yes
GO:0051932 synaptic transmission, GABAergic 37.5000 7 yes
GO:0071310 cellular response to organic substance 37.5000 4 yes
GO:0071420 cellular response to histamine 31.2500 5 yes
GO:1901699 cellular response to nitrogen compound 31.2500 4 yes
GO:0009893 positive regulation of metabolic process 31.2500 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.2500 5 no
GO:0010646 regulation of cell communication 31.2500 4 no
GO:0060078 regulation of postsynaptic membrane potential 31.2500 4 no
GO:0060255 regulation of macromolecule metabolic process 31.2500 4 no
GO:0014070 response to organic cyclic compound 31.2500 4 yes
GO:0034776 response to histamine 31.2500 5 yes
GO:0048523 negative regulation of cellular process 31.2500 4 yes
GO:0071407 cellular response to organic cyclic compound 31.2500 5 yes
GO:0071417 cellular response to organonitrogen compound 31.2500 4 yes
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0048522 positive regulation of cellular process 25.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 25.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0010941 regulation of cell death 18.7500 4 yes
GO:0042981 regulation of apoptotic process 18.7500 6 yes
GO:0043067 regulation of programmed cell death 18.7500 5 yes
GO:0048666 neuron development 18.7500 4 yes
GO:1901214 regulation of neuron death 12.5000 5 yes
GO:1901215 negative regulation of neuron death 12.5000 6 yes
GO:0007600 sensory perception 12.5000 4 yes
GO:0007605 sensory perception of sound 12.5000 6 yes
GO:0043066 negative regulation of apoptotic process 12.5000 7 yes
GO:0043069 negative regulation of programmed cell death 12.5000 6 yes
GO:0043523 regulation of neuron apoptotic process 12.5000 6 yes
GO:0043524 negative regulation of neuron apoptotic process 12.5000 7 yes
GO:0050954 sensory perception of mechanical stimulus 12.5000 5 yes
GO:0060119 inner ear receptor cell development 12.5000 5 yes
GO:0060548 negative regulation of cell death 12.5000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RHG32_HUMAN [view entry] [view interactions] Low throughput yes yes
BIG2_HUMAN [view entry] [view interactions] Low throughput yes yes
C1QBP_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRA1_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAK2_HUMAN [view interactions] Low throughput no yes
UBQL1_HUMAN [view interactions] Low throughput no yes
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] Low throughput yes yes
NPTN_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
GBRB2_HUMAN [view entry] [view interactions] Low throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
GBRB3_HUMAN [view entry] [view interactions] High throughput yes no
ARHGP_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes
GBRA2_HUMAN [view entry] [view interactions] High throughput yes no
GBRA6_HUMAN [view entry] [view interactions] Computational yes no
GBRB1_HUMAN [view entry] [view interactions] Computational yes no
GABR2_HUMAN [view entry] [view interactions] Computational yes yes