GBRB2_HUMAN
Evidence for PS localization
Functions
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed, PubMed, PubMed, PubMed). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed, PubMed). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer . The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (PubMed, PubMed). Functions also as histamine receptor and mediates cellular responses to histamine . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBRB2_HUMAN |
|---|---|---|---|---|
| GO:0004890 | GABA-A receptor activity | 43.7500 | 5 | yes |
| GO:0005216 | monoatomic ion channel activity | 43.7500 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 43.7500 | 6 | yes |
| GO:0005253 | monoatomic anion channel activity | 43.7500 | 5 | yes |
| GO:0005254 | chloride channel activity | 43.7500 | 6 | yes |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 43.7500 | 4 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 43.7500 | 4 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 43.7500 | 5 | yes |
| GO:0015267 | channel activity | 43.7500 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 43.7500 | 5 | yes |
| GO:0016917 | GABA receptor activity | 43.7500 | 4 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 43.7500 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 43.7500 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 43.7500 | 4 | yes |
| GO:0022836 | gated channel activity | 43.7500 | 5 | yes |
| GO:0022851 | GABA-gated chloride ion channel activity | 43.7500 | 6 | yes |
| GO:0099095 | ligand-gated monoatomic anion channel activity | 43.7500 | 6 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 31.2500 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 31.2500 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 31.2500 | 6 | yes |
| GO:0005237 | inhibitory extracellular ligand-gated monoatomic ion channel activity | 25.0000 | 7 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBRB2_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 56.2500 | 4 | yes |
| GO:0006811 | monoatomic ion transport | 50.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 50.0000 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 6 | yes |
| GO:0099536 | synaptic signaling | 50.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 50.0000 | 5 | yes |
| GO:0006820 | monoatomic anion transport | 43.7500 | 5 | yes |
| GO:0006821 | chloride transport | 43.7500 | 5 | yes |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | 43.7500 | 4 | yes |
| GO:0007416 | synapse assembly | 43.7500 | 6 | yes |
| GO:0015698 | inorganic anion transport | 43.7500 | 4 | yes |
| GO:0034329 | cell junction assembly | 43.7500 | 5 | yes |
| GO:0034330 | cell junction organization | 43.7500 | 4 | yes |
| GO:0050808 | synapse organization | 43.7500 | 5 | yes |
| GO:0051932 | synaptic transmission, GABAergic | 43.7500 | 8 | yes |
| GO:0098656 | monoatomic anion transmembrane transport | 43.7500 | 4 | yes |
| GO:0098661 | inorganic anion transmembrane transport | 43.7500 | 4 | yes |
| GO:1902476 | chloride transmembrane transport | 43.7500 | 5 | yes |
| GO:0010646 | regulation of cell communication | 43.7500 | 4 | no |
| GO:1904862 | inhibitory synapse assembly | 37.5000 | 7 | yes |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.5000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.5000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.5000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 31.2500 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 31.2500 | 4 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 31.2500 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.2500 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.2500 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 31.2500 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 31.2500 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | yes |
| GO:0034776 | response to histamine | 25.0000 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 25.0000 | 5 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 25.0000 | 4 | yes |
| GO:0071420 | cellular response to histamine | 25.0000 | 5 | yes |
| GO:1901699 | cellular response to nitrogen compound | 25.0000 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 25.0000 | 7 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0048666 | neuron development | 12.5000 | 4 | yes |
| GO:0060119 | inner ear receptor cell development | 12.5000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RHG32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAK2_HUMAN | [view interactions] | Low throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRASP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARHGP_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTK7_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| GBRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |